Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

COPI–TRAPPII activates Rab18 and regulates its lipid droplet association

(2016) Chunman Li et al.   EMBO JOURNAL

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Lipid droplets and steroidogenic cells

(2016) Wen-Jun Shen et al.   EXPERIMENTAL CELL RESEARCH

Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes

(2016) Wenyi Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting

(2016) Jian Cao et al.   NUCLEIC ACIDS RESEARCH

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

(2016) Martin Pagac et al.   Cell Reports

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

(2016) Xiaoyan Robert Bao et al.   eLife

Characterization of lipid droplets in steroidogenic MLTC-1 Leydig cells: Protein profiles and the morphological change induced by hormone stimulation

(2015) Tomohiro Yamaguchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1pΔNterm only in combination with Ldb16p

(2015) Sungwon Han et al.   BMC CELL BIOLOGY

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Modular Detection of GFP-Labeled Proteins for Rapid Screening by Electron Microscopy in Cells and Organisms

(2015) Nicholas Ariotti et al.   DEVELOPMENTAL CELL

The seipin complex Fld1/Ldb16 stabilizes ER–lipid droplet contact sites

(2015) Alexandra Grippa et al.   JOURNAL OF CELL BIOLOGY

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

(2015) Vineet Choudhary et al.   JOURNAL OF CELL BIOLOGY

Cytosolic lipid droplets: From mechanisms of fat storage to disease

(2014) David A. Gross et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Lipid droplet biogenesis

(2014) Florian Wilfling et al.   CURRENT OPINION IN CELL BIOLOGY

Rab8a-AS160-MSS4 Regulatory Circuit Controls Lipid Droplet Fusion and Growth

(2014) Lizhen Wu et al.   DEVELOPMENTAL CELL

Toward a Comprehensive Map of the Effectors of Rab GTPases

(2014) Alison K. Gillingham et al.   DEVELOPMENTAL CELL

Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites

(2014) Albert Pol et al.   JOURNAL OF CELL BIOLOGY

Rab18 and a Rab18 GEF complex are required for normal ER structure

(2014) Andreas Gerondopoulos et al.   JOURNAL OF CELL BIOLOGY

Cidea Control of Lipid Storage and Secretion in Mouse and Human Sebaceous Glands

(2014) S. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Loss-of-Function Mutations in TBC1D20 Cause Cataracts and Male Infertility in blind sterile Mice and Warburg Micro Syndrome in Humans

(2013) Ryan P. Liegel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Balancing the fat: lipid droplets and human disease

(2013) Natalie Krahmer et al.   EMBO Molecular Medicine

Mutation Spectrum inRAB3GAP1,RAB3GAP2, andRAB18and Genotype-Phenotype Correlations in Warburg Micro Syndrome and Martsolf Syndrome

(2013) Mark T. Handley et al.   HUMAN MUTATION

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The biophysics and cell biology of lipid droplets

(2013) Abdou Rachid Thiam et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue

(2013) LiZhen Wu et al.   Science China-Life Sciences

Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes

(2013) Zhiqi Sun et al.   Nature Communications

Rab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets

(2013) Shadi Salloum et al.   PLoS Pathogens

Lipid Droplets and Cellular Lipid Metabolism

(2012) Tobias C. Walther et al.   Annual Review of Biochemistry

CIDE Proteins and Lipid Metabolism

(2012) Li Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

RAB3GAP1,RAB3GAP2andRAB18: disease genes in Micro and Martsolf syndromes

(2012) Mark T. Handley et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Lipid Droplets Control the Maternal Histone Supply of Drosophila Embryos

(2012) Zhihuan Li et al.   CURRENT BIOLOGY

Controlling the size of lipid droplets: lipid and protein factors

(2012) Hongyuan Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Cidea promotes hepatic steatosis by sensing dietary fatty acids

(2012) Linkang Zhou et al.   HEPATOLOGY

The FATP1–DGAT2 complex facilitates lipid droplet expansion at the ER–lipid droplet interface

(2012) Ningyi Xu et al.   JOURNAL OF CELL BIOLOGY

Seipin: from human disease to molecular mechanism

(2012) Bethany R. Cartwright et al.   JOURNAL OF LIPID RESEARCH

Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets

(2012) Michitaka Suzuki et al.   MOLECULAR BIOLOGY OF THE CELL

Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids

(2012) Wenshan Wang et al.   NATURE MEDICINE

Isolating lipid droplets from multiple species

(2012) Yunfeng Ding et al.   Nature Protocols

A novel role for lipid droplets in the organismal antibacterial response

(2012) Preetha Anand et al.   eLife

Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome

(2011) Danai Bem et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

(2011) Natalie Krahmer et al.   Cell Metabolism

The Dsl1 Tethering Complex Actively Participates in Soluble NSF (N-Ethylmaleimide-sensitive Factor) Attachment Protein Receptor (SNARE) Complex Assembly at the Endoplasmic Reticulum inSaccharomyces cerevisiae

(2011) Melanie Diefenbacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dsl1 Protein Tethering Complex Is a Resident Endoplasmic Reticulum Complex, Which Interacts with Five Soluble NSF (N-Ethylmaleimide-sensitive Factor) Attachment Protein Receptors (SNAREs)

(2011) Christoph T. A. Meiringer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Role of Ancient Ubiquitous Protein 1 (AUP1) in Lipid Droplet Accumulation and Endoplasmic Reticulum (ER) Protein Quality Control

(2011) Elizabeth J. Klemm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

(2011) Jingyi Gong et al.   JOURNAL OF CELL BIOLOGY

Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae

(2011) N. Jacquier et al.   JOURNAL OF CELL SCIENCE

The role of lipid droplets in metabolic disease in rodents and humans

(2011) Andrew S. Greenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Rab18 Dynamics in Adipocytes in Relation to Lipogenesis, Lipolysis and Obesity

(2011) Marina R. Pulido et al.   PLoS One

Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation

(2011) D. A. Gross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets

(2011) Weihua Fei et al.   PLoS Genetics

Lipid droplets: size matters

(2011) M. Suzuki et al.   Microscopy

Seipin Is a Discrete Homooligomer

(2010) Derk Binns et al.   BIOCHEMISTRY

Fat-specific Protein 27 Undergoes Ubiquitin-dependent Degradation Regulated by Triacylglycerol Synthesis and Lipid Droplet Formation

(2010) Zongqian Nian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipid demixing and the birth of a lipid droplet

(2010) J. Zanghellini et al.   JOURNAL OF THEORETICAL BIOLOGY

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1

(2010) Eva Herker et al.   NATURE MEDICINE

Triglyceride Blisters in Lipid Bilayers: Implications for Lipid Droplet Biogenesis and the Mobile Lipid Signal in Cancer Cell Membranes

(2010) Himanshu Khandelia et al.   PLoS One

A Structure-Based Mechanism for Vesicle Capture by the Multisubunit Tethering Complex Dsl1

(2009) Yi Ren et al.   CELL

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

CIDE proteins and metabolic disorders

(2009) Jingyi Gong et al.   CURRENT OPINION IN LIPIDOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex

(2009) Arati Tripathi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

(2008) V. A. Payne et al.   DIABETES

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY

Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100

(2008) Y. Ohsaki et al.   JOURNAL OF CELL SCIENCE

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

(2008) Tsuguhito Ota et al.   JOURNAL OF CLINICAL INVESTIGATION

Imaging of Lipid Biosynthesis: How a Neutral Lipid Enters Lipid Droplets

(2008) Lars Kuerschner et al.   TRAFFIC