标题
The molecular principles of gene regulation by Polycomb repressive complexes
作者
关键词
-
出版物
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-08-16
DOI
10.1038/s41580-021-00398-y
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Voices on Diversity: Combating Racial Inequality to Increase Diversity
- (2021) Jessica Silva-Fisher et al. MOLECULAR CELL
- Parental nucleosome segregation and the inheritance of cellular identity
- (2021) Thelma M. Escobar et al. NATURE REVIEWS GENETICS
- JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications
- (2021) Vignesh Kasinath et al. SCIENCE
- Polycomb complexes redundantly maintain epidermal stem cell identity during development
- (2021) Idan Cohen et al. GENES & DEVELOPMENT
- Liquid chromatin Hi-C characterizes compartment-dependent chromatin interaction dynamics
- (2021) Houda Belaghzal et al. NATURE GENETICS
- H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
- (2021) Yichao Cai et al. Nature Communications
- Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy
- (2021) Miles K. Huseyin et al. Nature Communications
- BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome
- (2021) Nadezda A. Fursova et al. GENES & DEVELOPMENT
- Balancing cohesin eviction and retention prevents aberrant chromosomal interactions, Polycomb-mediated repression, and X-inactivation
- (2021) Andrea J. Kriz et al. MOLECULAR CELL
- H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos
- (2021) Hailiang Mei et al. NATURE GENETICS
- Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos
- (2021) Zhiyuan Chen et al. NATURE GENETICS
- The roles of Polycomb repressive complexes in mammalian development and cancer
- (2021) Andrea Piunti et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- (2021) Huitao Fan et al. NUCLEIC ACIDS RESEARCH
- Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness
- (2021) Tomas Pachano et al. NATURE GENETICS
- mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution
- (2021) Christopher M. Weber et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation
- (2020) Fabian Erdel et al. MOLECULAR CELL
- A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin
- (2020) Siming Chen et al. MOLECULAR CELL
- Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters
- (2020) Unmesh Jadhav et al. MOLECULAR CELL
- Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development
- (2020) Chew Yee Ngan et al. NATURE GENETICS
- Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes
- (2020) Constance Alabert et al. Cell Reports
- Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
- (2020) James D.P. Rhodes et al. Cell Reports
- Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping
- (2020) V. Loubiere et al. Science Advances
- Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions
- (2020) Idan Cohen et al. BIOESSAYS
- The many faces of Polycomb regulation by RNA
- (2020) Mafalda Almeida et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- A central role for canonical PRC1 in shaping the 3D nuclear landscape
- (2020) Shelagh Boyle et al. GENES & DEVELOPMENT
- RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division
- (2020) Jicheng Zhao et al. NATURE CELL BIOLOGY
- Chromatin replication and epigenetic cell memory
- (2020) Kathleen R. Stewart-Morgan et al. NATURE CELL BIOLOGY
- Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells
- (2020) J. A. Zepeda-Martinez et al. Science Advances
- Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation
- (2020) Amy L. Hughes et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters
- (2020) Mengjie Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells
- (2020) Yicheng Long et al. NATURE GENETICS
- Maternal H3K27me3-dependent autosomal and X chromosome imprinting
- (2020) Zhiyuan Chen et al. NATURE REVIEWS GENETICS
- A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation
- (2020) Jeannette Reinig et al. Nature Communications
- FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis
- (2020) Peng Xu et al. BLOOD
- Dynamics of RNA polymerase II and elongation factor Spt4/5 recruitment during activator-dependent transcription
- (2020) Grace A. Rosen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3
- (2020) Ksenia Finogenova et al. eLife
- Structural basis for PRC2 engagement with chromatin
- (2020) Eleanor Glancy et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
- (2019) Antoine Campagne et al. Nature Communications
- The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail
- (2019) Tyler M. Weaver et al. Scientific Reports
- RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2
- (2019) Qi Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- R-Loops Enhance Polycomb Repression at a Subset of Developmental Regulator Genes
- (2019) Konstantina Skourti-Stathaki et al. MOLECULAR CELL
- Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities
- (2019) Andrea Scelfo et al. MOLECULAR CELL
- Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression
- (2019) Nadezda A. Fursova et al. MOLECULAR CELL
- Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation
- (2019) Anne Laugesen et al. MOLECULAR CELL
- SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development
- (2019) Qianhua Xu et al. NATURE GENETICS
- Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase
- (2019) Krupa S. Jani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity
- (2019) Elisa Lavarone et al. Nature Communications
- Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2
- (2019) Aaron J. Plys et al. GENES & DEVELOPMENT
- lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA
- (2019) Megan D. Schertzer et al. MOLECULAR CELL
- Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
- (2019) Hagar F. Moussa et al. Nature Communications
- Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
- (2019) Kim Sneppen et al. Nature Communications
- PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
- (2019) Siddhant U. Jain et al. Nature Communications
- Specific Contributions of Cohesin-SA1 and Cohesin-SA2 to TADs and Polycomb Domains in Embryonic Stem Cells
- (2019) Ana Cuadrado et al. Cell Reports
- CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism
- (2019) Andrea Piunti et al. Science Advances
- PRC2 functions in development and congenital disorders
- (2019) Orla Deevy et al. DEVELOPMENT
- Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity
- (2019) Jonas Westergaard Højfeldt et al. MOLECULAR CELL
- PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation
- (2019) Evan Healy et al. MOLECULAR CELL
- G-tract RNA removes Polycomb repressive complex 2 from genes
- (2019) Manuel Beltran et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication
- (2019) Thelma M. Escobar et al. CELL
- EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
- (2019) Roberta Ragazzini et al. Nature Communications
- DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency
- (2019) Katy McLaughlin et al. Cell Reports
- Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos
- (2019) Zhenhai Du et al. MOLECULAR CELL
- Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression
- (2019) Simone Tamburri et al. MOLECULAR CELL
- PRC1 Catalytic Activity Is Central to Polycomb System Function
- (2019) Neil P. Blackledge et al. MOLECULAR CELL
- Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas
- (2018) Kristian W. Pajtler et al. ACTA NEUROPATHOLOGICA
- PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification
- (2018) Idan Cohen et al. Cell Stem Cell
- Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits
- (2018) Daniel T. Youmans et al. GENES & DEVELOPMENT
- The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells
- (2018) Gundula Streubel et al. MOLECULAR CELL
- Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2
- (2018) Chul-Hwan Lee et al. MOLECULAR CELL
- Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding
- (2018) Siming Chen et al. MOLECULAR CELL
- Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin
- (2018) Chul-Hwan Lee et al. MOLECULAR CELL
- A Family of Vertebrate-Specific Polycombs Encoded by the LCOR / LCORL Genes Balance PRC2 Subtype Activities
- (2018) Eric Conway et al. MOLECULAR CELL
- Capturing the Onset of PRC2-Mediated Repressive Domain Formation
- (2018) Ozgur Oksuz et al. MOLECULAR CELL
- MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding
- (2018) Matteo Perino et al. NATURE GENETICS
- Eukaryotic core promoters and the functional basis of transcription initiation
- (2018) Vanja Haberle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2
- (2018) Jonas W. Højfeldt et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes
- (2018) Simon Poepsel et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structures of human PRC2 with its cofactors AEBP2 and JARID2
- (2018) Vignesh Kasinath et al. SCIENCE
- Chromatin domains rich in inheritance
- (2018) Danny Reinberg et al. SCIENCE
- Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2
- (2018) Jonas W. Højfeldt et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes
- (2018) Simon Poepsel et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Combinatorial Control of Recruitment of a Variant PRC1.6 Complex in Embryonic Stem Cells
- (2018) Yikai Huang et al. Cell Reports
- MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6
- (2018) Bastian Stielow et al. PLoS Genetics
- Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in distal forelimb bud
- (2018) Nayuta Yakushiji-Kaminatsui et al. DEVELOPMENT
- Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes
- (2018) Hamish W. King et al. GENOME RESEARCH
- Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication
- (2018) Nazaret Reverón-Gómez et al. MOLECULAR CELL
- Promoter bivalency favors an open chromatin architecture in embryonic stem cells
- (2018) Glòria Mas et al. NATURE GENETICS
- Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
- (2018) Ho Lam Chan et al. Nature Communications
- The Implication of Early Chromatin Changes in X Chromosome Inactivation
- (2018) Jan Jakub Żylicz et al. CELL
- Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex
- (2018) Masafumi Tsuboi et al. DEVELOPMENTAL CELL
- PRC1 preserves epidermal tissue integrity independently of PRC2
- (2018) Idan Cohen et al. GENES & DEVELOPMENT
- Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation
- (2018) Roubina Tatavosian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Polycomb directs timely activation of germline genes in spermatogenesis
- (2017) So Maezawa et al. GENES & DEVELOPMENT
- Polycomb and Trithorax Group Genes inDrosophila
- (2017) Judith A. Kassis et al. GENETICS
- Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity
- (2017) Wukui Zhao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription
- (2017) M. Behfar Ardehali et al. MOLECULAR CELL
- Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines
- (2017) Xueyin Wang et al. MOLECULAR CELL
- Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation
- (2017) Sharmistha Kundu et al. MOLECULAR CELL
- hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing
- (2017) Greta Pintacuda et al. MOLECULAR CELL
- Polycomb-like proteins link the PRC2 complex to CpG islands
- (2017) Haojie Li et al. NATURE
- Maternal H3K27me3 controls DNA methylation-independent imprinting
- (2017) Azusa Inoue et al. NATURE
- Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers
- (2017) H. Courtney Hodges et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA
- (2017) Xueyin Wang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing
- (2017) Zhuo Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation
- (2017) Mafalda Almeida et al. SCIENCE
- Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning
- (2017) Mei Sheng Lau et al. SCIENCE
- Propagation of Polycomb-repressed chromatin requires sequence-specific recruitment to DNA
- (2017) Friederike Laprell et al. SCIENCE
- Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene
- (2017) Rory T. Coleman et al. SCIENCE
- Liquid phase condensation in cell physiology and disease
- (2017) Yongdae Shin et al. SCIENCE
- Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression
- (2017) Gozde Kar et al. Nature Communications
- Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers
- (2017) H. Courtney Hodges et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA
- (2017) Xueyin Wang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications
- (2017) Christopher C. Ebmeier et al. Cell Reports
- The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin
- (2017) David A. Brown et al. Cell Reports
- Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2
- (2017) Yicheng Long et al. eLife
- PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes
- (2017) Mitsuhiro Endoh et al. eLife
- Polycomb and Trithorax Group Genes inDrosophila
- (2017) Judith A. Kassis et al. GENETICS
- Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity
- (2017) Scott Berry et al. Cell Systems
- EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis
- (2016) Wendy Béguelin et al. CANCER CELL
- Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity
- (2016) Fulvio Chiacchiera et al. Cell Stem Cell
- PRC2 preserves intestinal progenitors and restricts secretory lineage commitment
- (2016) Fulvio Chiacchiera et al. EMBO JOURNAL
- The interaction of PRC2 with RNA or chromatin is mutually antagonistic
- (2016) Manuel Beltran et al. GENOME RESEARCH
- EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape
- (2016) Robert Liefke et al. MOLECULAR CELL
- EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells
- (2016) Malte Beringer et al. MOLECULAR CELL
- RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes
- (2016) Chaoliang Wei et al. MOLECULAR CELL
- Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1
- (2016) Hitoshi Aihara et al. MOLECULAR CELL
- Resetting Epigenetic Memory by Reprogramming of Histone Modifications in Mammals
- (2016) Hui Zheng et al. MOLECULAR CELL
- Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin
- (2016) Benjamin Z Stanton et al. NATURE GENETICS
- Dynamics of BAF–Polycomb complex opposition on heterochromatin in normal and oncogenic states
- (2016) Cigall Kadoch et al. NATURE GENETICS
- The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation
- (2016) Susan L Kloet et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
- (2016) Sarah Cooper et al. Nature Communications
- Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
- (2016) Neil Justin et al. Nature Communications
- Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
- (2016) Alexei Brooun et al. Nature Communications
- Chromatin topology is coupled to Polycomb group protein subnuclear organization
- (2016) Ajazul H. Wani et al. Nature Communications
- The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation
- (2016) Susan L Kloet et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A High-Density Map for Navigating the Human Polycomb Complexome
- (2016) Simon Hauri et al. Cell Reports
- The BAH domain of BAHD1 is a histone H3K27me3 reader
- (2016) Dan Zhao et al. Protein & Cell
- RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes
- (2016) Nathan R Rose et al. eLife
- Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin
- (2016) Chao Yu Zhen et al. eLife
- Systematic Discovery of Xist RNA Binding Proteins
- (2015) Ci Chu et al. CELL
- Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms
- (2015) Lluis Morey et al. Cell Stem Cell
- The quest for mammalian Polycomb response elements: are we there yet?
- (2015) Moritz Bauer et al. CHROMOSOMA
- The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development
- (2015) Robert S. Illingworth et al. GENES & DEVELOPMENT
- Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation
- (2015) Ana Raquel Pengelly et al. GENES & DEVELOPMENT
- Two distinct modes for propagation of histone PTMs across the cell cycle
- (2015) Constance Alabert et al. GENES & DEVELOPMENT
- Genome-wide activities of Polycomb complexes control pervasive transcription
- (2015) Hun-Goo Lee et al. GENOME RESEARCH
- Toward a Consensus on the Binding Specificity and Promiscuity of PRC2 for RNA
- (2015) Chen Davidovich et al. MOLECULAR CELL
- Calibrating ChIP-Seq with Nucleosomal Internal Standards to Measure Histone Modification Density Genome Wide
- (2015) Adrian T. Grzybowski et al. MOLECULAR CELL
- Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation
- (2015) Serena Sanulli et al. MOLECULAR CELL
- HOTAIR Forms an Intricate and Modular Secondary Structure
- (2015) Srinivas Somarowthu et al. MOLECULAR CELL
- Function and information content of DNA methylation
- (2015) Dirk Schübeler NATURE
- Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
- (2015) Stefan Schoenfelder et al. NATURE GENETICS
- R loops regulate promoter-proximal chromatin architecture and cellular differentiation
- (2015) Poshen B Chen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Clustering of mammalianHoxgenes with other H3K27me3 targets within an active nuclear domain
- (2015) Maxence Vieux-Rochas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2
- (2015) Chen Davidovich et al. RNA
- Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2
- (2015) L. Jiao et al. SCIENCE
- Ctbp2 Modulates NuRD-Mediated Deacetylation of H3K27 and Facilitates PRC2-Mediated H3K27me3 in Active Embryonic Stem Cell Genes During Exit from Pluripotency
- (2015) Tae Wan Kim et al. STEM CELLS
- BMI1–RING1B is an autoinhibited RING E3 ubiquitin ligase
- (2015) Asad M. Taherbhoy et al. Nature Communications
- R loops regulate promoter-proximal chromatin architecture and cellular differentiation
- (2015) Poshen B Chen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- PRC1 components exhibit different binding kinetics in Polycomb bodies
- (2014) Bernard Vandenbunder et al. BIOLOGY OF THE CELL
- Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation
- (2014) Neil P. Blackledge et al. CELL
- EZH2 Inhibitor Efficacy in Non-Hodgkin’s Lymphoma Does Not Require Suppression of H3K27 Monomethylation
- (2014) William D. Bradley et al. CHEMISTRY & BIOLOGY
- Polycomb Potentiates Meis2 Activation in Midbrain by Mediating Interaction of the Promoter with a Tissue-Specific Enhancer
- (2014) Takashi Kondo et al. DEVELOPMENTAL CELL
- Nascent RNA interaction keeps PRC2 activity poised and in check
- (2014) Syuzo Kaneko et al. GENES & DEVELOPMENT
- Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide
- (2014) Eva Madi Riising et al. MOLECULAR CELL
- Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome
- (2014) Robert K. McGinty et al. NATURE
- An AUTS2–Polycomb complex activates gene expression in the CNS
- (2014) Zhonghua Gao et al. NATURE
- Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression
- (2014) Reinhard Kalb et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A dimeric state for PRC2
- (2014) Chen Davidovich et al. NUCLEIC ACIDS RESEARCH
- The Histone Lysine Demethylase JMJD3/KDM6B Is Recruited to p53 Bound Promoters and Enhancer Elements in a p53 Dependent Manner
- (2014) Kristine Williams et al. PLoS One
- Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation
- (2014) P. Jermann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment
- (2014) Wei Yang et al. Nature Communications
- Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment
- (2014) Sarah Cooper et al. Cell Reports
- A Cbx8-Containing Polycomb Complex Facilitates the Transition to Gene Activation during ES Cell Differentiation
- (2014) Catherine Creppe et al. PLoS Genetics
- Long-Range Chromatin Contacts in Embryonic Stem Cells Reveal a Role for Pluripotency Factors and Polycomb Proteins in Genome Organization
- (2013) Matthew Denholtz et al. Cell Stem Cell
- Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells
- (2013) Ruiyu Xie et al. Cell Stem Cell
- SAM Domain Polymerization Links Subnuclear Clustering of PRC1 to Gene Silencing
- (2013) Kyoichi Isono et al. DEVELOPMENTAL CELL
- A double take on bivalent promoters
- (2013) P. Voigt et al. GENES & DEVELOPMENT
- The role of the nucleosome acidic patch in modulating higher order chromatin structure
- (2013) A. A. Kalashnikova et al. Journal of the Royal Society Interface
- The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes
- (2013) Alberto Frangini et al. MOLECULAR CELL
- Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation
- (2013) Xudong Wu et al. MOLECULAR CELL
- Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity
- (2013) Karin J. Ferrari et al. MOLECULAR CELL
- Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
- (2013) Karin Klauke et al. NATURE CELL BIOLOGY
- Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes
- (2013) Jin He et al. NATURE CELL BIOLOGY
- Promiscuous RNA binding by Polycomb repressive complex 2
- (2013) Chen Davidovich et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells
- (2013) Syuzo Kaneko et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Transcriptional regulation by histone modifications: towards a theory of chromatin re-organization during stem cell differentiation
- (2013) Hans Binder et al. PHYSICAL BIOLOGY
- Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain
- (2013) Stephen Antonysamy et al. PLoS One
- Noncoding RNA and Polycomb recruitment
- (2013) N. Brockdorff RNA
- A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb
- (2013) A. R. Pengelly et al. SCIENCE
- Chromatin Sampling—An Emerging Perspective on Targeting Polycomb Repressor Proteins
- (2013) Robert J. Klose et al. PLoS Genetics
- Ras-Induced Changes in H3K27me3 Occur after Those in Transcriptional Activity
- (2013) Masaki Hosogane et al. PLoS Genetics
- Mechanism of Transcription Initiation at an Activator-Dependent Promoter Defined by Single-Molecule Observation
- (2012) Larry J. Friedman et al. CELL
- Asymmetrically Modified Nucleosomes
- (2012) Philipp Voigt et al. CELL
- RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3
- (2012) Lígia Tavares et al. CELL
- MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthologs during ESC Differentiation
- (2012) Ana O'Loghlen et al. Cell Stem Cell
- Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells
- (2012) Lluis Morey et al. Cell Stem Cell
- Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs
- (2012) Emily Brookes et al. Cell Stem Cell
- Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells
- (2012) T. Clouaire et al. GENES & DEVELOPMENT
- PRC2 directly methylates GATA4 and represses its transcriptional activity
- (2012) A. He et al. GENES & DEVELOPMENT
- Polycomb function during oogenesis is required for mouse embryonic development
- (2012) E. Posfai et al. GENES & DEVELOPMENT
- The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation
- (2012) S. Chen et al. GENES & DEVELOPMENT
- Polycomb Repressive Complex 1 (PRC1) Disassembles RNA Polymerase II Preinitiation Complexes
- (2012) Lynn Lehmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CBX7 is a tumor suppressor in mice and humans
- (2012) Floriana Forzati et al. JOURNAL OF CLINICAL INVESTIGATION
- PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes
- (2012) Zhonghua Gao et al. MOLECULAR CELL
- Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors
- (2012) Ming Yu et al. MOLECULAR CELL
- A Map of General and Specialized Chromatin Readers in Mouse Tissues Generated by Label-free Interaction Proteomics
- (2012) H. Christian Eberl et al. MOLECULAR CELL
- BAP1 loss defines a new class of renal cell carcinoma
- (2012) Samuel Peña-Llopis et al. NATURE GENETICS
- Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells
- (2012) Pietro Vella et al. NUCLEIC ACIDS RESEARCH
- Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3 Lysine 27 Methylation
- (2012) W. Yuan et al. SCIENCE
- RYBP and Cbx7 Define Specific Biological Functions of Polycomb Complexes in Mouse Embryonic Stem Cells
- (2012) Lluis Morey et al. Cell Reports
- REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells
- (2012) Nikolaj Dietrich et al. PLoS Genetics
- Molecular architecture of human polycomb repressive complex 2
- (2012) Claudio Ciferri et al. eLife
- KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
- (2012) Anca M Farcas et al. eLife
- Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila
- (2011) Frédéric Bantignies et al. CELL
- A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes
- (2011) Vincent A. Stepanik et al. DEVELOPMENTAL BIOLOGY
- Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex
- (2011) Matthew L Bentley et al. EMBO JOURNAL
- An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment
- (2011) Magnus D Lynch et al. EMBO JOURNAL
- NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression
- (2011) Nicola Reynolds et al. EMBO JOURNAL
- Polycomb eviction as a new distant enhancer function
- (2011) D. Vernimmen et al. GENES & DEVELOPMENT
- Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge
- (2011) D. J. Grau et al. GENES & DEVELOPMENT
- CpG islands and the regulation of transcription
- (2011) A. M. Deaton et al. GENES & DEVELOPMENT
- H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation
- (2011) Wen Yuan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- REST Interacts with Cbx Proteins and Regulates Polycomb Repressive Complex 1 Occupancy at RE1 Elements
- (2011) X. Ren et al. MOLECULAR AND CELLULAR BIOLOGY
- L3MBTL2 Protein Acts in Concert with PcG Protein-Mediated Monoubiquitination of H2A to Establish a Repressive Chromatin Structure
- (2011) Patrick Trojer et al. MOLECULAR CELL
- Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks
- (2011) Frank W. Schmitges et al. MOLECULAR CELL
- A Polycomb-based switch underlying quantitative epigenetic memory
- (2011) Andrew Angel et al. NATURE
- esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function
- (2011) Lena Ho et al. NATURE CELL BIOLOGY
- Polycomb complexes act redundantly to repress genomic repeats and genes
- (2010) M. Leeb et al. GENES & DEVELOPMENT
- The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes
- (2010) Edwin Smith et al. MOLECULAR CELL
- Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2
- (2010) Aditi Kanhere et al. MOLECULAR CELL
- Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination
- (2010) Ragnhild Eskeland et al. MOLECULAR CELL
- Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq
- (2010) Jing Zhao et al. MOLECULAR CELL
- Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
- (2010) Johanna C. Scheuermann et al. NATURE
- Transcriptional activation of polycomb-repressed genes by ZRF1
- (2010) Holger Richly et al. NATURE
- Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes
- (2010) Diego Pasini et al. NUCLEIC ACIDS RESEARCH
- Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
- (2010) M.-C. Tsai et al. SCIENCE
- PRC2 Complexes with JARID2, MTF2, and esPRC2p48 in ES Cells to Modulate ES Cell Pluripotency and Somatic Cell Reprograming
- (2010) Zhuo Zhang et al. STEM CELLS
- Polycomb Group Targeting through Different Binding Partners of RING1B C-Terminal Domain
- (2010) Renjing Wang et al. STRUCTURE
- GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells
- (2010) Eric M. Mendenhall et al. PLoS Genetics
- CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing
- (2009) F. Tie et al. DEVELOPMENT
- CpG islands - ‘A rough guide’
- (2009) Robert S. Illingworth et al. FEBS LETTERS
- Role of the polycomb protein EED in the propagation of repressive histone marks
- (2009) Raphael Margueron et al. NATURE
- The role of the polycomb complex in silencing -globin gene expression in nonerythroid cells
- (2008) D. Garrick et al. BLOOD
- Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity
- (2008) M. Endoh et al. DEVELOPMENT
- Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation
- (2008) T. Nakagawa et al. GENES & DEVELOPMENT
- Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor
- (2008) N. Herranz et al. MOLECULAR AND CELLULAR BIOLOGY
- Changes in the Distributions and Dynamics of Polycomb Repressive Complexes during Embryonic Stem Cell Differentiation
- (2008) X. Ren et al. MOLECULAR AND CELLULAR BIOLOGY
- Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors
- (2008) Fabio Mohn et al. MOLECULAR CELL
- Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation
- (2008) Radha Raman Pandey et al. MOLECULAR CELL
- Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms
- (2008) Raphael Margueron et al. MOLECULAR CELL
- A model for transmission of the H3K27me3 epigenetic mark
- (2008) Klaus H. Hansen et al. NATURE CELL BIOLOGY
- Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
- (2008) Manching Ku et al. PLoS Genetics
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