Intertwined and Finely Balanced: Endoplasmic Reticulum Morphology, Dynamics, Function, and Diseases

Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites

(2021) Haoxi Wu et al.   DEVELOPMENTAL CELL

Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture

(2021) Menno Spits et al.   EMBO REPORTS

Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases

(2021) Jun Ren et al.   Nature Reviews Cardiology

ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER

(2021) Aubrey V. Weigel et al.   CELL

FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins

(2021) Fang Chen et al.   JOURNAL OF CELL BIOLOGY

VPS13D promotes peroxisome biogenesis

(2021) Heather A. Baldwin et al.   JOURNAL OF CELL BIOLOGY

VPS13D bridges the ER to mitochondria and peroxisomes via Miro

(2021) Andrés Guillén-Samander et al.   JOURNAL OF CELL BIOLOGY

COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers

(2021) Olga Shomron et al.   JOURNAL OF CELL BIOLOGY

The Nesprin-1/-2 ortholog ANC-1 regulates organelle positioning in C. elegans independently from its KASH or actin-binding domains

(2021) Hongyan Hao et al.   eLife

Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex

(2021) Mark Sicking et al.   Cells

Morphological Heterogeneity of the Endoplasmic Reticulum within Neurons and Its Implications in Neurodegeneration

(2021) Sreesha Sree et al.   Cells

The Unfolded Protein Response: An Overview

(2021) Adam Read et al.   Biology-Basel

STED and parallelized RESOLFT optical nanoscopy of the tubular endoplasmic reticulum and its mitochondrial contacts in neuronal cells

(2021) Martina Damenti et al.   NEUROBIOLOGY OF DISEASE

Network organisation and the dynamics of tubules in the endoplasmic reticulum

(2021) Hannah T. Perkins et al.   Scientific Reports

Amyotrophic Lateral Sclerosis (ALS): Stressed by Dysfunctional Mitochondria-Endoplasmic Reticulum Contacts (MERCs)

(2021) Junsheng Chen et al.   Cells

The Link between VAPB Loss of Function and Amyotrophic Lateral Sclerosis

(2021) Nica Borgese et al.   Cells

Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration

(2020) Zeynep Öztürk et al.   Frontiers in Neuroscience

Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases

(2020) Ji-Ae Choi et al.   Frontiers in Immunology

The Perinuclear ER Scales Nuclear Size Independently of Cell Size in Early Embryos

(2020) Richik Nilay Mukherjee et al.   DEVELOPMENTAL CELL

The Warburg Micro Syndrome‐associated Rab3GAP‐Rab18 module promotes autolysosome maturation through the Vps34 Complex I

(2020) Szabolcs Takáts et al.   FEBS Journal

Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease

(2020) Clara Berenguer-Escuder et al.   HUMAN MOLECULAR GENETICS

MTV proteins unveil ER- and microtubule-associated compartments in the plant vacuolar trafficking pathway

(2020) María Otilia Delgadillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of global structure on diffusive exploration of organelle networks

(2020) Aidan I. Brown et al.   Scientific Reports

Maintaining social contacts: The physiological relevance of organelle interactions

(2020) Beatriz S.C. Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nesprin-2 Recruitment of BicD2 to the Nuclear Envelope Controls Dynein/Kinesin-Mediated Neuronal Migration In Vivo

(2020) João Carlos Gonçalves et al.   CURRENT BIOLOGY

Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum

(2020) Noemi Antonella Guadagno et al.   JOURNAL OF CELL BIOLOGY

Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion

(2020) Nina Marie Pedersen et al.   JOURNAL OF CELL BIOLOGY

Vesicular and uncoated Rab1-dependent cargo carriers facilitate ER to Golgi transport

(2020) Laura M. Westrate et al.   JOURNAL OF CELL SCIENCE

PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria

(2020) Yael Elbaz-Alon et al.   Nature Communications

Sticking With It: ER-PM Membrane Contact Sites as a Coordinating Nexus for Regulating Lipids and Proteins at the Cell Cortex

(2020) Mohammad F. Zaman et al.   Frontiers in Cell and Developmental Biology

COPII mitigates ER stress by promoting formation of ER whorls

(2020) Fang Xu et al.   CELL RESEARCH

ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation

(2020) Jinshan Qin et al.   Nature Communications

Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation

(2020) Michiko Shirane et al.   Nature Communications

Positioning of endoplasmic reticulum exit sites around the Golgi depends on BicaudalD2 and Rab6 activity

(2020) Olga Shomron et al.   TRAFFIC

Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm

(2020) James F Pelletier et al.   eLife

The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes

(2020) Meng Lu et al.   Science Advances

Lipid Transfer–Dependent Endosome Maturation Mediated by Protrudin and PDZD8 in Neurons

(2020) Michiko Shirane   Frontiers in Cell and Developmental Biology

Altered interplay between endoplasmic reticulum and mitochondria in Charcot–Marie–Tooth type 2A neuropathy

(2019) Nathalie Bernard-Marissal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay between lipid lateral diffusion, dye concentration and membrane permeability unveiled by a combined spectroscopic and computational study of a model lipid bilayer

(2019) Muhammad Jan Akhunzada et al.   Scientific Reports

Quantitative analysis of plant ER architecture and dynamics

(2019) Charlotte Pain et al.   Nature Communications

Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity

(2019) Ginny G. Farías et al.   NEURON

Vesicular and non-vesicular lipid export from the ER to the secretory pathway

(2019) Kouichi Funato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

STIM1 is required for remodelling of the endoplasmic reticulum and microtubule cytoskeleton in steering growth cones

(2019) Macarena Pavez et al.   JOURNAL OF NEUROSCIENCE

Conserved role for Ataxin‐2 in mediating endoplasmic reticulum dynamics

(2019) Urko del Castillo et al.   TRAFFIC

COPII‐mediated trafficking at the ER/ERGIC interface

(2019) Jennifer Peotter et al.   TRAFFIC

Compartmentalization and Selective Tagging for Disposal of Misfolded Glycoproteins

(2019) Marina Shenkman et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cross-linked biopolymer networks with active motors: Mechanical response and intra-network transport

(2019) Bo Gong et al.   JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS

REEP3 and REEP4 determine the tubular morphology of the endoplasmic reticulum during mitosis

(2019) Darshan Kumar et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial fission requires DRP1 but not dynamins

(2019) Tiago Branco Fonseca et al.   NATURE

A network of nuclear envelope proteins and cytoskeletal force generators mediates movements of and within nuclei throughout Caenorhabditis elegans development

(2019) Daniel A Starr   EXPERIMENTAL BIOLOGY AND MEDICINE

Axonal transport and neurological disease

(2019) James N. Sleigh et al.   Nature Reviews Neurology

The functional universe of membrane contact sites

(2019) William A. Prinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytosolic aggregates in presence of non‐translocated proteins perturb endoplasmic reticulum structure and dynamics

(2019) Debdatto Mookherjee et al.   TRAFFIC

Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery

(2019) Souvik Modi et al.   Nature Communications

ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

(2019) Christopher J. Neufeldt et al.   Nature Microbiology

LRRK 2 regulates endoplasmic reticulum–mitochondrial tethering through the PERK ‐mediated ubiquitination pathway

(2019) Toshihiko Toyofuku et al.   EMBO JOURNAL

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

(2019) Marta Palomo-Guerrero et al.   eLife

Rab7a modulates ER stress and ER morphology

(2018) Duarte Mateus et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cholesterol transfer at endosomal-organelle membrane contact sites

(2018) Neale D. Ridgway et al.   CURRENT OPINION IN LIPIDOLOGY

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

Modeling the Geometry and Dynamics of the Endoplasmic Reticulum Network

(2018) Congping Lin et al.   IEEE-ACM Transactions on Computational Biology and Bioinformatics

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

(2018) Dijin Xu et al.   JOURNAL OF CELL BIOLOGY

Lysosome trafficking and signaling in health and neurodegenerative diseases

(2018) Pearl P.Y. Lie et al.   NEUROBIOLOGY OF DISEASE

Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2

(2018) Riccardo Filadi et al.   PHARMACOLOGICAL RESEARCH

Mechanisms of lysosomal positioning and movement

(2018) Birol Cabukusta et al.   TRAFFIC

Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering

(2018) Michiel Krols et al.   Cell Reports

Diffusion of Exit Sites on the Endoplasmic Reticulum: A Random Walk on a Shivering Backbone

(2018) Lorenz Stadler et al.   BIOPHYSICAL JOURNAL

A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission

(2018) Melissa J. Hoyer et al.   CELL

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Single particle trajectories reveal active endoplasmic reticulum luminal flow

(2018) David Holcman et al.   NATURE CELL BIOLOGY

Here, there, and everywhere: The importance of ER membrane contact sites

(2018) Haoxi Wu et al.   SCIENCE

Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales

(2018) Yuting Guo et al.   CELL

Dynamic nanoscale morphology of the ER surveyed by STED microscopy

(2018) Lena K. Schroeder et al.   JOURNAL OF CELL BIOLOGY

IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes

(2018) Peace Atakpa et al.   Cell Reports

Reciprocal regulation between lunapark and atlastin facilitates ER three-way junction formation

(2018) Xin Zhou et al.   Protein & Cell

Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia

(2017) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis

(2017) Rong Hua et al.   JOURNAL OF CELL BIOLOGY

ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER

(2017) Joseph L. Costello et al.   JOURNAL OF CELL BIOLOGY

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Mechanisms and functions of nuclear envelope remodelling

(2017) Rosemarie Ungricht et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structures of Mmm1 and Mdm12–Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sites

(2017) Hanbin Jeong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IncV, a FFAT motif-containingChlamydiaprotein, tethers the endoplasmic reticulum to the pathogen-containing vacuole

(2017) Rebecca Stanhope et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contacts between the endoplasmic reticulum and other membranes in neurons

(2017) Yumei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion

(2017) Joshua A. Lees et al.   SCIENCE

Hitchhiking: A Non-Canonical Mode of Microtubule-Based Transport

(2017) John Salogiannis et al.   TRENDS IN CELL BIOLOGY

Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration site

(2017) Madhu Sudhan Ravindran et al.   Nature Communications

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane

(2017) Rajesh Ghai et al.   Nature Communications

The flexibility and dynamics of the tubules in the endoplasmic reticulum

(2017) Pantelis Georgiades et al.   Scientific Reports

Sec61β facilitates the maintenance of endoplasmic reticulum homeostasis by associating microtubules

(2017) Yimeng Zhu et al.   Protein & Cell

miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and EffluxSignificance

(2016) Mireille Ouimet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Shaping the endoplasmic reticulum in vitro

(2016) Csilla-Maria Ferencz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

VAP, a Versatile Access Point for the Endoplasmic Reticulum: Review and analysis of FFAT-like motifs in the VAPome

(2016) Sarah E. Murphy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

(2016) Rui Dong et al.   CELL

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport

(2016) Emily R. Eden et al.   DEVELOPMENTAL CELL

Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1 ‐ and SOD1 ‐linked ALS

(2016) Seiji Watanabe et al.   EMBO Molecular Medicine

Dialogue between endoplasmic reticulum and mitochondria as a key actor of vascular dysfunction associated to metabolic disorders

(2016) Zainab Safiedeen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions

(2016) Yupeng Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinectin-dependent ER transport supports the focal complex maturation required for chemotaxis in shallow gradients

(2016) Inn Chuan Ng et al.   JOURNAL OF CELL SCIENCE

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration

(2016) Kavitha Rao et al.   MOLECULAR BIOLOGY OF THE CELL

Multiple dynamin family members collaborate to drive mitochondrial division

(2016) Jason E. Lee et al.   NATURE

Control of plasma membrane lipid homeostasis by the extended synaptotagmins

(2016) Yasunori Saheki et al.   NATURE CELL BIOLOGY

Broken Detailed Balance of Filament Dynamics in Active Networks

(2016) J. Gladrow et al.   PHYSICAL REVIEW LETTERS

Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites

(2016) Haijia Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER

(2016) J. Nixon-Abell et al.   SCIENCE

Shaping the Endoplasmic Reticulum into a Social Network

(2016) Hong Zhang et al.   TRENDS IN CELL BIOLOGY

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly

(2016) Inés Romero-Brey et al.   Viruses-Basel

Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network

(2016) Songyu Wang et al.   eLife

A phospholipid transfer function of ER-mitochondria encounter structure revealed in vitro

(2016) Rieko Kojima et al.   Scientific Reports

Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum/mitochondria contacts

(2015) Youngshin Lim et al.   ANNALS OF NEUROLOGY

Form Follows Function: The Importance of Endoplasmic Reticulum Shape

(2015) L.M. Westrate et al.   Annual Review of Biochemistry

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence

(2015) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

A sweet code for glycoprotein folding

(2015) Julio J. Caramelo et al.   FEBS LETTERS

Endoplasmic Reticulum Tubule Protein Reticulon 4 Associates with the Legionella pneumophila Vacuole and with Translocated Substrate Ceg9

(2015) Eva Haenssler et al.   INFECTION AND IMMUNITY

Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2 and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane Junctions

(2015) Chi-Lun Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisomes, lipid droplets, and endoplasmic reticulum “hitchhike” on motile early endosomes

(2015) Sofia C. Guimaraes et al.   JOURNAL OF CELL BIOLOGY

Ltc1 is an ER-localized sterol transporter and a component of ER–mitochondria and ER–vacuole contacts

(2015) Andrew Murley et al.   JOURNAL OF CELL BIOLOGY

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

(2015) Vineet Choudhary et al.   JOURNAL OF CELL BIOLOGY

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

(2015) Camilla Raiborg et al.   NATURE

STIM1 Is a Novel Component of ER-Chlamydia trachomatis Inclusion Membrane Contact Sites

(2015) Hervé Agaisse et al.   PLoS One

Three-dimensional architecture of extended synaptotagmin-mediated endoplasmic reticulum–plasma membrane contact sites

(2015) Rubén Fernández-Busnadiego et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly

(2015) Andrew P. AhYoung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational analysis of morphologies and phase transitions of cross-linked, semi-flexible polymer networks

(2015) Kei W. Müller et al.   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

Lam6 Regulates the Extent of Contacts between Organelles

(2015) Yael Elbaz-Alon et al.   Cell Reports

Human atlastin GTPases mediate differentiated fusion of endoplasmic reticulum membranes

(2015) Xiaoyu Hu et al.   Protein & Cell

A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport

(2015) Alberto T Gatta et al.   eLife

Interactions between plant endomembrane systems and the actin cytoskeleton

(2015) Pengwei Wang et al.   Frontiers in Plant Science

Loss of Association of REEP2 with Membranes Leads to Hereditary Spastic Paraplegia

(2014) Typhaine Esteves et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structure and Dynamics of ER: Minimal Networks and Biophysical Constraints

(2014) Congping Lin et al.   BIOPHYSICAL JOURNAL

A novel missense mutation confirms ATL3 as a gene for hereditary sensory neuropathy type 1

(2014) Dirk Fischer et al.   BRAIN

Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3

(2014) Uwe Kornak et al.   BRAIN

ER Contact Sites Define the Position and Timing of Endosome Fission

(2014) Ashley A. Rowland et al.   CELL

Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self-interaction

(2014) Ming-Jhan Wu et al.   CELLULAR MICROBIOLOGY

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Gain-of-Function Mutation in STIM1 (P.R304W) Is Associated with Stormorken Syndrome

(2014) Gilles Morin et al.   HUMAN MUTATION

A Dominant STIM1 Mutation Causes Stormorken Syndrome

(2014) Doriana Misceo et al.   HUMAN MUTATION

Protrudin Regulates Endoplasmic Reticulum Morphology and Function Associated with the Pathogenesis of Hereditary Spastic Paraplegia

(2014) Yutaka Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab18 and a Rab18 GEF complex are required for normal ER structure

(2014) Andreas Gerondopoulos et al.   JOURNAL OF CELL BIOLOGY

Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABA B receptors

(2014) José I. Valenzuela et al.   JOURNAL OF CELL SCIENCE

Childhood onset tubular aggregate myopathy associated with de novo STIM1 mutations

(2014) Carola Hedberg et al.   JOURNAL OF NEUROLOGY

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization

(2014) C.-Y. Deng et al.   JOURNAL OF NEUROSCIENCE

Unique Function of Kinesin Kif5A in Localization of Mitochondria in Axons

(2014) P. D. Campbell et al.   JOURNAL OF NEUROSCIENCE

ER sheet persistence is coupled to myosin 1c–regulated dynamic actin filament arrays

(2014) Merja Joensuu et al.   MOLECULAR BIOLOGY OF THE CELL

Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum–plasma membrane junctions

(2014) Minnie M. Wu et al.   MOLECULAR BIOLOGY OF THE CELL

Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis

(2014) V. Nesin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum

(2014) Shuliang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A model for the generation and interconversion of ER morphologies

(2014) Tom Shemesh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling semiflexible polymer networks

(2014) C. P. Broedersz et al.   REVIEWS OF MODERN PHYSICS

Phospholipid Synthesis and Transport in Mammalian Cells

(2014) Jean E. Vance   TRAFFIC

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

(2014) Florian Wilfling et al.   eLife

Opposing microtubule motors control motility, morphology and cargo segregation during ER-to-Golgi transport

(2014) A. K. Brown et al.   Biology Open

Constitutive Activation of the Calcium Sensor STIM1 Causes Tubular-Aggregate Myopathy

(2013) Johann Böhm et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca2+ transfer to sustain cell bioenergetics

(2013) Tito Calì et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

Stacked Endoplasmic Reticulum Sheets Are Connected by Helicoidal Membrane Motifs

(2013) Mark Terasaki et al.   CELL

Local Cytoskeletal and Organelle Interactions Impact Molecular-Motor-Driven Early Endosomal Trafficking

(2013) Allison L. Zajac et al.   CURRENT BIOLOGY

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Plasma membrane—endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis

(2013) Shabnam Tavassoli et al.   EMBO REPORTS

The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control

(2013) Amina Moustaqim-Barrette et al.   HUMAN MOLECULAR GENETICS

The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering

(2013) D. Ottolini et al.   HUMAN MOLECULAR GENETICS

The Endoplasmic Reticulum Coat Protein II Transport Machinery Coordinates Cellular Lipid Secretion and Cholesterol Biosynthesis

(2013) Lee G. D. Fryer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple mechanisms determine ER network morphology during the cell cycle inXenopusegg extracts

(2013) Songyu Wang et al.   JOURNAL OF CELL BIOLOGY

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER

(2013) F. Alpy et al.   JOURNAL OF CELL SCIENCE

Endoplasmic reticulum–endosome contact increases as endosomes traffic and mature

(2013) Jonathan R. Friedman et al.   MOLECULAR BIOLOGY OF THE CELL

Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation

(2013) J. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast spatiotemporal correlation spectroscopy to determine protein lateral diffusion laws in live cell membranes

(2013) C. Di Rienzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Structure and Interconnections with Other Organelles

(2013) A. R. English et al.   Cold Spring Harbor Perspectives in Biology

Effect of membrane tension on the physical properties of DOPC lipid bilayer membrane

(2012) A. Srinivas Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells

(2012) Jean E. Vance et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Autozygome-guided exome sequencing in retinal dystrophy patients reveals pathogenetic mutations and novel candidate disease genes

(2012) L. Abu-Safieh et al.   GENOME RESEARCH

Molecular basis for sculpting the endoplasmic reticulum membrane

(2012) Shaoyu Lin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Restructured endoplasmic reticulum generated by mutant amyotrophic lateral sclerosis-linked VAPB is cleared by the proteasome

(2012) G. Papiani et al.   JOURNAL OF CELL SCIENCE

Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12

(2012) Gladys Montenegro et al.   JOURNAL OF CLINICAL INVESTIGATION

ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p

(2012) Shuliang Chen et al.   NATURE CELL BIOLOGY

Rab10 GTPase regulates ER dynamics and morphology

(2012) Amber R. English et al.   NATURE CELL BIOLOGY

RNA Processing Bodies, Peroxisomes, Golgi Bodies, Mitochondria, and Endoplasmic Reticulum Tubule Junctions Frequently Pause at Cortical Microtubules

(2012) Takahiro Hamada et al.   PLANT AND CELL PHYSIOLOGY

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome

(2011) Danai Bem et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

(2011) Amr Al-Saif et al.   ANNALS OF NEUROLOGY

Transmembrane helices can induce domain formation in crowded model membranes

(2011) Jan Domański et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Weaving the Web of ER Tubules

(2011) Junjie Hu et al.   CELL

A Highly Dynamic ER-Derived Phosphatidylinositol-Synthesizing Organelle Supplies Phosphoinositides to Cellular Membranes

(2011) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

(2011) Kurt J. De Vos et al.   HUMAN MOLECULAR GENETICS

A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature

(2011) Matt West et al.   JOURNAL OF CELL BIOLOGY

A role for oxysterol-binding protein–related protein 5 in endosomal cholesterol trafficking

(2011) Ximing Du et al.   JOURNAL OF CELL BIOLOGY

Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae

(2011) N. Jacquier et al.   JOURNAL OF CELL SCIENCE

Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

(2011) Christopher D. Lynch et al.   MOLECULAR BIOLOGY OF THE CELL

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation

(2011) Fumiko Matsuzaki et al.   MOLECULAR BIOLOGY OF THE CELL

BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol

(2011) Roger Geiger et al.   NATURE CELL BIOLOGY

Roles of Dynein and Dynactin in Early Endosome Dynamics Revealed Using Automated Tracking and Global Analysis

(2011) Neftali Flores-Rodriguez et al.   PLoS One

Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes

(2011) X. Bian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

The Lipid Transfer Protein CERT Interacts with the Chlamydia Inclusion Protein IncD and Participates to ER-Chlamydia Inclusion Membrane Contact Sites

(2011) Isabelle Derré et al.   PLoS Pathogens

Lipid diffusion in planar membranes investigated by fluorescence correlation spectroscopy

(2010) Radek Macháň et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Anomalous Diffusion Reports on the Interaction of Misfolded Proteins with the Quality Control Machinery in the Endoplasmic Reticulum

(2010) Nina Malchus et al.   BIOPHYSICAL JOURNAL

Mechanisms Determining the Morphology of the Peripheral ER

(2010) Yoko Shibata et al.   CELL

The sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) is the third element in capacitative calcium entry

(2010) Isabel M. Manjarrés et al.   CELL CALCIUM

Further assembly required: construction and dynamics of the endoplasmic reticulum network

(2010) Seong H Park et al.   EMBO REPORTS

ER sliding dynamics and ER–mitochondrial contacts occur on acetylated microtubules

(2010) Jonathan R. Friedman et al.   JOURNAL OF CELL BIOLOGY

Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network

(2010) Seong H. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Amphipathic  -Helix AH2 Is a Major Determinant for the Oligomerization of Hepatitis C Virus Nonstructural Protein 4B

(2010) J. Gouttenoire et al.   JOURNAL OF VIROLOGY

Membrane contacts between endosomes and ER provide sites for PTP1B–epidermal growth factor receptor interaction

(2010) Emily R. Eden et al.   NATURE CELL BIOLOGY

Non-vesicular lipid transport by lipid-transfer proteins and beyond

(2010) Sima Lev   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function

(2010) A. Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry

(2010) Daniël Splinter et al.   PLOS BIOLOGY

A Class of Dynamin-like GTPases Involved in the Generation of the Tubular ER Network

(2009) Junjie Hu et al.   CELL

Visualizing the store-operated channel complex assembly in real time: Identification of SERCA2 as a new member

(2009) Alicia Sampieri et al.   CELL CALCIUM

A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum

(2009) Elisa Fasana et al.   FASEB JOURNAL

Role of kinesin-1 and cytoplasmic dynein in endoplasmic reticulum movement in VERO cells

(2009) M. J. Wozniak et al.   JOURNAL OF CELL SCIENCE

Coatomer-dependent protein delivery to lipid droplets

(2009) K. G. Soni et al.   JOURNAL OF CELL SCIENCE

Reduced Amyloid Deposition in Mice Overexpressing RTN3 Is Adversely Affected by Preformed Dystrophic Neurites

(2009) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Reticulon-4A (Nogo-A) Redistributes Protein Disulfide Isomerase to Protect Mice from SOD1-Dependent Amyotrophic Lateral Sclerosis

(2009) Y. S. Yang et al.   JOURNAL OF NEUROSCIENCE

Cisternal Organization of the Endoplasmic Reticulum during Mitosis

(2009) Lei Lu et al.   MOLECULAR BIOLOGY OF THE CELL

Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin

(2009) Genny Orso et al.   NATURE

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

(2009) K. J. Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Phases of membrane tubules pulled by molecular motors

(2009) N. S. Gov   Soft Matter

The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors

(2008) Hiroshi Tsuda et al.   CELL

STIM1 Is a MT-Plus-End-Tracking Protein Involved in Remodeling of the ER

(2008) Ilya Grigoriev et al.   CURRENT BIOLOGY

Regulated motion of glycoproteins revealed by direct visualization of a single cargo in the endoplasmic reticulum

(2008) Hisao Nagaya et al.   JOURNAL OF CELL BIOLOGY

Bap31 Is an Itinerant Protein That Moves between the Peripheral Endoplasmic Reticulum (ER) and a Juxtanuclear Compartment Related to ER-associated Degradation

(2008) Yuichi Wakana et al.   MOLECULAR BIOLOGY OF THE CELL

Coordinated Lipid Transfer between the Endoplasmic Reticulum and the Golgi Complex Requires the VAP Proteins and Is Essential for Golgi-mediated Transport

(2008) Diego Peretti et al.   MOLECULAR BIOLOGY OF THE CELL

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

(2008) Christian Eggeling et al.   NATURE

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Nonvesicular phospholipid transfer between peroxisomes and the endoplasmic reticulum

(2008) S. Raychaudhuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Proteins of the Endoplasmic Reticulum Induce High-Curvature Tubules

(2008) J. Hu et al.   SCIENCE

Kinesin-1 (uKHC/KIF5B) is Required for Bidirectional Motility of ER Exit Sites and Efficient ER-to-Golgi Transport

(2008) Vijay Gupta et al.   TRAFFIC

COPI Complex Is a Regulator of Lipid Homeostasis

(2008) Mathias Beller et al.   PLOS BIOLOGY