Article
Cell Biology
Xi Chen, Weijie Ma, Ye Yao, Qi Zhang, Jinghua Li, Xiaoling Wu, Chengjie Mei, Xiang Jiang, Yiran Chen, Ganggang Wang, Kunlei Wang, Yingyi Liu, Yonghua Guo, Zhisu Liu, Yufeng Yuan
Summary: The study identified SDPR as a tumor suppressor in HCC by promoting apoptosis through the activation of the ASK1-JNK/p38 MAPK signaling pathways. This inhibits tumor growth and migration by enhancing cell apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Konstantina-Eleni Bourouti, Christos Konstantaros, Catherine Gaitanaki, Ioanna-Katerina Aggeli
Summary: This study found that hyperosmotic stress triggered multiple signaling pathways in H9c2 cells, including the Integrated Stress Response (IRS), endoplasmic reticulum stress (ERS), and autophagy. The phosphorylation of eukaryotic translation initiation factor 2 (eIF2 alpha) and upregulation of immunoglobulin heavy-chain-binding protein (BiP) expression indicated the activation of IRS and ERS, respectively. In addition, the involvement of a Na+/H+ exchanger-1 (NHE-1) and NADPH oxidase (Nox) in eIF2 alpha phosphorylation was also demonstrated. Attenuation of p38-MAPK activity and late phase autophagy mitigated the detrimental effect of hyperosmotic stress on cell viability.
Article
Pharmacology & Pharmacy
Jiaming Yuan, Chenjuan Yao, Jing Tang, Yingqi Liu, Chunyan Huang, Shali Yu, Haiyan Wei, Yu Han, Gang Chen
Summary: The study revealed that under As2O3-induced ER stress conditions, GRP78 protein expression was enhanced, possibly due to increased biosynthesis of GRP78 protein. Additionally, the IRE1 alpha kinase/ASK1/p38 MAPK signaling pathway was found to play a key role in the upregulation of GRP78 protein in BEAS-2B cells.
Article
Biochemistry & Molecular Biology
Huan Li, Qin Yang, Zhen Huang, Cui Liang, Dian-Hong Zhang, Hui-Ting Shi, Jia-Qi Du, Bin-Bin Du, Yan-Zhou Zhang
Summary: Diabetic cardiomyopathy (DCM) is a heart dysfunction that occurs in patients with diabetes mellitus (DM). This study found that dual-specificity phosphatase 12 (DUSP12) plays an important role in DCM. Overexpression of DUSP12 worsens cardiac dysfunction and increases oxidative stress and apoptosis, while DUSP12 deficiency exacerbates these effects. The study also found that DUSP12 interacts with a specific signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, Research & Experimental
Qijing Wu, Juan Chen, Xiyin Zheng, Jing Song, Lulu Yin, Hai Guo, Qian Chen, Yi Liu, Qianli Ma, Hong Zhang, Qianqian Yang
Summary: The study aimed to evaluate the protective effect of kaempferol (KPF) in doxorubicin (DOX)-induced nephrotoxicity. The results showed that KPF could alleviate DOX-induced renal injury, improve proteinuria and renal function, restore antioxidant activity in kidneys, suppress oxidative stress, and inhibit the activation of the MAPK signaling pathway. In cell experiments, KPF also inhibited DOX-induced ROS overproduction, reduced cell damage and loss of viability. Therefore, KPF may provide a viable solution to lessen renal toxicity in cancer patients receiving DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Seongchun Min, Ji Yeon Kim, Hyo Min Cho, Sujin Park, Ji Min Hwang, Hyejin You, Young Chan Chae, Won-Jae Lee, Woong Sun, Dongmin Kang, Sanghyuk Lee, Sang Won Kang
Summary: This study reveals a novel signaling pathway in which mitochondria communicate with the cytosol via the release of heat shock protein 60, leading to the activation of survival genes in the nucleus.
Article
Biochemistry & Molecular Biology
Xuan Gao, Yong-Yue Gao, Hui-Ying Yan, Guang-Jie Liu, Yan Zhou, Tao Tao, Ting-Ting Yue, Cong Pang, Xiang-Xin Chen, Sen Gao, Ling-Yun Wu, Chun-Hua Hang, Wei Li
Summary: This study showed that PDK4 overexpression post-SAH may mitigate neuronal apoptosis by reducing oxidative stress through the ROS/ASK1/P38 pathway. PDK4 could potentially serve as a new therapeutic target to improve EBI after SAH.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Cell Biology
Hang Zhu, Maoxiang Zhao, Yundai Chen, Dandan Li
Summary: Overexpression of Bag5 can reverse catecholamine-induced endothelial cell damage by inhibiting ER stress, attenuating oxidative stress, and repressing inflammation to promote cell survival. Pathway analysis showed that the MAPK-ERK pathway controls Bag5 expression, suggesting a potential mechanism for catecholamine-induced endothelial cell damage.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Plant Sciences
Haiyang Chen, Huifen Zhou, Jiehong Yang, Haitong Wan, Yu He
Summary: This study investigated the protective mechanism of Guhong injection (GHI) on myocardial ischemia/reperfusion (MI/R) injury. The results showed that GHI activated glutathione S-transferase P (GST P) to inhibit the ASK1-JNK/p38 pathway, thereby alleviating oxidative stress and apoptosis, and exerting cardioprotective effects.
Article
Plant Sciences
Yuan Meng, Rui Feng, Zhao Yang, Tingting Liu, Taoguang Huo, Hong Jiang
Summary: This study found that arsenic in realgar passes through the blood-brain barrier and accumulates in the brain, causing damage to neurons, synapses, and myelin sheaths in the cerebral cortex and a decrease in total antioxidant capacity. The specific mechanism involves the excessive activation of Nrf2 regulated by upstream signaling molecules ERK1/2 and p38 MAPK.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuxin Zeng, Qing Yang, Yujuan Ouyang, Yanbin Lou, Hengmin Cui, Huidan Deng, Yanqiu Zhu, Yi Geng, Ping Ouyang, Lian Chen, Zhicai Zuo, Jing Fang, Hongrui Guo
Summary: The study reveals that nickel is harmful to male reproductive system by inducing damage to the blood-testis barrier (BTB) and causing testicular histopathological damage. Co-treatment with the antioxidant N-acetylcysteine (NAC) can alleviate the damage and exert its effects through the oxidative stress-mediated p38 MAPK signaling pathway.
Article
Pharmacology & Pharmacy
Wei Wei, Chenjian Peng, Renjun Gu, Xiwu Yan, Jiapeng Ye, Zhuicheng Xu, Xianjie Sheng, Guicheng Huang, Yang Guo
Summary: Urolithin A can attenuate RANKL-induced osteoclastogenesis by suppressing inflammation and activating the Nrf2 signaling pathway, thereby alleviating bone loss.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Jianlong Du, Xiaojun Xiang, Dan Xu, Junzhi Zhang, Wei Fang, Wei Xu, Kangsen Mai, Qinghui Ai
Summary: The study revealed that FXR activation could prevent abnormal lipid accumulation in large yellow croakers by regulating PPAR alpha and SREBP1, while high-fat diets suppressed FXR expression through ER stress-induced activation of JNK and P38 MAPK pathways. This research provides insights into the functions of FXR in vertebrate evolution and potential avenues for developing therapies for nutrition-related disorders.
Article
Medicine, Research & Experimental
Ana Carolina B. da C. Rodrigues, Larissa M. Bomfim, Sara P. Neves, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. Gurgel Rocha, Emmanoel V. Costa, Felipe M. A. da Silva, Waldireny C. Rocha, Hector H. F. Koolen, Daniel P. Bezerra
Summary: Tingenone (TG) and 22-hydroxytingenone (22-HTG) are quinonemethide triterpenes from the Amazonian plant Salacia impressifolia, showing potent cytotoxicity against AML HL-60 cell line through apoptosis pathway mediated by oxidative stress. These compounds are potential candidates for anti-AML therapy targeting thioredoxin.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Tsendsuren Tungalag, Dong Kwon Yang
Summary: Parkinson's disease is a neurodegenerative disorder with limited treatment options. Sinapic acid has shown potential as a neuroprotective agent against oxidative stress, mitochondrial dysfunction, and apoptosis, suggesting promising effects in the prevention and treatment of PD.