Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits

Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding

(2018) Siming Chen et al.   MOLECULAR CELL

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

(2018) Jonas W. Højfeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes

(2018) Simon Poepsel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of human PRC2 with its cofactors AEBP2 and JARID2

(2018) Vignesh Kasinath et al.   SCIENCE

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

(2018) Jonas W. Højfeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes

(2018) Simon Poepsel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polycomb-like proteins link the PRC2 complex to CpG islands

(2017) Haojie Li et al.   NATURE

The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

(2017) Yupeng He et al.   Nature Chemical Biology

Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis

(2017) Jun Xiao et al.   NATURE GENETICS

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

(2017) Jeongyoon Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity

(2017) Daniel Holoch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

(2017) Jeongyoon Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CTCF and cohesin regulate chromatin loop stability with distinct dynamics

(2017) Anders S Hansen et al.   eLife

Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres

(2016) Jens C. Schmidt et al.   CELL

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs

(2016) Anne Grijzenhout et al.   DEVELOPMENT

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells

(2016) Giorgio Oliviero et al.   MOLECULAR & CELLULAR PROTEOMICS

The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation

(2016) Susan L Kloet et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetic balance of gene expression by Polycomb and COMPASS families

(2016) Andrea Piunti et al.   SCIENCE

The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation

(2016) Susan L Kloet et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A High-Density Map for Navigating the Human Polycomb Complexome

(2016) Simon Hauri et al.   Cell Reports

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation

(2015) Serena Sanulli et al.   MOLECULAR CELL

A general method to improve fluorophores for live-cell and single-molecule microscopy

(2015) Jonathan B Grimm et al.   NATURE METHODS

Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

(2015) L. Jiao et al.   SCIENCE

Dynamics of CRISPR-Cas9 genome interrogation in living cells

(2015) Spencer C. Knight et al.   SCIENCE

Probing the target search of DNA-binding proteins in mammalian cells using TetR as model searcher

(2015) Davide Normanno et al.   Nature Communications

Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells

(2014) Jiji Chen et al.   CELL

CTCF induces histone variant incorporation, erases the H3K27me3 histone mark and opens chromatin

(2014) Oliver Weth et al.   NUCLEIC ACIDS RESEARCH

3D imaging of Sox2 enhancer clusters in embryonic stem cells

(2014) Zhe Liu et al.   eLife

Promiscuous RNA binding by Polycomb repressive complex 2

(2013) Chen Davidovich et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells

(2012) J. P. Fonseca et al.   GENES & DEVELOPMENT

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity

(2012) Cecilia Ballaré et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation

(2012) Gerard L Brien et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polycomb-Like 3 Promotes Polycomb Repressive Complex 2 Binding to CpG Islands and Embryonic Stem Cell Self-Renewal

(2012) Julie Hunkapiller et al.   PLoS Genetics

Molecular architecture of human polycomb repressive complex 2

(2012) Claudio Ciferri et al.   eLife

Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells

(2011) M. Casanova et al.   DEVELOPMENT

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

(2011) Frank W. Schmitges et al.   MOLECULAR CELL

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation

(2010) Emily Walker et al.   Cell Stem Cell

Mammalian Polycomb-Like Pcl2/Mtf2 Is a Novel Regulatory Component of PRC2 That Can Differentially Modulate Polycomb Activity both at the Hox Gene Cluster and at Cdkn2a Genes

(2010) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells

(2009) Jamy C. Peng et al.   CELL

Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells

(2009) Xiaohua Shen et al.   CELL

Dynamics of Telomeres and Promyelocytic Leukemia Nuclear Bodies in a Telomerase-negative Human Cell Line

(2009) Thibaud Jegou et al.   MOLECULAR BIOLOGY OF THE CELL

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2

(2009) Hana Kim et al.   NUCLEIC ACIDS RESEARCH

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS

Highly inclined thin illumination enables clear single-molecule imaging in cells

(2008) Makio Tokunaga et al.   NATURE METHODS