An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

(2021) Sarah O'Keefe et al.   JOURNAL OF CELL SCIENCE

Molecular communication of the membrane insertase YidC with translocase SecYEG affects client proteins

(2021) Anja Steudle et al.   Scientific Reports

A clearer picture of the ER translocon complex

(2020) Max Gemmer et al.   JOURNAL OF CELL SCIENCE

Squaring the EMC – how promoting membrane protein biogenesis impacts cellular functions and organismal homeostasis

(2020) Norbert Volkmar et al.   JOURNAL OF CELL SCIENCE

Structural basis for membrane insertion by the human ER membrane protein complex

(2020) Tino Pleiner et al.   SCIENCE

The architecture of EMC reveals a path for membrane protein insertion

(2020) John P O'Donnell et al.   eLife

Structure of the Inhibited State of the Sec Translocon

(2020) Samuel F. Gérard et al.   MOLECULAR CELL

Structure of the ER membrane complex, a transmembrane-domain insertase

(2020) Lin Bai et al.   NATURE

Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F

(2020) Guanghui Zong et al.   JOURNAL OF ORGANIC CHEMISTRY

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

(2020) Lakshmi E Miller-Vedam et al.   eLife

Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions

(2019) Klemens Wild et al.   NUCLEIC ACIDS RESEARCH

The Role of EMC during Membrane Protein Biogenesis

(2019) Patrick J. Chitwood et al.   TRENDS IN CELL BIOLOGY

Membrane Protein Integration and Topogenesis at the ER

(2019) Martin Spiess et al.   PROTEIN JOURNAL

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

(2019) Guanghui Zong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Ways of Tails: the GET Pathway and more

(2019) Nica Borgese et al.   PROTEIN JOURNAL

Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex

(2019) Songhai Tian et al.   Cell Reports

Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature

(2018) Jean-David Morel et al.   MOLECULAR & CELLULAR PROTEOMICS

The interaction network of the YidC insertase with the SecYEG translocon, SRP and the SRP receptor FtsY

(2018) Narcis-Adrian Petriman et al.   Scientific Reports

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

(2018) Sarah Haßdenteufel et al.   Cell Reports

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease

(2018) Caroline Demangel et al.   BIOLOGY OF THE CELL

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

(2018) Patrick J. Chitwood et al.   CELL

hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells

(2017) Sarah Haßdenteufel et al.   FEBS LETTERS

EMC3 coordinates surfactant protein and lipid homeostasis required for respiration

(2017) Xiaofang Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Synergistic Contribution of Tiglate and Cinnamate to Cytotoxicity of Ipomoeassin F

(2017) Guanghui Zong et al.   JOURNAL OF ORGANIC CHEMISTRY

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

Sort of unexpected

(2016) Martin R. Pool   NATURE

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

(2016) Naama Aviram et al.   NATURE

Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo

(2016) Jhon Rivera-Monroy et al.   Scientific Reports

Role of the Cytosolic Loop C2 and the C Terminus of YidC in Ribosome Binding and Insertion Activity

(2015) Yanping Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Integral Membrane Protein Insertion and Folding

(2015) Florian Cymer et al.   JOURNAL OF MOLECULAR BIOLOGY

Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-Epimer

(2015) Guanghui Zong et al.   JOURNAL OF ORGANIC CHEMISTRY

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

(2015) Bhalchandra Jadhav et al.   Nature Communications

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

(2015) Takunori Satoh et al.   eLife

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex

(2013) Magali Richard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase

(2012) P. Roboti et al.   JOURNAL OF CELL SCIENCE

SGTA antagonizes BAG6-mediated protein triage

(2012) P. Leznicki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis

(2012) Raymond J Louie et al.   Genome Medicine

Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle

(2011) Thomas Welte et al.   MOLECULAR BIOLOGY OF THE CELL

SRP Keeps Polypeptides Translocation-Competent by Slowing Translation to Match Limiting ER-Targeting Sites

(2008) Asvin K.K. Lakkaraju et al.   CELL

Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins

(2008) V. Favaloro et al.   JOURNAL OF CELL SCIENCE