Mitochondrial HSP70 Chaperone System—The Influence of Post-Translational Modifications and Involvement in Human Diseases

Mitochondrial proteases in human diseases

(2021) Maria Gomez‐Fabra Gala et al.   FEBS LETTERS

Mitochondrial Kinases and the Role of Mitochondrial Protein Phosphorylation in Health and Disease

(2021) Veronika Kotrasová et al.   Life-Basel

Mitochondrial matrix proteases: quality control and beyond

(2021) Karolina Szczepanowska et al.   FEBS Journal

Small Hsps as Therapeutic Targets of Cystic Fibrosis Transmembrane Conductance Regulator Protein

(2021) Stéphanie Simon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AAA+ ATPases in Protein Degradation: Structures, Functions and Mechanisms

(2020) Shuwen Zhang et al.   Biomolecules

Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code

(2020) Nitika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the m-AAA proteases AFG3L2 and SPG7 are causing isolated dominant optic atrophy

(2020) Majida Charif et al.   Neurology-Genetics

Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia

(2020) Andrew Crispin et al.   JOURNAL OF CLINICAL INVESTIGATION

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial proteins: from biogenesis to functional networks

(2019) Nikolaus Pfanner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Molecular Chaperone HSP70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA-Damage and MAPK/ERK Signaling Pathways

(2019) Wonkyoung Cho et al.   MOLECULAR AND CELLULAR BIOLOGY

A novel variant of the human mitochondrial DnaJ protein, Tid1, associates with a human disease exhibiting developmental delay and polyneuropathy

(2019) Malay Patra et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells

(2019) Dmytro Starenki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Complex Phosphorylation Patterns that Regulate the Activity of Hsp70 and Its Cochaperones

(2019) Velasco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates

(2019) Bonam et al.   Cells

LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response

(2018) Olga Zurita Rendón et al.   MOLECULAR AND CELLULAR BIOLOGY

Perrault syndrome type 3 caused by diverse molecular defects in CLPP

(2018) Erica J. Brodie et al.   Scientific Reports

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone

(2018) Svetlana Konovalova et al.   Redox Biology

Blocking nuclear export of HSPA8 after heat shock stress severely alters cell survival

(2018) Fengjuan Wang et al.   Scientific Reports

Hsp70 - a master regulator in protein degradation

(2017) María Rosario Fernández-Fernández et al.   FEBS LETTERS

Regulation of mitochondrial protein import by the nucleotide exchange factors GrpEL1 and GrpEL2 in human cells

(2017) Shubhi Srivastava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation in humanCLPXelevates levels ofδ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria

(2017) Yvette Y. Yien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mortalin overexpression predicts poor prognosis in early stage of non–small cell lung cancer

(2017) Jie Sun et al.   TUMOR BIOLOGY

An essential regulatory function of the DnaK chaperone dictates the decision between proliferation and maintenance in Caulobacter crescentus

(2017) Frederic D. Schramm et al.   PLoS Genetics

Tid1-S regulates the mitochondrial localization of EGFR in non-small cell lung carcinoma

(2017) T-H Wang et al.   Oncogenesis

Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration

(2017) David A. Patten et al.   JOURNAL OF ALZHEIMERS DISEASE

Post-translational modifications in mitochondria: protein signaling in the powerhouse

(2016) Amanda R. Stram et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly

(2016) Yuxi Shan et al.   MITOCHONDRION

Proteogenomics connects somatic mutations to signalling in breast cancer

(2016) Philipp Mertins et al.   NATURE

Heat Shock Proteins Promote Cancer: It's a Protection Racket

(2016) Stuart K. Calderwood et al.   TRENDS IN BIOCHEMICAL SCIENCES

The small heat shock protein αA-crystallin negatively regulates pancreatic tumorigenesis

(2016) Jifang Liu et al.   Oncotarget

Mitochondrial co-chaperone protein Tid1 is required for energy homeostasis during skeletal myogenesis

(2016) Li-Hao Cheng et al.   Stem Cell Research & Therapy

Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation

(2016) Bianca Hartmann et al.   eLife

CODAS Syndrome Is Associated with Mutations of LONP1, Encoding Mitochondrial AAA+ Lon Protease

(2015) Kevin A. Strauss et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations inLONP1, a mitochondrial matrix protease, cause CODAS syndrome

(2015) Esra Dikoglu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9

(2015) K. Schmitz-Abe et al.   BLOOD

Mortalin is Expressed by Astrocytes and Decreased in the Midbrain of Parkinson's Disease Patients

(2015) Travis J. Cook et al.   BRAIN PATHOLOGY

Modulation of the Chaperone DnaK Allosterism by the Nucleotide Exchange Factor GrpE

(2015) Roberto Melero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phosphoproteomic Comparison of B-RAFV600Eand MKK1/2 Inhibitors in Melanoma Cells

(2015) Scott A. Stuart et al.   MOLECULAR & CELLULAR PROTEOMICS

Stoichiometric expression of mtHsp40 and mtHsp70 modulates mitochondrial morphology and cristae structure via Opa1L cleavage

(2015) Byoungchun Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Human Mitochondrial Hsp70 (Mortalin): Shedding Light on ATPase Activity, Interaction with Adenosine Nucleotides, Solution Structure and Domain Organization

(2015) Paulo R. Dores-Silva et al.   PLoS One

Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics

(2015) Chia-Feng Tsai et al.   Nature Communications

Pathways of allosteric regulation in Hsp70 chaperones

(2015) Roman Kityk et al.   Nature Communications

Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia

(2015) Beryl Royer-Bertrand et al.   Scientific Reports

Suberoylanilide Hydroxamic Acid Treatment Reveals Crosstalks among Proteome, Ubiquitylome and Acetylome in Non-Small Cell Lung Cancer A549 Cell Line

(2015) Quan Wu et al.   Scientific Reports

Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosisy as a Target for Cancer Therapy?

(2015)   Oncotarget

Extracellular cell stress proteins as biomarkers of human disease

(2014) A. Graham Pockley et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Heterozygous missense mutations in the GLRX5 gene cause sideroblastic anemia in a Chinese patient

(2014) G. Liu et al.   BLOOD

Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenance

(2014) Gerald Pfeffer et al.   BRAIN

Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review

(2014) Imen Belhadj Slimen et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Essential Role of TID1 in Maintaining Mitochondrial Membrane Potential Homogeneity and Mitochondrial DNA Integrity

(2014) A. C.-H. Ng et al.   MOLECULAR AND CELLULAR BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone

(2014) Joseph Amick et al.   PROTEIN SCIENCE

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

(2014) L F Burbulla et al.   Cell Death & Disease

Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop

(2014) Sara Alvira et al.   Nature Communications

ATPase Subdomain IA Is a Mediator of Interdomain Allostery in Hsp70 Molecular Chaperones

(2014) Ignacio J. General et al.   PLoS Computational Biology

An Essential Nonredundant Role for Mycobacterial DnaK in Native Protein Folding

(2014) Allison Fay et al.   PLoS Genetics

Perrault Syndrome Is Caused by Recessive Mutations in CLPP, Encoding a Mitochondrial ATP-Dependent Chambered Protease

(2013) Emma M. Jenkinson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Changes in Small Heat Shock Proteins HSPB1, HSPB5 and HSPB8 in Mitochondria of the Failing Heart Following Myocardial Infarction in Rats

(2013) Tetsuro Marunouchi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease

(2013) Yu-Qing Jiang et al.   BRAIN RESEARCH

The potential role of small heat shock proteins in mitochondria

(2013) Liuwang Zeng et al.   CELLULAR SIGNALLING

Hsp60 chaperonopathies and chaperonotherapy: targets and agents

(2013) Francesco Cappello et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Complex Evolutionary Dynamics of Hsp70s: A Genomic and Functional Perspective

(2013) Jacek Kominek et al.   Genome Biology and Evolution

Structural and stability studies of the human mtHsp70-escort protein 1: An essential mortalin co-chaperone

(2013) P.R. Dores-Silva et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Functional Interaction of Mitochondrial Hsp70s with the Escort Protein Zim17 Is Critical for Fe/S Biogenesis and Substrate Interaction at the Inner Membrane Preprotein Translocase

(2013) Ilka Lewrenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors

(2013) Devin K. Schweppe et al.   Journal of Proteomics

A Y2H-seq approach defines the human protein methyltransferase interactome

(2013) Mareike Weimann et al.   NATURE METHODS

Nitric Oxide Regulates Mitochondrial Fatty Acid Metabolism Through Reversible Protein S-Nitrosylation

(2013) P.-T. Doulias et al.   Science Signaling

Hsp70 chaperone dynamics and molecular mechanism

(2013) Matthias P. Mayer   TRENDS IN BIOCHEMICAL SCIENCES

Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors

(2013) Pedro Casado et al.   GENOME BIOLOGY

Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines

(2012) Erin E. Gestl et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chaperone–protease networks in mitochondrial protein homeostasis

(2012) Wolfgang Voos   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane

(2012) Soung Jung Kim et al.   Cell Metabolism

Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinson's disease

(2012) Arvind Vittal Goswami et al.   HUMAN MOLECULAR GENETICS

Mitochondrial chaperone DnaJA3 induces Drp1-dependent mitochondrial fragmentation

(2012) Adam N. Elwi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Absence of a Human DnaJ Protein hTid-1SCorrelates with Aberrant Actin Cytoskeleton Organization in Lesional Psoriatic Skin

(2012) Ji Hye Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of DnaK Protein Complexed with Nucleotide Exchange Factor GrpE in DnaK Chaperone System

(2012) Ching-Chung Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The influence of ATP-dependent proteases on a variety of nucleoid-associated processes

(2012) L’uboš Ambro et al.   JOURNAL OF STRUCTURAL BIOLOGY

Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer

(2012) Martin Klammer et al.   MOLECULAR & CELLULAR PROTEOMICS

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential

(2012) Tuoen Liu et al.   PHARMACOLOGY & THERAPEUTICS

A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity

(2011) Peng Zhai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRAP-1, the mitochondrial Hsp90

(2011) Dario C. Altieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mortalin–p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

(2011) W-J Lu et al.   CELL DEATH AND DIFFERENTIATION

Reactivation of protein aggregates by mortalin and Tid1—the human mitochondrial Hsp70 chaperone system

(2011) Ohad Iosefson et al.   CELL STRESS & CHAPERONES

Unique Peptide Substrate Binding Properties of 110-kDa Heat-shock Protein (Hsp110) Determine Its Distinct Chaperone Activity

(2011) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simultaneous Detection of Changes in Protein Expression and Oxidative Modification as a Function of Age andAPOEGenotype

(2011) Robert M. DeKroon et al.   JOURNAL OF PROTEOME RESEARCH

MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization

(2011) Alwaleed K. Alkhaja et al.   MOLECULAR BIOLOGY OF THE CELL

The Molecular Chaperone Hsp70 Family Members Function by a Bidirectional Heterotrophic Allosteric Mechanism

(2011) Kelly P. da Silva et al.   PROTEIN AND PEPTIDE LETTERS

The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9

(2011) Michael T. Vu et al.   PROTEIN SCIENCE

Whole-Exome Sequencing Identifies Homozygous AFG3L2 Mutations in a Spastic Ataxia-Neuropathy Syndrome Linked to Mitochondrial m-AAA Proteases

(2011) Tyler Mark Pierson et al.   PLoS Genetics

Hsp60 expression, new locations, functions, and perspectives for cancer diagnosis and therapy

(2010) Francesco Cappello et al.   CANCER BIOLOGY & THERAPY

Versatile TPR domains accommodate different modes of target protein recognition and function

(2010) Rudi Kenneth Allan et al.   CELL STRESS & CHAPERONES

Independent evolution of the core domain and its flanking sequences in small heat shock proteins

(2010) Thomas Kriehuber et al.   FASEB JOURNAL

Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis

(2010) Lena F. Burbulla et al.   HUMAN MOLECULAR GENETICS

Understanding the Functional Interplay between Mammalian Mitochondrial Hsp70 Chaperone Machine Components

(2010) Arvind Vittal Goswami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28

(2010) Daniela Di Bella et al.   NATURE GENETICS

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Combining Alkaline Phosphatase Treatment and Hybrid Linear Ion Trap/Orbitrap High Mass Accuracy Liquid Chromatography−Mass Spectrometry Data for the Efficient and Confident Identification of Protein Phosphorylation

(2009) Hsin-Yi Wu et al.   ANALYTICAL CHEMISTRY

Effects of α-Crystallin on Lens Cell Function and Cataract Pathology

(2009) Usha Andley   CURRENT MOLECULAR MEDICINE

ATPase Domain and Interdomain Linker Play a Key Role in Aggregation of Mitochondrial Hsp70 Chaperone Ssc1

(2009) Marta Blamowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational screening of the mortalin gene (HSPA9) in Parkinson’s disease

(2009) Lorena De Mena et al.   JOURNAL OF NEURAL TRANSMISSION

Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer

(2009) B Y Ahn et al.   ONCOGENE

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Hsp60 Chaperonopathy Causes an Autosomal-Recessive Neurodegenerative Disorder Linked to Brain Hypomyelination and Leukodystrophy

(2008) Daniella Magen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Thirty years of protein translocation into mitochondria: Unexpectedly complex and still puzzling

(2008) Dejana Mokranjac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

From proliferative to neurological role of an hsp70 stress chaperone, mortalin

(2008) Custer C. Deocaris et al.   BIOGERONTOLOGY

αB-Crystallin Suppresses Pressure Overload Cardiac Hypertrophy

(2008) Asangi R.K. Kumarapeli et al.   CIRCULATION RESEARCH

Multiple Hsp70 Isoforms in the Eukaryotic Cytosol: Mere Redundancy or Functional Specificity?

(2008) Mehdi Kabani et al.   CURRENT GENOMICS

The Human Escort Protein Hep Binds to the ATPase Domain of Mitochondrial Hsp70 and Regulates ATP Hydrolysis

(2008) Peng Zhai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mortalin: A Protein Associated With Progression of Parkinson Disease?

(2008) Min Shi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Hsp104 and ClpB: protein disaggregating machines

(2008) Shannon M. Doyle et al.   TRENDS IN BIOCHEMICAL SCIENCES