Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson’s disease

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration

(2018) Veronica Ghiglieri et al.   Frontiers in Neurology

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

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Molecular architecture of the active mitochondrial protein gate

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Inhibition of mitochondrial protein import by mutant huntingtin

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Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms

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α-Synuclein and Mitochondria: Partners in Crime?

(2013) Ken Nakamura   Neurotherapeutics

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease

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Mitochondrial Biology and Parkinson's Disease

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Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency

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Mechanisms of Protein Sorting in Mitochondria

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Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

The mitochondrial UPR - protecting organelle protein homeostasis

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Mitochondrial protein import: from proteomics to functional mechanisms

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PUMA- and Bax-induced autophagy contributes to apoptosis

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Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import

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Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

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Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

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