Endothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover

Modulation of long-term endothelial-barrier integrity is conditional to the cross-talk between Akt and Src signaling

(2017) Fei Gao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy

(2017) Vincent Chung et al.   JAMA Oncology

Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms

(2016) Qi Wang et al.   CANCER CELL

AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation

(2016) Chia-Wei Li et al.   CANCER RESEARCH

Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover

(2016) Fei Gao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phase 2 study of MK-2206, an allosteric inhibitor of AKT, as second-line therapy for advanced gastric and gastroesophageal junction cancer: A SWOG cooperative group trial (S1005)

(2015) Ramesh K. Ramanathan et al.   CANCER

New insights in the control of vascular permeability

(2015) Marianna Trani et al.   CURRENT OPINION IN HEMATOLOGY

Genetic deletion and pharmacological inhibition of Akt1 isoform attenuates bladder cancer cell proliferation, motility and invasion

(2015) Harika Sabbineni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer

(2015) Khanh Do et al.   INVESTIGATIONAL NEW DRUGS

Glycogen synthase kinase 3 in Wnt signaling pathway and cancer

(2015) Nydia Tejeda-Muñoz et al.   IUBMB LIFE

Broad targeting of angiogenesis for cancer prevention and therapy

(2015) Zongwei Wang et al.   SEMINARS IN CANCER BIOLOGY

Preclinical and Early Clinical Evaluation of the Oral AKT Inhibitor, MK-2206, for the Treatment of Acute Myelogenous Leukemia

(2014) M. Y. Konopleva et al.   CLINICAL CANCER RESEARCH

Akt1 Mediates α-Smooth Muscle Actin Expression and Myofibroblast Differentiation via Myocardin and Serum Response Factor

(2013) Maha Abdalla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of interactions between prostate tumor cell-surface integrin and endothelial ICAM-1 by simvastatin inhibits micrometastasis

(2013) Belal AL-Husein et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tumor Endothelial Cells

(2013) A. C. Dudley   Cold Spring Harbor Perspectives in Medicine

P21 Activated Kinase-1 (Pak1) Promotes Prostate Tumor Growth and Microinvasion via Inhibition of Transforming Growth Factor β Expression and Enhanced Matrix Metalloproteinase 9 Secretion

(2012) Anna Goc et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Anticancer Efficacy of Simvastatin on Prostate Cancer Cells and Tumor Xenografts Is Associated with Inhibition of Akt and Reduced Prostate-Specific Antigen Expression

(2010) S. T. Kochuparambil et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Akt-Mediated Transactivation of the S1P 1 Receptor in Caveolin-Enriched Microdomains Regulates Endothelial Barrier Enhancement by Oxidized Phospholipids

(2009) Patrick A. Singleton et al.   CIRCULATION RESEARCH

The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt

(2009) P R Somanath et al.   ONCOGENE

MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells

(2009) D. Iliopoulos et al.   Science Signaling

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

(2008) Julie Gavard et al.   DEVELOPMENTAL CELL

The role of adherens junctions and VE-cadherin in the control of vascular permeability

(2008) E. Dejana et al.   JOURNAL OF CELL SCIENCE

VE-cadherin and claudin-5: it takes two to tango

(2008) Julie Gavard et al.   NATURE CELL BIOLOGY

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

(2008) Andrea Taddei et al.   NATURE CELL BIOLOGY

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

(2008) Christopher A Jones et al.   NATURE MEDICINE