PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around
出版年份 2019 全文链接
标题
PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around
作者
关键词
-
出版物
Cancers
Volume 11, Issue 8, Pages 1141
出版商
MDPI AG
发表日期
2019-08-09
DOI
10.3390/cancers11081141
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Effect of PTEN inactivating germline mutations on innate immune cell function and thyroid cancer-induced macrophages in patients with PTEN hamartoma tumor syndrome
- (2019) Yvette J. E. Sloot et al. ONCOGENE
- PTEN Mutations Trigger Resistance to Immunotherapy
- (2019) Feixiong Cheng et al. TRENDS IN MOLECULAR MEDICINE
- Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma
- (2019) Robert J. Motzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- MiR-183-5p is required for non-small cell lung cancer progression by repressing PTEN
- (2019) Huimin Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- PTEN inactivation induces epithelial-mesenchymal transition and metastasis by intranuclear translocation of β-catenin and snail/slug in non-small cell lung carcinoma cells
- (2019) Elumalai Perumal et al. LUNG CANCER
- Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
- (2019) Yu-Ru Lee et al. SCIENCE
- Upregulation of Long Noncoding RNA GAS5 Inhibits Lung Cancer Cell Proliferation and Metastasis via miR-205/PTEN Axis
- (2019) Lizhen Dong et al. MEDICAL SCIENCE MONITOR
- MicroRNA‐4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non‐small cell lung cancer
- (2019) Chunhua Ling et al. Cancer Medicine
- Next-Generation Sequencing Approach to Non–Small Cell Lung Carcinoma Yields More Actionable Alterations
- (2018) Mitra Mehrad et al. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
- Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex
- (2018) Anastasios Gkountakos et al. CARCINOGENESIS
- MicroRNA-130b targets PTEN to induce resistance to cisplatin in lung cancer cells by activating Wnt/β-catenin pathway
- (2018) Qiang Zhang et al. CELL BIOCHEMISTRY AND FUNCTION
- PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy
- (2018) Kenneth K.W. To et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- MiR-93-5p up-regulation is involved in non-small cell lung cancer cells proliferation and migration and poor prognosis
- (2018) Wei Yang et al. GENE
- Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse
- (2018) Karinna Almodovar et al. Journal of Thoracic Oncology
- Genomic alterations of plasma cell-free DNAs in small cell lung cancer and their clinical relevance
- (2018) Meijun Du et al. LUNG CANCER
- PTEN/PTENP1: ‘Regulating the regulator of RTK-dependent PI3K/Akt signalling’, new targets for cancer therapy
- (2018) Nahal Haddadi et al. Molecular Cancer
- CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy
- (2018) Junchao Cai et al. NATURE CELL BIOLOGY
- Targeting the PI3K pathway in cancer: are we making headway?
- (2018) Filip Janku et al. Nature Reviews Clinical Oncology
- The functions and regulation of the PTEN tumour suppressor: new modes and prospects
- (2018) Yu-Ru Lee et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- MicroRNA-146b promotes PI3K/AKT pathway hyperactivation and thyroid cancer progression by targeting PTEN
- (2018) Julia Ramírez-Moya et al. ONCOGENE
- EGFR, KRAS, BRAF, PTEN, and PIK3CA mutation in plasma of small cell lung cancer patients
- (2018) Hongyang Lu et al. OncoTargets and Therapy
- Targeting Nicotinamide N -Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells
- (2018) Duc-Hiep Bach et al. Molecular Therapy-Nucleic Acids
- Engineering PTEN-L for Cell-Mediated Delivery
- (2018) Sylvie J. Lavictoire et al. Molecular Therapy-Methods & Clinical Development
- MicroRNA-524 promotes cell proliferation by down-regulating PTEN expression in osteosarcoma
- (2018) Ming Zhuang et al. Cancer Cell International
- miRNA‑328 overexpression confers cisplatin resistance in non‑small cell lung cancer via targeting of PTEN
- (2018) Chunmei Wang et al. Molecular Medicine Reports
- Putative predictors of efficacy for immune checkpoint inhibitors in non-small-cell lung cancer: facing the complexity of the immune system
- (2017) Giulia Grizzi et al. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
- Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma
- (2017) Suzanne George et al. IMMUNITY
- The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein
- (2017) Muhan Chen et al. JOURNAL OF CELL BIOLOGY
- Mutations in TP53 , PIK3CA , PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes
- (2017) Paul A. VanderLaan et al. LUNG CANCER
- LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis
- (2017) Eun-Jeong Yu et al. PLoS One
- Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non–small-cell lung cancer
- (2017) Huake Sun et al. TUMOR BIOLOGY
- EYA2 promotes lung cancer cell proliferation by downregulating the expression of PTEN
- (2017) Zhaoming Li et al. Oncotarget
- PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer
- (2017) Prerna Malaney et al. CELL CYCLE
- PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer
- (2017) Michele Milella et al. Scientific Reports
- Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers
- (2016) Takashi Kohnoh et al. Cancer Cell International
- Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles
- (2016) Zhouyu Zhu et al. Oncotarget
- PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature
- (2016) Jian Xiao et al. Oncotarget
- The clinical significance of loss of FHIT and PTEN expression in 289 patients with non-small-cell lung cancer
- (2016) Xiu-Jun Chang et al. Translational Cancer Research
- Phase I trial of everolimus in combination with thoracic radiotherapy in non-small-cell lung cancer
- (2015) E. Deutsch et al. ANNALS OF ONCOLOGY
- Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-γ
- (2015) Chia-Ling Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Partial PTEN deletion is linked to poor prognosis in breast cancer
- (2015) P. Lebok et al. BMC CANCER
- MicroRNA-29b attenuates non-small cell lung cancer metastasis by targeting matrix metalloproteinase 2 and PTEN
- (2015) Hongyan Wang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- CpG hypermethylation contributes to decreased expression of PTEN during acquired resistance to gefitinib in human lung cancer cell lines
- (2015) Masashi Maeda et al. LUNG CANCER
- Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
- (2015) Sharad Shrestha et al. NATURE IMMUNOLOGY
- Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
- (2015) Alexandria Huynh et al. NATURE IMMUNOLOGY
- PTEN and PI3K/AKT in non-small-cell lung cancer
- (2015) Cristina Pérez-Ramírez et al. PHARMACOGENOMICS
- SLUG is a direct transcriptional repressor of PTEN tumor suppressor
- (2015) Berna Uygur et al. PROSTATE
- MicroRNA-92a promotes growth, metastasis, and chemoresistance in non-small cell lung cancer cells by targeting PTEN
- (2015) Ping Ren et al. TUMOR BIOLOGY
- Expression and clinical evidence of miR-494 and PTEN in non-small cell lung cancer
- (2015) Juan Wang et al. TUMOR BIOLOGY
- Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy
- (2015) W. Peng et al. Cancer Discovery
- Non-small-cell lung cancer
- (2015) Cesare Gridelli et al. Nature Reviews Disease Primers
- The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment
- (2015) M. D. Sharma et al. Science Advances
- PTEN: Multiple Functions in Human Malignant Tumors
- (2015) Michele Milella et al. Frontiers in Oncology
- Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function
- (2014) Antonella Papa et al. CELL
- Comprehensive molecular profiling of lung adenocarcinoma
- (2014) Eric A. Collisson et al. NATURE
- Correction: Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex
- (2014) Jiayun Lu et al. PLoS One
- A Unified Nomenclature and Amino Acid Numbering for Human PTEN
- (2014) R. Pulido et al. Science Signaling
- Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung
- (2014) Annika Stjernström et al. Cancer Medicine
- Phase II study of everolimus-erlotinib in previously treated patients with advanced non-small-cell lung cancer
- (2013) B. Besse et al. ANNALS OF ONCOLOGY
- miR-205 Targets PTEN and PHLPP2 to Augment AKT Signaling and Drive Malignant Phenotypes in Non-Small Cell Lung Cancer
- (2013) J. Cai et al. CANCER RESEARCH
- Identification of a Subset of Human Non–Small Cell Lung Cancer Patients with High PI3Kβ and Low PTEN Expression, More Prevalent in Squamous Cell Carcinoma
- (2013) Marie Cumberbatch et al. CLINICAL CANCER RESEARCH
- Loss of Phosphatase and Tensin Homolog (PTEN) Induces Leptin-mediated Leptin Gene Expression
- (2013) Ravi Ramesh Pathak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase II Study of Docetaxel in Combination with Everolimus for Second- or Third-Line Therapy of Advanced Non–Small-Cell Lung Cancer
- (2013) Suresh S. Ramalingam et al. Journal of Thoracic Oncology
- miR-205 promotes the growth, metastasis and chemoresistance of NSCLC cells by targeting PTEN
- (2013) LIN LEI et al. ONCOLOGY REPORTS
- Involvement of TGFβ-Induced Phosphorylation of the PTEN C-Terminus on TGFβ-Induced Acquisition of Malignant Phenotypes in Lung Cancer Cells
- (2013) Daisuke Aoyama et al. PLoS One
- A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival
- (2013) B. D. Hopkins et al. SCIENCE
- Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models
- (2012) J. M. Spoerke et al. CLINICAL CANCER RESEARCH
- Loss of Phosphatase and Tensin Homolog Protein Expression Is an Independent Poor Prognostic Marker in Lung Adenocarcinoma
- (2012) Naoki Yanagawa et al. Journal of Thoracic Oncology
- Brief Report: A Phase II “Window-of-Opportunity” Frontline Study of the mTOR Inhibitor, Temsirolimus Given as a Single Agent in Patients with Advanced NSCLC, an NCCTG Study
- (2012) Thanyanan Reungwetwattana et al. Journal of Thoracic Oncology
- MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN
- (2012) Zhi-Li Liu et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis
- (2012) Jun Qin et al. NATURE
- Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase
- (2012) Marianna Scrima et al. PLoS One
- The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells
- (2012) U. Putz et al. Science Signaling
- Reduction ofPtendose leads to neoplastic development in multiple organs ofPtenshRNAmice
- (2011) Hong Shen-Li et al. CANCER BIOLOGY & THERAPY
- Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs
- (2011) Yvonne Tay et al. CELL
- In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma
- (2011) Florian A. Karreth et al. CELL
- Loss of PTEN Expression is an Independent Poor Prognostic Factor in Non-small Cell Lung Cancer
- (2011) Seol Bong Yoo et al. Korean Journal of Pathology
- Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas
- (2010) Nicola Amodio et al. AMERICAN JOURNAL OF PATHOLOGY
- Loss of PTEN Expression by Blocking Nuclear Translocation of EGR1 in Gefitinib-Resistant Lung Cancer Cells Harboring Epidermal Growth Factor Receptor-Activating Mutations
- (2010) C. Yamamoto et al. CANCER RESEARCH
- Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo
- (2010) Renat Shaykhiev et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Subtle variations in Pten dose determine cancer susceptibility
- (2010) Andrea Alimonti et al. NATURE GENETICS
- Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors
- (2009) J.-C. Soria et al. ANNALS OF ONCOLOGY
- PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR
- (2009) M. L. Sos et al. CANCER RESEARCH
- The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
- (2009) Li-Bing Song et al. JOURNAL OF CLINICAL INVESTIGATION
- PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers
- (2009) Guang Jin et al. LUNG CANCER
- Urocanic acid-modified chitosan-mediated PTEN delivery via aerosol suppressed lung tumorigenesis in K-rasLA1 mice
- (2008) H Jin et al. CANCER GENE THERAPY
- Pten Inactivation Accelerates Oncogenic K-ras-Initiated Tumorigenesis in a Mouse Model of Lung Cancer
- (2008) K. Iwanaga et al. CANCER RESEARCH
- PTEN regulation by Akt–EGR1–ARF–PTEN axis
- (2008) Jianxiu Yu et al. EMBO JOURNAL
- Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis
- (2008) M. Escriva et al. MOLECULAR AND CELLULAR BIOLOGY
- A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
- (2008) M. Rahdar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More