Inhibition of breast cancer invasion by TIS21/BTG2/Pc3-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes

Inhibition of bladder cancer invasion by Sp1-mediated BTG2 expression via inhibition of DNA methyltransferase 1

(2014) Preethi Devanand et al.   FEBS Journal

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

B-cell translocation gene 2 mediates crosstalk between PI3K/Akt1 and NFκB pathways which enhances transcription of MnSOD by accelerating IκBα degradation in normal and cancer cells

(2013) Santhoshkumar Sundaramoorthy et al.   Cell Communication and Signaling

Regulation of Btg2/TIS21/PC3 expression via reactive oxygen species–protein kinase C–ΝFκΒ pathway under stress conditions

(2013) Muhammad Imran et al.   CELLULAR SIGNALLING

TIS21/BTG2 inhibits invadopodia formation by downregulating reactive oxygen species level in MDA-MB-231 cells

(2013) Jung-A. Choi et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion

(2012) Ghassan Mouneimne et al.   CANCER CELL

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

BTG2 suppresses cancer cell migration through inhibition of Src-FAK signaling by downregulation of reactive oxygen species generation in mitochondria

(2012) Seo-Kyung Lim et al.   CLINICAL & EXPERIMENTAL METASTASIS

Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells

(2012) Howard E. Boudreau et al.   FREE RADICAL BIOLOGY AND MEDICINE

Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

(2012) Hilla Solomon et al.   JOURNAL OF CELL SCIENCE

BTG2 loss and miR-21 upregulation contribute to prostate cell transformation by inducing luminal markers expression and epithelial–mesenchymal transition

(2012) V Coppola et al.   ONCOGENE

Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells

(2011) Nicole Grabinski et al.   CELLULAR SIGNALLING

Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene

(2011) Masato Katsuyama et al.   FEBS Journal

Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation

(2011) Hideki Yamaguchi et al.   JOURNAL OF CELL BIOLOGY

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB/HER inhibitor lapatinib

(2011) F Takahashi et al.   ONCOGENE

Akt1 deficiency delays tumor progression, vascular invasion and distant metastasis in a murine model of thyroid cancer

(2011) M Saji et al.   ONCOGENE

p53 Regulates the Ras Circuit to Inhibit the Expression of a Cancer-Related Gene Signature by Various Molecular Pathways

(2010) Y. Buganim et al.   CANCER RESEARCH

Distinct Biological Roles for the Akt Family in Mammary Tumor Progression: Figure 1.

(2010) Rachelle L. Dillon et al.   CANCER RESEARCH

BLT2 promotes the invasion and metastasis of aggressive bladder cancer cells through a reactive oxygen species-linked pathway

(2010) Eun-Young Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

Synaptotagmin-mediated vesicle fusion regulates cell migration

(2010) Richard A Colvin et al.   NATURE IMMUNOLOGY

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

(2010) Pierre-Olivier Estève et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Diaphanous-Related Formins Are Required for Invadopodia Formation and Invasion of Breast Tumor Cells

(2009) F. Lizarraga et al.   CANCER RESEARCH

Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2–reactive oxygen species-linked signaling pathway

(2009) Jung-A Choi et al.   CARCINOGENESIS

PI3K p110α and p110β have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts

(2009) R W Matheny et al.   CELL DEATH AND DIFFERENTIATION

Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma

(2009) Min Liu et al.   CELL RESEARCH

NAD(P)H Oxidase Mediates TGF- 1-Induced Activation of Kidney Myofibroblasts

(2009) C. D. Bondi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells

(2009) D. Iliopoulos et al.   Science Signaling

The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer

(2008) M. Schmidt et al.   CANCER RESEARCH

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer

(2008) Y. Rebecca Chin et al.   CELLULAR SIGNALLING

Positive regulation of the NADPH oxidase NOX4 promoter in vascular smooth muscle cells by E2F

(2008) Li Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop

(2008) Tae Jun Park et al.   HEPATOLOGY

WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells

(2008) Corina Sarmiento et al.   JOURNAL OF CELL BIOLOGY

TIS21/BTG2Negatively Regulates Estradiol-Stimulated Expansion of Hematopoietic Stem Cells by Derepressing Akt Phosphorylation and Inhibiting mTOR Signal Transduction

(2008) Bong Cho Kim et al.   STEM CELLS