A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis

Functional Repurposing Revealed by Comparing S. pombe and S. cerevisiae Genetic Interactions

(2012) Adam Frost et al.   CELL

Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

(2012) N. Shyh-Chang et al.   SCIENCE

Conserved rules govern genetic interaction degree across species

(2012) Elizabeth N Koch et al.   GENOME BIOLOGY

Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis

(2011) Peter W. Bircham et al.   Molecular BioSystems

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

(2011) Fred A Wright et al.   NATURE GENETICS

The Cystic Fibrosis Transmembrane Conductance Regulator's Expanding SNARE Interactome

(2011) Bor Luen Tang et al.   TRAFFIC

Using Biological Knowledge to Uncover the Mystery in the Search for Epistasis in Genome-Wide Association Studies

(2010) Marylyn D. Ritchie   ANNALS OF HUMAN GENETICS

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

A Novel ER J-protein DNAJB12 Accelerates ER-associated Degradation of Membrane Proteins Including CFTR

(2010) Yo-hei Yamamoto et al.   CELL STRUCTURE AND FUNCTION

Recursive expectation-maximization clustering: A method for identifying buffering mechanisms composed of phenomic modules

(2010) Jingyu Guo et al.   CHAOS

Targets for cystic fibrosis therapy: proteomic analysis and correction of mutant cystic fibrosis transmembrane conductance regulator

(2010) James F Collawn et al.   Expert Review of Proteomics

Intragenic Suppressing Mutations Correct the Folding and Intracellular Traffic of Misfolded Mutants of Yor1p, a Eukaryotic Drug Transporter

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Functional Rescue of a Misfolded Eukaryotic ATP-binding Cassette Transporter by Domain Replacement

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The endoplasmic reticulum–associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3–dependent degradation of nascent CFTRΔF508

(2010) Diane E. Grove et al.   MOLECULAR BIOLOGY OF THE CELL

Estimation of effect size distribution from genome-wide association studies and implications for future discoveries

(2010) Ju-Hyun Park et al.   NATURE GENETICS

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

(2010) Anastasia Baryshnikova et al.   NATURE METHODS

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Systematic discovery of nonobvious human disease models through orthologous phenotypes

(2010) K. L. McGary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genotype to Phenotype: A Complex Problem

(2010) R. D. Dowell et al.   SCIENCE

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

(2010) T. Okiyoneda et al.   SCIENCE

Molecular networks as sensors and drivers of common human diseases

(2009) Eric E. Schadt   NATURE

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

(2009) Jian Wang et al.   SCIENCE

Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells

(2008) Frédéric Bilan et al.   EXPERIMENTAL CELL RESEARCH

Evolutionary plasticity of genetic interaction networks

(2008) Julia Tischler et al.   NATURE GENETICS

Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

(2008) Patrick C. Phillips   NATURE REVIEWS GENETICS

Defining genetic interaction

(2008) R. Mani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

(2008) S. J. Dixon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast

(2008) A. Roguev et al.   SCIENCE