期刊
BIOCHIMIE
卷 185, 期 -, 页码 1-8出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2021.03.002
关键词
Na/K-ATPase (NKA); Cell adhesion; Motility; Migration; Cancer
资金
- Universidade Federal Fluminense (PROPPI/UFF)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
- Programa de Biotecnologia da Universidade Federal Fluminense (UFF)
- Programa de Pos Graduacao em Biologia Molecular Celular (UNIRIO)
- Universidade Federal do Estado do Rio de Janeiro (UNIRIO)
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) [E-26/010.000983/2019, E-26/203.290/2017, E-26/2010.592/2019]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
NKA is a p-type transmembrane enzyme formed by three different subunits and plays a crucial role in transporting sodium and potassium through the cell membrane as well as intracellular signaling. Changes in NKA function can impact pathological conditions like cancer, affecting cell adhesion, motility, and migration.
Na/K-ATPase (NKA) is a p-type transmembrane enzyme formed by three different subunits (alpha, beta, and gamma gamma). Primarily responsible for transporting sodium and potassium through the cell membrane, it also plays a critical role in intracellular signaling. The activation of diverse intracellular pathways may trigger cell death, survival, or even cell proliferation. Changes in the NKA functions or expression in isoforms subunits impact pathological conditions, such as cancer. The NKA function affects cell adhesion, motility, and migration, which are different in the physiological and pathological states. All enzyme subunits take part in the cell adhesion process, with the beta subunit being the most studied. Thus, herein we aim to highlight NKA' central role in cell adhesion, motility, and migration in cancer cells. (C) 2021 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
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