GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
出版年份 2021 全文链接
标题
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
作者
关键词
-
出版物
Nature Reviews Endocrinology
Volume 17, Issue 10, Pages 592-607
出版商
Springer Science and Business Media LLC
发表日期
2021-08-11
DOI
10.1038/s41574-021-00529-7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise
- (2021) Anders B. Klein et al. Nature Communications
- GDF15 Induces Anorexia through Nausea and Emesis
- (2020) Tito Borner et al. Cell Metabolism
- Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention
- (2020) Ernesto S. Nakayasu et al. Cell Metabolism
- Nonalcoholic Fatty Liver Disease Pandemic Fuels the Upsurge in Cardiovascular Diseases
- (2020) Jingjing Cai et al. CIRCULATION RESEARCH
- An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models
- (2020) Min Jeong Choi et al. DIABETOLOGIA
- Neutrophils as regulators of cardiovascular inflammation
- (2020) Carlos Silvestre-Roig et al. Nature Reviews Cardiology
- GDF15: A hormone conveying somatic distress to the brain
- (2020) Samuel M Lockhart et al. ENDOCRINE REVIEWS
- Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping
- (2020) Zhipeng Liu et al. JOURNAL OF HEPATOLOGY
- Mouse Thermoregulation: Introducing the Concept of the Thermoneutral Point
- (2020) Vojtěch Škop et al. Cell Reports
- GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss
- (2020) Tito Borner et al. Cell Reports
- Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice
- (2020) Ji Sun Moon et al. AGING CELL
- Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice
- (2020) Rowena Suriben et al. NATURE MEDICINE
- Folding the Mitochondrial UPR into the Integrated Stress Response
- (2020) Nadine S. Anderson et al. TRENDS IN CELL BIOLOGY
- The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling
- (2020) Amy A Worth et al. eLife
- GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates
- (2020) Danna M. Breen et al. Cell Metabolism
- AMPK mediates energetic stress‐induced liver GDF15
- (2020) Logan K. Townsend et al. FASEB JOURNAL
- Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis
- (2020) Olivier Govaere et al. Science Translational Medicine
- GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans
- (2019) Satish Patel et al. Cell Metabolism
- GDF15 reflects beta cell function in obese patients independently of the grade of impairment of glucose metabolism
- (2019) M.H. Schernthaner-Reiter et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice
- (2019) Henriette Frikke-Schmidt et al. Molecular Metabolism
- Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study
- (2019) Ching-Lung Cheung et al. EBioMedicine
- T-cell senescence contributes to abnormal glucose homeostasis in humans and mice
- (2019) Hyon-Seung Yi et al. Cell Death & Disease
- Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases
- (2019) Seung Joon Baek et al. PHARMACOLOGY & THERAPEUTICS
- Exercise Training Promotes a GDF15 Associated Reduction in Fat Mass in Older Adults with Obesity
- (2019) Hui Zhang et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS
- (2019) Vicky Wang-Wei Tsai et al. INTERNATIONAL JOURNAL OF OBESITY
- Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond
- (2019) Rui Liu et al. Frontiers in Immunology
- GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance
- (2019) Harding H. Luan et al. CELL
- Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
- (2019) Marc Foretz et al. Nature Reviews Endocrinology
- Brown Adipocytes Secrete GDF15 in Response to Thermogenic Activation
- (2019) Laura Campderrós et al. Obesity
- Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products
- (2019) Dongdong Wang et al. PHARMACOLOGICAL REVIEWS
- Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands
- (2019) Jie Li et al. eLife
- Glucagon-like peptide 1 (GLP-1)
- (2019) T.D. Müller et al. Molecular Metabolism
- GDF-15, a mitochondrial disease biomarker, is associated with the severity of multiple sclerosis
- (2019) Seitaro Nohara et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Resolving the fibrotic niche of human liver cirrhosis at single-cell level
- (2019) P. Ramachandran et al. NATURE
- ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation
- (2019) Zechuan Zhang et al. JOURNAL OF HEPATOLOGY
- GDF15 mediates the effects of metformin on body weight and energy balance
- (2019) Anthony P. Coll et al. NATURE
- Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice
- (2019) Carla Igual Gil et al. Scientific Reports
- Hepatic GDF15 is regulated by CHOP of the unfolded protein response and alleviates NAFLD progression in obese mice
- (2018) Ding Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The latest consensus on antiemetics
- (2018) Jørn Herrstedt CURRENT OPINION IN ONCOLOGY
- Cellular Energy Sensing and Metabolism—Implications for Treating Diabetes: The 2017 Outstanding Scientific Achievement Award Lecture
- (2018) Gregory R. Steinberg DIABETES
- Obesity
- (2018) Kishore M. Gadde et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Human Aging and Longevity Are Characterized by High Levels of Mitokines
- (2018) Maria Conte et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Mechanisms of NAFLD development and therapeutic strategies
- (2018) Scott L. Friedman et al. NATURE MEDICINE
- The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm
- (2018) Richard D. Palmiter TRENDS IN NEUROSCIENCES
- Reduced oxidative capacity in macrophages results in systemic insulin resistance
- (2018) Saet-Byel Jung et al. Nature Communications
- Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice
- (2018) Kook Hwan Kim et al. Scientific Reports
- Exercise increases circulating GDF15 in humans
- (2018) Maximilian Kleinert et al. Molecular Metabolism
- The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases
- (2018) Vicky W.W. Tsai et al. Cell Metabolism
- Metformin is the key factor for elevated plasma GDF-15 levels in type 2 diabetes: a nested, case-control study
- (2018) Andrea Natali et al. DIABETES OBESITY & METABOLISM
- Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry
- (2018) Loic Yengo et al. HUMAN MOLECULAR GENETICS
- Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry
- (2018) Sara L Pulit et al. HUMAN MOLECULAR GENETICS
- Genomic atlas of the human plasma proteome
- (2018) Benjamin B. Sun et al. NATURE
- GDF15 deficiency promotes high fat diet-induced obesity in mice
- (2018) Thanhvien Tran et al. PLoS One
- Association of Multiple Biomarkers With Risk of All-Cause and Cause-Specific Mortality After Acute Coronary Syndromes
- (2018) Daniel Lindholm et al. JAMA Cardiology
- Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity
- (2017) V W Tsai et al. INTERNATIONAL JOURNAL OF OBESITY
- Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
- (2017) Pedro M. Quirós et al. JOURNAL OF CELL BIOLOGY
- Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease
- (2017) Bo Kyung Koo et al. LIVER INTERNATIONAL
- Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
- (2017) Jer-Yuan Hsu et al. NATURE
- Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
- (2017) Valérie Turcot et al. NATURE GENETICS
- GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
- (2017) Linda Yang et al. NATURE MEDICINE
- GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
- (2017) Shannon E Mullican et al. NATURE MEDICINE
- The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
- (2017) Paul J Emmerson et al. NATURE MEDICINE
- Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys
- (2017) Yumei Xiong et al. Science Translational Medicine
- Over-expression of growth differentiation factor 15 (GDF15) preventing cold ischemia reperfusion (I/R) injury in heart transplantation through Foxo3a signaling
- (2017) Yixin Zhang et al. Oncotarget
- Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank
- (2017) Donald M. Lyall et al. JAMA Cardiology
- TGF-β contamination of purified recombinant GDF15
- (2017) Oddrun Elise Olsen et al. PLoS One
- GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury
- (2017) Hyo Kyun Chung et al. Scientific Reports
- Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance
- (2016) Xiao Yu Tian et al. Cell Metabolism
- Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease
- (2016) Kai C. Wollert et al. CLINICAL CHEMISTRY
- Growth Differentiation Factor 15 as a Novel Biomarker for Metformin
- (2016) Hertzel C. Gerstein et al. DIABETES CARE
- Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association
- (2016) Sheri R. Colberg et al. DIABETES CARE
- Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders
- (2016) Yasunori Fujita et al. Geriatrics & Gerontology International
- Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis
- (2016) Hyo Kyun Chung et al. JOURNAL OF CELL BIOLOGY
- Update on hypertrophic cardiomyopathy and a guide to the guidelines
- (2016) Srijita Sen-Chowdhry et al. Nature Reviews Cardiology
- Control of glioma cell migration and invasiveness by GDF-15
- (2016) Paula Codó et al. Oncotarget
- hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling
- (2016) Xingya Wang et al. Aging-US
- LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants: Fig. 1.
- (2015) Mitchell J. Machiela et al. BIOINFORMATICS
- GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice
- (2015) Eva Tomas et al. DIABETES
- Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice
- (2015) Kristy M. Heppner et al. DIABETOLOGIA
- Growth Differentiation Factor 15 (GDF-15) Plasma Levels Increase during Bleomycin- and Cisplatin-Based Treatment of Testicular Cancer Patients and Relate to Endothelial Damage
- (2015) Renske Altena et al. PLoS One
- Growth differentiation factor-15: a p53- and demethylation-upregulating gene represses cell proliferation, invasion, and tumorigenesis in bladder carcinoma cells
- (2015) Ke-Hung Tsui et al. Scientific Reports
- MAP3K11/GDF15 axis is a critical driver of cancer cachexia
- (2015) Lorena Lerner et al. Journal of Cachexia Sarcopenia and Muscle
- GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective
- (2015) Ramu Adela et al. Journal of Diabetes Research
- Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI
- (2015) Vicky Wang-Wei Tsai et al. PLoS One
- Mechanisms of Plaque Formation and Rupture
- (2014) Jacob Fog Bentzon et al. CIRCULATION RESEARCH
- GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK
- (2014) D. Beiroa et al. DIABETES
- NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism
- (2014) K Chrysovergis et al. INTERNATIONAL JOURNAL OF OBESITY
- Growth Differentiation Factor (GDF)-15 Blocks Norepinephrine-induced Myocardial Hypertrophy via a Novel Pathway Involving Inhibition of Epidermal Growth Factor Receptor Transactivation
- (2014) Xin-ye Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Maturation of Growth Differentiation Factor 15 in Human Placental Trophoblast Cells Depends on the Interaction With Matrix Metalloproteinase-26
- (2014) Sisi Li et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Neurobiology of food intake in health and disease
- (2014) Gregory J. Morton et al. NATURE REVIEWS NEUROSCIENCE
- The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract
- (2014) Vicky Wang-Wei Tsai et al. PLoS One
- GDF15 Is a Novel Biomarker for Impaired Fasting Glucose
- (2014) Jun Hwa Hong et al. Diabetes & Metabolism Journal
- Genetic identification of a neural circuit that suppresses appetite
- (2013) Matthew E. Carter et al. NATURE
- The Genotype-Tissue Expression (GTEx) project
- (2013) John Lonsdale et al. NATURE GENETICS
- Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity
- (2013) Xingya Wang et al. Obesity
- TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator
- (2013) Vicky Wang-Wei Tsai et al. PLoS One
- GDF-15 for Prognostication of Cardiovascular and Cancer Morbidity and Mortality in Men
- (2013) Lars Wallentin et al. PLoS One
- Growth Differentiation Factor‐15 Deficiency Inhibits Atherosclerosis Progression by Regulating Interleukin‐6–Dependent Inflammatory Response to Vascular Injury
- (2013) Gabriel A. Bonaterra et al. Journal of the American Heart Association
- Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE−/− mice from the development of atherosclerosis
- (2012) Heiko Johnen et al. CARDIOVASCULAR PATHOLOGY
- Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial
- (2012) Tibor Kempf et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- GDF-15 prevents platelet integrin activation and thrombus formation
- (2012) J. Rossaint et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Third universal definition of myocardial infarction
- (2012) Kristian Thygesen et al. Nature Reviews Cardiology
- Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets
- (2012) Laurence Macia et al. PLoS One
- Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15
- (2012) Vicky W. W. Tsai et al. Journal of Cachexia Sarcopenia and Muscle
- Growth Differentiation Factor-15: a New Biomarker in Cardiovascular Disease
- (2011) Tibor Kempf et al. HERZ
- Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis
- (2011) Saskia C.A. de Jager et al. JOURNAL OF EXPERIMENTAL MEDICINE
- GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
- (2011) Tibor Kempf et al. NATURE MEDICINE
- AMP-activated protein kinase (AMPK) 1 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
- (2011) H. M. O'Neill et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity
- (2010) Christoph Zechner et al. Cell Metabolism
- The Relationship between Insulin Resistance and the Cardiovascular Biomarker Growth Differentiation Factor-15 in Obese Patients
- (2010) G. Vila et al. CLINICAL CHEMISTRY
- Macrophage inhibitory cytokine-1 is increased in individuals before type 2 diabetes diagnosis but is not an independent predictor of type 2 diabetes: the Whitehall II study
- (2010) Maren Carstensen et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Growth-differentiation factor-15, endoglin and N-terminal pro-brain natriuretic peptide induction in athletes participating in an ultramarathon foot race
- (2009) Isabelle Tchou et al. BIOMARKERS
- Macrophage Inhibitory Cytokine 1: A New Prognostic Marker in Prostate Cancer
- (2009) D. A. Brown et al. CLINICAL CANCER RESEARCH
- Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet
- (2009) Ivana Dostálová et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications
- (2009) Elisa Fabbrini et al. HEPATOLOGY
- Peripheral mechanisms in the control of appetite and related experimental therapies in obesity
- (2009) Michael Camilleri REGULATORY PEPTIDES
- Population-Based Prevention of Obesity
- (2008) Shiriki K. Kumanyika et al. CIRCULATION
- Proposal for a Universal Definition of Cerebral Infarction
- (2008) Jeffrey L. Saver STROKE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started