Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Article
Multidisciplinary Sciences
Alessandro De Vita, Chiara Liverani, Roberto Molinaro, Jonathan O. Martinez, Kelly A. Hartman, Chiara Spadazzi, Giacomo Miserocchi, Francesca Taraballi, Michael Evangelopoulos, Federica Pieri, Alberto Bongiovanni, Laura Mercatali, Ennio Tasciotti, Toni Ibrahim
Summary: Targeting the tumor microenvironment has emerged as a new approach in cancer treatment, with a novel ECM-targeting nanotherapeutic showing superior inhibition of TNBC cell growth.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Divya Ramchandani, Mirela Berisa, Diamile A. Tavarez, Zhuoning Li, Matthew Miele, Yang Bai, Sharrell B. Lee, Yi Ban, Noah Dephoure, Ronald C. Hendrickson, Suzanne M. Cloonan, Dingcheng Gao, Justin R. Cross, Linda T. Vahdat, Vivek Mittal
Summary: Copper chelation reduces TNBC metastasis by inactivating Complex IV in sensitive SOX2/OCT4+ cells, showing potential to enrich patient populations in next-generation therapeutic trials.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Jingnan Zhang, Ze Zhang, Zhenlin Huang, Manlin Li, Fan Yang, Zeqi Wu, Qian Guo, Xiyu Mei, Bin Lu, Changhong Wang, Zhengtao Wang, Lili Ji
Summary: This study reported that a natural compound isotoosendanin (ITSN) reduced TNBC metastasis by inhibiting TGF-P-induced EMT and the formation of invadopodia. ITSN can directly interact with TGF-P receptor type-1 (TGFPR1) and abrogated the kinase activity of TGFPR1, thereby blocking the TGF-P-initiated downstream signaling pathway. Moreover, ITSN also improved the inhibitory efficacy of programmed cell death 1 ligand 1 (PD-L1) antibody for TNBC in vivo via inhibiting the TGF-P-mediated EMT in the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Genetics & Heredity
Justine Marsolier, Pacome Prompsy, Adeline Durand, Anne-Marie Lyne, Camille Landragin, Amandine Trouchet, Sabrina Tenreira Bento, Almut Eisele, Sophie Foulon, Lea Baudre, Kevin Grosselin, Mylene Bohec, Sylvain Baulande, Ahmed Dahmani, Laura Sourd, Eric Letouze, Anne-Vincent Salomon, Elisabetta Marangoni, Leila Perie, Celine Vallot
Summary: The persistence of drug-resistant cancer cells is a major clinical challenge, particularly in triple-negative breast cancer. This study reveals that the repressive histone mark H3K27me3 plays a crucial role in regulating cell fate and chemotherapy tolerance in cancer cells. Manipulating H3K27me3 levels effectively enhances the potential of cancer cells to tolerate chemotherapy and delays tumor recurrence. These findings underscore the importance of understanding chromatin landscapes in shaping cancer cell response to initial therapy.
Article
Biochemistry & Molecular Biology
Xiang Chen, Margaret Clement, M. John Hicks, Poonam Sarkar, M. Waleed Gaber, Tsz-Kwong Man
Summary: This study found that lysyl oxidase (LOX) expression was associated with cytoplasmic mislocalization of p27 in osteosarcoma. Higher LOX expression promoted cell proliferation, migration, and invasiveness, and resulted in pulmonary metastases. The upregulation of phospho-FAK was identified as the mechanism by which LOX promotes osteosarcoma metastasis. FAK inhibition may be a promising therapeutic strategy to reduce LOX-mediated metastasis in osteosarcoma.
Article
Biochemistry & Molecular Biology
Nataliya Migulina, Gavin Tjin, Alen Faiz, Theo Borghuis, Fenghua Zhao, Hans J. Kaper, Marit Metzlar, Eline van Dijk, Prashant K. Sharma, Wim Timens, Reinoud Gosens, Corry-Anke Brandsma, Janette K. Burgess
Summary: This study investigated the effects of smoking and COPD on LOs gene and protein expression in the airways and found that LOs alterations may be related to smoking and contribute to impaired airway function in COPD, providing potential novel targets for prevention or treatment of small airways changes in COPD.
Article
Biochemistry & Molecular Biology
Stefano Zapperi, Caterina A. M. La Porta
Summary: Finding prognostic and predictive markers for TNBC is highly desirable, and the recently developed transcriptomic test ARIADNE shows promising capabilities in this regard.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Mohammed Alaouna, Clement Penny, Rodney Hull, Thulo Molefi, Nkhensani Chauke-Malinga, Richard Khanyile, Malose Makgoka, Meshack Bida, Zodwa Dlamini
Summary: Triple negative breast cancer (TNBC) is an aggressive subtype that lacks certain receptors. Phytochemicals, such as curcumin, resveratrol, and EGCG, show promise in inhibiting TNBC pathways. However, their limited bioavailability and lack of clinical evidence pose challenges for their use as single therapies. More research is needed to understand the role of phytochemicals in TNBC therapy and develop effective delivery mechanisms. This review discusses the potential of phytochemicals as a treatment option for TNBC.
Article
Oncology
Seung-Mo Kim, Eun-Jung Lim, Ki-Chun Yoo, Yi Zhao, Jae-Hyeok Kang, Eun-Ji Lim, Incheol Shin, Seok-Gu Kang, Han Woong Lim, Su-Jae Lee
Summary: This study investigates the molecular mechanisms of ECM remodeling and the interaction between GBM-educated MSLCs and GBMs in tumor progression. The findings provide mechanistic insights into the pro-infiltrative tumor microenvironment and highlight a potential therapeutic target for suppressing GBM infiltration.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yang Liu, Yu Fang, Lili Bao, Feng Wu, Shilong Wang, Siyu Hao
Summary: This study analyzed cellular gene expression profiles from five TNBC patients and characterized the EMT process using scRNA-seq. The identification of dysregulated transcription factors and cell-cell communications shed light on potential treatment targets for TNBC, enhancing the understanding of EMT in the tumor microenvironment.
Article
Oncology
Ingrid Espinoza, Chandra Kurapaty, Cheol-Hong Park, Travis Vander Steen, Celina G. Kleer, Elizabeth Wiley, Alfred Rademaker, Elisabet Cuyas, Sara Verdura, Maria Buxo, Carol Reynolds, Javier A. Menendez, Ruth Lupu
Summary: Triple-negative/basal-like breast cancer is characterized by aggressive biological features. Targeting CCN1/CYR61 may have therapeutic value in suppressing the biological aggressiveness of this type of breast cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Cell Biology
Hao Fang, Kai Fu, Ping Shi, Zhen Zhao, Fei Yang, Yan Liu
Summary: This study reveals that LOXL1 is transcriptionally regulated by FOXF2 and activates the Wnt/β-catenin signaling pathway to promote malignant phenotypes, EMT progression, and angiogenesis in BCPAP cells.
CELLULAR SIGNALLING
(2024)
Article
Oncology
Qun Lin, Xiaolin Fang, Gehao Liang, Qing Luo, Yinghuan Cen, Yu Shi, Shijie Jia, Juanmei Li, Wenqian Yang, Andrew J. Sanders, Chang Gong, Wenguo Jiang
Summary: CTNND1 downregulation plays a critical role in facilitating bone metastasis of TNBC, and may serve as a potential biomarker for predicting the risk of bone metastases in TNBC patients.