Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?

The chlamydial organismSimkania negevensisforms ER vacuole contact sites and inhibits ER-stress

(2014) Adrian Mehlitz et al.   CELLULAR MICROBIOLOGY

Shiga toxins expressed by human pathogenic bacteria induce immune responses in host cells

(2014) Moo-Seung Lee et al.   JOURNAL OF MICROBIOLOGY

Toxoplasma gondii induce apoptosis of neural stem cells via endoplasmic reticulum stress pathway

(2014) TENG WANG et al.   PARASITOLOGY

A new paradigm: innate immune sensing of viruses via the unfolded protein response

(2014) Judith A. Smith   Frontiers in Microbiology

When ER stress reaches a dead end

(2013) Hery Urra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RETRACTED: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling

(2013) Jin A. Cho et al.   Cell Host & Microbe

Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from theBrucellaProtein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry

(2013) Greg A. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis

(2013) Yuko Akazawa et al.   PLoS One

Sensing of Bacterial Type IV Secretion via the Unfolded Protein Response

(2013) M. F. de Jong et al.   mBio

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

Brucella Modulates Secretory Trafficking via Multiple Type IV Secretion Effector Proteins

(2013) Sebenzile Myeni et al.   PLoS Pathogens

Brucella Induces an Unfolded Protein Response via TcpB That Supports Intracellular Replication in Macrophages

(2013) Judith A. Smith et al.   PLoS Pathogens

Cytomegalovirus Downregulates IRE1 to Repress the Unfolded Protein Response

(2013) Sebastian Stahl et al.   PLoS Pathogens

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

(2013) Suzana P. Salcedo et al.   Frontiers in Cellular and Infection Microbiology

Blockade of XBP1 splicing by inhibition of IRE1  is a promising therapeutic option in multiple myeloma

(2012) N. Mimura et al.   BLOOD

The Legionella pneumophila Effector DrrA Is Sufficient to Stimulate SNARE-Dependent Membrane Fusion

(2012) Kohei Arasaki et al.   Cell Host & Microbe

Selective Subversion of Autophagy Complexes Facilitates Completion of the Brucella Intracellular Cycle

(2012) Tregei Starr et al.   Cell Host & Microbe

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Activation of the unfolded protein response by Listeria monocytogenes

(2012) Helena Pillich et al.   CELLULAR MICROBIOLOGY

Bacterial Type IV secretion systems: versatile virulence machines

(2012) Daniel E Voth et al.   Future Microbiology

The interplay between endoplasmic reticulum stress and inflammation

(2012) Sumaira Z Hasnain et al.   IMMUNOLOGY AND CELL BIOLOGY

Reactive Oxygen Species-Triggered Trophoblast Apoptosis Is Initiated by Endoplasmic Reticulum Stress via Activation of Caspase-12, CHOP, and the JNK Pathway in Toxoplasma gondii Infection in Mice

(2012) Xiucai Xu et al.   INFECTION AND IMMUNITY

The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner

(2012) Mhairi Baird et al.   LABORATORY INVESTIGATION

ChlamydiaeAssemble a Pathogen Synapse to Hijack the Host Endoplasmic Reticulum

(2012) Maud Dumoux et al.   TRAFFIC

The Mammalian Endoplasmic Reticulum-Associated Degradation System

(2012) J. A. Olzmann et al.   Cold Spring Harbor Perspectives in Biology

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

(2012) P Menu et al.   Cell Death & Disease

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

(2011) Anu Chaudhary et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation of microtubule dynamics by a TIR domain protein from the intracellular pathogenBrucella melitensis

(2011) Girish K. Radhakrishnan et al.   BIOCHEMICAL JOURNAL

In search of Brucella abortus type IV secretion substrates: screening and identification of four proteins translocated into host cells through VirB system

(2011) María Inés Marchesini et al.   CELLULAR MICROBIOLOGY

Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2

(2011) Marie de Barsy et al.   CELLULAR MICROBIOLOGY

Brucellosis and type IV secretion

(2011) Maarten F de Jong et al.   Future Microbiology

ATF6β is a host cellular target of theToxoplasma gondiivirulence factor ROP18

(2011) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rotavirus Infection Induces the Unfolded Protein Response of the Cell and Controls It through the Nonstructural Protein NSP3

(2011) V. Trujillo-Alonso et al.   JOURNAL OF VIROLOGY

Host Proteasomal Degradation Generates Amino Acids Essential for Intracellular Bacterial Growth

(2011) C. T. D. Price et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

Rotavirus infection activates the UPR but modulates its activity

(2011) Jose Zambrano et al.   Virology Journal

The Lipid Transfer Protein CERT Interacts with the Chlamydia Inclusion Protein IncD and Participates to ER-Chlamydia Inclusion Membrane Contact Sites

(2011) Isabelle Derré et al.   PLoS Pathogens

Type IVB Secretion Systems of Legionella and Other Gram-Negative Bacteria

(2011) Hiroki Nagai et al.   Frontiers in Microbiology

XBP-1 Couples Endoplasmic Reticulum Stress to Augmented IFN-  Induction via a cis-Acting Enhancer in Macrophages

(2010) L. Zeng et al.   JOURNAL OF IMMUNOLOGY

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Induction of ER Stress in Macrophages of Tuberculosis Granulomas

(2010) Tracie A. Seimon et al.   PLoS One

RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP

(2010) K. Malathi et al.   RNA

Subtilase Cytotoxin Activates MAP Kinases through PERK and IRE1 Branches of the Unfolded Protein Response

(2010) Yang Zhao et al.   TOXICOLOGICAL SCIENCES

Legionella pneumophila Promotes Functional Interactions between Plasma Membrane Syntaxins and Sec22b

(2010) Kohei Arasaki et al.   TRAFFIC

BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response

(2010) David Pincus et al.   PLOS BIOLOGY

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

(2009) Sebastian Schuck et al.   JOURNAL OF CELL BIOLOGY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

ATF6  induces XBP1-independent expansion of the endoplasmic reticulum

(2009) H. Bommiasamy et al.   JOURNAL OF CELL SCIENCE

Host ER–parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation inToxoplasma gondii–infected dendritic cells

(2009) Romina S. Goldszmid et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Subcytotoxic Dose of Subtilase Cytotoxin Prevents Lipopolysaccharide-Induced Inflammatory Responses, Depending on its Capacity to Induce the Unfolded Protein Response

(2009) D. Harama et al.   JOURNAL OF IMMUNOLOGY

Subversion of Innate Immune Responses by Brucella through the Targeted Degradation of the TLR Signaling Adapter, MAL

(2009) D. Sengupta et al.   JOURNAL OF IMMUNOLOGY

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

The structural biology of type IV secretion systems

(2009) Rémi Fronzes et al.   NATURE REVIEWS MICROBIOLOGY

ER Stress Controls Iron Metabolism Through Induction of Hepcidin

(2009) C. Vecchi et al.   SCIENCE

The Glyceraldehyde-3-Phosphate Dehydrogenase and the Small GTPase Rab 2 Are Crucial for Brucella Replication

(2009) Emilie Fugier et al.   PLoS Pathogens

Inclusion Biogenesis and Reactivation of Persistent Chlamydia trachomatis Requires Host Cell Sphingolipid Biosynthesis

(2009) D. Kesley Robertson et al.   PLoS Pathogens

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways

(2008) Jennifer J. Wolfson et al.   CELLULAR MICROBIOLOGY

Subtilase cytotoxin, produced by Shiga-toxigenic Escherichia coli, transiently inhibits protein synthesis of Vero cells via degradation of BiP and induces cell cycle arrest at G1 by downregulation of cyclin D1

(2008) Naoko Morinaga et al.   CELLULAR MICROBIOLOGY

Type IV secretion systems: tools of bacterial horizontal gene transfer and virulence

(2008) Mario Juhas et al.   CELLULAR MICROBIOLOGY

Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells

(2008) Sang-Yun Lee et al.   CELLULAR MICROBIOLOGY

Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by theBrucellatype IV secretion system

(2008) Maarten F. de Jong et al.   MOLECULAR MICROBIOLOGY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain–containing proteins

(2008) Christine Cirl et al.   NATURE MEDICINE

Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1

(2008) Suzana P. Salcedo et al.   PLoS Pathogens

Brucella Intracellular Replication Requires Trafficking Through the Late Endosomal/Lysosomal Compartment

(2008) Tregei Starr et al.   TRAFFIC

RNAi Screen of Endoplasmic Reticulum–Associated Host Factors Reveals a Role for IRE1α in Supporting Brucella Replication

(2008) Qing-Ming Qin et al.   PLoS Pathogens

Activation of the Unfolded Protein Response Is Required for Defenses against Bacterial Pore-Forming Toxin In Vivo

(2008) Larry J. Bischof et al.   PLoS Pathogens