标题
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
作者
关键词
-
出版物
NATURE
Volume 531, Issue 7594, Pages 335-340
出版商
Springer Nature
发表日期
2016-03-09
DOI
10.1038/nature17188
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development
- (2014) Andrew C Kruse et al. CURRENT OPINION IN PHARMACOLOGY
- Molecular Determinants of Allosteric Modulation at the M1Muscarinic Acetylcholine Receptor
- (2014) Alaa Abdul-Ridha et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanistic Insights into Allosteric Structure-Function Relationships at the M1Muscarinic Acetylcholine Receptor
- (2014) Alaa Abdul-Ridha et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Muscarinic acetylcholine receptors: novel opportunities for drug development
- (2014) Andrew C. Kruse et al. NATURE REVIEWS DRUG DISCOVERY
- Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis
- (2014) Thor Seneca Thorsen et al. STRUCTURE
- Allosteric and Biased G Protein-Coupled Receptor Signaling Regulation: Potentials for New Therapeutics
- (2014) Etienne Khoury et al. Frontiers in Endocrinology
- ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein Function
- (2013) Gershon Celniker et al. ISRAEL JOURNAL OF CHEMISTRY
- Molecular Basis for the Long Duration of Action and Kinetic Selectivity of Tiotropium for the Muscarinic M3 Receptor
- (2013) Christofer S. Tautermann et al. JOURNAL OF MEDICINAL CHEMISTRY
- Activation and allosteric modulation of a muscarinic acetylcholine receptor
- (2013) Andrew C. Kruse et al. NATURE
- Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
- (2012) Kazuko Haga et al. NATURE
- Structure and dynamics of the M3 muscarinic acetylcholine receptor
- (2012) Andrew C. Kruse et al. NATURE
- Linking Crystallographic Model and Data Quality
- (2012) P. A. Karplus et al. SCIENCE
- Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors
- (2012) Eugene Chun et al. STRUCTURE
- The Role of Transmembrane Domain 3 in the Actions of Orthosteric, Allosteric, and Atypical Agonists of the M4 Muscarinic Acetylcholine Receptor
- (2011) K. Leach et al. MOLECULAR PHARMACOLOGY
- SwissDock, a protein-small molecule docking web service based on EADock DSS
- (2011) A. Grosdidier et al. NUCLEIC ACIDS RESEARCH
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Impact of species variability and ‘probe-dependence’ on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor
- (2010) S Suratman et al. BRITISH JOURNAL OF PHARMACOLOGY
- Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective
- (2010) Nicolas Guex et al. ELECTROPHORESIS
- Structural Determinants of Allosteric Agonism and Modulation at the M4Muscarinic Acetylcholine Receptor
- (2010) Vindhya Nawaratne et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders
- (2010) Gregory J. Digby et al. Molecular BioSystems
- Allosteric modulation of G protein-coupled receptors: A pharmacological perspective
- (2010) Peter Keov et al. NEUROPHARMACOLOGY
- ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids
- (2010) H. Ashkenazy et al. NUCLEIC ACIDS RESEARCH
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M1-preferring receptor agonists
- (2009) Julia N. Heinrich et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- A Selective Allosteric Potentiator of the M1 Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning
- (2009) J. K. Shirey et al. JOURNAL OF NEUROSCIENCE
- Crystallizing membrane proteins using lipidic mesophases
- (2009) Martin Caffrey et al. Nature Protocols
- Molecular Mechanisms of Action and In Vivo Validation of an M4 Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties
- (2009) Katie Leach et al. NEUROPSYCHOPHARMACOLOGY
- Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation
- (2009) L. Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders
- (2009) P. Jeffrey Conn et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia
- (2008) Anantha Shekhar et al. AMERICAN JOURNAL OF PSYCHIATRY
- New Insights into the Function of M4 Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)
- (2008) V. Nawaratne et al. MOLECULAR PHARMACOLOGY
- Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
- (2008) P. Jeffrey Conn et al. NATURE REVIEWS DRUG DISCOVERY
- Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia
- (2008) W. Y. Chan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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