Polθ reverse transcribes RNA and promotes RNA-templated DNA repair

Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining

(2021) Gurushankar Chandramouly et al.   Cell Reports

Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase ζ

(2020) Chance Meers et al.   MOLECULAR CELL

One-step enzymatic modification of RNA 3′ termini using polymerase θ

(2019) Crystal Thomas et al.   NUCLEIC ACIDS RESEARCH

Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers

(2019) Jung-Hoon Yoon et al.   CELL

Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response

(2019) Andrew A. Kelso et al.   PLoS Genetics

Genetic determinants of cellular addiction to DNA polymerase theta

(2019) Wanjuan Feng et al.   Nature Communications

Molecular basis of microhomology-mediated end-joining by purified full-length Polθ

(2019) Samuel J. Black et al.   Nature Communications

Beyond PARP—POLθ as an anticancer target

(2018) Geoff S. Higgins et al.   SCIENCE

Transcriptional inaccuracy threshold attenuates differences in RNA-dependent DNA synthesis fidelity between retroviral reverse transcriptases

(2018) Alba Sebastián-Martín et al.   Scientific Reports

Human DNA polymerase η accommodates RNA for strand extension

(2017) Yan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair

(2017) Olga M. Mazina et al.   MOLECULAR CELL

Viral reverse transcriptases

(2017) Luis Menéndez-Arias et al.   VIRUS RESEARCH

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA

(2017) Alex N. Zelensky et al.   Nature Communications

DNA polymerase θ (POLQ), double-strand break repair, and cancer

(2016) Richard D. Wood et al.   DNA REPAIR

Processing ribonucleotides incorporated during eukaryotic DNA replication

(2016) Jessica S. Williams et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides

(2016) Tatiana Kent et al.   NUCLEIC ACIDS RESEARCH

Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining

(2016) Tatiana Kent et al.   eLife

Innate Reverse Transcriptase Activity of DNA Polymerase for Isothermal RNA Direct Detection

(2015) Chao Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribonucleotides in DNA: Origins, repair and consequences

(2014) Jessica S. Williams et al.   DNA REPAIR

A Role for DNA Polymerase θ in Promoting Replication through Oxidative DNA Lesion, Thymine Glycol, in Human Cells

(2014) Jung-Hoon Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for DNA polymerase θ in the timing of DNA replication

(2014) Anne Fernandez-Vidal et al.   Nature Communications

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid

(2013) Elżbieta Nowak et al.   NUCLEIC ACIDS RESEARCH

Lesion Bypass Activity of DNA Polymerase θ (POLQ) Is an Intrinsic Property of the Pol Domain and Depends on Unique Sequence Inserts

(2010) Matthew Hogg et al.   JOURNAL OF MOLECULAR BIOLOGY

Low-fidelity DNA synthesis by human DNA polymerase theta

(2008) M. E. Arana et al.   NUCLEIC ACIDS RESEARCH

DNA polymerase θ (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct

(2007) Mineaki Seki et al.   DNA REPAIR