Challenges to optimizing RNA nanostructures for large scale production and controlled therapeutic properties

Optimization of the Split-Spinach Aptamer for Monitoring Nanoparticle Assembly Involving Multiple Contiguous RNAs

(2019) Jack O’Hara et al.   Nanomaterials

Detection of Endotoxin in Nano-formulations Using Limulus Amoebocyte Lysate (LAL) Assays

(2019) Barry W. Neun et al.   Jove-Journal of Visualized Experiments

Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells

(2019) Enping Hong et al.   MOLECULES

Selective tissue targeting of synthetic nucleic acid drugs

(2019) Punit P. Seth et al.   JOURNAL OF CLINICAL INVESTIGATION

One-Pot Production of RNA Nanoparticles via Automated Processing and Self Assembly

(2019) Daniel L Jasinski et al.   ACS Nano

Multimodal Polysilsesquioxane Nanoparticles for Combinatorial Therapy and Gene Delivery in Triple-Negative Breast Cancer

(2019) Ridhima Juneja et al.   ACS Applied Materials & Interfaces

Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds

(2019) Floris A. S. Engelhardt et al.   ACS Nano

Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts

(2019) Jacob L. Litke et al.   NATURE BIOTECHNOLOGY

Smart-Responsive Nucleic Acid Nanoparticles (NANPs) with the Potential to Modulate Immune Behavior

(2019) Chandler et al.   Nanomaterials

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

(2019) Martin Panigaj et al.   ACS Nano

A cationic amphiphilic co-polymer as a carrier of nucleic acid nanoparticles (Nanps) for controlled gene silencing, immunostimulation, and biodistribution

(2019) Justin R. Halman et al.   Nanomedicine-Nanotechnology Biology and Medicine

Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology

(2019) Yuhua Weng et al.   Molecular Therapy-Nucleic Acids

Innate immune responses triggered by nucleic acids inspire the design of immunomodulatory nucleic acid nanoparticles (NANPs)

(2019) Morgan Chandler et al.   CURRENT OPINION IN BIOTECHNOLOGY

A guide to large-scale RNA sample preparation

(2018) Lorenzo Baronti et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Structure and Composition Define Immunorecognition of Nucleic Acid Nanoparticles

(2018) Enping Hong et al.   NANO LETTERS

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vivo production of RNA nanostructures via programmed folding of single-stranded RNAs

(2018) Mo Li et al.   Nature Communications

Magnetic nanoparticles loaded with functional RNA nanoparticles

(2018) Melissa Cruz-Acuña et al.   Nanoscale

RNA Fibers as Optimized Nanoscaffolds for siRNA Coordination and Reduced Immunological Recognition

(2018) Lauren Rackley et al.   ADVANCED FUNCTIONAL MATERIALS

Biotechnological mass production of DNA origami

(2017) Florian Praetorius et al.   NATURE

Programmable Nucleic Acid Based Polygons with Controlled Neuroimmunomodulatory Properties for Predictive QSAR Modeling

(2017) Morgan Brittany Johnson et al.   Small

A Fluorescent Split Aptamer for Visualizing RNA–RNA Assembly In Vivo

(2017) Khalid K. Alam et al.   ACS Synthetic Biology

Advances in time course extracellular production of human pre-miR-29b from Rhodovulum sulfidophilum

(2016) Patrícia Pereira et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Ring Catalog: A resource for designing self-assembling RNA nanostructures

(2016) Lorena Parlea et al.   METHODS

Multistrand Structure Prediction of Nucleic Acid Assemblies and Design of RNA Switches

(2016) Eckart Bindewald et al.   NANO LETTERS

Cellular Delivery of RNA Nanoparticles

(2016) Lorena Parlea et al.   ACS Combinatorial Science

Fluorescence Blinking as an Output Signal for Biosensing

(2016) Brandon Roark et al.   ACS Sensors

In-Gel Imaging of RNA Processing Using Broccoli Reveals Optimal Aptamer Expression Strategies

(2015) Grigory S. Filonov et al.   CHEMISTRY & BIOLOGY

Strategy for selecting nanotechnology carriers to overcome immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics

(2015) Marina A Dobrovolskaia et al.   Expert Opinion on Drug Delivery

Rapid NMR screening of RNA secondary structure and binding

(2015) Christina Helmling et al.   JOURNAL OF BIOMOLECULAR NMR

Bolaamphiphiles as carriers for siRNA delivery: From chemical syntheses to practical applications

(2015) Kshitij Gupta et al.   JOURNAL OF CONTROLLED RELEASE

RNA as a stable polymer to build controllable and defined nanostructures for material and biomedical applications

(2015) Hui Li et al.   Nano Today

Oxime ether lipids containing hydroxylated head groups are more superior siRNA delivery agents than their nonhydroxylated counterparts

(2015) Kshitij Gupta et al.   Nanomedicine

Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification

(2015) Amy Chan et al.   Molecular Therapy-Nucleic Acids

Multifunctional RNA Nanoparticles

(2014) Kirill A. Afonin et al.   NANO LETTERS

Stable RNA nanoparticles as potential new generation drugs for cancer therapy

(2013) Yi Shu et al.   ADVANCED DRUG DELIVERY REVIEWS

A widespread self-cleaving ribozyme class is revealed by bioinformatics

(2013) Adam Roth et al.   Nature Chemical Biology

Activation of different split functionalities on re-association of RNA–DNA hybrids

(2013) Kirill A. Afonin et al.   Nature Nanotechnology

Co-transcriptional production of RNA–DNA hybrids for simultaneous release of multiple split functionalities

(2013) Kirill A. Afonin et al.   NUCLEIC ACIDS RESEARCH

In Silico, In Vitro, and In Vivo Studies Indicate the Potential Use of Bolaamphiphiles for Therapeutic siRNAs Delivery

(2013) Taejin Kim et al.   Molecular Therapy-Nucleic Acids

Co-transcriptional Assembly of Chemically Modified RNA Nanoparticles Functionalized with siRNAs

(2012) Kirill A. Afonin et al.   NANO LETTERS

A short adaptive path from DNA to RNA polymerases

(2012) C. Cozens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

A brief review of DNA and RNA chemical synthesis: Figure 1

(2011) Marvin H. Caruthers   BIOCHEMICAL SOCIETY TRANSACTIONS

Artificial RNA aptamer production by the marine bacterium Rhodovulum sulfidophilum: Improvement of the aptamer yield using a mutated transcriptional promoter

(2011) Hiromichi Suzuki et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Large scale expression and purification of recombinant RNA in Escherichia coli

(2011) Luc Ponchon et al.   METHODS

Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics

(2011) Dan Shu et al.   Nature Nanotechnology

Organization of Intracellular Reactions with Rationally Designed RNA Assemblies

(2011) C. J. Delebecque et al.   SCIENCE

The ARiBo tag: a reliable tool for affinity purification of RNAs under native conditions

(2010) Geneviève Di Tomasso et al.   NUCLEIC ACIDS RESEARCH

Extracellular Production of an RNA Aptamer by Ribonuclease-Free Marine Bacteria Harboring Engineered Plasmids: a Proposal for Industrial RNA Drug Production

(2009) H. Suzuki et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A generic protocol for the expression and purification of recombinant RNA in Escherichia coli using a tRNA scaffold

(2009) Luc Ponchon et al.   Nature Protocols