Increased fidelity of protein synthesis extends lifespan

New methods to calculate concordance factors for phylogenomic datasets

(2020) Bui Quang Minh et al.   MOLECULAR BIOLOGY AND EVOLUTION

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

(2019) Jianling Xie et al.   CURRENT BIOLOGY

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

(2019) Xiao Tian et al.   CELL

Interactive Tree Of Life (iTOL) v4: recent updates and new developments

(2019) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

The cell stress response: extreme times call for post‐transcriptional measures

(2019) Mariavittoria Pizzinga et al.   Wiley Interdisciplinary Reviews-RNA

Parallelization of MAFFT for large-scale multiple sequence alignments

(2018) Tsukasa Nakamura et al.   BIOINFORMATICS

Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis

(2018) Tamara Suhm et al.   Cell Metabolism

Mosaic Analysis inDrosophila

(2018) Federico Germani et al.   GENETICS

Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster

(2018) Janet S. Mason et al.   PLoS One

Decoding on the ribosome depends on the structure of the mRNA phosphodiester backbone

(2018) Hannah E. Keedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mosaic Analysis inDrosophila

(2018) Federico Germani et al.   GENETICS

Facing up to the global challenges of ageing

(2018) Linda Partridge et al.   NATURE

Powerful and interpretable behavioural features for quantitative phenotyping of Caenorhabditis elegans

(2018) Avelino Javer et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

ZNF598 Is a Quality Control Sensor of Collided Ribosomes

(2018) Szymon Juszkiewicz et al.   MOLECULAR CELL

RNA polymerase III limits longevity downstream of TORC1

(2017) Danny Filer et al.   NATURE

Ensemble cryo-EM elucidates the mechanism of translation fidelity

(2017) Anna B. Loveland et al.   NATURE

ModelFinder: fast model selection for accurate phylogenetic estimates

(2017) Subha Kalyaanamoorthy et al.   NATURE METHODS

Ribosome dynamics during decoding

(2017) Marina V. Rodnina et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The control of translational accuracy is a determinant of healthy ageing in yeast

(2017) Tobias von der Haar et al.   Open Biology

Sequential and counter-selectable cassettes for fission yeast

(2016) Hanna Amelina et al.   BMC BIOTECHNOLOGY

A Ribosomal Perspective on Proteostasis and Aging

(2016) Kristan K. Steffen et al.   Cell Metabolism

Genetic drift, selection and the evolution of the mutation rate

(2016) Michael Lynch et al.   NATURE REVIEWS GENETICS

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution

(2016) Tarek Hilal et al.   Nature Communications

ggtree: anrpackage for visualization and annotation of phylogenetic trees with their covariates and other associated data

(2016) Guangchuang Yu et al.   Methods in Ecology and Evolution

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity

(2015) Cathy Slack et al.   CELL

Functional characterization of C. elegans Y-box-binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes

(2014) Andreas Arnold et al.   NUCLEIC ACIDS RESEARCH

Protein mistranslation: friend or foe?

(2014) Liuís Ribas de Pouplana et al.   TRENDS IN BIOCHEMICAL SCIENCES

Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence

(2014) Meng C. Wang et al.   PLoS Genetics

TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast

(2013) Charalampos Rallis et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The Ribosome as a Hub for Protein Quality Control

(2013) Sebastian Pechmann et al.   MOLECULAR CELL

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

A database of Caenorhabditis elegans behavioral phenotypes

(2013) Eviatar Yemini et al.   NATURE METHODS

A holidic medium for Drosophila melanogaster

(2013) Matthew D W Piper et al.   NATURE METHODS

Nutrient Signaling in Protein Homeostasis: An Increase in Quantity at the Expense of Quality

(2013) C. S. Conn et al.   Science Signaling

Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

(2013) Joshua G Dunn et al.   eLife

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila

(2012) Iain Rogers et al.   PLoS One

A Study on the Effect of Surface Lysine to Arginine Mutagenesis on Protein Stability and Structure Using Green Fluorescent Protein

(2012) Sriram Sokalingam et al.   PLoS One

Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans

(2011) Aric N. Rogers et al.   Cell Metabolism

Error-Prone and Error-Restrictive Mutations Affecting Ribosomal Protein S12

(2011) Deepali Agarwal et al.   JOURNAL OF MOLECULAR BIOLOGY

Evolutionary optimization of speed and accuracy of decoding on the ribosome

(2011) I. Wohlgemuth et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Hyperaccurate and Error-Prone Ribosomes Exploit Distinct Mechanisms during tRNA Selection

(2010) Hani S. Zaher et al.   MOLECULAR CELL

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Cellular mechanisms that control mistranslation

(2010) Noah M. Reynolds et al.   NATURE REVIEWS MICROBIOLOGY

A comprehensive analysis of translational missense errors in the yeast Saccharomyces cerevisiae

(2010) E. B. Kramer et al.   RNA

Fidelity at the Molecular Level: Lessons from Protein Synthesis

(2009) Hani S. Zaher et al.   CELL

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

What recent ribosome structures have revealed about the mechanism of translation

(2009) T. Martin Schmeing et al.   NATURE

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

(2008) D. Allan Drummond et al.   CELL

DNA damage and ageing: new-age ideas for an age-old problem

(2008) George A. Garinis et al.   NATURE CELL BIOLOGY