Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

A supramolecular assembly mediates lentiviral DNA integration

(2017) Allison Ballandras-Colas et al.   SCIENCE

Retroviral DNA Integration

(2016) Paul Lesbats et al.   CHEMICAL REVIEWS

Crystal structure of the Rous sarcoma virus intasome

(2016) Zhiqi Yin et al.   NATURE

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function

(2016) Allison Ballandras-Colas et al.   NATURE

Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement

(2015) Frank DiMaio et al.   NATURE METHODS

Key determinants of target DNA recognition by retroviral intasomes

(2015) Erik Serrao et al.   Retrovirology

Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes

(2015) Serban L. Ilca et al.   Nature Communications

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

(2015) Timothy Grant et al.   eLife

Uneven Genetic Robustness of HIV-1 Integrase

(2014) Suzannah J. Rihn et al.   JOURNAL OF VIROLOGY

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding

(2014) Erik Serrao et al.   NUCLEIC ACIDS RESEARCH

Engineered Hyperactive Integrase for Concerted HIV-1 DNA Integration

(2014) Min Li et al.   PLoS One

A Homology Model of HIV-1 Integrase and Analysis of Mutations Designed to Test the Model

(2013) Barry C. Johnson et al.   JOURNAL OF MOLECULAR BIOLOGY

Likelihood-based classification of cryo-EM images using FREALIGN

(2013) Dmitry Lyumkis et al.   JOURNAL OF STRUCTURAL BIOLOGY

Optimod – An automated approach for constructing and optimizing initial models for single-particle electron microscopy

(2013) Dmitry Lyumkis et al.   JOURNAL OF STRUCTURAL BIOLOGY

Biochemical Characterization of Novel Retroviral Integrase Proteins

(2013) Allison Ballandras-Colas et al.   PLoS One

HIV DNA Integration

(2013) R. Craigie et al.   Cold Spring Harbor Perspectives in Medicine

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Assembly of prototype foamy virus strand transfer complexes on product DNA bypassing catalysis of integration

(2012) Zhiqi Yin et al.   PROTEIN SCIENCE

HIV integrase as a target for antiretroviral therapy

(2012) Daria J. Hazuda   Current Opinion in HIV and AIDS

A Bayesian View on Cryo-EM Structure Determination

(2011) Sjors H.W. Scheres   JOURNAL OF MOLECULAR BIOLOGY

Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir

(2011) P. K. Quashie et al.   JOURNAL OF VIROLOGY

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

(2011) S. Hare et al.   MOLECULAR PHARMACOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nucleoprotein Intermediates in HIV-1 DNA Integration Visualized by Atomic Force Microscopy

(2010) Svetlana Kotova et al.   JOURNAL OF MOLECULAR BIOLOGY

A clustering approach to multireference alignment of single-particle projections in electron microscopy

(2010) C.O.S. Sorzano et al.   JOURNAL OF STRUCTURAL BIOLOGY

Retroviral intasome assembly and inhibition of DNA strand transfer

(2010) Stephen Hare et al.   NATURE

The mechanism of retroviral integration from X-ray structures of its key intermediates

(2010) Goedele N. Maertens et al.   NATURE

Structure-based modeling of the functional HIV-1 intasome and its inhibition

(2010) L. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance

(2010) S. Hare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Interactions between HIV-1 Integrase and the Two Viral DNA Ends within the Synaptic Complex that Mediates Concerted Integration

(2009) Sibes Bera et al.   JOURNAL OF MOLECULAR BIOLOGY

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

(2009) Stephen Hare et al.   PLoS Pathogens

Structural Basis for Functional Tetramerization of Lentiviral Integrase

(2009) Stephen Hare et al.   PLoS Pathogens

Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein

(2008) Christopher J. McKee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY