Squaring the EMC – how promoting membrane protein biogenesis impacts cellular functions and organismal homeostasis

Pre-emptive Quality Control of a Misfolded Membrane Protein by Ribosome-Driven Effects

(2020) Ramya Lakshminarayan et al.   CURRENT BIOLOGY

Disrupted ER membrane protein complex–mediated topogenesis drives congenital neural crest defects

(2020) Jonathan Marquez et al.   JOURNAL OF CLINICAL INVESTIGATION

A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration

(2019) João P. L. Coelho et al.   Nature Communications

The Role of EMC during Membrane Protein Biogenesis

(2019) Patrick J. Chitwood et al.   TRENDS IN CELL BIOLOGY

The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection

(2019) David L. Lin et al.   Cell Reports

ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice

(2019) Liangyao Xiong et al.   CELL DEATH AND DIFFERENTIATION

Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex

(2019) Songhai Tian et al.   Cell Reports

The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins

(2019) Ashley M Ngo et al.   eLife

Evidence for interaction between Hsp90 and the ER membrane complex

(2018) Tambudzai Kudze et al.   CELL STRESS & CHAPERONES

Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control

(2018) Alina Guna et al.   CURRENT BIOLOGY

CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity

(2018) Nicholas J. Kramer et al.   NATURE GENETICS

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours

(2018) Miguel G. Toscano et al.   Frontiers in Immunology

The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms

(2018) Arvin B. Tam et al.   DEVELOPMENTAL CELL

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis

(2018) Norbert Volkmar et al.   JOURNAL OF CELL SCIENCE

Crystal structure of a membrane-bound O-acyltransferase

(2018) Dan Ma et al.   NATURE

Ubiquitin-dependent protein degradation at the endoplasmic reticulum and nuclear envelope

(2018) Adrian B. Mehrtash et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

EMC3 coordinates surfactant protein and lipid homeostasis required for respiration

(2017) Xiaofang Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the Unfolded Protein Response by Lipid Bilayer Stress

(2017) Kristina Halbleib et al.   MOLECULAR CELL

Mouse Genome Database (MGD)-2018: knowledgebase for the laboratory mouse

(2017) Cynthia L Smith et al.   NUCLEIC ACIDS RESEARCH

Loss-of-function mutation inMirta22/Emc10rescues specific schizophrenia-related phenotypes in a mouse model of the 22q11.2 deletion

(2017) Anastasia Diamantopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum

(2017) S. Andrei Anghel et al.   Cell Reports

A novel splice variant in EMC1 is associated with cerebellar atrophy, visual impairment, psychomotor retardation with epilepsy

(2017) Thenral S. Geetha et al.   Molecular Genetics & Genomic Medicine

Monoallelic and Biallelic Variants in EMC1 Identified in Individuals with Global Developmental Delay, Hypotonia, Scoliosis, and Cerebellar Atrophy

(2016) Tamar Harel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SLC25A46is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome

(2016) Alexandre Janer et al.   EMBO Molecular Medicine

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

(2016) Rong Zhang et al.   NATURE

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

(2016) Caleb D. Marceau et al.   NATURE

EMC6/TMEM93 suppresses glioblastoma proliferation by modulating autophagy

(2016) X Shen et al.   Cell Death & Disease

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

(2016) George Savidis et al.   Cell Reports

EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus

(2016) Parikshit Bagchi et al.   eLife

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components

(2015) Shriya Raj et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

Lipid-dependent regulation of the unfolded protein response

(2015) Romain Volmer et al.   CURRENT OPINION IN CELL BIOLOGY

Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway

(2015) Satoshi Ninagawa et al.   JOURNAL OF CELL BIOLOGY

1H NMR Metabolic Profiling of Plasma Reveals Additional Phenotypes in Knockout Mouse Models

(2015) Fay Probert et al.   JOURNAL OF PROTEOME RESEARCH

A YidC-like Protein in the Archaeal Plasma Membrane

(2015) Marta T. Borowska et al.   STRUCTURE

TRP and Rhodopsin Transport Depends on Dual XPORT ER Chaperones Encoded by an Operon

(2015) Zijing Chen et al.   Cell Reports

A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death

(2015) Hongming Ma et al.   Cell Reports

A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane

(2015) Madhu Sudhan Ravindran et al.   PLoS Pathogens

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

(2015) Takunori Satoh et al.   eLife

Human hematopoietic signal peptide-containing secreted 1 (hHSS1) modulates genes and pathways in glioma: implications for the regulation of tumorigenicity and angiogenesis

(2014) Katiana S Junes-Gill et al.   BMC CANCER

Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources

(2014) Gene-Wei Li et al.   CELL

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

A Conserved Endoplasmic Reticulum Membrane Protein Complex (EMC) Facilitates Phospholipid Transfer from the ER to Mitochondria

(2014) Sujoy Lahiri et al.   PLOS BIOLOGY

A Cytosolic Chaperone Complexes with Dynamic Membrane J-Proteins and Mobilizes a Nonenveloped Virus out of the Endoplasmic Reticulum

(2014) Christopher Paul Walczak et al.   PLoS Pathogens

Derepression of a Neuronal Inhibitor due to miRNA Dysregulation in a Schizophrenia-Related Microdeletion

(2013) Bin Xu et al.   CELL

β-Propeller Blades as Ancestral Peptides in Protein Evolution

(2013) Klaus O. Kopec et al.   PLoS One

Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex

(2013) Magali Richard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Biology of the Endoplasmic Reticulum and the Golgi Apparatus through Proteomics

(2013) J. Smirle et al.   Cold Spring Harbor Perspectives in Biology

A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy

(2012) Yanjun Li et al.   Autophagy

How do mutations in GJB1 cause X-linked Charcot–Marie–Tooth disease?

(2012) Kleopas A. Kleopa et al.   BRAIN RESEARCH

Autozygome-guided exome sequencing in retinal dystrophy patients reveals pathogenetic mutations and novel candidate disease genes

(2012) L. Abu-Safieh et al.   GENOME RESEARCH

The Mammalian Endoplasmic Reticulum-Associated Degradation System

(2012) J. A. Olzmann et al.   Cold Spring Harbor Perspectives in Biology

A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis

(2012) Raymond J Louie et al.   Genome Medicine

G Protein-Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication

(2012) Caroline Le Sommer et al.   PLoS Neglected Tropical Diseases

Mechanisms for quality control of misfolded transmembrane proteins

(2011) Scott A. Houck et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Role of the Endoplasmic Reticulum-associated Degradation (ERAD) Pathway in Degradation of Hepatitis C Virus Envelope Proteins and Production of Virus Particles

(2011) Mohsan Saeed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis

(2011) Peter W. Bircham et al.   Molecular BioSystems

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

(2011) Ethan J Greenblatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BiP and Multiple DNAJ Molecular Chaperones in the Endoplasmic Reticulum Are Required for Efficient Simian Virus 40 Infection

(2011) E. C. Goodwin et al.   mBio

hHSS1: a novel secreted factor and suppressor of glioma growth located at chromosome 19q13.33

(2010) Katiana S. Junes-Gill et al.   JOURNAL OF NEURO-ONCOLOGY

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response

(2009) Stefka D. Spassieva et al.   BIOCHEMICAL JOURNAL

Glycoproteomics Analysis of Human Liver Tissue by Combination of Multiple Enzyme Digestion and Hydrazide Chemistry

(2009) Rui Chen et al.   JOURNAL OF PROTEOME RESEARCH

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL

Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast

(2008) Giselle Ring et al.   FEBS LETTERS

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Membrane phospholipid synthesis and endoplasmic reticulum function

(2008) Paolo Fagone et al.   JOURNAL OF LIPID RESEARCH

RNA interference screen for human genes associated with West Nile virus infection

(2008) Manoj N. Krishnan et al.   NATURE

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2

(2007) Angela Goytain et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY