The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis

Na/K-ATPase: Their role in cell adhesion and migration in cancer

(2021) Camila Ignácio da Silva et al.   BIOCHIMIE

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment

(2020) Eleni Maniati et al.   Cell Reports

Natural Products: Implication in Cancer Prevention and Treatment through Modulating Various Biological Activities

(2020) Shehwaz Anwar et al.   Anti-Cancer Agents in Medicinal Chemistry

PARP Inhibitors in First-Line Therapy of Ovarian Cancer: Are There Any Doubts?

(2020) Elisena Franzese et al.   Frontiers in Oncology

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

(2019) Francesca Nazio et al.   CELL DEATH AND DIFFERENTIATION

Quantitative high-throughput screening using an organotypic model identifies compounds that inhibit ovarian cancer metastasis.

(2019) Hilary A Kenny et al.   MOLECULAR CANCER THERAPEUTICS

Plumbagin-induced oxidative stress leads to inhibition of Na+/K+-ATPase (NKA) in canine cancer cells

(2019) Yousef Alharbi et al.   Scientific Reports

Imaging Collagen Alterations in STICs and High Grade Ovarian Cancers in the Fallopian Tubes by Second Harmonic Generation Microscopy

(2019) Eric C. Rentchler et al.   Cancers

Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk

(2019) Peter C. Hart et al.   Cell Reports

Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway

(2018) Zhong Wang et al.   ACTA PHARMACOLOGICA SINICA

Molecular targets and anti-cancer potential of escin

(2018) Dorothy H.J. Cheong et al.   CANCER LETTERS

Escin induces apoptosis in human bladder cancer cells: An in vitro and in vivo study

(2018) Chen-Li Cheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics

(2017) Alexandra Naba et al.   JOURNAL OF PROTEOME RESEARCH

Anticancer and Immunogenic Properties of Cardiac Glycosides

(2017) Naira Schneider et al.   MOLECULES

Escin induces apoptosis in human renal cancer cells through G2/M arrest and reactive oxygen species-modulated mitochondrial pathways

(2017) Sheau-Yun Yuan et al.   ONCOLOGY REPORTS

Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells in vitro and in vivo

(2017) Jian Zhu et al.   Cell Death & Disease

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers

(2017) Oliver M.T. Pearce et al.   Cancer Discovery

The positive clinical therapeutically effects of Escin on advanced thyroid cancer

(2017) Jin-Yu Mei et al.   Cancer Medicine

Cardiac glycosides use and the risk and mortality of cancer; systematic review and meta-analysis of observational studies

(2017) Mohamed Hosny Osman et al.   PLoS One

CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma

(2016) J. Walton et al.   CANCER RESEARCH

Digoxin therapy is not associated with improved survival in epithelial ovarian cancer: A SEER-Medicare database analysis

(2016) Tilley Jenkins Vogel et al.   GYNECOLOGIC ONCOLOGY

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status

(2016) F. Coscia et al.   Nature Communications

Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression

(2016) Yuhui Wang et al.   Oncotarget

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

(2015) Hilary A. Kenny et al.   Nature Communications

Paclitaxel Through the Ages of Anticancer Therapy: Exploring Its Role in Chemoresistance and Radiation Therapy

(2015) Anna Barbuti et al.   Cancers

Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion

(2014) Hilary A. Kenny et al.   JOURNAL OF CLINICAL INVESTIGATION

 -Escin Inhibits NNK-Induced Lung Adenocarcinoma and ALDH1A1 and RhoA/Rock Expression in A/J Mice and Growth of H460 Human Lung Cancer Cells

(2013) J. M. R. Patlolla et al.   Cancer Prevention Research

Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo

(2012) Yong-Wei Wang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

MMP-2 functions as an early response protein in ovarian cancer metastasis

(2011) Hilary A. Kenny et al.   CELL CYCLE

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Escin, a Natural Mixture of Triterpene Saponins, Exhibits Antitumor Activity Against Hepatocellular Carcinoma

(2009) Xue-ying Zhou et al.   PLANTA MEDICA

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY