TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

(2016) Yong Pan et al.   Aging-US

grofit: Fitting Biological Growth Curves withR

(2015) Matthias Kahm et al.   Journal of Statistical Software

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Cell Size Control in Yeast

(2012) Jonathan J. Turner et al.   CURRENT BIOLOGY

TORC1 of fission yeast is rapamycin-sensitive

(2012) Terunao Takahara et al.   GENES TO CELLS

Composition and Acidification of the Culture Medium Influences Chronological Aging Similarly in Vineyard and Laboratory Yeast

(2011) Christopher J. Murakami et al.   PLoS One

FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity

(2011) Alex Lublin et al.   PLoS One

The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe

(2011) N. Ikai et al.   Open Biology

Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control

(2010) Kyoko Ikeda et al.   CELL CYCLE

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway

(2010) Alice Zuin et al.   EMBO JOURNAL

Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin

(2010) A. Nakashima et al.   JOURNAL OF CELL SCIENCE

Lessons on longevity from budding yeast

(2010) Matt Kaeberlein   NATURE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress

(2009) S. Hartmuth et al.   JOURNAL OF CELL SCIENCE

Genome-Wide Screen of Genes Required for Caffeine Tolerance in Fission Yeast

(2009) Isabel A. Calvo et al.   PLoS One

Cellular quiescence: are controlling genes conserved?

(2009) Mitsuhiro Yanagida   TRENDS IN CELL BIOLOGY

Pro-Aging Effects of Glucose Signaling through a G Protein-Coupled Glucose Receptor in Fission Yeast

(2009) Antoine E. Roux et al.   PLoS Genetics

Review: Caffeine: Neuroprotective Functions in Cognition and Alzheimer's Disease

(2008) Andi Rosso et al.   American Journal of Alzheimers Disease and Other Dementias

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Caffeine extends yeast lifespan by targeting TORC1

(2008) Valeria Wanke et al.   MOLECULAR MICROBIOLOGY

Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation

(2008) Luis López-Maury et al.   NATURE REVIEWS GENETICS

Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tirosine kinase receptor (TrkB) content in mice

(2008) M.S. Costa et al.   NEUROSCIENCE

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

(2008) Min Wei et al.   PLoS Genetics