Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation

Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier

(2021) Yelixza I. Avila et al.   MOLECULES

In Situ Covalent Functionalization of DNA Origami Virus-like Particles

(2021) Grant A. Knappe et al.   ACS Nano

Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)

(2021) Weina Ke et al.   ADVANCED DRUG DELIVERY REVIEWS

Nucleic acid nanoparticles (NANPs) as molecular tools to direct desirable and avoid undesirable immunological effects

(2021) M. Brittany Johnson et al.   ADVANCED DRUG DELIVERY REVIEWS

Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine—Specific Cancer Targeting with Undetectable Toxicity

(2021) Daniel W. Binzel et al.   CHEMICAL REVIEWS

The Recognition of and Reactions to Nucleic Acid Nanoparticles by Human Immune Cells

(2021) Dominika Bila et al.   MOLECULES

2021: an immunotherapy odyssey and the rise of nucleic acid nanotechnology

(2021) Martin Panigaj et al.   Nanomedicine

Rapid prototyping of arbitrary 2D and 3D wireframe DNA origami

(2021) Hyungmin Jun et al.   NUCLEIC ACIDS RESEARCH

Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells

(2020) M. Brittany Johnson et al.   Journal of Neuroinflammation

Challenges to optimizing RNA nanostructures for large scale production and controlled therapeutic properties

(2020) Morgan Chandler et al.   Nanomedicine

Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology

(2020) Kirill A. Afonin et al.   ACS Nano

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

(2020) Rémi Veneziano et al.   Nature Nanotechnology

Opportunities and challenges for the clinical translation of structured DNA assemblies as gene therapeutic delivery and vaccine vectors

(2020) Marina A. Dobrovolskaia et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

A DNA nanodevice-based vaccine for cancer immunotherapy

(2020) Shaoli Liu et al.   NATURE MATERIALS

Use of human peripheral blood mononuclear cells to define immunological properties of nucleic acid nanoparticles

(2020) Marina A. Dobrovolskaia et al.   Nature Protocols

The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification

(2020) Morgan Brittany Johnson et al.   NUCLEIC ACIDS RESEARCH

Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells

(2019) Enping Hong et al.   MOLECULES

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

Genetically Encoded, Functional Single‐Strand RNA Origami: Anticoagulant

(2019) Abhichart Krissanaprasit et al.   ADVANCED MATERIALS

Programming Structured DNA Assemblies to Probe Biophysical Processes

(2019) Eike-Christian Wamhoff et al.   Annual Review of Biophysics

Care for Rare: Spotlight on Rare Diseases

(2019) Kusumika Mukherjee   TRENDS IN PHARMACOLOGICAL SCIENCES

National Cancer Institute Alliance for nanotechnology in cancer—Catalyzing research and translation toward novel cancer diagnostics and therapeutics

(2019) Christopher M. Hartshorn et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Bioproduction of pure, kilobase-scale single-stranded DNA

(2019) Tyson R. Shepherd et al.   Scientific Reports

NCI Centers of Cancer Nanotechnology Excellence (CCNEs) – A full story to set the record straight

(2019) Piotr Grodzinski   JOURNAL OF CONTROLLED RELEASE

Tuning the size, shape and structure of RNA nanoparticles for favorable cancer targeting and immunostimulation

(2019) Sijin Guo et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

(2019) Martin Panigaj et al.   ACS Nano

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

(2019) Na Kong et al.   Science Translational Medicine

Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology

(2019) Yuhua Weng et al.   Molecular Therapy-Nucleic Acids

Innate immune responses triggered by nucleic acids inspire the design of immunomodulatory nucleic acid nanoparticles (NANPs)

(2019) Morgan Chandler et al.   CURRENT OPINION IN BIOTECHNOLOGY

An RNA Origami Octahedron with Intrinsic siRNAs for Potent Gene Knockdown

(2018) Hans Christian Høiberg et al.   Biotechnology Journal

Dynamic Behavior of RNA Nanoparticles Analyzed by AFM on a Mica/Air Interface

(2018) Sameer Sajja et al.   LANGMUIR

A DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy

(2018) Jianbing Liu et al.   NANO LETTERS

Structure and Composition Define Immunorecognition of Nucleic Acid Nanoparticles

(2018) Enping Hong et al.   NANO LETTERS

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

An RNA Origami Octahedron with Intrinsic siRNAs for Potent Gene Knockdown

(2018) Hans Christian Høiberg et al.   Biotechnology Journal

The Oligonucleotide Safety Working Group (OSWG)

(2018) Dave Schubert et al.   Nucleic Acid Therapeutics

Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers

(2018) Mikhail Durymanov et al.   Frontiers in Pharmacology

RNA Fibers as Optimized Nanoscaffolds for siRNA Coordination and Reduced Immunological Recognition

(2018) Lauren Rackley et al.   ADVANCED FUNCTIONAL MATERIALS

Rationally Designed DNA-Origami Nanomaterials for Drug Delivery In Vivo

(2018) Qiao Jiang et al.   ADVANCED MATERIALS

RNA–DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-κB in human cells

(2018) Weina Ke et al.   NUCLEIC ACIDS RESEARCH

FDA-Approved Oligonucleotide Therapies in 2017

(2017) Cy A. Stein et al.   MOLECULAR THERAPY

Versatile RNA tetra-U helix linking motif as a toolkit for nucleic acid nanotechnology

(2017) My N. Bui et al.   Nanomedicine-Nanotechnology Biology and Medicine

Biotechnological mass production of DNA origami

(2017) Florian Praetorius et al.   NATURE

Delivery technologies for genome editing

(2017) Hao Yin et al.   NATURE REVIEWS DRUG DISCOVERY

Programmable Nucleic Acid Based Polygons with Controlled Neuroimmunomodulatory Properties for Predictive QSAR Modeling

(2017) Morgan Brittany Johnson et al.   Small

Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

(2017) Nandhini Ponnuswamy et al.   Nature Communications

Protein Coating of DNA Nanostructures for Enhanced Stability and Immunocompatibility

(2017) Henni Auvinen et al.   Advanced Healthcare Materials

A Simple and Cost-Effective Approach for In Vitro Production of Sliced siRNAs as Potent Triggers for RNAi

(2017) Guihua Sun et al.   Molecular Therapy-Nucleic Acids

DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior

(2016) Cathal J. Kearney et al.   ADVANCED MATERIALS

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

Designer nanoscale DNA assemblies programmed from the top down

(2016) R. Veneziano et al.   SCIENCE

Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology

(2015) Dan Shu et al.   ACS Nano

Delivery of RNA Nanoparticles into Colorectal Cancer Metastases Following Systemic Administration

(2015) Piotr Rychahou et al.   ACS Nano

Daunorubicin-Loaded DNA Origami Nanostructures Circumvent Drug-Resistance Mechanisms in a Leukemia Model

(2015) Patrick D. Halley et al.   Small

Oligo Safety Working Group Exaggerated Pharmacology Subcommittee Consensus Document

(2015) Doug Kornbrust et al.   Nucleic Acid Therapeutics

In Silico Design and Enzymatic Synthesis of Functional RNA Nanoparticles

(2014) Kirill A. Afonin et al.   ACCOUNTS OF CHEMICAL RESEARCH

DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy

(2014) Qian Zhang et al.   ACS Nano

Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles

(2014) Kirill A. Afonin et al.   ACS Nano

Multifunctional RNA Nanoparticles

(2014) Kirill A. Afonin et al.   NANO LETTERS

Considerations for Assessment of Reproductive and Developmental Toxicity of Oligonucleotide-Based Therapeutics

(2014) Joy Cavagnaro et al.   Nucleic Acid Therapeutics

Stable RNA nanoparticles as potential new generation drugs for cancer therapy

(2013) Yi Shu et al.   ADVANCED DRUG DELIVERY REVIEWS

Activation of different split functionalities on re-association of RNA–DNA hybrids

(2013) Kirill A. Afonin et al.   Nature Nanotechnology

Co-transcriptional production of RNA–DNA hybrids for simultaneous release of multiple split functionalities

(2013) Kirill A. Afonin et al.   NUCLEIC ACIDS RESEARCH

DNA Origami as a Carrier for Circumvention of Drug Resistance

(2012) Qiao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

Design and self-assembly of siRNA-functionalized RNA nanoparticles for use in automated nanomedicine

(2011) Kirill A Afonin et al.   Nature Protocols

The emerging field of RNA nanotechnology

(2010) Peixuan Guo   Nature Nanotechnology