Structural and mechanistic insights into amyloid‐β and α‐synuclein fibril formation and polyphenol inhibitor efficacy in phospholipid bilayers

The molecular chaperone β-casein prevents amorphous and fibrillar aggregation of α-lactalbumin by stabilisation of dynamic disorder

(2020) Henry M. Sanders et al.   BIOCHEMICAL JOURNAL

Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

(2020) Thomas C. T. Michaels et al.   Nature Chemistry

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

(2020) Patrick Flagmeier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies

(2020) Gabriela Henríquez et al.   ACS Chemical Neuroscience

Interactions of α-synuclein oligomers with lipid membranes

(2020) Greta Musteikytė et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology

(2020) Senthil T. Kumar et al.   NEUROBIOLOGY OF DISEASE

The role of lipids in α-synuclein misfolding and neurotoxicity

(2019) Cathryn L Ugalde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy

(2019) David C. Bode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GM1 Ganglioside role in the interaction of Alpha-synuclein with lipid membranes: Morphology and structure

(2019) F. Perissinotto et al.   BIOPHYSICAL CHEMISTRY

The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG

(2019) Tomas Sneideris et al.   Biomolecules

Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement

(2018) Rubén Corpas et al.   MOLECULAR NEUROBIOLOGY

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

(2018) Johnny Habchi et al.   Nature Chemistry

Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases

(2018) AgnèsRioux Bilan et al.   Neural Regeneration Research

Disruptive membrane interactions of alpha-synuclein aggregates

(2018) Aditya Iyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β

(2017) Kyle J. Korshavn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions

(2017) Amulya Nidhi Shrivastava et al.   NEURON

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein

(2016) Albert Konijnenberg et al.   ANALYTICAL CHEMISTRY

Polyglutamine aggregates impair lipid membrane integrity and enhance lipid membrane rigidity

(2016) Chian Sing Ho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments

(2016) Montserrat Serra-Batiste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of synaptic vesicle assembly promoted by α-synuclein

(2016) Giuliana Fusco et al.   Nature Communications

Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives

(2016) Amit Pithadia et al.   Journal of Diabetes Research

Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles

(2015) Michael T. Marty et al.   ANALYTICAL CHEMISTRY

Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study

(2015) Fabio Lolicato et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Resveratrol reduces amyloid-beta (Aβ1–42)-induced paralysis through targeting proteostasis in an Alzheimer model of Caenorhabditis elegans

(2015) Charlotte Regitz et al.   EUROPEAN JOURNAL OF NUTRITION

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau

(2015) Anna Pavlova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity

(2014) Benedetta Mannini et al.   ACS Chemical Biology

Capping of Aβ42 Oligomers by Small Molecule Inhibitors

(2014) Ziao Fu et al.   BIOCHEMISTRY

Lipids in cell biology: how can we understand them better?

(2014) Eleonora Muro et al.   MOLECULAR BIOLOGY OF THE CELL

A mass spectrometry–based hybrid method for structural modeling of protein complexes

(2014) Argyris Politis et al.   NATURE METHODS

Effects of Metal Ion Adduction on the Gas-Phase Conformations of Protein Ions

(2013) Tawnya G. Flick et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Electrochemical Detection of Amyloid-Beta Aggregation in the Presence of Resveratrol

(2013) Vinci W. S. Hung et al.   JOURNAL OF THE ELECTROCHEMICAL SOCIETY

Novel insights into protein misfolding diseases revealed by ion mobility-mass spectrometry

(2013) Danielle M. Williams et al.   MASS SPECTROMETRY REVIEWS

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-  species

(2013) S.-J. Hyung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ammonium hydroxide treatment of Aβ produces an aggregate free solution suitable for biophysical and cell culture characterization

(2013) Timothy M. Ryan et al.   PeerJ

Unraveling the Mechanism of Electrospray Ionization

(2012) Lars Konermann et al.   ANALYTICAL CHEMISTRY

The small heat-shock protein αB-crystallin uses different mechanisms of chaperone action to prevent the amorphous versus fibrillar aggregation of α-lactalbumin

(2012) Melissa Kulig et al.   BIOCHEMICAL JOURNAL

Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation

(2012) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2

(2011) Indu R. Chandrashekaran et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Folding and misfolding of alpha-synuclein on membranes

(2011) Igor Dikiy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Membrane and surface interactions of Alzheimer’s Aβ peptide - insights into the mechanism of cytotoxicity

(2011) Thomas L. Williams et al.   FEBS Journal

Lipid matrix plays a role in Abeta fibril kinetics and morphology

(2011) Marc-Antoine Sani et al.   FEBS LETTERS

Protein–Protein Binding Affinities in Solution Determined by Electrospray Mass Spectrometry

(2011) Jiangjiang Liu et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

The Lipid-binding Domain of Wild Type and Mutant α-Synuclein

(2010) Elka R. Georgieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effect of Alzheimer’s Aβ Aggregation State on the Permeation of Biomimetic Lipid Vesicles

(2010) Thomas L. Williams et al.   LANGMUIR

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

(2009) Ishu Saraogi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibiting Islet Amyloid Polypeptide Fibril Formation by the Red Wine Compound Resveratrol

(2009) Rajesh Mishra et al.   CHEMBIOCHEM

The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds

(2009) Sean A. Hudson et al.   FEBS Journal

Elucidating the Mechanism of Lipid Membrane-Induced IAPP Fibrillogenesis and Its Inhibition by the Red Wine Compound Resveratrol: A Synchrotron X-ray Reflectivity Study

(2009) Florian Evers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

(2009) Ying Feng et al.   NEUROTOXICOLOGY

Amyloid-  Peptide (A ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: A  Dimers and Trimers Correlate with Neurotoxicity

(2008) L. W. Hung et al.   JOURNAL OF NEUROSCIENCE

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Islet Amyloid Polypeptide Forms Rigid Lipid–Protein Amyloid Fibrils on Supported Phospholipid Bilayers

(2007) Yegor A. Domanov et al.   JOURNAL OF MOLECULAR BIOLOGY