The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification

Characterization of Cationic Bolaamphiphile Vesicles for siRNA Delivery into Tumors and Brain

(2020) Taejin Kim et al.   Molecular Therapy-Nucleic Acids

Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells

(2020) M. Brittany Johnson et al.   Journal of Neuroinflammation

Challenges to optimizing RNA nanostructures for large scale production and controlled therapeutic properties

(2020) Morgan Chandler et al.   Nanomedicine

Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology

(2020) Kirill A. Afonin et al.   ACS Nano

Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells

(2019) Enping Hong et al.   MOLECULES

Multimodal Polysilsesquioxane Nanoparticles for Combinatorial Therapy and Gene Delivery in Triple-Negative Breast Cancer

(2019) Ridhima Juneja et al.   ACS Applied Materials & Interfaces

Smart-Responsive Nucleic Acid Nanoparticles (NANPs) with the Potential to Modulate Immune Behavior

(2019) Chandler et al.   Nanomaterials

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

(2019) Martin Panigaj et al.   ACS Nano

A cationic amphiphilic co-polymer as a carrier of nucleic acid nanoparticles (Nanps) for controlled gene silencing, immunostimulation, and biodistribution

(2019) Justin R. Halman et al.   Nanomedicine-Nanotechnology Biology and Medicine

Innate immune responses triggered by nucleic acids inspire the design of immunomodulatory nucleic acid nanoparticles (NANPs)

(2019) Morgan Chandler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Nucleic acids delivering nucleic acids

(2018) Silvia Catuogno et al.   ADVANCED DRUG DELIVERY REVIEWS

Combination and inducible adjuvants targeting nucleic acid sensors

(2018) Burcu Temizoz et al.   CURRENT OPINION IN PHARMACOLOGY

Structure and Composition Define Immunorecognition of Nucleic Acid Nanoparticles

(2018) Enping Hong et al.   NANO LETTERS

Magnetic nanoparticles loaded with functional RNA nanoparticles

(2018) Melissa Cruz-Acuña et al.   Nanoscale

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

(2018) Parisa Foroozandeh et al.   Nanoscale Research Letters

RNA–DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-κB in human cells

(2018) Weina Ke et al.   NUCLEIC ACIDS RESEARCH

Cytosolic nucleic acid sensors and innate immune regulation

(2017) Daisuke Ori et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Versatile RNA tetra-U helix linking motif as a toolkit for nucleic acid nanotechnology

(2017) My N. Bui et al.   Nanomedicine-Nanotechnology Biology and Medicine

Human microglia and astrocytes express cGAS-STING viral sensing components

(2017) Austin M. Jeffries et al.   NEUROSCIENCE LETTERS

Identification of an optimized 2′- O -methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8

(2017) Felix C.F. Schmitt et al.   RNA

Assessment and comparison of thermal stability of phosphorothioate-DNA, DNA, RNA, 2′-F RNA, and LNA in the context of Phi29 pRNA 3WJ

(2017) Xijun Piao et al.   RNA

Programmable Nucleic Acid Based Polygons with Controlled Neuroimmunomodulatory Properties for Predictive QSAR Modeling

(2017) Morgan Brittany Johnson et al.   Small

RNA versatility, flexibility, and thermostability for practice in RNA nanotechnology and biomedical applications

(2017) Farzin Haque et al.   Wiley Interdisciplinary Reviews-RNA

Size, Shape, and Sequence-Dependent Immunogenicity of RNA Nanoparticles

(2017) Sijin Guo et al.   Molecular Therapy-Nucleic Acids

Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system

(2016) Yoelvis Garcia-Mesa et al.   JOURNAL OF NEUROVIROLOGY

Programmable RNA microstructures for coordinated delivery of siRNAs

(2016) Jaimie Marie Stewart et al.   Nanoscale

2′Fluoro Modification Differentially Modulates the Ability of RNAs to Activate Pattern Recognition Receptors

(2016) Youngju Lee et al.   Nucleic Acid Therapeutics

Immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics

(2015) Marina A Dobrovolskaia et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant

(2015) Vladimir Beljanski et al.   JOURNAL OF VIROLOGY

Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles

(2014) Kirill A. Afonin et al.   ACS Nano

Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response

(2014) D. Olagnier et al.   JOURNAL OF VIROLOGY

Multifunctional RNA Nanoparticles

(2014) Kirill A. Afonin et al.   NANO LETTERS

Enhancing immunomodulation on innate immunity by shape transition among RNA triangle, square and pentagon nanovehicles

(2014) Emil F. Khisamutdinov et al.   NUCLEIC ACIDS RESEARCH

Nanoparticles as drug delivery systems

(2014) Agnieszka Z. Wilczewska et al.   Pharmacological Reports

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

TLR Agonists as Modulators of the Innate Immune Response and Their Potential as Agents Against Infectious Disease

(2014) Edin J. Mifsud et al.   Frontiers in Immunology

RIG-I Detects Triphosphorylated RNA of Listeria monocytogenes during Infection in Non-Immune Cells

(2013) Cristina Amparo Hagmann et al.   PLoS One

Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity

(2013) Marie-Line Goulet et al.   PLoS Pathogens

A Sendai Virus-Derived RNA Agonist of RIG-I as a Virus Vaccine Adjuvant

(2012) L. Martínez-Gil et al.   JOURNAL OF VIROLOGY

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Selection of Molecular Structure and Delivery of RNA Oligonucleotides to Activate TLR7 versus TLR8 and to Induce High Amounts of IL-12p70 in Primary Human Monocytes

(2009) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Nucleic Acids as Therapeutic Agents

(2008) Luis Alvarez-Salas   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemical Modification of siRNAs for In Vivo Use

(2008) Mark A. Behlke   OLIGONUCLEOTIDES

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE