Polycomb complexes redundantly maintain epidermal stem cell identity during development

FDA approves an inhibitor of a novel ‘epigenetic writer’

(2020) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions

(2020) Idan Cohen et al.   BIOESSAYS

Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA

(2019) Unmesh Jadhav et al.   MOLECULAR CELL

Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR2-mediated signalling

(2019) Minh Binh Nguyen et al.   EXPERIMENTAL DERMATOLOGY

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

(2019) Nadezda A. Fursova et al.   MOLECULAR CELL

Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression

(2019) Carmit Bar et al.   Cell Reports

PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation

(2019) Evan Healy et al.   MOLECULAR CELL

PRC1 Catalytic Activity Is Central to Polycomb System Function

(2019) Neil P. Blackledge et al.   MOLECULAR CELL

PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification

(2018) Idan Cohen et al.   Cell Stem Cell

Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer

(2018) Yejing Ge et al.   NATURE REVIEWS GENETICS

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

(2018) Minh Binh Nguyen et al.   Nature Communications

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes

(2018) Hamish W. King et al.   GENOME RESEARCH

SMARTcleaner: identify and clean off-target signals in SMART ChIP-seq analysis

(2018) Dejian Zhao et al.   BMC BIOINFORMATICS

PRC1 preserves epidermal tissue integrity independently of PRC2

(2018) Idan Cohen et al.   GENES & DEVELOPMENT

Polycomb complexes PRC1 and their function in hematopoiesis

(2017) Miguel Vidal et al.   EXPERIMENTAL HEMATOLOGY

The interplay of epigenetic marks during stem cell differentiation and development

(2017) Yaser Atlasi et al.   NATURE REVIEWS GENETICS

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity

(2016) Fulvio Chiacchiera et al.   Cell Stem Cell

PRC2 preserves intestinal progenitors and restricts secretory lineage commitment

(2016) Fulvio Chiacchiera et al.   EMBO JOURNAL

Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells

(2016) Martijn A.J. Koppens et al.   GASTROENTEROLOGY

Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program

(2016) Tomokatsu Ikawa et al.   GENES & DEVELOPMENT

Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development

(2016) Katherine L. Dauber et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration

(2016) Melanie von Schimmelmann et al.   NATURE NEUROSCIENCE

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Dynamic stem cell states: naive to primed pluripotency in rodents and humans

(2016) Leehee Weinberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition

(2016) Brian Egan et al.   PLoS One

Survival of skin cancer stem cells requires the Ezh2 polycomb group protein

(2015) Gautam Adhikary et al.   CARCINOGENESIS

RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restrictingMeis2expression

(2015) Nayuta Yakushiji-Kaminatsui et al.   DEVELOPMENT

BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance

(2015) Roberta Ferretti et al.   GENES & DEVELOPMENT

The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane

(2015) Matthew L. Fisher et al.   MOLECULAR CARCINOGENESIS

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development

(2014) Weipeng Mu et al.   GENES & DEVELOPMENT

An AUTS2–Polycomb complex activates gene expression in the CNS

(2014) Zhonghua Gao et al.   NATURE

Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment

(2014) Sarah Cooper et al.   Cell Reports

Polycomb complexes in stem cells and embryonic development

(2013) L. Aloia et al.   DEVELOPMENT

Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells

(2013) Evan S Bardot et al.   EMBO JOURNAL

The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes

(2013) Alberto Frangini et al.   MOLECULAR CELL

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

The Transcriptional and Epigenomic Foundations of Ground State Pluripotency

(2012) Hendrik Marks et al.   CELL

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

(2012) Zhonghua Gao et al.   MOLECULAR CELL

Identifying ChIP-seq enrichment using MACS

(2012) Jianxing Feng et al.   Nature Protocols

Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity

(2012) Mitsuhiro Endoh et al.   PLoS Genetics

p63 regulatesSatb1to control tissue-specific chromatin remodeling during development of the epidermis

(2011) Michael Y. Fessing et al.   JOURNAL OF CELL BIOLOGY

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

(2010) I. J. Majewski et al.   BLOOD

Polycomb complexes act redundantly to repress genomic repeats and genes

(2010) M. Leeb et al.   GENES & DEVELOPMENT

Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis

(2010) Jingxuan Yang et al.   JOURNAL OF CELL BIOLOGY

Polycomb Group Proteins Are Key Regulators of Keratinocyte Function

(2010) Richard L. Eckert et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Charting histone modifications and the functional organization of mammalian genomes

(2010) Vicky W. Zhou et al.   NATURE REVIEWS GENETICS

seqMINER: an integrated ChIP-seq data interpretation platform

(2010) Tao Ye et al.   NUCLEIC ACIDS RESEARCH

Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells

(2010) D. Evseenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Mechanisms of Polycomb gene silencing: knowns and unknowns

(2009) Jeffrey A. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A global view of genomic information – moving beyond the gene and the master regulator

(2009) John S. Mattick et al.   TRENDS IN GENETICS

The Bmi-1 polycomb group gene in skin cancer: regulation of function by (−)-epigallocatechin-3-gallate

(2008) Sivaprakasam Balasubramanian et al.   NUTRITION REVIEWS

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

(2008) Manching Ku et al.   PLoS Genetics