Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries

Local rewiring of genome–nuclear lamina interactions by transcription

(2020) Laura Brueckner et al.   EMBO JOURNAL

Visualizing the genome in high resolution challenges our textbook understanding

(2020) Melike Lakadamyali et al.   NATURE METHODS

Monitoring the spatio-temporal organization and dynamics of the genome

(2020) Haitham A Shaban et al.   NUCLEIC ACIDS RESEARCH

Zooming in on chromosome dynamics

(2020) John K. Eykelenboom et al.   CELL CYCLE

Super-resolution in situ analysis of active ribosomal DNA chromatin organization in the nucleolus

(2020) Andreas Maiser et al.   Scientific Reports

Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation

(2020) J. Yuyang Lu et al.   Cell Reports

Regulation and Roles of the Nucleolus in Embryonic Stem Cells: From Ribosome Biogenesis to Genome Organization

(2020) Shivani Gupta et al.   Stem Cell Reports

Ribosomal DNA and the nucleolus in the context of genome organization

(2019) Tamara A. Potapova et al.   CHROMOSOME RESEARCH

Lamina Associated Domains and Gene Regulation in Development and Cancer

(2019) Silke J.A. Lochs et al.   Cells

The chromatin-associated protein PWO1 interacts with plant nuclear lamin-like components to regulate nuclear size

(2019) Pawel Mikulski et al.   PLANT CELL

Ribosomal DNA harbors an evolutionarily conserved clock of biological aging

(2019) Meng Wang et al.   GENOME RESEARCH

Promoter-Intrinsic and Local Chromatin Features Determine Gene Repression in LADs

(2019) Christ Leemans et al.   CELL

Genome–lamina interactions are established de novo in the early mouse embryo

(2019) Máté Borsos et al.   NATURE

Two contrasting classes of nucleolus-associated domains in mouse fibroblast heterochromatin

(2019) Anastassiia Vertii et al.   GENOME RESEARCH

Heterochromatin drives compartmentalization of inverted and conventional nuclei

(2019) Martin Falk et al.   NATURE

Nascent Pre-rRNA Sorting via Phase Separation Drives the Assembly of Dense Fibrillar Components in the Human Nucleolus

(2019) Run-Wen Yao et al.   MOLECULAR CELL

Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance

(2019) Sahana Holla et al.   CELL

Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies

(2018) Spencer C. Knight et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus

(2018) Sofia A. Quinodoz et al.   CELL

A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity

(2018) Michelle Percharde et al.   CELL

Lamins Organize the Global Three-Dimensional Genome from the Nuclear Periphery

(2018) Xiaobin Zheng et al.   MOLECULAR CELL

MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization

(2018) Indrabahadur Singh et al.   NATURE GENETICS

Nucleolar Function in Lifespan Regulation

(2018) Varnesh Tiku et al.   TRENDS IN CELL BIOLOGY

Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome

(2018) G. Bonora et al.   Nature Communications

The long-range interaction map of ribosomal DNA arrays

(2018) Shoukai Yu et al.   PLoS Genetics

Heterochromatin: Guardian of the Genome

(2018) Aniek Janssen et al.   Annual Review of Cell and Developmental Biology

Nucleolus and chromatin

(2018) Christian Schöfer et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler

(2018) Yu Chen et al.   JOURNAL OF CELL BIOLOGY

Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation

(2018) Roubina Tatavosian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRISPR-Sirius: RNA scaffolds for signal amplification in genome imaging

(2018) Hanhui Ma et al.   NATURE METHODS

Coaching from the sidelines: the nuclear periphery in genome regulation

(2018) Abigail Buchwalter et al.   NATURE REVIEWS GENETICS

PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX

(2017) Erwan Delbarre et al.   GENOME RESEARCH

Ki-67 Contributes to Normal Cell Cycle Progression and Inactive X Heterochromatin in p21 Checkpoint-Proficient Human Cells

(2017) Xiaoming Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Lamin B2 Modulates Nucleolar Morphology, Dynamics, and Function

(2017) Ayantika Sen Gupta et al.   MOLECULAR AND CELLULAR BIOLOGY

The p150N domain of chromatin assembly factor-1 regulates Ki-67 accumulation on the mitotic perichromosomal layer

(2017) Timothy D. Matheson et al.   MOLECULAR BIOLOGY OF THE CELL

Ten principles of heterochromatin formation and function

(2017) Robin C. Allshire et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nucleolus association of chromosomal domains is largely maintained in cellular senescence despite massive nuclear reorganisation

(2017) Stefan Dillinger et al.   PLoS One

Independent active and thermodynamic processes govern the nucleolus assembly in vivo

(2017) Hanieh Falahati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ki-67 and the Chromosome Periphery Compartment in Mitosis

(2017) Daniel G. Booth et al.   TRENDS IN CELL BIOLOGY

Nucleolar expansion and elevated protein translation in premature aging

(2017) Abigail Buchwalter et al.   Nature Communications

Lamin B Receptor: Interplay between Structure, Function and Localization

(2017) Eleni Nikolakaki et al.   Cells

Nucleolus Precursor Bodies and Ribosome Biogenesis in Early Mammalian Embryos: Old Theories and New Discoveries1

(2016) Helena Fulka et al.   BIOLOGY OF REPRODUCTION

Nucleophosmin: from structure and function to disease development

(2016) Joseph K. Box et al.   BMC MOLECULAR BIOLOGY

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

The redundancy of the mammalian heterochromatic compartment

(2016) Joan C Ritland Politz et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Nucleolar organizer regions: genomic ‘dark matter’ requiring illumination

(2016) Brian McStay   GENES & DEVELOPMENT

Perichromosomal protein Ki67 supports mitotic chromosome architecture

(2016) Masatoshi Takagi et al.   GENES TO CELLS

A Portrait of Ribosomal DNA Contacts with Hi-C Reveals 5S and 45S rDNA Anchoring Points in the Folded Human Genome

(2016) Shoukai Yu et al.   Genome Biology and Evolution

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

(2016) Kevin Gesson et al.   GENOME RESEARCH

Ki-67 acts as a biological surfactant to disperse mitotic chromosomes

(2016) Sara Cuylen et al.   NATURE

Super-resolution imaging reveals distinct chromatin folding for different epigenetic states

(2016) Alistair N. Boettiger et al.   NATURE

Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow

(2016) Hanhui Ma et al.   NATURE BIOTECHNOLOGY

Small nucleoli are a cellular hallmark of longevity

(2016) Varnesh Tiku et al.   Nature Communications

Identification of Nucleolus-Associated Chromatin Domains Reveals a Role for the Nucleolus in 3D Organization of the A. thaliana Genome

(2016) Frédéric Pontvianne et al.   Cell Reports

The cell proliferation antigen Ki-67 organises heterochromatin

(2016) Michal Sobecki et al.   eLife

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

(2016) Diana M Mitrea et al.   eLife

The nuclear lamina in health and disease

(2016) Agnieszka Dobrzynska et al.   Nucleus

The nuclear lamina in health and disease

(2016) Agnieszka Dobrzynska et al.   Nucleus

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

(2015) Jop Kind et al.   CELL

Grabbing the genome by the NADs

(2015) Timothy D. Matheson et al.   CHROMOSOMA

Networking in the nucleus: a spotlight on LEM-domain proteins

(2015) Lacy J Barton et al.   CURRENT OPINION IN CELL BIOLOGY

Alu element-containing RNAs maintain nucleolar structure and function

(2015) M. Caudron-Herger et al.   EMBO JOURNAL

Nuclear lamins are not required for lamina-associated domain organization in mouse embryonic stem cells

(2015) M. Amendola et al.   EMBO REPORTS

Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins

(2015) Jennifer C. Harr et al.   JOURNAL OF CELL BIOLOGY

Identification of lamin B–regulated chromatin regions based on chromatin landscapes

(2015) Xiaobin Zheng et al.   MOLECULAR BIOLOGY OF THE CELL

Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C

(2015) Borbala Mifsud et al.   NATURE GENETICS

Three-dimensional genome architecture: players and mechanisms

(2015) Ana Pombo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multicolor CRISPR labeling of chromosomal loci in human cells

(2015) Hanhui Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constitutive heterochromatin formation and transcription in mammals

(2015) Nehmé Saksouk et al.   Epigenetics & Chromatin

Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes

(2015) Brian J. Beliveau et al.   Nature Communications

The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation

(2015) Fan Yang et al.   GENOME BIOLOGY

Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin

(2015) Eivind G Lund et al.   Nucleus

Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin

(2015) Eivind G Lund et al.   Nucleus

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

Construction of synthetic nucleoli and what it tells us about propagation of sub-nuclear domains through cell division

(2014) Alice Grob et al.   CELL CYCLE

lncRNA Maturation to Initiate Heterochromatin Formation in the Nucleolus Is Required for Exit from Pluripotency in ESCs

(2014) Nataša Savić et al.   Cell Stem Cell

Pioneer transcription factors in cell reprogramming

(2014) Makiko Iwafuchi-Doi et al.   GENES & DEVELOPMENT

Functional and topological characteristics of mammalian regulatory domains

(2014) O. Symmons et al.   GENOME RESEARCH

Loss of Nucleolar Histone Chaperone NPM1 Triggers Rearrangement of Heterochromatin and Synergizes with a Deficiency in DNA Methyltransferase DNMT3A to Drive Ribosomal DNA Transcription

(2014) Karl Holmberg Olausson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular basis of emerin-emerin and emerin-BAF interactions

(2014) J. M. Berk et al.   JOURNAL OF CELL SCIENCE

A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli

(2014) Corey L. Smith et al.   MOLECULAR BIOLOGY OF THE CELL

Topologically associating domains are stable units of replication-timing regulation

(2014) Benjamin D. Pope et al.   NATURE

An overview of pre-ribosomal RNA processing in eukaryotes

(2014) Anthony K. Henras et al.   Wiley Interdisciplinary Reviews-RNA

Functional redundancy in the nuclear compartmentalization of the late-replicating genome

(2014) Tobias Ragoczy et al.   Nucleus

Stochastic genome-nuclear lamina interactions

(2014) Jop Kind et al.   Nucleus

Something Silent This Way Forms: The Functional Organization of the Repressive Nuclear Compartment

(2013) Joan C. Ritland Politz et al.   Annual Review of Cell and Developmental Biology

Developmentally Regulated Subnuclear Genome Reorganization Restricts Neural Progenitor Competence in Drosophila

(2013) Minoree Kohwi et al.   CELL

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Single-Cell Dynamics of Genome-Nuclear Lamina Interactions

(2013) Jop Kind et al.   CELL

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation

(2013) Irina Solovei et al.   CELL

Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast

(2013) Benjamin J Alper et al.   EMBO JOURNAL

Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging

(2013) Austen R. D. Ganley et al.   FEMS YEAST RESEARCH

Heterochromatin establishment at pericentromeres depends on nuclear position

(2013) J. W. Jachowicz et al.   GENES & DEVELOPMENT

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

β-Globin cis-elements determine differential nuclear targeting through epigenetic modifications

(2013) Qian Bian et al.   JOURNAL OF CELL BIOLOGY

The Nucleoplasmin Homolog NLP Mediates Centromere Clustering and Anchoring to the Nucleolus

(2013) Jan Padeken et al.   MOLECULAR CELL

The Hierarchy of the 3D Genome

(2013) Johan H. Gibcus et al.   MOLECULAR CELL

DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina

(2012) Joseph M. Zullo et al.   CELL

Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations

(2012) Yu Zhang et al.   CELL

Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear Periphery

(2012) Benjamin D. Towbin et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence

(2012) W. Meuleman et al.   GENOME RESEARCH

The Nuclear Envelope Protein Emerin Binds Directly to Histone Deacetylase 3 (HDAC3) and Activates HDAC3 Activity

(2012) Justin Demmerle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lamin B Receptor Recognizes Specific Modifications of Histone H4 in Heterochromatin Formation

(2012) Yasuhiro Hirano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lamins at a glance

(2012) C. Y. Ho et al.   JOURNAL OF CELL SCIENCE

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Spatial partitioning of the regulatory landscape of the X-inactivation centre

(2012) Elphège P. Nora et al.   NATURE

The nuclear lamins: flexibility in function

(2012) Brian Burke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Versatile design and synthesis platform for visualizing genomes with Oligopaint FISH probes

(2012) B. J. Beliveau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation-Driven Nucleolar Association of the Mouse Imprinted Kcnq1 Locus

(2012) Andrew M. Fedoriw et al.   G3-Genes Genomes Genetics

Nucleolar Association and Transcriptional Inhibition through 5S rDNA in Mammals

(2012) Andrew M. Fedoriw et al.   PLoS Genetics

An EDMD Mutation in C. elegans Lamin Blocks Muscle-Specific Gene Relocation and Compromises Muscle Integrity

(2011) Anna Mattout et al.   CURRENT BIOLOGY

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome organization in and around the nucleolus

(2011) Attila Németh et al.   TRENDS IN GENETICS

The lamin protein family

(2011) Travis A Dittmer et al.   GENOME BIOLOGY

Genome–nuclear lamina interactions and gene regulation

(2010) Jop Kind et al.   CURRENT OPINION IN CELL BIOLOGY

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

(2010) Claudio Guetg et al.   EMBO JOURNAL

The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin

(2010) Elaine Sanij et al.   Epigenetics

Wisely chosen paths - regulation of rRNA synthesis

(2010) Ingrid Grummt   FEBS Journal

Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin

(2010) Francine Bruston et al.   FEBS LETTERS

Global survey of escape from X inactivation by RNA-sequencing in mouse

(2010) F. Yang et al.   GENOME RESEARCH

High-Resolution Whole-Genome Sequencing Reveals That Specific Chromatin Domains from Most Human Chromosomes Associate with Nucleoli

(2010) Silvana van Koningsbruggen et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation

(2010) Daan Peric-Hupkes et al.   MOLECULAR CELL

Open chromatin in pluripotency and reprogramming

(2010) Alexandre Gaspar-Maia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global Chromatin Architecture Reflects Pluripotency and Lineage Commitment in the Early Mouse Embryo

(2010) Kashif Ahmed et al.   PLoS One

The Nucleolus

(2010) T. Pederson   Cold Spring Harbor Perspectives in Biology

Initial Genomics of the Human Nucleolus

(2010) Attila Németh et al.   PLoS Genetics

Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2

(2010) Kohta Ikegami et al.   GENOME BIOLOGY

The nuclear envelope—a scaffold for silencing?

(2009) Benjamin D Towbin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis

(2009) I. Hiratani et al.   GENOME RESEARCH

Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells

(2009) Bo Wen et al.   NATURE GENETICS

Reassessing the abundance of H3K9me2 chromatin domains in embryonic stem cells

(2009) Guillaume J Filion et al.   NATURE GENETICS

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

The Epigenetics of rRNA Genes: From Molecular to Chromosome Biology

(2008) Brian McStay et al.   Annual Review of Cell and Developmental Biology

A new role of the rDNA and nucleolus in the nucleus—rDNA instability maintains genome integrity

(2008) Takehiko Kobayashi   BIOESSAYS

The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus

(2008) Christine Mayer et al.   EMBO REPORTS

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence

(2008) R. Ileng Kumaran et al.   JOURNAL OF CELL BIOLOGY

Kcnq1ot1/Lit1 Noncoding RNA Mediates Transcriptional Silencing by Targeting to the Perinucleolar Region

(2008) F. Mohammad et al.   MOLECULAR AND CELLULAR BIOLOGY

Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation

(2008) Radha Raman Pandey et al.   MOLECULAR CELL

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Transcriptional repression mediated by repositioning of genes to the nuclear lamina

(2008) K. L. Reddy et al.   NATURE

Recruitment to the Nuclear Periphery Can Alter Expression of Genes in Human Cells

(2008) Lee E. Finlan et al.   PLoS Genetics