Use of human peripheral blood mononuclear cells to define immunological properties of nucleic acid nanoparticles

Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells

(2019) Enping Hong et al.   MOLECULES

Rational vaccinology with spherical nucleic acids

(2019) Shuya Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smart-Responsive Nucleic Acid Nanoparticles (NANPs) with the Potential to Modulate Immune Behavior

(2019) Chandler et al.   Nanomaterials

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

(2019) Martin Panigaj et al.   ACS Nano

Nucleic Acid Nanoparticles at a Crossroads of Vaccines and Immunotherapies

(2019) Marina A. Dobrovolskaia   MOLECULES

A cationic amphiphilic co-polymer as a carrier of nucleic acid nanoparticles (Nanps) for controlled gene silencing, immunostimulation, and biodistribution

(2019) Justin R. Halman et al.   Nanomedicine-Nanotechnology Biology and Medicine

Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology

(2019) Yuhua Weng et al.   Molecular Therapy-Nucleic Acids

Innate immune responses triggered by nucleic acids inspire the design of immunomodulatory nucleic acid nanoparticles (NANPs)

(2019) Morgan Chandler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Addressing barriers to effective cancer immunotherapy with nanotechnology: achievements, challenges, and roadmap to the next generation of nanoimmunotherapeutics

(2018) Enping Hong et al.   ADVANCED DRUG DELIVERY REVIEWS

Recent advances in DNA nanotechnology

(2018) Pongphak Chidchob et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Dynamic Behavior of RNA Nanoparticles Analyzed by AFM on a Mica/Air Interface

(2018) Sameer Sajja et al.   LANGMUIR

Structure and Composition Define Immunorecognition of Nucleic Acid Nanoparticles

(2018) Enping Hong et al.   NANO LETTERS

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pre-existing anti-polyethylene glycol antibody reduces the therapeutic efficacy and pharmacokinetics of PEGylated liposomes

(2018) Yuan-Chin Hsieh et al.   Theranostics

Magnetic nanoparticles loaded with functional RNA nanoparticles

(2018) Melissa Cruz-Acuña et al.   Nanoscale

RNA–DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-κB in human cells

(2018) Weina Ke et al.   NUCLEIC ACIDS RESEARCH

Composing RNA Nanostructures from a Syntax of RNA Structural Modules

(2017) Cody Geary et al.   NANO LETTERS

Versatile RNA tetra-U helix linking motif as a toolkit for nucleic acid nanotechnology

(2017) My N. Bui et al.   Nanomedicine-Nanotechnology Biology and Medicine

Programmable Nucleic Acid Based Polygons with Controlled Neuroimmunomodulatory Properties for Predictive QSAR Modeling

(2017) Morgan Brittany Johnson et al.   Small

Postmarketing safety surveillance of trivalent recombinant influenza vaccine: Reports to the Vaccine Adverse Event Reporting System

(2017) Emily Jane Woo et al.   VACCINE

Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery

(2017) Kelsey A. Gregg et al.   mBio

A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol

(2017) Chia-Jung Chang et al.   Nature Communications

Role of Type I and II Interferons in Colorectal Cancer and Melanoma

(2017) Simone Di Franco et al.   Frontiers in Immunology

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

(2016) Bing-Mae Chen et al.   ANALYTICAL CHEMISTRY

Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles

(2016) Mark A. Boerneke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ring Catalog: A resource for designing self-assembling RNA nanostructures

(2016) Lorena Parlea et al.   METHODS

The RNA 3D Motif Atlas: Computational methods for extraction, organization and evaluation of RNA motifs

(2016) Lorena G. Parlea et al.   METHODS

Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures

(2016) Djin-Ye Oh et al.   MOLECULAR & CELLULAR PROTEOMICS

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

Multistrand Structure Prediction of Nucleic Acid Assemblies and Design of RNA Switches

(2016) Eckart Bindewald et al.   NANO LETTERS

Pre-clinical immunotoxicity studies of nanotechnology-formulated drugs: Challenges, considerations and strategy

(2015) Marina A. Dobrovolskaia   JOURNAL OF CONTROLLED RELEASE

Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials — Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm

(2015) S. Vessillier et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Investigations of Interferon-Lambda for the Treatment of Cancer

(2015) Andrew Stiff et al.   Journal of Innate Immunity

RNA as a stable polymer to build controllable and defined nanostructures for material and biomedical applications

(2015) Hui Li et al.   Nano Today

Immunomodulatory spherical nucleic acids

(2015) Aleksandar F. Radovic-Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anticancer Cytokines: Biology and Clinical Effects of Interferon-α2, Interleukin (IL)-2, IL-15, IL-21, and IL-12

(2015) Theofanis Floros et al.   SEMINARS IN ONCOLOGY

Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification

(2015) Amy Chan et al.   Molecular Therapy-Nucleic Acids

Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles

(2014) Kirill A. Afonin et al.   ACS Nano

Multifunctional RNA Nanoparticles

(2014) Kirill A. Afonin et al.   NANO LETTERS

Enhancing immunomodulation on innate immunity by shape transition among RNA triangle, square and pentagon nanovehicles

(2014) Emil F. Khisamutdinov et al.   NUCLEIC ACIDS RESEARCH

A DNA Nanostructure Platform for Directed Assembly of Synthetic Vaccines

(2012) Xiaowei Liu et al.   NANO LETTERS

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides

(2011) Jiang Li et al.   ACS Nano

Polyvalent Immunostimulatory Nanoagents with Self-Assembled CpG Oligonucleotide-Conjugated Gold Nanoparticles

(2011) Min Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic RNA–protein complex shaped like an equilateral triangle

(2011) Hirohisa Ohno et al.   Nature Nanotechnology

Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics

(2011) Dan Shu et al.   Nature Nanotechnology

Design and self-assembly of siRNA-functionalized RNA nanoparticles for use in automated nanomedicine

(2011) Kirill A Afonin et al.   Nature Protocols

Self-assembling RNA square

(2011) S. M. Dibrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro assembly of cubic RNA-based scaffolds designed in silico

(2010) Kirill A. Afonin et al.   Nature Nanotechnology

MyD88 and interferon-α/β are differentially required for dendritic cell maturation but dispensable for development of protective memory againstListeria

(2009) Miguel A. Tam et al.   IMMUNOLOGY

Modeling HIV persistence, the latent reservoir, and viral blips

(2009) Libin Rong et al.   JOURNAL OF THEORETICAL BIOLOGY

Addition of interferon-alpha to a standard maturation cocktail induces CD38 up-regulation and increases dendritic cell function

(2009) Redas Trepiakas et al.   VACCINE