Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis
出版年份 2021 全文链接
标题
Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis
作者
关键词
Cucurbitacin, TLR4, ROS, Calcium, Pyroptosis
出版物
PHARMACOLOGICAL RESEARCH
Volume 170, Issue -, Pages 105748
出版商
Elsevier BV
发表日期
2021-07-02
DOI
10.1016/j.phrs.2021.105748
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
- (2020) Ye Yang et al. BMC CANCER
- TLR4-mediated pyroptosis in human hepatoma-derived HuH-7 cells induced by a branched-chain polyunsaturated fatty acid, geranylgeranoic acid
- (2020) Suemi Yabuta et al. BIOSCIENCE REPORTS
- N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
- (2020) Mausita Karmakar et al. Nature Communications
- TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury
- (2020) Shun Xu et al. Cell Death & Disease
- Defying Death: The (W)hole Truth about the Fate of GSDMD Pores
- (2019) Charles L. Evavold et al. IMMUNITY
- The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding
- (2019) Sara Mouasni et al. Cell Death & Disease
- Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer
- (2019) Pengfei Liu et al. MOLECULES
- Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential
- (2019) Sukant Garg et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection
- (2019) Hanne Dubois et al. PLoS Pathogens
- The role of pyroptosis in cancer: pro-cancer or pro-“host”?
- (2019) Xiaojing Xia et al. Cell Death & Disease
- TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease
- (2019) Youliang Wang et al. Frontiers in Endocrinology
- Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation
- (2019) Chang Jia et al. Cell Death & Disease
- Pyroptosis: A new frontier in cancer
- (2019) Yuan Fang et al. BIOMEDICINE & PHARMACOTHERAPY
- Effects of doxorubicin on the heart: From molecular mechanisms to intervention strategies
- (2019) Nanthip Prathumsap et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling
- (2019) Xueliang Chen et al. Cell Death & Disease
- Modulation of Protein-Interaction States through the Cell Cycle
- (2018) Lingyun Dai et al. CELL
- Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture
- (2018) Nathalia M. de Vasconcelos et al. CELL DEATH AND DIFFERENTIATION
- Cucurbitacin-B attenuates CCl4 -induced hepatic fibrosis in mice through inhibition of STAT-3
- (2018) Alaliaa M. Sallam et al. Chemical Biology & Drug Design
- Toll-like receptors in immunity and inflammatory diseases: Past, present, and future
- (2018) Kumar Vijay INTERNATIONAL IMMUNOPHARMACOLOGY
- Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
- (2018) Fengjiao Wang et al. International Journal of Biological Sciences
- Cell death-based treatment of lung adenocarcinoma
- (2018) Tatiana V. Denisenko et al. Cell Death & Disease
- RNF25 promotes gefitinib resistance in EGFR-mutant NSCLC cells by inducing NF-κB-mediated ERK reactivation
- (2018) Jung Hee Cho et al. Cell Death & Disease
- Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis
- (2018) Bo Zhou et al. CELL RESEARCH
- The role of Ca2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis
- (2018) Xiaoshan Wu et al. LABORATORY INVESTIGATION
- ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation
- (2018) Sebastian Rühl et al. SCIENCE
- Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson’s disease
- (2018) Sandra Franco-Iborra et al. Cell Death & Disease
- Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells
- (2017) Xuewen Liu et al. ONCOLOGY REPORTS
- Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
- (2017) Jianjin Shi et al. TRENDS IN BIOCHEMICAL SCIENCES
- Gasdermins: Effectors of Pyroptosis
- (2017) Stephen B. Kovacs et al. TRENDS IN CELL BIOLOGY
- Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer
- (2017) Qi Zhang et al. Oncotarget
- Protective Effects of Cucurbitacin B on Acute Lung Injury Induced by Sepsis in Rats
- (2017) Shu Hua et al. MEDICAL SCIENCE MONITOR
- Activation of apoptosis signalling pathways by reactive oxygen species
- (2016) Maureen Redza-Dutordoir et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Inflammasome-dependent IL-1β release depends upon membrane permeabilisation
- (2016) F Martín-Sánchez et al. CELL DEATH AND DIFFERENTIATION
- Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity
- (2016) Brooke A. Napier et al. JOURNAL OF EXPERIMENTAL MEDICINE
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
- (2016) Yuan He et al. NATURE
- Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis
- (2015) S. Shukla et al. Cancer Prevention Research
- Cucurbitacin B inhibits immunomodulatory function and the inflammatory response in macrophages
- (2015) Minju Kim et al. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury
- (2015) Miaomiao Wei et al. MOLECULAR IMMUNOLOGY
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- Hepatoprotective and proapoptotic effect of Ecballium elaterium on CCl4-induced hepatotoxicity in rats
- (2015) El Moataz Bellah El Naggar et al. Asian Pacific Journal of Tropical Medicine
- Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells
- (2014) MENG ZHANG et al. Molecular Medicine Reports
- Cucurbitacin B potently suppresses non-small-cell lung cancer growth: Identification of intracellular thiols as critical targets
- (2013) Hina Kausar et al. CANCER LETTERS
- p53 regulates a non-apoptotic death induced by ROS
- (2013) J Montero et al. CELL DEATH AND DIFFERENTIATION
- Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status
- (2013) Joshua Jabaut et al. FREE RADICAL BIOLOGY AND MEDICINE
- Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial–mesenchymal transition
- (2011) Mi-Sook Lee et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na + /Ca 2+ exchange
- (2010) Alexander V. Zhdanov et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer
- (2010) Gabriela B Iwanski et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells
- (2009) N. H. Thoennissen et al. CANCER RESEARCH
- Cucurbitane-Type Triterpenoids from the Stems ofCucumis melo
- (2009) Chuan Chen et al. JOURNAL OF NATURAL PRODUCTS
- Small Cell Lung Cancer
- (2009) Taimur Sher et al. MAYO CLINIC PROCEEDINGS
- Pyroptosis: host cell death and inflammation
- (2009) Tessa Bergsbaken et al. NATURE REVIEWS MICROBIOLOGY
- How mitochondria produce reactive oxygen species
- (2008) Michael P. Murphy BIOCHEMICAL JOURNAL
- Antitumor Effects of Doxorubicin Followed by Zoledronic Acid in a Mouse Model of Breast Cancer
- (2008) P. D. Ottewell et al. JNCI-Journal of the National Cancer Institute
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now