Genetic drift, selection and the evolution of the mutation rate

Mutation and Human Exceptionalism: Our Future Genetic Load

(2016) M. Lynch   GENETICS

Evolution of the Insertion-Deletion Mutation Rate Across the Tree of Life

(2016) Way Sung et al.   G3-Genes Genomes Genetics

Nascent RNA folding mitigates transcription-associated mutagenesis

(2015) Xiaoshu Chen et al.   GENOME RESEARCH

Asymmetric Context-Dependent Mutation Patterns Revealed through Mutation–Accumulation Experiments

(2015) Way Sung et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evidence for recent, population-specific evolution of the human mutation rate

(2015) Kelley Harris   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription-Associated Mutagenesis

(2014) Sue Jinks-Robertson et al.   Annual Review of Genetics

Genome-Wide Linkage-Disequilibrium Profiles from Single Individuals

(2014) Michael Lynch et al.   GENETICS

Mutation Rate, Spectrum, Topology, and Context-Dependency in the DNA Mismatch Repair-Deficient Pseudomonas fluorescens ATCC948

(2014) Hongan Long et al.   Genome Biology and Evolution

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition

(2014) Scott A. Lujan et al.   GENOME RESEARCH

Experimental evolution and the dynamics of genomic mutation rate modifiers

(2014) Y Raynes et al.   HEREDITY

Estimation of the Spontaneous Mutation Rate in Heliconius melpomene

(2014) Peter D. Keightley et al.   MOLECULAR BIOLOGY AND EVOLUTION

Genome sequencing of normal cells reveals developmental lineages and mutational processes

(2014) Sam Behjati et al.   NATURE

Yeast mutation accumulation experiment supports elevated mutation rates at highly transcribed sites

(2014) Xiaoshu Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stalled transcription complexes promote DNA repair at a distance

(2014) N. M. Haines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary meandering of intermolecular interactions along the drift barrier

(2014) Michael Lynch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-induced mutagenesis and complex adaptation

(2014) Y. Ram et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Strong male bias drives germline mutation in chimpanzees

(2014) O. Venn et al.   SCIENCE

8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage

(2014) Chris M. Rands et al.   PLoS Genetics

Estimation of the Spontaneous Mutation Rate per Nucleotide Site in a Drosophila melanogaster Full-Sib Family

(2013) Peter D. Keightley et al.   GENETICS

Emergence of DNA Polymerase   Antimutators That Escape Error-Induced Extinction in Yeast

(2013) L. N. Williams et al.   GENETICS

Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome?

(2013) X. Chen et al.   Genome Biology and Evolution

Genomic mutation rates that neutralize adaptive evolution and natural selection

(2013) P. J. Gerrish et al.   Journal of the Royal Society Interface

No Gene-Specific Optimization of Mutation Rate in Escherichia coli

(2013) X. Chen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Accelerated gene evolution through replication–transcription conflicts

(2013) Sandip Paul et al.   NATURE

Evaluating evolutionary models of stress-induced mutagenesis in bacteria

(2013) R. Craig MacLean et al.   NATURE REVIEWS GENETICS

Transcription-replication encounters, consequences and genomic instability

(2013) Anne Helmrich et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Normal Mutation Rate Variants Arise in a Mutator (Mut S) Escherichia coli Population

(2013) María-Carmen Turrientes et al.   PLoS One

Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly

(2013) C. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the Mutational Topology of the Bacterial Genome

(2013) Patricia L. Foster et al.   G3-Genes Genomes Genetics

The Rate and Effects of Spontaneous Mutation on Fitness Traits in the Social Amoeba, Dictyostelium discoideum

(2013) David W. Hall et al.   G3-Genes Genomes Genetics

The Evolution of Low Mutation Rates in Experimental Mutator Populations of Saccharomyces cerevisiae

(2012) Michael J. McDonald et al.   CURRENT BIOLOGY

Genomic evidence for elevated mutation rates in highly expressed genes

(2012) Chungoo Park et al.   EMBO REPORTS

Rates and Fitness Consequences of New Mutations in Humans

(2012) Peter D. Keightley   GENETICS

Evidence of non-random mutation rates suggests an evolutionary risk management strategy

(2012) Iñigo Martincorena et al.   NATURE

Rate of de novo mutations and the importance of father’s age to disease risk

(2012) Augustine Kong et al.   NATURE

Estimating the human mutation rate using autozygosity in a founder population

(2012) Catarina D Campbell et al.   NATURE GENETICS

Amino Acid Repeats Cause Extraordinary Coding Sequence Variation in the Social Amoeba Dictyostelium discoideum

(2012) Clea Scala et al.   PLoS One

Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing

(2012) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary layering and the limits to cellular perfection

(2012) M. Lynch   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load

(2012) S. Wielgoss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drift-barrier hypothesis and mutation-rate evolution

(2012) W. Sung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleosomes Suppress Spontaneous Mutations Base-Specifically in Eukaryotes

(2012) Xiaoshu Chen et al.   SCIENCE

Changes in transcriptional orientation are associated with increases in evolutionary rates of enterobacterial genes

(2011) Chieh-Hua Lin et al.   BMC BIOINFORMATICS

The Lower Bound to the Evolution of Mutation Rates

(2011) Michael Lynch   Genome Biology and Evolution

Mutation Rates across Budding Yeast Chromosome VI Are Correlated with Replication Timing

(2011) Gregory I. Lang et al.   Genome Biology and Evolution

A high-resolution map of human evolutionary constraint using 29 mammals

(2011) Kerstin Lindblad-Toh et al.   NATURE

Genome-wide evidence for selection acting on single amino acid repeats

(2010) W. Haerty et al.   GENOME RESEARCH

Rate, molecular spectrum, and consequences of human mutation

(2010) M. Lynch   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

No evidence for elemental-based streamlining of prokaryotic genomes

(2010) Sara Vieira-Silva et al.   TRENDS IN ECOLOGY & EVOLUTION

Evolution of the mutation rate

(2010) Michael Lynch   TRENDS IN GENETICS

The Relationship among Gene Expression, the Evolution of Gene Dosage, and the Rate of Protein Evolution

(2010) Jean-François Gout et al.   PLoS Genetics

Co-Orientation of Replication and Transcription Preserves Genome Integrity

(2010) Anjana Srivatsan et al.   PLoS Genetics

Human mutation rate associated with DNA replication timing

(2009) John A Stamatoyannopoulos et al.   NATURE GENETICS

Optimization of DNA polymerase mutation rates during bacterial evolution

(2009) E. Loh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cellular, Developmental and Population-Genetic Determinants of Mutation-Rate Evolution

(2008) M. Lynch   GENETICS

Transcription induces strand-specific mutations at the 5' end of human genes

(2008) P. Polak et al.   GENOME RESEARCH

The Enhanced DNA Replication Fidelity of a Mutant Herpes Simplex Virus Type 1 DNA Polymerase Is Mediated by an Improved Nucleotide Selectivity and Reduced Mismatch Extension Ability

(2008) W. Tian et al.   JOURNAL OF VIROLOGY

The Proteomic Constraint and Its Role in Molecular Evolution

(2008) S. E. Massey   MOLECULAR BIOLOGY AND EVOLUTION