p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer

Lipid-Induced Endoplasmic Reticulum Stress Impairs Selective Autophagy at the Step of Autophagosome-Lysosome Fusion in Hepatocytes

(2016) Koichiro Miyagawa et al.   AMERICAN JOURNAL OF PATHOLOGY

TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

(2016) Kazunori Hashimoto et al.   ANTIOXIDANTS & REDOX SIGNALING

Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet

(2016) Stephen L. Slocum et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

(2016) Graeme Hewitt et al.   Autophagy

Autophagy, lipophagy and lysosomal lipid storage disorders

(2016) Carl Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

(2016) Atsushi Umemura et al.   CANCER CELL

Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal cancer

(2016) Xiaoyu Qin et al.   CANCER LETTERS

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth

(2016) H. Satoh et al.   CANCER RESEARCH

Dehydroepiandrosterone triggers autophagic cell death in human hepatoma cell line HepG2 via JNK-mediated p62/SQSTM1 expression

(2016) Rolando Vegliante et al.   CARCINOGENESIS

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Pathogenesis of nonalcoholic steatohepatitis

(2016) Wensheng Liu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

Function of Autophagy in Nonalcoholic Fatty Liver Disease

(2016) Mark J. Czaja   DIGESTIVE DISEASES AND SCIENCES

Depletion of autophagy receptor p62/SQSTM1 enhances the efficiency of gene delivery in mammalian cells

(2016) Megumi Tsuchiya et al.   FEBS LETTERS

Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation

(2016) Hyun Min Kim et al.   GENE

Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice

(2016) Hua Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of glucose metabolism by p62/SQSTM1 through HIF1α

(2016) Ke Chen et al.   JOURNAL OF CELL SCIENCE

Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma

(2016) Chun Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma

(2016) Takayuki Shimizu et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

(2016) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

Cell-specific overactivation of nuclear erythroid 2 p45-related factor 2-mediated gene expression in myeloid cells decreases hepatic ischemia/reperfusion injury

(2016) Lung-Yi Lee et al.   LIVER TRANSPLANTATION

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance

(2016) Lucie Popineau et al.   MOLECULAR AND CELLULAR BIOLOGY

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

(2016) Ji-An Pan et al.   MOLECULAR CELL

Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62

(2016) Yanan Wang et al.   MOLECULAR CELL

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA

(2016) L-Z Xu et al.   ONCOGENE

HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis

(2016) Regina Medvedev et al.   Oxidative Medicine and Cellular Longevity

The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance

(2016) A. L. Furfaro et al.   Oxidative Medicine and Cellular Longevity

NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis

(2016) Hui Wang et al.   Science Translational Medicine

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

Hepatitis C Virus Infection Induces Autophagy as a Prosurvival Mechanism to Alleviate Hepatic ER-Stress Response

(2016) Srikanta Dash et al.   Viruses-Basel

Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer

(2016) Tania M. Puvirajesinghe et al.   Nature Communications

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

(2016) Tetsuya Saito et al.   Nature Communications

A genetic basis for the variation in the vulnerability of cancer to DNA damage

(2016) Brian D. Yard et al.   Nature Communications

Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer

(2016) Anna M. Schläfli et al.   Oncotarget

Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas

(2016) Olivia Adams et al.   Oncotarget

Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis

(2016) Marta Anna Kowalik et al.   Oncotarget

NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming

(2016) Kate E. Hawkins et al.   Cell Reports

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62

(2016) Rowena DeJesus et al.   eLife

Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB

(2015) Paul G. Thomes et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

High Expression of p62 Protein Is Associated with Poor Prognosis and Aggressive Phenotypes in Endometrial Cancer

(2015) Reiko Iwadate et al.   AMERICAN JOURNAL OF PATHOLOGY

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity

(2015) Jeong Su Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p62 regulates CD40-mediated NFκB activation in macrophages through interaction with TRAF6

(2015) Kristina Seibold et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

(2015) Maria A. O’Connell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma

(2015) Mingxin Zhang et al.   BMC CANCER

Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

(2015) Maria Peiris-Pagès et al.   Cell Metabolism

The switch from ER stress-induced apoptosis to autophagy via ROS-mediated JNK/p62 signals: A survival mechanism in methotrexate-resistant choriocarcinoma cells

(2015) Yun Shen et al.   EXPERIMENTAL CELL RESEARCH

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Crosstalk between Nrf2 and Notch signaling

(2015) Nobunao Wakabayashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease

(2015) N. U. Ashraf et al.   FREE RADICAL RESEARCH

Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis

(2015) Patrizia Zavattari et al.   HEPATOLOGY

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

The Role of Autophagy in Hepatocellular Carcinoma

(2015) Yoo Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy

(2015) Rui Guo et al.   JOURNAL OF HEPATOLOGY

LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells

(2015) Peidu Jiang et al.   METHODS

The enemy of my enemy is my friend

(2015) Isaac S. Harris et al.   NATURE

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

(2015) Hyunjoo Cha-Molstad et al.   NATURE CELL BIOLOGY

Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming

(2015) Yasong Wu et al.   NATURE CELL BIOLOGY

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

(2015) Shlomi Finkin et al.   NATURE IMMUNOLOGY

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress

(2015) Laura Antonucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Hepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagy

(2015) Daniela Ploen   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation

(2015) B Liu et al.   Cell Death & Disease

Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity

(2015) Masashi Kanayama et al.   Nature Communications

TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

(2015) Fang Hua et al.   Nature Communications

Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent

(2015) Maria Giovanna Sabbieti et al.   Oncotarget

miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo

(2015) Li-Yin Yeh et al.   Oncotarget

Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells

(2015) In-geun Ryoo et al.   Oncotarget

Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade

(2015) Juan F. Linares et al.   Cell Reports

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

(2015) Junghyun Lim et al.   PLoS Genetics

The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism

(2015) Sílvia S. Chambel et al.   Biomed Research International

P62/Ubiquitin IHC Expression Correlated with Clinicopathologic Parameters and Outcome in Gastrointestinal Carcinomas

(2015) Amr Mohamed et al.   Frontiers in Oncology

Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State

(2015) Masahiko Yamaguchi et al.   PLoS One

Pilot study of p62 DNA vaccine in dogs with mammary tumors

(2015) Vladimir Gabai et al.   Oncotarget

p62/SQSTM1 Plays a Protective Role in Oxidative Injury of Steatotic Liver in a Mouse Hepatectomy Model

(2014) Sanae Haga et al.   ANTIOXIDANTS & REDOX SIGNALING

NOX2-generated oxidative stress is associated with severity of ultrasound liver steatosis in patients with non-alcoholic fatty liver disease

(2014) Maria Del Ben et al.   BMC GASTROENTEROLOGY

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis

(2014) Tania Valencia et al.   CANCER CELL

Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition

(2014) Atsushi Umemura et al.   Cell Metabolism

Dynamic Changes in Intracellular ROS Levels Regulate Airway Basal Stem Cell Homeostasis through Nrf2-Dependent Notch Signaling

(2014) Manash K. Paul et al.   Cell Stem Cell

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1

(2014) Seung-Hyun Ro et al.   FEBS Journal

p62/SQSTM1 synergizes with autophagy for tumor growth in vivo

(2014) H. Wei et al.   GENES & DEVELOPMENT

Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice

(2014) Takeo Toshima et al.   HEPATOLOGY

Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis

(2014) Jean Charles Nault et al.   HEPATOLOGY

Evolving Concepts in the Pathogenesis of NASH: Beyond Steatosis and Inflammation

(2014) William Peverill et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Steatosis and Steatohepatitis: Complex Disorders

(2014) Kira Bettermann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Feasibility Analysis of p62 (SQSTM1)—Encoding DNA Vaccine as a Novel Cancer Immunotherapy

(2014) Vladimir L. Gabai et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Effect of Everolimus on Survival in Advanced Hepatocellular Carcinoma After Failure of Sorafenib

(2014) Andrew X. Zhu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation

(2014) Jung-Hyun Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy

(2014) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?

(2014) Zoon Tariq et al.   LIVER INTERNATIONAL

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

(2014) P. J. Meakin et al.   MOLECULAR AND CELLULAR BIOLOGY

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

Exploration of liver cancer genomes

(2014) Tatsuhiro Shibata et al.   Nature Reviews Gastroenterology & Hepatology

Sequestosome 1/p62 facilitates HER2-induced mammary tumorigenesis through multiple signaling pathways

(2014) X Cai-McRae et al.   ONCOGENE

p62/SQSTM1 Accumulation in Squamous Cell Carcinoma of Head and Neck Predicts Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitors

(2014) Wen-Liang Kuo et al.   PLoS One

Regulation of cell proliferation and migration by p62 through stabilization of Twist1

(2014) L. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Receptor Signals to NF- B Are Transmitted by a Cytosolic p62-Bcl10-Malt1-IKK Signalosome

(2014) S. Paul et al.   Science Signaling

Activation of the Nrf2-ARE Pathway in Hepatocytes Protects Against Steatosis in Nutritionally Induced Non-alcoholic Steatohepatitis in Mice

(2014) Lung-Yi Lee et al.   TOXICOLOGICAL SCIENCES

Autophagy in hepatitis C virus-host interactions: Potential roles and therapeutic targets for liver-associated diseases

(2014) Po-Yuan Ke   WORLD JOURNAL OF GASTROENTEROLOGY

Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: A controversial issue

(2014) Wilhelmus J Kwanten   WORLD JOURNAL OF GASTROENTEROLOGY

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

Hepatoprotective role of Sestrin2 against chronic ER stress

(2014) Hwan-Woo Park et al.   Nature Communications

Myeloid Malignancies with Chromosome 5q Deletions Acquire a Dependency on an Intrachromosomal NF-κB Gene Network

(2014) Jing Fang et al.   Cell Reports

p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-κB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche

(2014) Kyung Hee Chang et al.   Cell Reports

Lipopolysaccharide Stimulates p62-Dependent Autophagy-Like Aggregate Clearance in Hepatocytes

(2014) Christine Chen et al.   Biomed Research International

Autophagy and Non-Alcoholic Fatty Liver Disease

(2014) Vanessa J. Lavallard et al.   Biomed Research International

Autophagy in HCV Infection: Keeping Fat and Inflammation at Bay

(2014) Tiziana Vescovo et al.   Biomed Research International

Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity

(2014) Sharon Manley et al.   Redox Biology

Ethanol-induced oxidant stress modulates hepatic autophagy and proteasome activity

(2014) Terrence M. Donohue et al.   Redox Biology

ER stress and hepatic lipid metabolism

(2014) Huiping Zhou et al.   Frontiers in Genetics

Functions of autophagy in normal and diseased liver

(2013) Mark J. Czaja et al.   Autophagy

A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

(2013) Guang-Zhi Jin et al.   BMC CANCER

Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy

(2013) Jae Myung Park et al.   CANCER BIOLOGY & THERAPY

SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer

(2013) Lianjie Li et al.   CANCER CELL

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

(2013) Hironori Satoh et al.   CANCER RESEARCH

The Paradoxical Role of Nrf2 in Tumor Biology

(2013) Hui Shen et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Nrf2 is a potential therapeutic target in radioresistance in human cancer

(2013) Suna Zhou et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

New Insights Into the Role of Sequestosome 1/p62 Mutant Proteins in the Pathogenesis of Paget's Disease of Bone

(2013) Sarah L. Rea et al.   ENDOCRINE REVIEWS

Impaired autophagy response in human hepatocellular carcinoma

(2013) Lili Bao et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Role of p62/SQSTM1 in liver physiology and pathogenesis

(2013) Sharon Manley et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Involvement of free radicals and oxidative stress in NAFLD/NASH

(2013) Y. Sumida et al.   FREE RADICAL RESEARCH

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Identification of driver genes in hepatocellular carcinoma by exome sequencing

(2013) Sean P. Cleary et al.   HEPATOLOGY

Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis

(2013) Ulrike A. Köhler et al.   HEPATOLOGY

Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.

(2013) Robert J. Wong et al.   HEPATOLOGY

Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease

(2013) Yuka Fukuo et al.   HEPATOLOGY RESEARCH

Autophagy in Prostate Cancer and Androgen Suppression Therapy

(2013) Elio Ziparo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death

(2013) Sandro Silva-Gomes et al.   JOURNAL OF HEPATOLOGY

Prognostic Impact of p62 Expression in Cutaneous Malignant Melanoma

(2013) Robert A. Ellis et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Deficiency of p62/Sequestosome 1 Causes Hyperphagia Due to Leptin Resistance in the Brain

(2013) H. Harada et al.   JOURNAL OF NEUROSCIENCE

Nrf2 deletion causes “benign” simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet

(2013) Chunhua Wang et al.   Lipids in Health and Disease

Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling

(2013) N. Wakabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells

(2013) Juan F. Linares et al.   MOLECULAR CELL

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1

(2013) Tiziana Zotti et al.   MOLECULAR IMMUNOLOGY

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Liver autophagy: much more than just taking out the trash

(2013) Jaime L. Schneider et al.   Nature Reviews Gastroenterology & Hepatology

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Association of p62/SQSTM1 Excess and Oral Carcinogenesis

(2013) Takuma Inui et al.   PLoS One

Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching

(2013) Y. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of Somatic Cell Reprogramming by ERas-Akt-FoxO1 Signaling Axis

(2013) Yong Yu et al.   STEM CELLS

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Autophagy proteins in prostate cancer: Relation with anaerobic metabolism and Gleason score11The study was financially supported by the Tumor and Angiogenesis Research Group.

(2013) Alexandra Giatromanolaki et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Endoplasmic Reticulum Stress in Nonalcoholic Fatty Liver Disease

(2012) Michael J. Pagliassotti   Annual Review of Nutrition

Involvement of kinase PKC-zeta in the p62/p62P392L-driven activation of NF-κB in human osteoclasts

(2012) Estelle Chamoux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

(2012) Jianhua Ling et al.   CANCER CELL

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma

(2012) Daisuke Inoue et al.   CANCER SCIENCE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

The transcription factor NF-E2-related Factor 2 (Nrf2): a protooncogene?

(2012) Phillip Shelton et al.   FASEB JOURNAL

Expression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer

(2012) Junjeong Choi et al.   HISTOPATHOLOGY

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

(2012) Manohar Pilli et al.   IMMUNITY

The atypical PKCs in inflammation: NF-κB and beyond

(2012) Maria T. Diaz-Meco et al.   IMMUNOLOGICAL REVIEWS

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Sequestosome 1/p62, a Scaffolding Protein, Is a Newly Identified Partner of IRS-1 Protein

(2012) Thangiah Geetha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication of Hepatitis C Virus RNA on Autophagosomal Membranes

(2012) Donna Sir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Aggregation of Ubiquitinated Proteins Is a Cytosolic Unfolded Protein Response to Inflammation and Endoplasmic Reticulum Stress

(2012) Xian-De Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein

(2012) Nathan D. Camp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62 Links β-adrenergic input to mitochondrial function and thermogenesis

(2012) Timo D. Müller et al.   JOURNAL OF CLINICAL INVESTIGATION

Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet

(2012) Kosuke Okada et al.   JOURNAL OF GASTROENTEROLOGY

Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice

(2012) Yuji Tanaka et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function

(2012) J. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

(2012) Cécile Guichard et al.   NATURE GENETICS

p62/SQSTM1/A170: Physiology and pathology

(2012) Masaaki Komatsu et al.   PHARMACOLOGICAL RESEARCH

Tissue Specific Induction of p62/Sqstm1 by Farnesoid X Receptor

(2012) Jessica A. Williams et al.   PLoS One

Keap1 degradation by autophagy for the maintenance of redox homeostasis

(2012) K. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice

(2012) S. Menon et al.   Science Signaling

Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury

(2012) Hong-Min Ni et al.   TOXICOLOGICAL SCIENCES

p62: a versatile multitasker takes on cancer

(2012) Jorge Moscat et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hepatitis C Virus and Cellular Stress Response: Implications to Molecular Pathogenesis of Liver Diseases

(2012) Po-Yuan Ke et al.   Viruses-Basel

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

(2012) Yoichiro Mitsuishi et al.   Frontiers in Oncology

Autophagy: A novel guardian of HCV against innate immune response

(2011) Po-Yuan Ke et al.   Autophagy

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

Feedback on Fat: p62-mTORC1-Autophagy Connections

(2011) Jorge Moscat et al.   CELL

The role of oxidative stress in non-alcoholic steatohepatitis

(2011) G.H. Koek et al.   CLINICA CHIMICA ACTA

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

(2011) Anabela P. Rolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Upregulation of Nrf2 Expression in Non-Alcoholic Fatty Liver and Steatohepatitis

(2011) Weihua Xu et al.   HEPATO-GASTROENTEROLOGY

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

(2011) Yoshihiro Inami et al.   JOURNAL OF CELL BIOLOGY

TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer

(2011) Daniel T. Starczynowski et al.   JOURNAL OF CLINICAL INVESTIGATION

Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets

(2011) Jiong Li et al.   JOURNAL OF HEPATOLOGY

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Regulation of lipid droplets by autophagy

(2011) Hanqing Dong et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

p62+ Hyaline Inclusions in Intrahepatic Cholangiocarcinoma Associated With Viral Hepatitis or Alcoholic Liver Disease

(2010) Shinichi Aishima et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophaghy in HepG2 E47 cells

(2010) Defeng Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol Suppresses Oxidative Stress and Inflammatory Response in Diethylnitrosamine-Initiated Rat Hepatocarcinogenesis

(2010) A. Bishayee et al.   Cancer Prevention Research

Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

(2010) A. Puissant et al.   CANCER RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

A functional role for the p62–ERK1 axis in the control of energy homeostasis and adipogenesis

(2010) Sang Jun Lee et al.   EMBO REPORTS

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

(2010) Ian M. Copple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

(2010) Brigit E. Riley et al.   JOURNAL OF CELL BIOLOGY

Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro

(2010) Po-Yuan Ke et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy Negatively Regulates Keratinocyte Inflammatory Responses via Scaffolding Protein p62/SQSTM1

(2010) H.-M. Lee et al.   JOURNAL OF IMMUNOLOGY

In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C

(2010) Tarik Asselah et al.   JOURNAL OF PATHOLOGY

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

(2010) Neil R. Kitteringham et al.   Journal of Proteomics

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Regulation of Notch1 Signaling by Nrf2: Implications for Tissue Regeneration

(2010) N. Wakabayashi et al.   Science Signaling

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet☆

(2010) Yu-Kun Jennifer Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

(2009) Hirokazu Sugimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NF-κB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy

(2009) Jian-Min Wu et al.   CANCER LETTERS

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

(2009) Melinda S. Yates et al.   CARCINOGENESIS

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Histopathology of Non-Alcoholic Fatty Liver Disease

(2009) Elizabeth M. Brunt   Clinics in Liver Disease

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

(2009) Soona Shin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

(2009) Sudhir Chowdhry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

(2009) Serhiy Pankiv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy

(2009) Tomokazu Mizui et al.   JOURNAL OF GASTROENTEROLOGY

The Sequestosome 1/p62 Attenuates Cytokine Gene Expression in Activated Macrophages by Inhibiting IFN Regulatory Factor 8 and TNF Receptor-Associated Factor 6/NF- B Activity

(2009) J. Y. Kim et al.   JOURNAL OF IMMUNOLOGY

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma

(2009) Ledu Zhou et al.   MEDICAL ONCOLOGY

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer

(2008) T. O. Khor et al.   Cancer Prevention Research

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

(2008) Tatsuhiro Shibata et al.   GASTROENTEROLOGY

Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response

(2008) Donna Sir et al.   HEPATOLOGY

NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet

(2008) Y. Tanaka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62

(2008) J-P Pursiheimo et al.   ONCOGENE

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

(2008) N. Anderson et al.   PHARMACOLOGICAL REVIEWS

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA