标题
Targeting Akt in cancer for precision therapy
作者
关键词
-
出版物
Journal of Hematology & Oncology
Volume 14, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-08-21
DOI
10.1186/s13045-021-01137-8
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1
- (2021) Roger Belizaire et al. BLOOD
- Follicular lymphoma-associated BTK mutations are inactivating resulting in augmented AKT activation
- (2021) Nan Hu et al. CLINICAL CANCER RESEARCH
- Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling
- (2021) Stefanie Chan et al. Frontiers in Cell and Developmental Biology
- Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway
- (2021) Yijin Chen et al. CLINICAL SCIENCE
- PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer
- (2021) Laura C. A. Galbraith et al. ONCOGENE
- Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis
- (2021) Nico Hinz et al. Cells
- Chemical Phosphoproteomics Sheds New Light on the Targets and Modes of Action of AKT Inhibitors
- (2021) Svenja Wiechmann et al. ACS Chemical Biology
- Spectrum of PIK3CA/AKT mutations across molecular subtypes of triple-negative breast cancer
- (2021) Sandeep Kumar et al. BREAST CANCER RESEARCH AND TREATMENT
- An updated patent review of Akt inhibitors (2016-present)
- (2021) Yu Guo et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Downregulation of ARID1B, a tumor-suppressor in the WNT subgroup medulloblastoma, activates multiple oncogenic signaling pathways
- (2021) Akash Deogharkar et al. HUMAN MOLECULAR GENETICS
- The potential role of nucleophosmin (NPM1) in the development of cancer
- (2021) Fateme Karimi Dermani et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Emerging Roles for AKT Isoform Preference in Cancer Progression Pathways
- (2021) Seamus E. Degan et al. MOLECULAR CANCER RESEARCH
- SENP3 loss promotes M2 macrophage polarization and breast cancer progression
- (2021) Ming Xiao et al. Molecular Oncology
- Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway
- (2021) Takeshi Fujino et al. Nature Communications
- Prospective high-throughput genome profiling of advanced cancers: results of the PERMED-01 clinical trial
- (2021) François Bertucci et al. Genome Medicine
- The metastasis suppressor protein NM23-H1 modulates the PI3K-AKT axis through interaction with the p110α catalytic subunit
- (2021) Francesco Paolo Pennino et al. Oncogenesis
- Characterization of AKT Somatic Mutations in Chinese Breast Cancer Patients
- (2021) Lingzhu Wen et al. Cancer Management and Research
- Frequency of CDH1 Germline Mutations in Non-Gastric Cancers
- (2021) Giulia Massari et al. Cancers
- Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer
- (2021) Lillian M. Smyth et al. npj Breast Cancer
- Targeting Na + /K + ‐ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma
- (2021) Songpeng Yang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Ipatasertib plus abiraterone and prednisolone in metastatic castration-resistant prostate cancer (IPATential150): a multicentre, randomised, double-blind, phase 3 trial
- (2021) Christopher Sweeney et al. LANCET
- Early detection of pancreatic cancer using DNA-based molecular approaches
- (2021) Aatur D. Singhi et al. Nature Reviews Gastroenterology & Hepatology
- Pursuing Precision: Receptor Tyrosine Kinase Inhibitors for Treatment of Pediatric Solid Tumors
- (2021) Andrew J. Bellantoni et al. Cancers
- Elucidating the Molecular Basis of Sorafenib Resistance in HCC: Current Findings and Future Directions
- (2021) Francesca Fornari et al. Journal of Hepatocellular Carcinoma
- Overcoming tamoxifen resistance in oestrogen receptor‐positive breast cancer using the novel thiosemicarbazone anti‐cancer agent, DpC
- (2020) Sundus N. Maqbool et al. BRITISH JOURNAL OF PHARMACOLOGY
- Protein kinase A facilitates relaxation of mouse ileum via phosphorylation of neuronal nitric oxide synthase
- (2020) Damian D. Guerra et al. BRITISH JOURNAL OF PHARMACOLOGY
- USP 1 deubiquitinates Akt to inhibit PI 3K‐Akt‐FoxO signaling in muscle during prolonged starvation
- (2020) Dana Goldbraikh et al. EMBO REPORTS
- Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma
- (2020) Qian Zhu et al. Journal of Hematology & Oncology
- Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial
- (2020) Robert H Jones et al. LANCET ONCOLOGY
- AKT regulates mitotic progression of mammalian cells by phosphorylating MASTL leading to PP2A inactivation
- (2020) Irfana Reshi et al. MOLECULAR AND CELLULAR BIOLOGY
- Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan
- (2020) Chen Khuan Wong et al. MOLECULAR CANCER RESEARCH
- The Communication between the PI3K/AKT/mTOR Pathway and Y-Box Binding Protein-1 in Gynecological Cancer
- (2020) Monika Sobočan et al. Cancers
- Role of Akt Activation in PARP Inhibitor Resistance in Cancer
- (2020) Ferenc Gallyas Jr et al. Cancers
- Crosstalk between HSPA5 arginylation and sequential ubiquitination leads to AKT degradation through autophagy flux
- (2020) Hyo Jeong Kim et al. Autophagy
- Inhibitors in AKTion: ATP-competitive vs allosteric
- (2020) Glorianne Lazaro et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity
- (2020) Eleftherios Kostaras et al. BRITISH JOURNAL OF CANCER
- Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination With Fulvestrant in Patients With AKT1E17K-Mutant, ER-Positive Metastatic Breast Cancer
- (2020) Lillian M Smyth et al. CLINICAL CANCER RESEARCH
- Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts
- (2020) Albert Gris-Oliver et al. CLINICAL CANCER RESEARCH
- Activating AKT1 and PIK3CA Mutations in Metastatic Castration-Resistant Prostate Cancer
- (2020) Cameron Herberts et al. EUROPEAN UROLOGY
- MK-2206 and Standard Neoadjuvant Chemotherapy Improves Response in Patients With Human Epidermal Growth Factor Receptor 2–Positive and/or Hormone Receptor–Negative Breast Cancers in the I-SPY 2 Trial
- (2020) A. Jo Chien et al. JOURNAL OF CLINICAL ONCOLOGY
- HNF4A-AS1/hnRNPU/CTCF axis as a therapeutic target for aerobic glycolysis and neuroblastoma progression
- (2020) Huajie Song et al. Journal of Hematology & Oncology
- Emerging therapeutic agents for advanced non-small cell lung cancer
- (2020) Ruqin Chen et al. Journal of Hematology & Oncology
- Biomarker-driven management strategies for peripheral T cell lymphoma
- (2020) Erin Mulvey et al. Journal of Hematology & Oncology
- Fulvestrant plus capivasertib for metastatic breast cancer
- (2020) Ethan B Ludmir et al. LANCET ONCOLOGY
- Fulvestrant plus capivasertib for metastatic breast cancer – Authors' reply
- (2020) Robert H Jones et al. LANCET ONCOLOGY
- Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
- (2020) Helmut Sies et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Pan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation
- (2020) Zhaoqi Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK
- (2020) Nurbubu T. Moldogazieva et al. Cancers
- Personalized Medicine: Recent Progress in Cancer Therapy
- (2020) Valentina Gambardella et al. Cancers
- Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions
- (2020) Bachar Samra et al. Journal of Hematology & Oncology
- Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
- (2020) Yonghan He et al. Journal of Hematology & Oncology
- Circulating Cell-Free DNA-Based Liquid Biopsy Markers for the Non-Invasive Prognosis and Monitoring of Metastatic Pancreatic Cancer
- (2020) Marta Toledano-Fonseca et al. Cancers
- Dual EGFR blockade with cetuximab and erlotinib combined with anti-VEGF antibody bevacizumab in advanced solid tumors: a phase 1 dose escalation triplet combination trial
- (2020) Vivek Subbiah et al. Experimental Hematology & Oncology
- ACOT4 accumulation via AKT-mediated phosphorylation promotes pancreatic tumourigenesis
- (2020) Chenming Ni et al. CANCER LETTERS
- BCMA-targeted immunotherapy for multiple myeloma
- (2020) Bo Yu et al. Journal of Hematology & Oncology
- Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma
- (2020) Yunzhen Qian et al. Journal of Hematology & Oncology
- High-throughput approaches for precision medicine in high-grade serous ovarian cancer
- (2020) Meinusha Govindarajan et al. Journal of Hematology & Oncology
- Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial
- (2020) Nicholas C Turner et al. LANCET ONCOLOGY
- Development and characterization of protein kinase B/AKT isoform-specific nanobodies
- (2020) Tijs Merckaert et al. PLoS One
- Systematic Analysis of Aberrant Biochemical Networks and Potential Drug Vulnerabilities Induced by Tumor Suppressor Loss in Malignant Pleural Mesothelioma
- (2020) Haitang Yang et al. Cancers
- WNK1 regulates uterine homeostasis and its ability to support pregnancy
- (2020) Ru-pin Alicia Chi et al. JCI Insight
- Mechanism of action biomarkers predicting response to AKT inhibition in the I-SPY 2 breast cancer trial
- (2020) Denise M. Wolf et al. npj Breast Cancer
- The biological function and clinical significance of SF3B1 mutations in cancer
- (2020) Zhixia Zhou et al. Biomarker Research
- An AKT2-specific nanobody that targets the hydrophobic motif induces cell cycle arrest, autophagy and loss of focal adhesions in MDA-MB-231 cells
- (2020) Tijs Merckaert et al. BIOMEDICINE & PHARMACOTHERAPY
- Mutant SF3B1 promotes AKT- and NF-κB–driven mammary tumorigenesis
- (2020) Bo Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- AKT1 E17K Inhibits Cancer Cell Migration by Abrogating β-Catenin Signaling
- (2020) Sizhi Paul Gao et al. MOLECULAR CANCER RESEARCH
- BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN
- (2020) Rong Deng et al. Molecular Oncology
- Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex
- (2020) Xuxiao He et al. PLOS BIOLOGY
- Effect of Capivasertib in Patients With an AKT1 E17K-Mutated Tumor
- (2020) Kevin Kalinsky et al. JAMA Oncology
- Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer
- (2020) Krystal Villalobos-Ayala et al. Cancers
- Complex roles of cAMP–PKA–CREB signaling in cancer
- (2020) Hongying Zhang et al. Experimental Hematology & Oncology
- PKA at a Cross-Road of Signaling Pathways Involved in the Regulation of Glioblastoma Migration and Invasion by the Neuropeptides VIP and PACAP
- (2019) Souheyla Bensalma et al. Cancers
- Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
- (2019) Xinran Li et al. Nature Communications
- SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
- (2019) Guihua Wang et al. NATURE CELL BIOLOGY
- Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy
- (2019) Shuang Qin et al. Journal of Hematology & Oncology
- Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis
- (2019) Yi-Hua Jan et al. Journal of Hematology & Oncology
- AKT as a Therapeutic Target for Cancer
- (2019) Mengqiu Song et al. CANCER RESEARCH
- BEECH: A dose-finding run-in followed by a randomised phase 2 study assessing the efficacy of AKT inhibitor capivasertib (AZD5363) combined with paclitaxel in patients with oestrogen receptor-positive advanced or metastatic breast cancer, and in a PIK3CA mutant sub-population
- (2019) N C Turner et al. ANNALS OF ONCOLOGY
- Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children
- (2019) Adam J. de Smith et al. GENES CHROMOSOMES & CANCER
- CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis
- (2019) Xiao-Lu Ma et al. Journal of Hematology & Oncology
- Treatment and monitoring of Philadelphia chromosome-positive leukemia patients: recent advances and remaining challenges
- (2019) Simona Soverini et al. Journal of Hematology & Oncology
- AKT1E17K activates focal adhesion kinase and promotes melanoma brain metastasis
- (2019) David A Kircher et al. MOLECULAR CANCER RESEARCH
- FAIRLANE, a double-blind placebo-controlled randomized phase II trial of neoadjuvant ipatasertib plus paclitaxel for early triple-negative breast cancer
- (2019) M Oliveira et al. ANNALS OF ONCOLOGY
- SAE1 promotes human glioma progression through activating AKT SUMOylation-mediated signaling pathways
- (2019) Yanfang Yang et al. Cell Communication and Signaling
- MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer
- (2019) Qiming Wang et al. Journal of Hematology & Oncology
- Targeting mTOR for cancer therapy
- (2019) Hui Hua et al. Journal of Hematology & Oncology
- MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression
- (2019) Yao Jiang et al. Nature Communications
- PTEN Tumor-Suppressor: The Dam of Stemness in Cancer
- (2019) Francesca Luongo et al. Cancers
- Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling
- (2019) Michael G. Sugiyama et al. Frontiers in Cell and Developmental Biology
- Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells
- (2019) Jordan A. Cockfield et al. Cancers
- Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells
- (2019) Nicola Bougen-Zhukov et al. Cancers
- PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around
- (2019) Anastasios Gkountakos et al. Cancers
- Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity
- (2019) Lena Quambusch et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Distinct functions of AKT isoforms in breast cancer: a comprehensive review
- (2019) Nico Hinz et al. Cell Communication and Signaling
- Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis
- (2019) Yinying Dong et al. Journal of Hematology & Oncology
- CAR-T “the living drugs”, immune checkpoint inhibitors, and precision medicine: a new era of cancer therapy
- (2019) Delong Liu Journal of Hematology & Oncology
- Opposing effects of NPM1wt and NPM1c mutants on AKT signaling in AML
- (2019) Zhuo Ren et al. LEUKEMIA
- Pan-cancer whole-genome analyses of metastatic solid tumours
- (2019) Peter Priestley et al. NATURE
- Proliferation and AKT Activity Biomarker Analyses after Capivasertib (AZD5363) Treatment of Patients with ER+ Invasive Breast Cancer (STAKT)
- (2019) John F.R. Robertson et al. CLINICAL CANCER RESEARCH
- Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial
- (2019) Peter Schmid et al. JOURNAL OF CLINICAL ONCOLOGY
- Simultaneously inactivating Src and AKT by saracatinib/capivasertib co-delivery nanoparticles to improve the efficacy of anti-Src therapy in head and neck squamous cell carcinoma
- (2019) Liwei Lang et al. Journal of Hematology & Oncology
- Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer
- (2019) Hitendra Patel et al. Journal of Hematology & Oncology
- Long-term overall survival and prognostic score predicting survival: the IMPACT study in precision medicine
- (2019) Apostolia-Maria Tsimberidou et al. Journal of Hematology & Oncology
- Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY 1125976 in Advanced Solid Cancer—Lack of Association between Activating AKT Mutation and AKT Inhibition-Derived Efficacy
- (2019) Andreas Schneeweiss et al. Cancers
- AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity
- (2018) Sanja Brolih et al. BMC CANCER
- Endothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover
- (2018) Fei Gao et al. BRITISH JOURNAL OF CANCER
- Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation
- (2018) Junmei Cairns et al. EMBO REPORTS
- Molecular targeted therapy: treating cancer with specificity
- (2018) Yeuan Ting Lee et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Complex roles of the old drug aspirin in cancer chemoprevention and therapy
- (2018) Hui Hua et al. MEDICINAL RESEARCH REVIEWS
- Precision Medicine in Hormone Receptor-Positive Breast Cancer
- (2018) Azadeh Nasrazadani et al. Frontiers in Oncology
- Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer
- (2018) Nikos Koundouros et al. Frontiers in Oncology
- The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers
- (2018) Pedram Razavi et al. CANCER CELL
- Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis
- (2018) Nam Chu et al. CELL
- Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt
- (2018) Shu-Lin Liu et al. MOLECULAR CELL
- Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
- (2018) Benjamin D. Hopkins et al. NATURE
- Phosphatidylinositol 3-kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities
- (2018) Sherri Z. Millis et al. CANCER
- Pharmacoinformatic Approaches to Design Novel Inhibitors of Protein Kinase B Pathways in Cancer
- (2018) Noreen Akhtar et al. CURRENT CANCER DRUG TARGETS
- Akt‐mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth
- (2018) Saverio Marchi et al. EMBO JOURNAL
- A phase II, randomised study of mFOLFOX6 with or without the Akt inhibitor ipatasertib in patients with locally advanced or metastatic gastric or gastroesophageal junction cancer
- (2018) Y.-J. Bang et al. EUROPEAN JOURNAL OF CANCER
- Randomized Phase II Study Evaluating Akt Blockade with Ipatasertib, in Combination with Abiraterone, in Patients with Metastatic Prostate Cancer with and without PTEN Loss
- (2018) Johann S. de Bono et al. CLINICAL CANCER RESEARCH
- AKT Inhibition in Solid Tumors With AKT1 Mutations
- (2017) David M. Hyman et al. JOURNAL OF CLINICAL ONCOLOGY
- GAB2 Amplification in Squamous Cell Lung Cancer of Non-Smokers
- (2017) Yu Rang Park et al. JOURNAL OF KOREAN MEDICAL SCIENCE
- Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
- (2017) Sung-Bae Kim et al. LANCET ONCOLOGY
- PI(3,4,5)P 3 Engagement Restricts Akt Activity to Cellular Membranes
- (2017) Michael Ebner et al. MOLECULAR CELL
- Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis
- (2017) E Agarwal et al. ONCOGENE
- AKT inhibition is an effective treatment strategy in ARID1A-deficient gastric cancer cells
- (2017) Dakeun Lee et al. OncoTargets and Therapy
- Accelerating Discovery of Functional Mutant Alleles in Cancer
- (2017) Matthew T. Chang et al. Cancer Discovery
- Regulation of Serine-Threonine Kinase Akt Activation by NAD + -Dependent Deacetylase SIRT7
- (2017) Jia Yu et al. Cell Reports
- Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations
- (2017) Guanhua Rao et al. Scientific Reports
- PHLPPing through history: a decade in the life of PHLPP phosphatases
- (2016) A. T. Grzechnik et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms
- (2016) Qi Wang et al. CANCER CELL
- PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
- (2016) Pau Castel et al. CANCER CELL
- Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein
- (2016) Shin Yee Hong et al. CELLULAR SIGNALLING
- Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4
- (2016) Astrid Grottke et al. PLoS One
- Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial
- (2016) Tracy L. Stockley et al. Genome Medicine
- Landscape of Phosphatidylinositol-3-Kinase Pathway Alterations Across 19 784 Diverse Solid Tumors
- (2016) Sherri Z. Millis et al. JAMA Oncology
- Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas
- (2016) V. Vidimar et al. Science Advances
- Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation
- (2016) Jae Won Chang et al. Scientific Reports
- mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR
- (2015) Yancun Yin et al. CELL RESEARCH
- The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin
- (2015) Lisa M. DiPilato et al. MOLECULAR AND CELLULAR BIOLOGY
- AKT Antagonist AZD5363 Influences Estrogen Receptor Function in Endocrine-Resistant Breast Cancer and Synergizes with Fulvestrant (ICI182780) In Vivo
- (2015) R. Ribas et al. MOLECULAR CANCER THERAPEUTICS
- Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition
- (2015) S. J. Davis et al. MOLECULAR CANCER THERAPEUTICS
- Inhibition of breast cancer invasion by TIS21/BTG2/Pc3-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes
- (2015) J-A Choi et al. ONCOGENE
- SUMO modification of Akt regulates global SUMOylation and substrate SUMOylation specificity through Akt phosphorylation of Ubc9 and SUMO1
- (2015) C H Lin et al. ONCOGENE
- ARID1A gene mutation in ovarian and endometrial cancers (Review)
- (2015) TAKASHI TAKEDA et al. ONCOLOGY REPORTS
- Natural inhibitors of PI3K/AKT signaling in breast cancer: Emphasis on newly-discovered molecular mechanisms of action
- (2015) Yaghoub Safdari et al. PHARMACOLOGICAL RESEARCH
- Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression
- (2015) Kristen M. Turner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AKT1 Activation Promotes Development of Melanoma Metastases
- (2015) Joseph H. Cho et al. Cell Reports
- Discovery of Inter-Domain Stabilizers—A Novel Assay System for Allosteric Akt Inhibitors
- (2014) Zhizhou Fang et al. ACS Chemical Biology
- A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation
- (2014) Kimberly C Wiegand et al. BMC CANCER
- Akt1 and Akt3 Exert Opposing Roles in the Regulation of Vascular Tumor Growth
- (2014) T. L. Phung et al. CANCER RESEARCH
- Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy
- (2014) D J Roberts et al. CELL DEATH AND DIFFERENTIATION
- GSK3 Protein Positively Regulates Type I Insulin-like Growth Factor Receptor through Forkhead Transcription Factors FOXO1/3/4
- (2014) Xiaodong Huo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
- (2014) Pengda Liu et al. NATURE
- SUMOylation regulates AKT1 activity
- (2014) C F de la Cruz-Herrera et al. ONCOGENE
- How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?
- (2014) H Lincet et al. ONCOGENE
- Akt SUMOylation Regulates Cell Proliferation and Tumorigenesis
- (2013) R. Li et al. CANCER RESEARCH
- Carboxyl-Terminal Modulator Protein Positively Regulates Akt Phosphorylation and Acts as an Oncogenic Driver in Breast Cancer
- (2013) Y.-P. Liu et al. CANCER RESEARCH
- TRAF4 Is a Critical Molecule for Akt Activation in Lung Cancer
- (2013) W. Li et al. CANCER RESEARCH
- Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle
- (2013) Guillermo Risso et al. CELL CYCLE
- A Novel Germline Mutation in Exon 10 of theSMAD4Gene in a Familial Juvenile Polyposis
- (2013) Myung Jin Jee et al. Gut and Liver
- Akt-dependent Activation of the Heart 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase (PFKFB2) Isoenzyme by Amino Acids
- (2013) Laura Novellasdemunt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer
- (2013) Tjalling Bosse et al. MODERN PATHOLOGY
- The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis
- (2012) Chia-Hsin Chan et al. CELL
- Molecular alterations in AKT and its protein activation in human lung carcinomas
- (2012) Yoh Dobashi et al. HUMAN PATHOLOGY
- GLUT4 exocytosis
- (2012) Jacqueline Stöckli et al. JOURNAL OF CELL SCIENCE
- Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer
- (2012) Reetta Virtakoivu et al. MOLECULAR BIOLOGY OF THE CELL
- Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
- (2012) Trevor J. Pugh et al. NATURE
- N-cadherin regulates mammary tumor cell migration through Akt3 suppression
- (2012) S Chung et al. ONCOGENE
- EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex
- (2012) Guo Li et al. Nature Communications
- Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes
- (2012) Gongda Xue et al. Cancer Discovery
- The Akt kinases: Isoform specificity in metabolism and cancer
- (2011) Eva Gonzalez et al. CELL CYCLE
- Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2
- (2011) Hae Mi Joo et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Gefitinib as first-line treatment for patients with advanced non-small-cell lung cancer with activating epidermal growth factor receptor mutation: Review of the evidence
- (2011) C. Gridelli et al. LUNG CANCER
- TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation
- (2011) Yi-Hung Ou et al. MOLECULAR CELL
- ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
- (2011) Shuji Wakatsuki et al. NATURE CELL BIOLOGY
- Akt1 deficiency delays tumor progression, vascular invasion and distant metastasis in a murine model of thyroid cancer
- (2011) M Saji et al. ONCOGENE
- I B kinase and TANK-binding kinase 1 activate AKT by direct phosphorylation
- (2011) X. Xie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
- (2011) N. R. Sundaresan et al. Science Signaling
- Proapoptotic Kinase MST2 Coordinates Signaling Crosstalk between RASSF1A, Raf-1, and Akt
- (2010) D. Romano et al. CANCER RESEARCH
- Akt2 regulates expression of the actin-bundling protein palladin
- (2010) Y. Rebecca Chin et al. FEBS LETTERS
- The Actin-Bundling Protein Palladin Is an Akt1-Specific Substrate that Regulates Breast Cancer Cell Migration
- (2010) Y. Rebecca Chin et al. MOLECULAR CELL
- ARID1AMutations in Endometriosis-Associated Ovarian Carcinomas
- (2010) Kimberly C. Wiegand et al. NEW ENGLAND JOURNAL OF MEDICINE
- Vimentin is a novel AKT1 target mediating motility and invasion
- (2010) Q-S Zhu et al. ONCOGENE
- Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition
- (2010) Wen-I Wu et al. PLoS One
- Somatic mutations are present in all members of the AKT family in endometrial carcinoma
- (2009) A Dutt et al. BRITISH JOURNAL OF CANCER
- The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas
- (2009) K Shoji et al. BRITISH JOURNAL OF CANCER
- Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression
- (2009) R. L. Dillon et al. CANCER RESEARCH
- GAB2 Amplifications Refine Molecular Classification of Melanoma
- (2009) K. A. Chernoff et al. CLINICAL CANCER RESEARCH
- The E3 Ligase TTC3 Facilitates Ubiquitination and Degradation of Phosphorylated Akt
- (2009) Futoshi Suizu et al. DEVELOPMENTAL CELL
- FoxM1, a critical regulator of oxidative stress during oncogenesis
- (2009) Hyun Jung Park et al. EMBO JOURNAL
- Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation
- (2009) Y Liao et al. ONCOGENE
- Focal amplification and oncogene dependency of GAB2 in breast cancer
- (2009) M Bocanegra et al. ONCOGENE
- The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
- (2009) W.-L. Yang et al. SCIENCE
- Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition
- (2009) Véronique Calleja et al. PLOS BIOLOGY
- A novel AKT3 mutation in melanoma tumours and cell lines
- (2008) M A Davies et al. BRITISH JOURNAL OF CANCER
- Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis
- (2008) Veronique Nogueira et al. CANCER CELL
- An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer
- (2008) K. Stemke-Hale et al. CANCER RESEARCH
- Ca2+-store-dependent and -independent reversal of Stim1 localization and function
- (2008) J. T. Smyth et al. JOURNAL OF CELL SCIENCE
- Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin
- (2008) Tomoya Kitamura et al. NATURE CELL BIOLOGY
- AKT1 E17K in human solid tumours
- (2008) F E Bleeker et al. ONCOGENE
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started