Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
出版年份 2021 全文链接
标题
Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
作者
关键词
-
出版物
Oxidative Medicine and Cellular Longevity
Volume 2021, Issue -, Pages 1-36
出版商
Hindawi Limited
发表日期
2021-07-21
DOI
10.1155/2021/3268136
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- Genistein inhibits the proliferation and differentiation of MCF-7 and 3T3-L1 cells via the regulation of ERα expression and induction of apoptosis
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- Genistein ameliorates parathyroid hormone-induced epithelial-to-mesenchymal transition and inhibits expression of connective tissue growth factor in human renal proximal tubular cells
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- Genistein Reinforces the Inhibitory Effect of Cisplatin on Liver Cancer Recurrence and Metastasis after Curative Hepatectomy
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- Genistein downregulates onco-miR-1260b and inhibits Wnt-signalling in renal cancer cells
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- DNA methylation and histone modifications of Wnt genes by genistein during colon cancer development
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- Genistein Ameliorates Adverse Cardiac Effects Induced by Arsenic Trioxide Through Preventing Cardiomyocytes Apoptosis
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- Genistein: the potential for efficacy in rheumatoid arthritis
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- Genistein Down-Regulates miR-223 Expression in Pancreatic Cancer Cells
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- Genistein and endothelial function in postmenopausal women with metabolic syndrome
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- Combination of low dose of genistein and daidzein has synergistic preventive effects on isogenic human prostate cancer cells when compared with individual soy isoflavone
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- Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells
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- Genistein in the Metabolic Syndrome: Results of a Randomized Clinical Trial
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- Involvement of Nuclear Factor κB (NF-κB) in the Downregulation of Cyclo-Oxygenase-2 (COX-2) by Genistein in Gastric Cancer Cells
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- The Synergistic Apoptotic Interaction of Indole-3-Carbinol and Genistein with TRAIL on Endometrial Cancer Cells
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- Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: Partial mediation by the transcription factor NFAT1
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- Genistein Induces G2/M Arrest in Gastric Cancer Cells by Increasing the Tumor Suppressor PTEN Expression
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- Genistein attenuates cancer stem cell characteristics in gastric cancer through the downregulation of Gli1
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- Genistein Sensitizes Bladder Cancer Cells to HCPT Treatment In Vitro and In Vivo via ATM/NF-κB/IKK Pathway-Induced Apoptosis
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- Genistein Inhibits Prostate Cancer Cell Growth by Targeting miR-34a and Oncogenic HOTAIR
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- Differential Effects of Genistein on Prostate Cancer Cells Depend on Mutational Status of the Androgen Receptor
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- Combination of LC3 shRNA Plasmid Transfection and Genistein Treatment Inhibited Autophagy and Increased Apoptosis in Malignant Neuroblastoma in Cell Culture and Animal Models
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- A Phase 2 Cancer Chemoprevention Biomarker Trial of Isoflavone G-2535 (Genistein) in Presurgical Bladder Cancer Patients
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- Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial
- (2012) S. A. Khan et al. Cancer Prevention Research
- Genistein Inhibits Cell Growth and Induces Apoptosis Through Up-regulation of miR-34a in Pancreatic Cancer Cells
- (2012) Jun Xia et al. CURRENT DRUG TARGETS
- Inhibition of proliferation and induction of G1-phase cell-cycle arrest by dFMGEN, a novel genistein derivative, in lung carcinoma A549 cells
- (2012) Bo Peng et al. DRUG AND CHEMICAL TOXICOLOGY
- Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study
- (2012) Joan Lappe et al. EUROPEAN JOURNAL OF NUTRITION
- A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells
- (2012) Xudong Di et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Effect of the genistein metabolite on leptin secretion in murine adipocytes in vitro
- (2012) Toshio Niwa et al. FOOD CHEMISTRY
- Genistein induces growth arrest and suppresses telomerase activity in brain tumor cells
- (2012) Aik Kia Khaw et al. GENES CHROMOSOMES & CANCER
- Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo
- (2012) HUI LI et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Anticancer activities of genistein-topotecan combination in prostate cancer cells
- (2012) Vanessa Hörmann et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling
- (2012) Lei-Guo Ming et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Genistein Affects Histone Modifications on Dickkopf-Related Protein 1 (DKK1) Gene in SW480 Human Colon Cancer Cell Line
- (2012) Huan Wang et al. PLoS One
- Genistein Suppresses Prostate Cancer Growth through Inhibition of Oncogenic MicroRNA-151
- (2012) Takeshi Chiyomaru et al. PLoS One
- Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study
- (2012) Guang-Rong Yan et al. PROTEOMICS
- Effects of standardized phytoestrogen on Taiwanese menopausal women
- (2012) Tzay-Shing Yang et al. Taiwanese Journal of Obstetrics & Gynecology
- Genistein enhances the effect of trichostatin A on inhibition of A549 cell growth by increasing expression of TNF receptor-1
- (2012) Tzu-Chin Wu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- 7-difluoromethoxyl-5,4’-di-n-octylgenistein inhibits growth of gastric cancer cells through downregulating forkhead box M1
- (2012) Hong-Lin Xiang WORLD JOURNAL OF GASTROENTEROLOGY
- Sensitization of Cervical Cancer Cells to Cisplatin by Genistein: The Role of NFB and Akt/mTOR Signaling Pathways
- (2012) K. Sahin et al. Journal of Oncology
- Genistein in Sanfilippo disease: A randomized controlled crossover trial
- (2011) Jessica de Ruijter et al. ANNALS OF NEUROLOGY
- Soy Isoflavones in the Prevention of Menopausal Bone Loss and Menopausal Symptoms
- (2011) Silvina Levis ARCHIVES OF INTERNAL MEDICINE
- Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity
- (2011) Wentao Qi et al. BMC CANCER
- Oxidative Stress in Preretinopathic Diabetes Subjects and Antioxidants
- (2011) Marcella Nebbioso et al. Diabetes Technology & Therapeutics
- IGF-I receptor signaling pathway is involved in the neuroprotective effect of genistein in the neuroblastoma SK-N-SH cells
- (2011) Quan-Gui Gao et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Genistein effects on stromal cells determines epithelial proliferation in endometrial co-cultures
- (2011) Brante P. Sampey et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Genistein attenuates WNT signaling by up-regulating sFRP2 in a human colon cancer cell line
- (2011) Yukun Zhang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- The Bone-Protective Effect of Genistein in the Animal Model of Bilateral Ovariectomy: Roles of Phytoestrogens and PTH/PTHR1 Against Post-Menopausal Osteoporosis
- (2011) Qing Miao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Eudragit nanoparticles containing genistein: formulation, development, and bioavailability assessment
- (2011) Linhua Wu et al. International Journal of Nanomedicine
- Improving Bioavailability and Stability of Genistein by Complexation with High-Amylose Corn Starch
- (2011) Revital Cohen et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Genistein Selectively Inhibits Estrogen-Induced Cell Proliferation and Other Responses to Hormone Stimulation in the Prepubertal Rat Uterus
- (2011) Leonardo Gaete et al. JOURNAL OF MEDICINAL FOOD
- Effects of genistein and daidzein on hippocampus neuronal cell proliferation and BDNF expression in H19-7 neural cell line
- (2011) Meixia Pan et al. Journal of Nutrition Health & Aging
- Efficacy and Safety of Short-Term Genistein Intervention in Patients with Localized Prostate Cancer Prior to Radical Prostatectomy: A Randomized, Placebo-Controlled, Double-Blind Phase 2 Clinical Trial
- (2011) Bato Lazarevic et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study
- (2011) T. Y. Tai et al. OSTEOPOROSIS INTERNATIONAL
- Disposition of soy isoflavones in normal human breast tissue
- (2010) Selin Bolca et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-κB
- (2010) Bo Zhang et al. ANTI-CANCER DRUGS
- Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: Role of Akt and nuclear factor-κB
- (2010) Yong Ma et al. CANCER LETTERS
- Genistein Aglycone: A Dual Mode of Action Anti-Osteoporotic Soy Isoflavone Rebalancing Bone Turnover Towards Bone Formation
- (2010) A. Bitto et al. CURRENT MEDICINAL CHEMISTRY
- Genistein inhibits osteolytic bone metastasis and enhances bone mineral in nude mice
- (2010) Yanyan Zhang et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- A phase II study of isoflavones, erlotinib, and gemcitabine in advanced pancreatic cancer
- (2010) Bassel Fuad El-Rayes et al. INVESTIGATIONAL NEW DRUGS
- Biomarkers of Dietary Exposure Are Associated with Lower Risk of Breast Fibroadenomas in Chinese Women
- (2010) S. Coosje Dijkstra et al. JOURNAL OF NUTRITION
- The effect of synthetic genistein on menopause symptom management in healthy postmenopausal women: A multi-center, randomized, placebo-controlled study
- (2010) Malkanthi Evans et al. MATURITAS
- Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity
- (2010) Yumiko Toyohira et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Effects of a High Dose, Aglycone-Rich Soy Extract on Prostate-Specific Antigen and Serum Isoflavone Concentrations in Men With Localized Prostate Cancer
- (2010) Ralph W. deVere White et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Reduction of leptin secretion by soy isoflavonoids in murine adipocytes in vitro
- (2010) Toshio Niwa et al. Phytochemistry Letters
- Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis
- (2009) Lin Yan et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Genistein Inhibits Cell Growth by Modulating Various Mitogen-Activated Protein Kinases and AKT in Cervical Cancer Cells
- (2009) Su-Hyeon Kim et al. Annals of the New York Academy of Sciences
- Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells
- (2009) Nishant Mohan et al. BRAIN RESEARCH
- BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer
- (2009) S. Majid et al. CARCINOGENESIS
- Repressive effect of the phytoestrogen genistein on estradiol-induced uterine leiomyoma cell proliferation
- (2009) Asako Miyake et al. GYNECOLOGICAL ENDOCRINOLOGY
- Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification
- (2009) Subhasree Roy Choudhury et al. INVESTIGATIONAL NEW DRUGS
- Effect of Genistein on vasculogenic mimicry formation by human uveal melanoma cells
- (2009) Rihong Cong et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells
- (2009) Joseph George et al. JOURNAL OF NEUROSCIENCE RESEARCH
- MEK4 Function, Genistein Treatment, and Invasion of Human Prostate Cancer Cells
- (2009) Li Xu et al. JNCI-Journal of the National Cancer Institute
- Effects of high-dose isoflavones on metabolic and inflammatory markers in healthy postmenopausal women
- (2009) Cornelia Charles et al. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
- Enhanced interaction between focal adhesion and adherens junction proteins: Involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement
- (2009) Xiaoguang Sun et al. MICROVASCULAR RESEARCH
- Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts
- (2009) S. Karmakar et al. NEUROSCIENCE
- Genistein Suppresses Spontaneous Oviduct Tumorigenesis in Quail
- (2009) Kazim Sahin et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Soy Food Consumption and Risk of Prostate Cancer: A Meta-Analysis of Observational Studies
- (2009) Ye Won Hwang et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Efficacy of genistein aglycone on some cardiovascular risk factors and homocysteine levels: A follow-up study
- (2009) H. Marini et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation
- (2009) Christopher D. Gardner et al. PROSTATE
- Phase II trial of isoflavone in prostate-specific antigen recurrent prostate cancer after previous local therapy
- (2008) John M Pendleton et al. BMC CANCER
- Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients
- (2008) Srilatha Swami et al. INTERNATIONAL JOURNAL OF CANCER
- Orally Administered Isoflavones Are Present as Glucuronides in the Human Prostate
- (2008) Laurent Guy et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Pueraria Mirifica Phytoestrogens Improve Dyslipidemia in Postmenopausal Women Probably by Activating Estrogen Receptor Subtypes
- (2008) Shinichi Okamura et al. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
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