标题
Structure and function of retroviral integrase
作者
关键词
-
出版物
NATURE REVIEWS MICROBIOLOGY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-07-09
DOI
10.1038/s41579-021-00586-9
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture.
- (2021) Anne Bruggemans et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Long Dissociation of Bictegravir from HIV-1 Integrase-DNA Complexes
- (2021) Kirsten L. White et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Cone-shaped HIV-1 capsids are transported through intact nuclear pores
- (2021) Vojtech Zila et al. CELL
- HIV-1 cores retain their integrity until minutes before uncoating in the nucleus
- (2021) Chenglei Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins
- (2021) Sriram Aiyer et al. STRUCTURE
- Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome
- (2021) Krishan K. Pandey et al. Communications Biology
- A Peptide Derived from Lens Epithelium–Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies
- (2020) Min Li et al. JOURNAL OF MOLECULAR BIOLOGY
- Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation
- (2020) Jamie A. Greig et al. MOLECULAR CELL
- HIV-1 uncoats in the nucleus near sites of integration
- (2020) Ryan C. Burdick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells
- (2020) David P. Hoffman et al. SCIENCE
- Structural basis for strand-transfer inhibitor binding to HIV intasomes
- (2020) Dario Oliveira Passos et al. SCIENCE
- Structural basis of second-generation HIV integrase inhibitor action and viral resistance
- (2020) Nicola J. Cook et al. SCIENCE
- Susceptibility to HIV-1 integrase strand transfer inhibitors (INSTIs) in highly treatment-experienced patients failing an INSTI-based regimen
- (2020) Maria M. Santoro et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Exploring histone loading on HIV DNA reveals a dynamic nucleosome positioning between unintegrated and integrated viral genome
- (2020) Shinichi Machida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cabotegravir Plus Rilpivirine: First Approval
- (2020) A. Markham DRUGS
- Structural basis of host protein hijacking in human T-cell leukemia virus integration
- (2020) Veer Bhatt et al. Nature Communications
- HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
- (2020) Ashwanth C. Francis et al. Nature Communications
- Accumulation of integrase strand transfer inhibitor resistance mutations confers high-level resistance to dolutegravir in non-B subtype HIV-1 strains from patients failing raltegravir in Uganda
- (2020) Emmanuel Ndashimye et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro
- (2020) Devin E. Christensen et al. SCIENCE
- Assembly intermediates of orthoreovirus captured in the cell
- (2020) Geoff Sutton et al. Nature Communications
- Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ
- (2020) Michał S. Barski et al. Nature Communications
- Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries
- (2020) Aizhan Bizhanova et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- High rate of virological failure and HIV drug resistance in semi-rural Gabon and implications for dolutegravir-based regimen efficacy
- (2020) Jéordy D Engone-Ondo et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Allosteric HIV integrase inhibitors promote formation of inactive branched polymers via homomeric carboxy-terminal domain interactions
- (2020) Kushol Gupta et al. STRUCTURE
- Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA
- (2020) Shelby Winans et al. PLoS Pathogens
- 5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors
- (2019) Kevin M. Peese et al. JOURNAL OF MEDICINAL CHEMISTRY
- HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the Nuclear Pore Complex
- (2019) David Alejandro Bejarano et al. eLife
- HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
- (2019) Pratibha C Koneru et al. eLife
- A systematic review of the genetic mechanisms of dolutegravir resistance
- (2019) Soo-Yon Rhee et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Inhibition of HTLV-1 Infection by HIV-1 First- and Second-Generation Integrase Strand Transfer Inhibitors
- (2019) Michał S. Barski et al. Frontiers in Microbiology
- Structure of a P element transposase–DNA complex reveals unusual DNA structures and GTP-DNA contacts
- (2019) George E. Ghanim et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- NHEJ pathway is involved in post-integrational DNA repair due to Ku70 binding to HIV-1 integrase
- (2019) Ekaterina Knyazhanskaya et al. Retrovirology
- Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer
- (2019) Marcus D. Wilson et al. Nature Communications
- LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells
- (2019) Gary LeRoy et al. Science Advances
- Structure of H3K36-methylated nucleosome–PWWP complex reveals multivalent cross-gyre binding
- (2019) Haibo Wang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration
- (2018) Damien Bonnard et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Accumulation of multiple mutations in vivo confers cross-resistance to new and existing integrase inhibitors
- (2018) Wendy W Zhang et al. JOURNAL OF INFECTIOUS DISEASES
- Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants
- (2018) Steven J. Smith et al. Retrovirology
- Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis
- (2018) Madushi Wanaguru et al. PLoS Pathogens
- Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration
- (2018) Vasudevan Achuthan et al. Cell Host & Microbe
- Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler
- (2018) Yu Chen et al. JOURNAL OF CELL BIOLOGY
- Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing
- (2017) Ashley C. Hoyte et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The FACT Complex Promotes Avian Leukosis Virus DNA Integration
- (2017) Shelby Winans et al. JOURNAL OF VIROLOGY
- Structural basis for spumavirus GAG tethering to chromatin
- (2017) Paul Lesbats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- X-ray crystal structure of the N-terminal region of Moloney murine leukemia virus integrase and its implications for viral DNA recognition
- (2017) Rongjin Guan et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity
- (2017) Céline Amadori et al. Retrovirology
- Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome
- (2017) Dario Oliveira Passos et al. SCIENCE
- A supramolecular assembly mediates lentiviral DNA integration
- (2017) Allison Ballandras-Colas et al. SCIENCE
- The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency
- (2016) Lei Feng et al. ACS Chemical Biology
- Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile
- (2016) Manuel Tsiang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis
- (2016) Jacques J. Kessl et al. CELL
- A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase
- (2016) Emil Peter Thrane Hertz et al. MOLECULAR CELL
- Crystal structure of the Rous sarcoma virus intasome
- (2016) Zhiqi Yin et al. NATURE
- Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function
- (2016) Allison Ballandras-Colas et al. NATURE
- Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction
- (2016) Brandon L. Crowe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin
- (2016) Gregory A. Sowd et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies
- (2016) Nanjie Deng et al. PROTEIN SCIENCE
- HIV-1 capsid is involved in post-nuclear entry steps
- (2016) Nan-Yu Chen et al. Retrovirology
- Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase
- (2016) Kushol Gupta et al. PLOS BIOLOGY
- A bend, flip and trap mechanism for transposon integration
- (2016) Elizabeth R Morris et al. eLife
- LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV
- (2016) Lenard S. Vranckx et al. EBioMedicine
- LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes
- (2015) Parmit Kumar Singh et al. GENES & DEVELOPMENT
- Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation
- (2015) Juan Fontana et al. JOURNAL OF VIROLOGY
- Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication
- (2015) Shewit S. Tekeste et al. JOURNAL OF VIROLOGY
- Structural basis for retroviral integration into nucleosomes
- (2015) Daniel P. Maskell et al. NATURE
- Structural and sequencing analysis of local target DNA recognition by MLV integrase
- (2015) S. Aiyer et al. NUCLEIC ACIDS RESEARCH
- B′-protein phosphatase 2A is a functional binding partner of delta-retroviral integrase
- (2015) Goedele N. Maertens NUCLEIC ACIDS RESEARCH
- The discovery of HTLV-1, the first pathogenic human retrovirus
- (2015) John M. Coffin PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Key determinants of target DNA recognition by retroviral intasomes
- (2015) Erik Serrao et al. Retrovirology
- Intasome architecture and chromatin density modulate retroviral integration into nucleosome
- (2015) Mohamed Benleulmi et al. Retrovirology
- Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif
- (2015) Petr Tesina et al. Nature Communications
- Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor
- (2014) Craig Fenwick et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- HIV-1 Integrase Variants Retarget Viral Integration and Are Associated with Disease Progression in a Chronic Infection Cohort
- (2014) Jonas Demeulemeester et al. Cell Host & Microbe
- Allosteric Inhibition of Human Immunodeficiency Virus Integrase
- (2014) Kushol Gupta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase
- (2014) Nikoloz Shkriabai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enhancers Are Major Targets for Murine Leukemia Virus Vector Integration
- (2014) S. S. De Ravin et al. JOURNAL OF VIROLOGY
- Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction
- (2014) Sriram Aiyer et al. NUCLEIC ACIDS RESEARCH
- MLV integration site selection is driven by strong enhancers and active promoters
- (2014) Matthew C. LaFave et al. NUCLEIC ACIDS RESEARCH
- Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes
- (2014) Ross C. Larue et al. NUCLEIC ACIDS RESEARCH
- Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding
- (2014) Erik Serrao et al. NUCLEIC ACIDS RESEARCH
- Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1
- (2014) Lee D. Fader et al. ACS Medicinal Chemistry Letters
- Resistance to HIV integrase strand transfer inhibitors: in vitro findings and clinical consequences
- (2014) Jay A. Grobler et al. Current Opinion in Virology
- Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly
- (2014) Amanda J. Price et al. PLoS Pathogens
- A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase
- (2014) Amit Sharma et al. PLoS Pathogens
- Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus Integration
- (2013) Saumya Shree Gupta et al. JOURNAL OF VIROLOGY
- Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes
- (2013) Jocelyn O. Eidahl et al. NUCLEIC ACIDS RESEARCH
- Non-Catalytic Site HIV-1 Integrase Inhibitors Disrupt Core Maturation and Induce a Reverse Transcription Block in Target Cells
- (2013) Mini Balakrishnan et al. PLoS One
- Biochemical Characterization of Novel Retroviral Integrase Proteins
- (2013) Allison Ballandras-Colas et al. PLoS One
- Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation
- (2013) K. A. Jurado et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BET proteins promote efficient murine leukemia virus integration at transcription start sites
- (2013) A. Sharma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag
- (2013) William M. Schneider et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions
- (2013) Belete Desimmie et al. Retrovirology
- Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage
- (2013) Erwann Le Rouzic et al. Retrovirology
- The Foamy Virus Gag Proteins: What Makes Them Different?
- (2013) Erik Müllers Viruses-Basel
- The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites
- (2013) Jan De Rijck et al. Cell Reports
- p12 Tethers the Murine Leukemia Virus Pre-integration Complex to Mitotic Chromosomes
- (2013) Efrat Elis et al. PLoS Pathogens
- Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity
- (2013) Kenneth A. Matreyek et al. PLoS Pathogens
- 3′-Processing and strand transfer catalysed by retroviral integrasein crystallo
- (2012) Stephen Hare et al. EMBO JOURNAL
- A nucleosomal surface defines an integration hotspot for the Saccharomyces cerevisiae Ty1 retrotransposon
- (2012) J. A. Baller et al. GENOME RESEARCH
- New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action
- (2012) Manuel Tsiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration
- (2012) Y. Koh et al. JOURNAL OF VIROLOGY
- The Mu transpososome structure sheds light on DDE recombinase evolution
- (2012) Sherwin P. Montaño et al. NATURE
- Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins
- (2012) Gary LeRoy et al. GENOME BIOLOGY
- The Mu story: how a maverick phage moved the field forward
- (2012) Rasika M Harshey Mobile DNA
- Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes
- (2011) Kendra E. Hightower et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones
- (2011) N. A. Gillet et al. BLOOD
- Gammaretroviral Integration into Nucleosomal Target DNA In Vivo
- (2011) S. L. Roth et al. JOURNAL OF VIROLOGY
- Sequential Deletion of the Integrase (Gag-Pol) Carboxyl Terminus Reveals Distinct Phenotypic Classes of Defective HIV-1
- (2011) K. D. Mohammed et al. JOURNAL OF VIROLOGY
- Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors
- (2011) Y. Koh et al. JOURNAL OF VIROLOGY
- The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3
- (2011) S. Rahman et al. MOLECULAR AND CELLULAR BIOLOGY
- Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)
- (2011) S. Hare et al. MOLECULAR PHARMACOLOGY
- HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency
- (2011) Torsten Schaller et al. PLoS Pathogens
- HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2
- (2011) Karen E. Ocwieja et al. PLoS Pathogens
- Retroviral intasome assembly and inhibition of DNA strand transfer
- (2010) Stephen Hare et al. NATURE
- The mechanism of retroviral integration from X-ray structures of its key intermediates
- (2010) Goedele N. Maertens et al. NATURE
- Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
- (2010) Frauke Christ et al. Nature Chemical Biology
- Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance
- (2010) S. Hare et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular Architecture of the Mos1 Paired-End Complex: The Structural Basis of DNA Transposition in a Eukaryote
- (2009) Julia M. Richardson et al. CELL
- Cooperative binding of two acetylation marks on a histone tail by a single bromodomain
- (2009) Jeanne Morinière et al. NATURE
- A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75
- (2009) Stephen Hare et al. PLoS Pathogens
- Structural Basis for Functional Tetramerization of Lentiviral Integrase
- (2009) Stephen Hare et al. PLoS Pathogens
- The Terminal (Catalytic) Adenosine of the HIV LTR Controls the Kinetics of Binding and Dissociation of HIV Integrase Strand Transfer Inhibitors
- (2008) David R. Langley et al. BIOCHEMISTRY
- Three-Dimensional Analysis of Budding Sites and Released Virus Suggests a Revised Model for HIV-1 Morphogenesis
- (2008) Lars-Anders Carlson et al. Cell Host & Microbe
- Identification and Characterization of PWWP Domain Residues Critical for LEDGF/p75 Chromatin Binding and Human Immunodeficiency Virus Type 1 Infectivity
- (2008) M.-C. Shun et al. JOURNAL OF VIROLOGY
- Functional and structural characterization of the integrase from the prototype foamy virus
- (2008) Eugene Valkov et al. NUCLEIC ACIDS RESEARCH
- Chromatin Tethering of Incoming Foamy Virus by the Structural Gag Protein
- (2008) Joelle Tobaly-Tapiero et al. TRAFFIC
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