Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β

Thioflavin T-Silent Denaturation Intermediates Support the Main-Chain-Dominated Architecture of Amyloid Fibrils

(2016) Sayaka Noda et al.   BIOCHEMISTRY

Analysis of the Amyloidogenic Potential of Pufferfish (Takifugu rubripes) Islet Amyloid Polypeptide Highlights the Limitations of Thioflavin-T Assays and the Difficulties in Defining Amyloidogenicity

(2016) Amy G. Wong et al.   BIOCHEMISTRY

The Role of Cholesterol in Driving IAPP-Membrane Interactions

(2016) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

Amyloid-β adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation

(2016) Kyle J. Korshavn et al.   CHEMICAL COMMUNICATIONS

Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes

(2016) Amit S. Pithadia et al.   CHEMICAL COMMUNICATIONS

Lipid-assisted protein transport: A diffusion-reaction model supported by kinetic experiments and molecular dynamics simulations

(2016) Carmelo La Rosa et al.   JOURNAL OF CHEMICAL PHYSICS

Structural Polymorphism of Alzheimer’s β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study

(2016) Matthew R. Elkins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases

(2016) Valerio Chiurchiù et al.   Oxidative Medicine and Cellular Longevity

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

(2016) Céline Galvagnion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

(2016) Paolo Arosio et al.   Nature Communications

Phosphorylation modifies the molecular stability of β-amyloid deposits

(2016) Nasrollah Rezaei-Ghaleh et al.   Nature Communications

Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update

(2015) Melissa A. Bradley-Whitman et al.   ARCHIVES OF TOXICOLOGY

Oligomers of Parkinson’s Disease-Related α-Synuclein Mutants Have Similar Structures but Distinctive Membrane Permeabilization Properties

(2015) Anja N. D. Stefanovic et al.   BIOCHEMISTRY

Ca2+ Interacts with Glu-22 of Aβ(1–42) and Phospholipid Bilayers to Accelerate the Aβ(1–42) Aggregation Below the Critical Micelle Concentration

(2015) Xinyao Yi et al.   BIOCHEMISTRY

Biophysical Comparison of Soluble Amyloid-β(1–42) Protofibrils, Oligomers, and Protofilaments

(2015) Michael R. Nichols et al.   BIOCHEMISTRY

Supersaturation-Limited and Unlimited Phase Spaces Compete to Produce Maximal Amyloid Fibrillation near the Critical Micelle Concentration of Sodium Dodecyl Sulfate

(2015) Masatomo So et al.   LANGMUIR

Agitation of amyloid proteins to speed aggregation measured by ThT fluorescence: A call for standardization

(2015) Kiersten M. Batzli et al.   Materials Science & Engineering C-Materials for Biological Applications

Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein

(2015) Nuzhat Ahsan et al.   Scientific Reports

How Do Membranes Initiate Alzheimer’s Disease? Formation of Toxic Amyloid Fibrils by the Amyloid β-Protein on Ganglioside Clusters

(2014) Katsumi Matsuzaki   ACCOUNTS OF CHEMICAL RESEARCH

Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation

(2014) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cold Denaturation of α-Synuclein Amyloid Fibrils

(2014) Tatsuya Ikenoue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preparation Protocols of Aβ(1–40) Promote the Formation of Polymorphic Aggregates and Altered Interactions with Lipid Bilayers

(2014) Elizabeth A. Yates et al.   BIOCHEMISTRY

Binding of Aβ peptide creates lipid density depression in DMPC bilayer

(2014) Christopher Lockhart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs

(2014) Hyunbum Jang et al.   CHEMICAL SOCIETY REVIEWS

Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease

(2014) Samuel A. Kotler et al.   CHEMICAL SOCIETY REVIEWS

Small Liposomes Accelerate the Fibrillation of Amyloid β (1–40)

(2014) Mayu S. Terakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical and structural basis for polymorphism in amyloid fibrils

(2014) Robert Tycko   PROTEIN SCIENCE

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Different effects of Alzheimer's peptide Aβ(1–40) oligomers and fibrils on supported lipid membranes

(2013) Claudio Canale et al.   BIOPHYSICAL CHEMISTRY

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

(2013) Sunil Kumar et al.   CHEMICAL COMMUNICATIONS

Conformational Stability of Mammalian Prion Protein Amyloid Fibrils Is Dictated by a Packing Polymorphism within the Core Region

(2013) Nathan J. Cobb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Domains of Aβ Facilitate Aggregation on and Association with Lipid Bilayers

(2013) Elizabeth A. Yates et al.   JOURNAL OF MOLECULAR BIOLOGY

Familial Alzheimer’s Disease Osaka Mutant (ΔE22) β-Barrels Suggest an Explanation for the Different Aβ1–40/42 Preferred Conformational States Observed by Experiment

(2013) Hyunbum Jang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: towards a unifying description of conformational transitions, oligomerization and membrane damage

(2013) Martina Pannuzzo et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Common mechanism unites membrane poration by amyloid and antimicrobial peptides

(2013) N. B. Last et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F Nuclear Magnetic Resonance-Detected Kinetics of Monomer Consumption

(2012) Yuta Suzuki et al.   BIOCHEMISTRY

Effects of Point Substitutions on the Structure of Toxic Alzheimer’s β-Amyloid Channels: Atomic Force Microscopy and Molecular Dynamics Simulations

(2012) Laura Connelly et al.   BIOCHEMISTRY

Proline Kink Angle Distributions for GWALP23 in Lipid Bilayers of Different Thicknesses

(2012) Johanna M. Rankenberg et al.   BIOCHEMISTRY

Analysis of the Inhibition and Remodeling of Islet Amyloid Polypeptide Amyloid Fibers by Flavanols

(2012) Ping Cao et al.   BIOCHEMISTRY

Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation

(2012) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

How Type II Diabetes-Related Islet Amyloid Polypeptide Damages Lipid Bilayers

(2012) Chang-Chun Lee et al.   BIOPHYSICAL JOURNAL

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Multiple Substitutions of Methionine 129 in Human Prion Protein Reveal Its Importance in the Amyloid Fibrillation Pathway

(2012) Sofie Nyström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interactions of Alzheimer's Aβ Protofilaments with Lipid Membranes

(2012) Florentina Tofoleanu et al.   JOURNAL OF MOLECULAR BIOLOGY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Well-defined lipid interfaces for protein adsorption studies

(2012) Cristina Satriano et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Outer membrane phospholipase A in phospholipid bilayers: A model system for concerted computational and experimental investigations of amino acid side chain partitioning into lipid bilayers

(2011) Patrick J. Fleming et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Oxidative Stress and Cell Membranes in the Pathogenesis of Alzheimer's Disease

(2011) Paul H. Axelsen et al.   PHYSIOLOGY

Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation

(2011) Fernando Terán Arce et al.   Soft Matter

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Self-Assembling Pathway of HiApp Fibrils within Lipid Bilayers

(2010) Silvia Scalisi et al.   CHEMBIOCHEM

Pathological aspects of lipid peroxidation

(2010) Anne Negre-Salvayre et al.   FREE RADICAL RESEARCH

β-Barrel Topology of Alzheimer's β-Amyloid Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid  -Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils

(2010) B. O'Nuallain et al.   JOURNAL OF NEUROSCIENCE

Oxidation Changes Physical Properties of Phospholipid Bilayers: Fluorescence Spectroscopy and Molecular Simulations

(2010) Lenka Beranova et al.   LANGMUIR

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

The interaction of amyloid Aβ(1–40) with lipid bilayers and ganglioside as studied by 31P solid-state NMR

(2008) Yasumoto Nakazawa et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

(2008) Domenico Praticò   TRENDS IN PHARMACOLOGICAL SCIENCES