Effect of Reactive Oxygen Species on the Endoplasmic Reticulum and Mitochondria during Intracellular Pathogen Infection of Mammalian Cells

Functions of ROS in Macrophages and Antimicrobial Immunity

(2021) Marc Herb et al.   Antioxidants

From Flies to Men: ROS and the NADPH Oxidase in Phagocytes

(2021) Zohreh Mansoori Moghadam et al.   Frontiers in Cell and Developmental Biology

Spatial properties of reactive oxygen species govern pathogen-specific immune system responses

(2020) Eunice To et al.   ANTIOXIDANTS & REDOX SIGNALING

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Mitochondrial Functions in Infection and Immunity

(2020) Varnesh Tiku et al.   TRENDS IN CELL BIOLOGY

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases

(2020) Ji-Ae Choi et al.   Frontiers in Immunology

SARS-CoV-2 and viral sepsis: observations and hypotheses

(2020) Hui Li et al.   LANCET

Reciprocal Regulation of Mitochondrial Fission and Fusion

(2020) Rasha Sabouny et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hepatitis C Virus Proteins Core and NS5A Are Highly Sensitive to Oxidative Stress-Induced Degradation after eIF2α/ATF4 Pathway Activation

(2020) W. Alfredo Ríos-Ocampo et al.   Viruses-Basel

Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways

(2020) Chenyang Duan et al.   Cell Death & Disease

Mitochondrial reactive oxygen species as major effectors of antimicrobial immunity

(2020) Elena Shekhova   PLoS Pathogens

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

(2020) Jing Liu et al.   EBioMedicine

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

(2020) Rubens Cecchini et al.   MEDICAL HYPOTHESES

Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing

(2019) Yifan Zhang et al.   NATURE IMMUNOLOGY

Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

(2019) Ru‑Zhou Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit

(2019) Francisco J. Roca et al.   CELL

Reactive oxygen species‐mediated endoplasmic reticulum stress response induces apoptosis of Mycobacterium avium ‐infected macrophages by activating regulated IRE1‐dependent decay pathway

(2019) Dam Go et al.   CELLULAR MICROBIOLOGY

Hyperactivation of the NLRP3 inflammasome protects mice against influenza A virus infection via IL-1β mediated neutrophil recruitment

(2019) Junling Niu et al.   CYTOKINE

Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

(2019) Burgos-Morón et al.   Journal of Clinical Medicine

Selenium, Selenoproteins and Viral Infection

(2019) Olivia M. Guillin et al.   Nutrients

Mitofusin 2-Deficiency Suppresses Mycobacterium tuberculosis Survival in Macrophages

(2019) Junghwan Lee et al.   Cells

mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer

(2019) Karen Griselda de la Cruz López et al.   Frontiers in Oncology

Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1

(2018) Ik-Jung Kim et al.   Cell Host & Microbe

Targeting oxidant-dependent mechanisms for the treatment of respiratory diseases and their comorbidities

(2018) Neil C Thomson   CURRENT OPINION IN PHARMACOLOGY

TNF-α–mediated ER stress causes elimination of Mycobacterium fortuitum reservoirs by macrophage apoptosis

(2018) Sung-Man Oh et al.   FASEB JOURNAL

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

Mechanisms of Hemolysis During Sepsis

(2018) Katharina Effenberger-Neidnicht et al.   INFLAMMATION

Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion

(2018) Liming Yan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

(2018) Angelika S. Rambold et al.   TRENDS IN IMMUNOLOGY

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

(2018) Edgar Djaha Yoboue et al.   Cell Death & Disease

Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion

(2018) Liming Yan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria

(2018) Elodie Lobet et al.   Scientific Reports

Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism

(2018) Anusha Angajala et al.   Frontiers in Immunology

Phagocytosis influences the intracellular survival of Mycobacterium smegmatis via the endoplasmic reticulum stress response

(2018) Seon-Hwa Kim et al.   Cell and Bioscience

Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus

(2018) Basel H. Abuaita et al.   Cell Host & Microbe

The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders

(2018) Anuradha Tarafdar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria, Oxidative Stress and Innate Immunity

(2018) Yuxin Chen et al.   Frontiers in Physiology

The cellular stress response in hepatitis C virus infection: A balancing act to promote viral persistence and host cell survival

(2018) W. Alfredo Ríos-Ocampo et al.   VIRUS RESEARCH

Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin

(2017) Bin Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission

(2017) Suvagata Roy Chowdhury et al.   JOURNAL OF CELL BIOLOGY

Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies

(2017) Konstantinos Mantzarlis et al.   Oxidative Medicine and Cellular Longevity

Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives

(2017) Joanna Obacz et al.   Science Signaling

Evolutionary Convergence and Divergence in NLR Function and Structure

(2017) Etienne Meunier et al.   TRENDS IN IMMUNOLOGY

Calreticulin modulates the intracellular survival of mycobacteria by regulating ER-stress-mediated apoptosis

(2017) Sung Hee Jo et al.   Oncotarget

Altered mitochondrial dynamics as a consequence of Venezuelan Equine encephalitis virus infection

(2017) Forrest Keck et al.   Virulence

Small Molecule Mediated Restoration of Mitochondrial Function Augments Anti-Mycobacterial Activity of Human Macrophages Subjected to Cholesterol Induced Asymptomatic Dyslipidemia

(2017) Suman Asalla et al.   Frontiers in Cellular and Infection Microbiology

Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives

(2017) Joanna Obacz et al.   Science Signaling

Hepatitis C virus infection

(2017) Michael P. Manns et al.   Nature Reviews Disease Primers

The Concerted Action of Mitochondrial Dynamics and Positioning: New Characters in Cancer Onset and Progression

(2017) Diana Pendin et al.   Frontiers in Oncology

Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections

(2016) Zhenguang Li et al.   ARCHIVES OF VIROLOGY

Regulation of Mitofusin1 by Mahogunin Ring Finger-1 and the proteasome modulates mitochondrial fusion

(2016) Rukmini Mukherjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TLR9 mediates S. aureus killing inside osteoblasts via induction of oxidative stress

(2016) Walid Mohamed et al.   BMC MICROBIOLOGY

Targeting mitochondria: how intravacuolar bacterial pathogens manipulate mitochondria

(2016) Laura F. Fielden et al.   CELL AND TISSUE RESEARCH

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission

(2016) Laura D. Osellame et al.   JOURNAL OF CELL SCIENCE

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

(2016) Johan Garaude et al.   NATURE IMMUNOLOGY

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

The Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages

(2016) Ji-Ye Han et al.   Scientific Reports

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

Defective B-cell proliferation and maintenance of long-term memory in patients with chronic granulomatous disease

(2015) Nicola Cotugno et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Cellular stress responses in hepatitis C virus infection: Mastering a two-edged sword

(2015) Claudia Vasallo et al.   VIRUS RESEARCH

The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production

(2015) Basel H. Abuaita et al.   mBio

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus

(2015) Mao Xia et al.   Oncotarget

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Mycobacterium tuberculosis 38-kDa antigen induces endoplasmic reticulum stress-mediated apoptosis via toll-like receptor 2/4

(2014) Yun-Ji Lim et al.   APOPTOSIS

ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use

(2014) Rebeca Acín-Pérez et al.   Cell Metabolism

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

(2014) Arvind Panday et al.   Cellular & Molecular Immunology

Oxidative Stress in Cardiovascular Disease

(2014) Gábor Csányi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Redox controls UPR to control redox

(2014) D. Eletto et al.   JOURNAL OF CELL SCIENCE

Pneumococcal Hydrogen Peroxide–Induced Stress Signaling Regulates Inflammatory Genes

(2014) Maria Loose et al.   JOURNAL OF INFECTIOUS DISEASES

Mitophagy Enhances Oncolytic Measles Virus Replication by Mitigating DDX58/RIG-I-Like Receptor Signaling

(2014) M. Xia et al.   JOURNAL OF VIROLOGY

Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?

(2014) Jean Celli et al.   NATURE REVIEWS MICROBIOLOGY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Are Reactive Oxygen Species Always Detrimental to Pathogens?

(2013) Claudia N. Paiva et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Endoplasmic Reticulum Stress and Nox-Mediated Reactive Oxygen Species Signaling in the Peripheral Vasculature: Potential Role in Hypertension

(2013) Celio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

(2013) Krishnendu Sinha et al.   ARCHIVES OF TOXICOLOGY

A 28-kDa Splice Variant of NADPH Oxidase-4 Is Nuclear-Localized and Involved in Redox Signaling in Vascular Cells

(2013) Narayana Anilkumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of inositol 1,4,5-trisphosphate receptors during endoplasmic reticulum stress

(2013) Santeri Kiviluoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

(2013) Joshua H. Y. Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Red ginseng extract inhibits the expression of MCP-1 and iNOS in Helicobacter pylori-infected gastric epithelial cells by suppressing the activation of NADPH oxidase and Jak2/Stat3

(2013) Soon Ok Cho et al.   JOURNAL OF ETHNOPHARMACOLOGY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

(2013) Christopher Lupfer et al.   NATURE IMMUNOLOGY

HCV and Oxidative Stress in the Liver

(2013) Alexander Ivanov et al.   Viruses-Basel

Sensing of Bacterial Type IV Secretion via the Unfolded Protein Response

(2013) M. F. de Jong et al.   mBio

Characterizing virulence-specific perturbations in the mitochondrial function of macrophages infected with mycobacterium tuberculosis

(2013) Shilpa Jamwal et al.   Scientific Reports

Brucella Induces an Unfolded Protein Response via TcpB That Supports Intracellular Replication in Macrophages

(2013) Judith A. Smith et al.   PLoS Pathogens

Mycobacterium kansasii-induced death of murine macrophages involves endoplasmic reticulum stress responses mediated by reactive oxygen species generation or calpain activation

(2012) Yun-Ji Lim et al.   APOPTOSIS

Inhibition of HSV-1 by chemoattracted neutrophils: supernatants of corneal epithelial cells (HCE) and macrophages (THP-1) treated with virus components chemoattract neutrophils (PMN), and supernatants of PMN treated with these conditioned media inhibit viral growth

(2012) Kozaburo Hayashi et al.   ARCHIVES OF VIROLOGY

Monocyte chemotactic protein-induced protein (MCPIP) promotes inflammatory angiogenesis via sequential induction of oxidative stress, endoplasmic reticulum stress and autophagy

(2012) Arpita Roy et al.   CELLULAR SIGNALLING

Reactive Oxygen Production Induced by the Gut Microbiota: Pharmacotherapeutic Implications

(2012) R. M. Jones et al.   CURRENT MEDICINAL CHEMISTRY

Infections associated with chronic granulomatous disease: linking genetics to phenotypic expression

(2012) Josef Ben-Ari et al.   Expert Review of Anti-Infective Therapy

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

TLR7 and TLR9 in SLE: when sensing self goes wrong

(2012) T. Celhar et al.   IMMUNOLOGIC RESEARCH

An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases

(2012) Bidur Bhandary et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The TLR7/8 Agonist CL097 Primes N -Formyl-Methionyl-Leucyl-Phenylalanine–Stimulated NADPH Oxidase Activation in Human Neutrophils: Critical Role of p47phox Phosphorylation and the Proline Isomerase Pin1

(2012) Karama Makni-Maalej et al.   JOURNAL OF IMMUNOLOGY

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Ultraviolet radiation damages self noncoding RNA and is detected by TLR3

(2012) Jamie J Bernard et al.   NATURE MEDICINE

TLR2/MyD88/NF-κB Pathway, Reactive Oxygen Species, Potassium Efflux Activates NLRP3/ASC Inflammasome during Respiratory Syncytial Virus Infection

(2012) Jesus Segovia et al.   PLoS One

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Dual Oxidase 2 is Essential for the Toll-Like Receptor 5-Mediated Inflammatory Response in Airway Mucosa

(2011) Jung-Hee Joo et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Human Cytomegalovirus Induces Multiple Means To Combat Reactive Oxygen Species

(2011) C. Tilton et al.   JOURNAL OF VIROLOGY

Role of neutrophils and NADPH phagocyte oxidase in host defense against respiratory infection with virulent Francisella tularensis in mice

(2011) Rhonda KuoLee et al.   MICROBES AND INFECTION

Regulation of reactive oxygen species generation in cell signaling

(2011) Yun Soo Bae et al.   MOLECULES AND CELLS

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Endoplasmic Reticulum Stress Pathway-Mediated Apoptosis in Macrophages Contributes to the Survival of Mycobacterium tuberculosis

(2011) Yun-Ji Lim et al.   PLoS One

Listeria monocytogenestransiently alters mitochondrial dynamics during infection

(2011) Fabrizia Stavru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death

(2011) P. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy

(2011) Ross Vlahos et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Antimicrobial Actions of Reactive Oxygen Species

(2011) F. C. Fang   mBio

Oxidative stress caused by mitochondrial calcium overload

(2010) Tsung-I Peng et al.   Annals of the New York Academy of Sciences

Redox Regulation of Endothelial Canonical Transient Receptor Potential Channels

(2010) Donna L. Cioffi   ANTIOXIDANTS & REDOX SIGNALING

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Endoplasmic reticulum stress response is involved inMycobacterium tuberculosisprotein ESAT-6-mediated apoptosis

(2010) Hong-Hee Choi et al.   FEBS LETTERS

Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection

(2010) Nabora Soledad Reyes de Mochel et al.   HEPATOLOGY

Identification and functions of pattern-recognition receptors

(2010) Yutaro Kumagai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

(2010) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3negCD127+ Immune Cells in Spleen and Mucosa

(2010) L. Van Maele et al.   JOURNAL OF IMMUNOLOGY

CXCL1 Regulates Pulmonary Host Defense to Klebsiella Infection via CXCL2, CXCL5, NF- B, and MAPKs

(2010) S. Cai et al.   JOURNAL OF IMMUNOLOGY

Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells

(2010) Tsuey-Ching Yang et al.   MICROBES AND INFECTION

The microbicidal and cytoregulatory roles of NADPH oxidases

(2010) Hung-Chi Yang et al.   MICROBES AND INFECTION

Reactive oxygen species mediate inflammatory cytokine release and EGFR-dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin

(2010) B Rada et al.   Mucosal Immunology

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

(2009) Andrew G. Cox et al.   BIOCHEMICAL JOURNAL

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses

(2009) S. Lipinski et al.   JOURNAL OF CELL SCIENCE

NOD1 and NOD2 Mediate Sensing of Periodontal Pathogens

(2009) T. Okugawa et al.   JOURNAL OF DENTAL RESEARCH

Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages

(2009) Célio X. C. Santos et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hepatitis C Virus (HCV) Proteins Induce NADPH Oxidase 4 Expression in a Transforming Growth Factor  -Dependent Manner: a New Contributor to HCV-Induced Oxidative Stress

(2009) H. E. Boudreau et al.   JOURNAL OF VIROLOGY

Mitochondrial gateways to cancer

(2009) Lorenzo Galluzzi et al.   MOLECULAR ASPECTS OF MEDICINE

Mitochondrial generation of free radicals and hypoxic signaling

(2009) Robert O. Poyton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth

(2008) Ehab H. Sarsour et al.   AGING CELL

Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells

(2008) Sang-Yun Lee et al.   CELLULAR MICROBIOLOGY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the Unfolded Protein Response Is Required for Defenses against Bacterial Pore-Forming Toxin In Vivo

(2008) Larry J. Bischof et al.   PLoS Pathogens

Ero1 and redox homeostasis in the endoplasmic reticulum

(2007) Carolyn S. Sevier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Toll-like receptor 9-stimulated monocyte chemoattractant protein-1 is mediated via JNK-cytosolic phospholipase A2-ROS signaling

(2007) Jin-Gu Lee et al.   CELLULAR SIGNALLING