Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential

Multifunctional neuroprotective effect of Withanone, a compound from Withania somnifera roots in alleviating cognitive dysfunction

(2018) Anjali Pandey et al.   CYTOKINE

UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells

(2018) Sanam Sane et al.   Molecular Oncology

Loss of lamin B1 is a biomarker to quantify cellular senescence in photoaged skin

(2017) Audrey Shimei Wang et al.   Scientific Reports

Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis

(2016) Y. Na et al.   CANCER RESEARCH

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

(2016) Yinyin Li et al.   IMMUNITY

Withanolides against TLR4-Activated Innate Inflammatory Signalling Pathways: A Comparative Computational and Experimental Study

(2016) Preethi M. Purushotham et al.   PHYTOTHERAPY RESEARCH

Mammalian telomeres and their partnership with lamins

(2016) Romina Burla et al.   Nucleus

Mammalian telomeres and their partnership with lamins

(2016) Romina Burla et al.   Nucleus

Functional Characterisation of Anticancer Activity in the Aqueous Extract of Helicteres angustifolia L. Roots

(2016) Kejuan Li et al.   PLoS One

hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies

(2015) Miguel Gallardo et al.   CANCER CELL

Functional Significance of Point Mutations in Stress Chaperone Mortalin and Their Relevance to Parkinson Disease

(2015) Renu Wadhwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CARF (Collaborator of ARF) overexpression in p53-deficient cells promotes carcinogenesis

(2015) Rajkumar S. Kalra et al.   Molecular Oncology

Combinations of Ashwagandha Leaf Extracts Protect Brain-Derived Cells against Oxidative Stress and Induce Differentiation

(2015) Navjot Shah et al.   PLoS One

Collaborator of ARF (CARF) Regulates Proliferative Fate of Human Cells by Dose-dependent Regulation of DNA Damage Signaling

(2014) Caroline T. Cheung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Withanone-Rich Combination of Ashwagandha Withanolides Restricts Metastasis and Angiogenesis through hnRNP-K

(2014) R. Gao et al.   MOLECULAR CANCER THERAPEUTICS

Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells

(2014) D Starenki et al.   ONCOGENE

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Therapeutic Applications of Herbal Medicines for Cancer Patients

(2013) Shu-Yi Yin et al.   Evidence-based Complementary and Alternative Medicine

Heterogeneous Nuclear Ribonucleoprotein K (hnRNP-K) Promotes Tumor Metastasis by Induction of Genes Involved in Extracellular Matrix, Cell Movement, and Angiogenesis

(2013) Ran Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

(2013) J.-W. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epoxide group relationship with cytotoxicity in withanolide derivatives from Withania somnifera

(2013) Pallavi Joshi et al.   STEROIDS

Differential Activities of the Two Closely Related Withanolides, Withaferin A and Withanone: Bioinformatics and Experimental Evidences

(2012) Kirti Vaishnavi et al.   PLoS One

Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A /C-depleted cells

(2011) Olga Moiseeva et al.   AGING CELL

Mortalin–p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

(2011) W-J Lu et al.   CELL DEATH AND DIFFERENTIATION

Withanone binds to mortalin and abrogates mortalin–p53 complex: Computational and experimental evidence

(2011) Abhinav Grover et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells

(2011) Arpita Konar et al.   PLoS One

The role of Lamin A in cytoskeleton organization in colorectal cancer cells

(2011) Clare R. Foster et al.   Nucleus

Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin

(2010) Wen-Jing Lu et al.   INTERNATIONAL JOURNAL OF CANCER

Selective Killing of Cancer Cells by Ashwagandha Leaf Extract and Its Component Withanone Involves ROS Signaling

(2010) Nashi Widodo et al.   PLoS One

Deceleration of Senescence in Normal Human Fibroblasts by Withanone Extracted From Ashwagandha Leaves

(2009) N. Widodo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Selective killing of cancer cells by leaf extract of Ashwagandha: Components, activity and pathway analyses

(2008) Nashi Widodo et al.   CANCER LETTERS

Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme

(2008) Dong Yin et al.   INTERNATIONAL JOURNAL OF CANCER