Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management
出版年份 2021 全文链接
标题
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management
作者
关键词
Cardiotoxicity, Doxorubicin, Oxidative stress, DNMT 1, Histone deacetylase, micro RNAs
出版物
BIOMEDICINE & PHARMACOTHERAPY
Volume 139, Issue -, Pages 111708
出版商
Elsevier BV
发表日期
2021-05-13
DOI
10.1016/j.biopha.2021.111708
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Proanthocyanidin alleviates doxorubicin‐induced cardiac injury by inhibiting NF‐ k B pathway and modulating oxidative stress, cell cycle, and fibrogenesis
- (2021) Kadry M. Sadek et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Telomerase therapy attenuates cardiotoxic effects of doxorubicin
- (2021) Shambhabi Chatterjee et al. MOLECULAR THERAPY
- Peptide Szeto‑Schiller 31 ameliorates doxorubicin‑induced cardiotoxicity by inhibiting the activation of the p38 MAPK signaling pathway
- (2021) Li Zhang et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Hydrogen sulfide ameliorates doxorubicin‑induced myocardial fibrosis in rats via the PI3K/AKT/mTOR pathway
- (2021) Liangui Nie et al. Molecular Medicine Reports
- Cardiac Protective Effect of Kirenol against Doxorubicin-Induced Cardiac Hypertrophy in H9c2 Cells through Nrf2 Signaling via PI3K/AKT Pathways
- (2021) Abdullah M. Alzahrani et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Protective Effect of Two Alkaloids from Hippophae rhamnoides Linn. against Doxorubicin-Induced Toxicity in H9c2 Cardiomyoblasts
- (2021) Wenna Zhou et al. MOLECULES
- Xinmailong Attenuates Doxorubicin-Induced Lysosomal Dysfunction and Oxidative Stress in H9c2 Cells via HO-1
- (2021) Yu Jiang et al. Oxidative Medicine and Cellular Longevity
- Compound Danshen Dripping Pill inhibits doxorubicin or isoproterenol-induced cardiotoxicity
- (2021) Ke Feng et al. BIOMEDICINE & PHARMACOTHERAPY
- Calycosin-triblock copolymer nanomicelles attenuate doxorubicin-induced cardiotoxicity through upregulation of ERp57
- (2021) Xiaoyan Wang et al. Arabian Journal of Chemistry
- The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity
- (2020) Kerstin N. Timm et al. CARDIOVASCULAR DRUGS AND THERAPY
- Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity Through Promoting Mitochondrial Autophagy
- (2020) Haixia Xu et al. Frontiers in Physiology
- The Role of Antioxidants in Ameliorating Cyclophosphamide-Induced Cardiotoxicity
- (2020) Muluken Altaye Ayza et al. Oxidative Medicine and Cellular Longevity
- Heat Shock Protein 22 Attenuates Doxorubicin-Induced Cardiotoxicity via Regulating Inflammation and Apoptosis
- (2020) Yin Lan et al. Frontiers in Pharmacology
- Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-κB signaling pathway inhibition
- (2020) Xingjuan Fan et al. NEUROLOGICAL RESEARCH
- Mitophagy inhibitor liensinine suppresses doxorubicin-induced cardiotoxicity through inhibition of Drp1-mediated maladaptive mitochondrial fission
- (2020) Xinyue Liang et al. PHARMACOLOGICAL RESEARCH
- Review on the Role of Epigenetic Modifications in Doxorubicin-Induced Cardiotoxicity
- (2020) Himani Kumari et al. Frontiers in Cardiovascular Medicine
- Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress
- (2020) Dan Zhao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Anticancer property of ginsenoside Rh2 from ginseng
- (2020) Xun Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Xanthine oxidase inhibition attenuates doxorubicin-induced cardiotoxicity in mice
- (2020) Yoshiro Tanaka et al. FREE RADICAL BIOLOGY AND MEDICINE
- Thymoquinone attenuates doxorubicin‐cardiotoxicity in rats
- (2020) Derya Karabulut et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- MiR-181c protects cardiomyocyte injury by preventing cell apoptosis through PI3K/Akt signaling pathway
- (2020) Xiaoli Li et al. Cardiovascular Diagnosis and Therapy
- Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner
- (2020) Wei Yu et al. Cardiovascular Diagnosis and Therapy
- Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage
- (2020) Goowon Yang et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Tranilast prevents doxorubicin-induced myocardial hypertrophy and angiotensin II synthesis in rats
- (2020) Chengchuang Zhan et al. LIFE SCIENCES
- Management of Blood Cholesterol
- (2019) Francis J. Alenghat et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The Preventive Role of ACE Inhibitors/Angiotensin-II Receptor Blockers and β–Adrenergic Blockers in Anthracycline and Trastuzumab-Induced Cardiotoxicity.
- (2019) Julia B. Blanter et al. Cardiology in Review
- Toxicology of Trastuzumab: An Insight into Mechanisms of Cardiotoxicity
- (2019) Jie An et al. CURRENT CANCER DRUG TARGETS
- CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression
- (2019) Henrike Tscheschner et al. PLoS One
- Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis
- (2019) Zahra Tavakoli Dargani et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades
- (2019) Dong Liu et al. Aging-US
- Targeting Extracellular Heat Shock Protein 70 Ameliorates Doxorubicin‐Induced Heart Failure Through Resolution of Toll‐Like Receptor 2–Mediated Myocardial Inflammation
- (2019) Peng Liu et al. Journal of the American Heart Association
- Potential targets for intervention against doxorubicin-induced cardiotoxicity based on genetic studies: a systematic review of the literature
- (2019) Yan Chen et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway
- (2019) Huiwen Ren et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Molecular mechanism of doxorubicin-induced cardiomyopathy – An update
- (2018) Kaviyarasi Renu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- HDAC6 inhibition protects cardiomyocytes against doxorubicin-induced acute damage by improving α-tubulin acetylation
- (2018) Rui Song et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development
- (2018) Constance E. Clare et al. Annual Review of Animal Biosciences
- Updates in Anthracycline-Mediated Cardiotoxicity
- (2018) Canan G. Nebigil et al. Frontiers in Pharmacology
- Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation
- (2018) Jing Lu et al. Acta Pharmaceutica Sinica B
- Anthracycline cardiotoxicity: an update on mechanisms, monitoring and prevention
- (2017) Peter A Henriksen HEART
- Role of microRNAs in doxorubicin-induced cardiotoxicity: an overview of preclinical models and cancer patients
- (2017) Clarissa Ruggeri et al. HEART FAILURE REVIEWS
- LCZ696 improves cardiac function via alleviating Drp1-mediated mitochondrial dysfunction in mice with doxorubicin-induced dilated cardiomyopathy
- (2017) Yan Xia et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Modeling Human Myocardium Exposure to Doxorubicin Defines the Risk of Heart Failure from Low-Dose Doxorubicin
- (2017) Emanuela Salvatorelli et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Intravenous administration of mitochondria for treating experimental Parkinson's disease
- (2017) Xianxun Shi et al. MITOCHONDRION
- Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity
- (2017) André Ferreira et al. TOXICOLOGY
- Impact of Frequency of Multi-Vitamin/Multi-Mineral Supplement Intake on Nutritional Adequacy and Nutrient Deficiencies in U.S. Adults
- (2017) Jeffrey Blumberg et al. Nutrients
- Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity
- (2017) Navid Koleini et al. Oncotarget
- Differential roles of caspase-1 and caspase-11 in infection and inflammation
- (2017) Si Ming Man et al. Scientific Reports
- Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes
- (2017) Liqun Zhao et al. Scientific Reports
- Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy
- (2016) J. J. Bartlett et al. BIOCHEMICAL JOURNAL
- New signal transduction paradigms in anthracycline-induced cardiotoxicity
- (2016) Alessandra Ghigo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management
- (2016) Giuseppe Curigliano et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Progress on the cardiotoxicity of sunitinib: Prognostic significance, mechanism and protective therapies
- (2016) Yi Yang et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Autophagy: an adaptive physiological countermeasure to cellular senescence and ischaemia/reperfusion-associated cardiac arrhythmias
- (2016) Istvan Lekli et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation
- (2015) Z Li et al. CELL DEATH AND DIFFERENTIATION
- MiR-21 Protected Cardiomyocytes against Doxorubicin-Induced Apoptosis by Targeting BTG2
- (2015) Zhongyi Tong et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- MicroRNA-208a Silencing Attenuates Doxorubicin Induced Myocyte Apoptosis and Cardiac Dysfunction
- (2015) Hasahya Tony et al. Oxidative Medicine and Cellular Longevity
- Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis
- (2015) L Roca-Alonso et al. Cell Death & Disease
- Renal erythropoietin-producing cells in health and disease
- (2015) Tomokazu Souma et al. Frontiers in Physiology
- Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation
- (2014) Yoshihiko Ichikawa et al. JOURNAL OF CLINICAL INVESTIGATION
- Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin
- (2014) Jenelle Govender et al. JOURNAL OF PINEAL RESEARCH
- Echinochrome A Protects Mitochondrial Function in Cardiomyocytes against Cardiotoxic Drugs
- (2014) Seung Jeong et al. Marine Drugs
- Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron
- (2014) Tomáš Šimůnek et al. Pharmacological Reports
- Metformin Protects Cardiomyocyte from Doxorubicin Induced Cytotoxicity through an AMP-Activated Protein Kinase Dependent Signaling Pathway: An In Vitro Study
- (2014) Laura C. Kobashigawa et al. PLoS One
- Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase
- (2014) Y. Liu et al. Science Translational Medicine
- Emerging Paradigms in Cardiomyopathies Associated With Cancer Therapies
- (2013) Bonnie Ky et al. CIRCULATION RESEARCH
- Basic concepts of epigenetics
- (2013) Michal Inbar-Feigenberg et al. FERTILITY AND STERILITY
- Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase
- (2013) Mohammad T Elnakish et al. JOURNAL OF PATHOLOGY
- Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor
- (2013) Mayel Gharanei et al. PLoS One
- Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin
- (2013) Baoxu Pang et al. Nature Communications
- Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways
- (2012) Jian Ma et al. CARDIOVASCULAR RESEARCH
- Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced CardiotoxicityIn VitroandIn Vivo
- (2012) Hongbo Wang et al. Evidence-based Complementary and Alternative Medicine
- Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies
- (2012) Yanti Octavia et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Perturbation of microRNAs in Rat Heart during Chronic Doxorubicin Treatment
- (2012) Caterina Vacchi-Suzzi et al. PLoS One
- Metabolic fingerprint of ischaemic cardioprotection: importance of the malate-aspartate shuttle
- (2011) T. T. Nielsen et al. CARDIOVASCULAR RESEARCH
- Non-coding RNAs as regulators of gene expression and epigenetics
- (2011) M. U. Kaikkonen et al. CARDIOVASCULAR RESEARCH
- Activation of AMP-Activated Protein Kinase Contributes to Doxorubicin-Induced Cell Death and Apoptosis in Cultured Myocardial H9c2 Cells
- (2011) Min-Bin Chen et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Nonlinear pharmacokinetics of visnagin in rats after intravenous bolus administration
- (2011) Karin G. Haug et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Cardiotoxicity in Patients Treated With Bevacizumab Is Potentially Reversible
- (2011) Eliza A. Hawkes et al. JOURNAL OF CLINICAL ONCOLOGY
- Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
- (2011) Ryan Lister et al. NATURE
- p53 Regulates Oxidative Stress-Mediated Retrograde Signaling: A Novel Mechanism for Chemotherapy-Induced Cardiac Injury
- (2011) Joyce M. Velez et al. PLoS One
- Schisandrin B Prevents Doxorubicin-Induced Chronic Cardiotoxicity and Enhances Its Anticancer Activity In Vivo
- (2011) Yang Xu et al. PLoS One
- DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria
- (2011) Lisa S. Shock et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice
- (2010) Kaushik Vedam et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Nox2 NADPH Oxidase Promotes Pathologic Cardiac Remodeling Associated with Doxorubicin Chemotherapy
- (2010) Y. Zhao et al. CANCER RESEARCH
- Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway
- (2010) Takahiro Horie et al. CARDIOVASCULAR RESEARCH
- Epoetin Alfa in Patients With Advanced-Stage Hodgkin's Lymphoma: Results of the Randomized Placebo-Controlled GHSG HD15EPO Trial
- (2010) Andreas Engert et al. JOURNAL OF CLINICAL ONCOLOGY
- Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction
- (2010) A. Das et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy
- (2010) Rui A. Carvalho et al. TOXICOLOGY
- Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro
- (2009) Partha Mukhopadhyay et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- NADPH oxidases participate to doxorubicin-induced cardiac myocyte apoptosis
- (2009) Mylène Gilleron et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Extracellular Heat Shock Protein 60, Cardiac Myocytes, and Apoptosis
- (2009) Se-Chan Kim et al. CIRCULATION RESEARCH
- Resveratrol treatment protects against doxorubicin-induced cardiotoxicity by alleviating oxidative damage
- (2009) Elif Tatlidede et al. FREE RADICAL RESEARCH
- Regulation of Rac1 by Simvastatin in Endothelial Cells
- (2009) Ruqin Kou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death
- (2009) Satoru Kobayashi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alteration of Matrix Metalloproteinases in Selective Left Ventricular Adriamycin-Induced Cardiomyopathy in the Pig
- (2009) Andreas Goetzenich et al. JOURNAL OF HEART AND LUNG TRANSPLANTATION
- Epigenetics: Definition, Mechanisms and Clinical Perspective
- (2009) Cathérine Dupont et al. SEMINARS IN REPRODUCTIVE MEDICINE
- Acute Doxorubicin Cardiotoxicity Is Associated With p53-Induced Inhibition of the Mammalian Target of Rapamycin Pathway
- (2008) Wuqiang Zhu et al. CIRCULATION
- Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A
- (2008) Katey Rayner et al. CIRCULATION RESEARCH
- Heat Shock Protein 20 Interacting With Phosphorylated Akt Reduces Doxorubicin-Triggered Oxidative Stress and Cardiotoxicity
- (2008) Guo-Chang Fan et al. CIRCULATION RESEARCH
- Erythropoietin Pretreatment Protects Against Acute Chemotherapy Toxicity in Isolated Rat Hearts
- (2008) Amandine Ramond et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Reactive Nitrogen Species Is Required for the Activation of the AMP-activated Protein Kinase by Statinin Vivo
- (2008) Hyoung Chul Choi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Anthracycline Cardiotoxicity: From Bench to Bedside
- (2008) Luca Gianni et al. JOURNAL OF CLINICAL ONCOLOGY
- DNA methylation landscapes: provocative insights from epigenomics
- (2008) Miho M. Suzuki et al. NATURE REVIEWS GENETICS
- Interaction of anthracyclines with iron responsive element mRNAs
- (2008) Joshua C. Canzoneri et al. NUCLEIC ACIDS RESEARCH
- Ghrelin prevents doxorubicin-induced cardiotoxicity through TNF-alpha/NF-κB pathways and mitochondrial protective mechanisms
- (2008) Zhiwei Xu et al. TOXICOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search