Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

(2017) Daniel J. Foster et al.   NEURON

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

(2017) David Moreno Delgado et al.   eLife

Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers

(2016) Colleen M. Niswender et al.   ACS Chemical Neuroscience

G Protein–Coupled Receptor Heteromers

(2016) Ivone Gomes et al.   Annual Review of Pharmacology and Toxicology

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation

(2016) Jean-Pierre Changeux et al.   CELL

Organization and functions of mGlu and GABAB receptor complexes

(2016) Jean-Philippe Pin et al.   NATURE

Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors

(2016) Joshua Levitz et al.   NEURON

Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex

(2016) Nikhil J. Pandya et al.   PROTEOMICS

Conformational dynamics of a class C G-protein-coupled receptor

(2015) Reza Vafabakhsh et al.   NATURE

Dual agonist occupancy of AT1-R–α2C-AR heterodimers results in atypical Gs-PKA signaling

(2015) Morgane Bellot et al.   Nature Chemical Biology

Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS

(2014) S. Yin et al.   JOURNAL OF NEUROSCIENCE

CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out

(2014) Nevin A. Lambert et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk proposal: Weighing the evidence for Class A GPCR dimers, the evidence favours dimers

(2014) Michel Bouvier et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

(2014) Andrew S. Doré et al.   NATURE

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer

(2014) Li Xue et al.   Nature Chemical Biology

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

(2014) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

(2014) H. Wu et al.   SCIENCE

Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy

(2014) Linnea Olofsson et al.   Nature Communications

G protein-coupled receptor dimers: look like their parents, but act like teenagers!

(2013) Jaime Wertman et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors

(2013) E. Doumazane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

GABAB Receptor Subunit GB1 at the Cell Surface Independently Activates ERK1/2 through IGF-1R Transactivation

(2012) Guillaume A. Baloucoune et al.   PLoS One

Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

(2012) D. El Moustaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Inter- and Intrasubunit Rearrangements During Activation of Dimeric Metabotropic Glutamate Receptor 1

(2012) V. Hlavackova et al.   Science Signaling

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

(2011) Eneko Urizar et al.   Nature Chemical Biology

Dimers and beyond: The functional puzzles of class C GPCRs

(2011) Julie Kniazeff et al.   PHARMACOLOGY & THERAPEUTICS

Interdomain movements in metabotropic glutamate receptor activation

(2011) S. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trans-activation between 7TM domains: implication in heterodimeric GABABreceptor activation

(2010) Carine Monnier et al.   EMBO JOURNAL

A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors

(2010) Etienne Doumazane et al.   FASEB JOURNAL

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

(2010) Laura Albizu et al.   Nature Chemical Biology

Functional crosstalk between GPCRs: with or without oligomerization

(2009) Laurent Prezeau et al.   CURRENT OPINION IN PHARMACOLOGY

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

(2009) Yang Han et al.   Nature Chemical Biology

GABA-B1 Receptors are Coupled to the ERK1/2 MAP Kinase Pathway in the Absence of GABA-B2 Subunits

(2008) Maxime Richer et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Identification of a serotonin/glutamate receptor complex implicated in psychosis

(2008) Javier González-Maeso et al.   NATURE

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

(2008) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

(2008) Damien Maurel et al.   NATURE METHODS

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY