Article
Agriculture, Multidisciplinary
Edouard Pelonnier-Magimel, Georgia Lytra, Celine Franc, Laura Farris, Philippe Darriet, Jean-Christophe Barbe
Summary: Red wines produced without the addition of any SO2 have become a new consumer trend. Research has shown that sensory differences exist between wines produced with and without the use of SO2. This study aims to further understand the aromatic characteristics of these wines and identifies methyl salicylate as a compound impacted by the use of SO2. The research also found that methyl salicylate is significantly higher in wines without added SO2 and has a significant impact on the fruity aromas and freshness of the wine.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Eva Lopez-Rituerto, Klavs M. Sorensen, Francesco Savorani, Soren B. Engelsen, Alberto Avenoza, Jesus M. Peregrina, Jesus H. Busto
Summary: Proton nuclear magnetic resonance (H-1-NMR) is a quantitative and unbiased analytical technique that can be used to monitor quantitative changes in wine metabolites during the winemaking process. This study demonstrates the potential of NMR as a process analytical technology tool in the wine industry, by monitoring amino acids, organic acids, and polyphenols.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Renan Dal-Fabbro, Leopoldo Cosme-Silva, Fernanda Rezende Silva Martins de Oliveira, Leticia Cabrera Capalbo, Flavia Alfredo Plazza, Edilson Ervolino, Luciano Tavares Angelo Cintra, Joao Eduardo Gomes-Filho
Summary: The study showed that red wine consumption before induction of apical periodontitis in rats can reduce inflammation, TRAP marking, and periapical bone resorption, while alcohol has the opposite effect. Administration of resveratrol and quercetin was more effective in reducing inflammation and periapical bone resorption in apical periodontitis.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Cell Biology
Clarisse Cornebise, Maude Perus, Francois Hermetet, Josep Valls-Fonayet, Tristan Richard, Virginie Aires, Dominique Delmas
Summary: Age-related macular degeneration (AMD) is a common ocular disease that affects the retina and causes central vision loss. Current treatments mainly focus on the late stage of the disease, but recent studies suggest the importance of preventive treatments and good dietary habits in reducing the risk of advanced AMD. To investigate this, the study examined the effects of resveratrol (RSV) and red wine extract (RWE) on oxidative stress and inflammation in retinal cells. The results showed that both RSV and RWE could prevent oxidative stress and DNA damage, as well as inhibit the secretion of proinflammatory cytokines. Interestingly, RWE had a greater protective effect compared to RSV alone, despite having a lower concentration in the extract. These findings suggest that RWE and RSV may have potential as preventive nutritional supplements for AMD.
Article
Biochemistry & Molecular Biology
Quanjie Li, Yao Zheng, Yi Sun, Gangchun Xu
Summary: This study found that resveratrol supplementation in red tilapia (Oreochromis niloticus) promotes fatty acid β-oxidation in the blood, liver, and liver cells associated with apoptosis and the MAPK/PPAR signaling pathway. RES was also found to regulate the expression of genes related to apoptosis and fatty acid metabolism.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Food Science & Technology
Laura Brianso-Llort, Olga Simo-Servat, Lorena Ramos-Perez, Javier Torres-Torronteras, Cristina Hernandez, Rafael Simo, David M. Selva
Summary: The study found that red wine rich in resveratrol can reduce total cholesterol in both men and women, and only increase SHBG levels in women, which may be beneficial for cardiovascular protection. Further research is needed to explore the potential enhancement of SHBG by resveratrol in cardiovascular protection between women and men.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Food Science & Technology
Neziha Yagmur Diker, Vahap Murat Kutluay
Summary: Moderate red wine consumption has shown to decrease the risk of cardiovascular diseases and have beneficial effects on patients with type 2 diabetes mellitus. This study analyzed 116 red wine compounds with a polyphenolic structure using network pharmacology, and identified key compounds that target AKT1, STAT3, and IL6.
Review
Nutrition & Dietetics
Samuel R. Weaver, Catarina Rendeiro, Helen M. McGettrick, Andrew Philp, Samuel J. E. Lucas
Summary: Red wine polyphenols (RWP) have shown significant improvements in blood pressure and vascular health in both animal and human studies. However, the benefits are more prominent in animal models compared to human populations.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yao Zheng, Yulu Shi, Xiaoxi Yang, Jiancao Gao, Zhijuan Nie, Gangchun Xu
Summary: This study investigates the effects and potential mechanisms of RES on lipid metabolism and liver damage in red tilapia. RES is found to alleviate fatty liver lesions in red tilapia by activating the sirt1 gene, regulating the PPAR pathway and related genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Biology
Sven Klaschik, Richard K. Ellerkmann, Jennifer Gehlen, Stilla Frede, Tobias Hilbert
Summary: The study showed that aging improves the quality of red wine, while young red wine can induce cell stress and damage, reducing cytoprotective proteins significantly. Aged red wines performed better in aroma and overall quality, but worse in optical appearance compared to young red wines.
OPEN LIFE SCIENCES
(2021)
Review
Multidisciplinary Sciences
Arash Bahramzadeh, Kosar Bolandnazar, Reza Meshkani
Summary: This review provides a summary of the role of resveratrol in insulin resistance in skeletal muscle and its related mechanisms. Through analyzing various results from cell culture, animal, and human studies, it is found that resveratrol has positive effects on insulin resistance.
Review
Biochemistry & Molecular Biology
Francesca Serio, Giovanni Imbriani, Mattia Acito, Massimo Moretti, Francesco Paolo Fanizzi, Antonella De Donno, Giuseppe Valacchi
Summary: Wine is a complex mixture primarily composed of water and ethyl alcohol, as well as various other molecules that contribute to its specific characteristics. Moderate red wine consumption has been found to significantly reduce the risk of cardiovascular disease, based on available literature. However, more research is needed to determine the specific components responsible for these effects.
Article
Chemistry, Analytical
Milleno D. Mota, Marilena Meira, Juceni P. David, Erika M. de Oliveira Ribeiro, Hugo N. Brandao, Ademir E. do Vale, Jorge M. David
Summary: This study developed a fast, simple, sensitive, and low-cost method for identifying resveratrol in different red wines, predicting its content through principal component analysis and multivariate calibration. The multivariate method demonstrated a good predictive capacity for determining resveratrol concentrations in commercial red wines.
CURRENT ANALYTICAL CHEMISTRY
(2021)
Article
Food Science & Technology
Xinlong Cheng, Xue Han, Liangfu Zhou, Yasai Sun, Qian Zhou, Xuan Lin, Zhe Gao, Jie Wang, Wen Zhao
Summary: Limited evidence suggests that the antioxidant polyphenols in Cabernet Sauvignon dry red wine can prevent cardiovascular diseases. This study found that oral administration of Cabernet Sauvignon reduced atherosclerotic lesion size, alleviated hyperlipidemia, and regulated lipid metabolism in mice. The beneficial effects may be mediated by various polyphenols present in the wine, which can reduce inflammation, restore endothelial function, regulate hepatic lipid metabolism, and modulate gut microbiota composition.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Acoustics
Zhen-Dan Xue, Qing-An Zhang, Hong-Rong Zheng
Summary: Ultrasound promotes the formation of acetaldehyde in model wine solutions by inducing hydroxyl radicals and 1-hydroxyethyl free radicals, with the latter having an inverse relationship with acetaldehyde formation. Additionally, the presence of Fe2+ and ethanol also influence the generation of acetaldehyde.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Filomena Battista, Rosario Oliva, Pompea Del Vecchio, Roland Winter, Luigi Petraccone
Summary: LL-III, a cationic antimicrobial peptide, exhibits strong toxicity to bacteria, fungi, and tumors, with low toxicity to eukaryotic cells. Studies have shown that LL-III interacts preferentially with anionic lipids, inducing the formation of lipid domains and increasing membrane permeability in a non-disruptive manner, indicating intracellular targeting mode of action. This peptide also shows interaction with plasmid DNA, suggesting a possible intracellular target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Martin Mueller, Florian Platten, Martin Dulle, Bjorn Fischer, Werner Hoheisel, Peter Serno, Stefan Egelhaaf, Joerg Breitkreutz
Summary: The precipitation process and physicochemical properties of precipitates formed by regorafenib in amorphous solid dispersions were investigated. Different crystalline and amorphous precipitates were identified, and the controlled formation of defined amorphous structures in-vivo could be a promising future drug formulation strategy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Marta Salvador-Castell, Nicholas J. Brooks, Roland Winter, Judith Peters, Philippe M. Oger
Summary: This study characterizes the effects of the apolar polyisoprenoid squalane on the permeability and fluidity of archaeal model membrane bilayers, revealing its potential role in helping Archaea adapt to extreme conditions. Squalane can enhance solute permeation and decrease proton permeability, which may be utilized to create chemically resistant liposomes (archeaosomes) for drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Nisrine Jahmidi-Azizi, Rosario Oliva, Stewart Gault, Charles S. Cockell, Roland Winter
Summary: Protein-ligand interactions are essential for all biological processes, and our study focused on how salts found on Mars affect these interactions. We found that magnesium chloride and sulfate have minimal impact on protein-ligand binding, but perchlorate ions strongly affect this process. Despite harsh conditions on Mars, the biochemical reactions studied could still be theoretically possible.
Article
Biochemistry & Molecular Biology
Nisrine Jahmidi-Azizi, Stewart Gault, Charles S. Cockell, Rosario Oliva, Roland Winter
Summary: The study found that Mg2+ salts reduce the binding tendency of ThT to tRNA, mainly due to the interaction of ThT with the salt anions. Pressure favors ligand binding regardless of the type of salt.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Christoph Zunke, Joerg Bewerunge, Florian Platten, Stefan U. Egelhaaf, Aljaz Godec
Summary: The research investigates particle dynamics in complex environments using colloidal particles moving in a laser speckle pattern as a model system. The study reveals that the particles explore the speckle in a fractal manner, which can be traced back to the underlying medium with an adjustable fractal dimension.
Article
Multidisciplinary Sciences
Kyongok Kang, Florian Platten
Summary: Proteins in their native state are marginally stable and tend to aggregate, which can lead to undesired processes or properties. Controlling protein aggregation is crucial in various fields, and electric fields show promising prospects in this aspect.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Jim-Marcel Knop, Sanjib K. Mukherjee, Stewart Gault, Charles S. Cockell, Roland Winter
Summary: The study found that under high pressure and high salt concentrations, including perchlorates, the stability of DNA molecules is minimally affected, and they do not represent a barrier to the stability of nucleic acids in deep subsurface conditions on Mars.
Article
Biology
Loreto Misuraca, Antonino Calio, Josephine G. LoRicco, Ingo Hoffmann, Roland Winter, Bruno Deme, Judith Peters, Philippe M. Oger
Summary: The stability of proto-membranes in hydrothermal systems is a debated issue. This study explores the use of alkanes to increase membrane stability and adaptability to temperature fluctuations.
Article
Biology
Rebecca Sternke-Hoffmann, Thomas Pauly, Rasmus K. Norrild, Jan Hansen, Florian Tucholski, Magnus Haraldson Hoie, Paolo Marcatili, Mathieu Dupre, Magalie Duchateau, Martial Rey, Christian Malosse, Sabine Metzger, Amelie Boquoi, Florian Platten, Stefan U. Egelhaaf, Julia Chamot-Rooke, Roland Fenk, Luitgard Nagel-Steger, Rainer Haas, Alexander K. Buell
Summary: Researchers introduce a new systematic workflow for the biophysical characterization of multiple myeloma patient-derived immunoglobulin light chains (IgLCs) and find that in vivo aggregation behavior is unlikely to be linked to any single biophysical or biochemical parameter. They also discover that the potential to form amyloid fibrils is widespread in IgLC sequences and not limited to those sequences that form fibrils in patients.
Article
Chemistry, Physical
Jan Hansen, Carolyn J. Moll, Leticia Lopez Flores, Ramon Castaneda-Priego, Magdaleno Medina-Noyola, Stefan U. Egelhaaf, Florian Platten
Summary: The interplay between liquid-liquid phase separation and dynamical arrest can produce gels and glasses with applications in various fields. Protein solutions exhibit interesting equilibrium and non-equilibrium behaviors, and this study investigates the effect of attractive and repulsive forces on the phase behavior of lysozyme in brine. Experimental measurements and theoretical predictions are in good qualitative agreement, shedding light on the new phenomenology observed in the system.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Jan Hansen, Stefan U. Egelhaaf, Florian Platten
Summary: Liquid-liquid phase separation (LLPS) of protein solutions is influenced by complex protein-protein interactions. The extended law of corresponding states (ELCS) suggests that the thermodynamics, structure, and dynamics of these systems can be rationalized. This study systematically tests this claim through experimental analysis. The results show that various quantities, including spinodal lines and relaxation rate of concentration fluctuations, exhibit corresponding-states behavior.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Loreto Misuraca, Roland Winter, Bruno Deme, Philippe M. Oger, Judith Peters
Summary: Lipid membranes play a vital role in living systems and the origin of life. This study investigated the mesophase structure and fluidity of protomembranes formed by ancient lipids. The results showed that these prebiotic model membranes exhibited stable vesicular structures and fluid-like lipid dynamic properties at low temperatures, but formed micellar structures at high temperatures.
Article
Chemistry, Physical
Jan Hansen, Rajeevann Uthayakumar, Jan Skov Pedersen, Stefan U. Egelhaaf, Florian Platten
Summary: Ethanol affects the phase behavior and interactions of protein solutions, as well as altering the dielectric properties of solutions. The observed trends in cloud-point temperatures can be explained using changes in B-2, which quantitatively agree with experimental results. Interactions between proteins, described by the DLVO potential, along with consideration of dielectric solution properties and electrostatic screening, play a key role in these effects.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Physical
Lorena Hentschel, Jan Hansen, Stefan U. Egelhaaf, Florian Platten
Summary: This study experimentally determined and theoretically analyzed the dependence of the molar crystallization enthalpy of lysozyme solutions on physicochemical solution parameters. The results were obtained through isothermal microcalorimetry and van't Hoff analysis, showing a two-state crystallization process with the enthalpy value negatively correlated with thermal energy per molecule. Additionally, the molar crystallization entropy was analyzed, with a model capturing the dependence of van't Hoff entropy on salt concentration and pH, complementing the analysis of crystallization thermodynamics.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)