Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Overexpression of POLQ Confers a Poor Prognosis in Early Breast Cancer Patients

(2015)   Oncotarget

Reconstructing the coding and non-coding RNA regulatory networks of miRNAs and mRNAs in breast cancer

(2014) Sheng Yang et al.   GENE

Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans

(2014) S. F. Roerink et al.   GENOME RESEARCH

A Role for DNA Polymerase θ in Promoting Replication through Oxidative DNA Lesion, Thymine Glycol, in Human Cells

(2014) Jung-Hoon Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for DNA polymerase θ in the timing of DNA replication

(2014) Anne Fernandez-Vidal et al.   Nature Communications

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

(2014) Wouter Koole et al.   Nature Communications

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

DNA Repair Gene Patterns as Prognostic and Predictive Factors in Molecular Breast Cancer Subtypes

(2013) L. Santarpia et al.   ONCOLOGIST

TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres

(2013) Albert Ribes-Zamora et al.   Cell Reports

Use of knowledge-based restraints inphenix.refineto improve macromolecular refinement at low resolution

(2012) Jeffrey J. Headd et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

DNA polymerase POLQ and cellular defense against DNA damage

(2012) Matthew J. Yousefzadeh et al.   DNA REPAIR

Amino Acid Templating Mechanisms in Selection of Nucleotides Opposite Abasic Sites by a Family A DNA Polymerase

(2012) Samra Obeid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Retrohoming of Linear Group II Intron RNAs in Drosophila melanogaster Occurs by Both DNA Ligase 4–Dependent and –Independent Mechanisms

(2012) Travis B. White et al.   PLoS Genetics

DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients

(2012) C Allera-Moreau et al.   Oncogenesis

The Structure of a High Fidelity DNA Polymerase Bound to a Mismatched Nucleotide Reveals an “Ajar” Intermediate Conformation in the Nucleotide Selection Mechanism

(2011) Eugene Y. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Phenix software for automated determination of macromolecular structures

(2011) Paul D. Adams et al.   METHODS

Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase  

(2011) K. Asagoshi et al.   NUCLEIC ACIDS RESEARCH

Promiscuous DNA synthesis by human DNA polymerase θ

(2011) Matthew Hogg et al.   NUCLEIC ACIDS RESEARCH

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown

(2010) Geoff S. Higgins et al.   CANCER RESEARCH

Lesion Bypass Activity of DNA Polymerase θ (POLQ) Is an Intrinsic Property of the Pol Domain and Depends on Unique Sequence Inserts

(2010) Matthew Hogg et al.   JOURNAL OF MOLECULAR BIOLOGY

Quantifying the energetic contributions of desolvation and π-electron density during translesion DNA synthesis

(2010) Edward A. Motea et al.   NUCLEIC ACIDS RESEARCH

Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity

(2010) Kei-ichi Takata et al.   NUCLEIC ACIDS RESEARCH

Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions

(2010) Amy Marie Yu et al.   NUCLEIC ACIDS RESEARCH

DNA polymerase   up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

(2010) F. Lemee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila

(2010) Sze Ham Chan et al.   PLoS Genetics

Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations

(2009) Young-Sam Lee et al.   CELL

Nucleic acid polymerases use a general acid for nucleotidyl transfer

(2009) Christian Castro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human DNA polymerase   possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

(2009) R. Prasad et al.   NUCLEIC ACIDS RESEARCH

Lack of DNA Polymerase θ (POLQ) Radiosensitizes Bone Marrow Stromal CellsIn Vitroand Increases Reticulocyte Micronuclei after Total-Body Irradiation

(2009) Julie P. Goff et al.   RADIATION RESEARCH

Reevaluation of the role of DNA polymerase θ in somatic hypermutation of immunoglobulin genes

(2008) Stella A. Martomo et al.   DNA REPAIR

Low-fidelity DNA synthesis by human DNA polymerase theta

(2008) M. E. Arana et al.   NUCLEIC ACIDS RESEARCH

DNA polymerase θ (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct

(2007) Mineaki Seki et al.   DNA REPAIR