Editorial Material
Cardiac & Cardiovascular Systems
Ivan Stankovic, Marc R. Dweck, Nina Ajmone Marsan, Jutta Bergler-Klein, Espen Holte, Robert Manka, Jeanette Schulz-Menger, Marta Sitges, Kristina H. Haugaa
Summary: Early and late cardiovascular toxicities related to cancer treatments can complicate the clinical course of patients, making early detection and treatment essential. Cardiac imaging plays a pivotal role in detecting and monitoring cardiac toxicity in oncology patients in Europe and beyond, although there are gaps between guidelines recommendations and everyday clinical practice.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Rachel E. Ohman, Eric H. Yang, Melissa L. Abel
Summary: Minority and underresourced communities face higher rates of fatal cancer and cardiovascular disease. Disparities in treatment-associated cardiotoxicity show that black breast cancer survivors have elevated risk, while female patients treated with certain drugs have higher risks compared with male patients. Large-scale studies are needed to better understand racial, ethnic, socioeconomic, and gender disparities in cardio-oncology.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Katarina Yaros, Benay Eksi, Alvin Chandra, Kartik Agusala, Lorenz H. Lehmann, Vlad G. Zaha
Summary: Cardiovascular imaging plays an important role in the care of cancer patients, as they face increased risks of cardiovascular complications. Currently established imaging modalities are evolving towards increased specificity, while new modalities are emerging to target earlier stages of cardiovascular disease. Choosing suitable imaging modalities for individual patients is crucial for successful risk stratification. Future imaging tools have the potential to provide insights into the molecular pathology of cardiovascular complications associated with cancer and oncological therapies.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Oncology
Juan C. Lopez-Mattei, Eric H. Yang, Maros Ferencik, Lauren A. Baldassarre, Susan Dent, Matthew J. Budoff
Summary: Cardiac computed tomography (CT) plays a crucial role in identifying cardiovascular diseases, evaluating myocardial toxicity, and is especially important in patients who are not suitable for cardiac magnetic resonance imaging.
JACC: CARDIOONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Johanna E. J. Jacobs, Ipek Guler, Jurgen Duchenne, Stefan Janssens, Lucas N. L. Van Aelst
Summary: Cardiovascular morbidity and mortality are common in cancer patients and survivors, highlighting the need for adequate risk prediction tools for systematic screening and rigorous cardiovascular follow-up. Existing risk scores for cardiotoxicity are suboptimal and should be interpreted with caution.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Oncology
Shruti Rajesh Patel, Giselle Alexandra Suero-Abreu, Angela Ai, Maya K. K. Ramachandran, Kelly Meza, Narjust Florez
Summary: Cardio-oncology focuses on reducing cardiovascular risks, detecting and treating cardiovascular diseases in cancer patients. Disparities in cardio-oncologic care exist among different populations due to factors such as cancer screening rates, genetic risk factors, cultural stressors, tobacco exposure rates, and physical inactivity. Barriers to care also exist in minority groups and low-income populations. Urgent efforts are needed to address these disparities.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Yinghui Wang, Yonggang Wang, Xiaorong Han, Jian Sun, Cheng Li, Binay Kumar Adhikari, Jin Zhang, Xiao Miao, Zhaoyang Chen
Summary: Cardiovascular disease (CVD) and cancer are leading causes of death worldwide. The adverse effects of anti-tumor therapy, particularly on the cardiovascular system, have gained significant attention. Incidence of cardiovascular events is higher than tumor recurrence rate, and CVD and malignant tumors share common risk factors. Clinicians should understand this relationship, provide primary and secondary prevention strategies, and follow proper treatment methods.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Carlos D. Vera, Agustin Rodriguez Lopez, Alex S. Ewaneewane, Kasey Lewis, Sophia Parmisano, Gema Mondejar-Parreno, Chandan Upadhyaya, Mckay Mullen
Summary: Cancer and cardiovascular diseases are the top two causes of death in the United States. While novel therapies have slowed down cancer mortality rate, there has been an increase in cardiac failures due to the toxicity of cancer treatments. Understanding the mechanisms behind this relationship is crucial in properly treating patients at risk of developing cardiac failure. Currently, early-stage biomarkers of inflammation and angiogenesis are used to detect cardiotoxicity before it becomes irreversible, with the aim of minimizing the adverse effects of cancer therapies. In the field of cardio-oncology, there is growing focus on gender and racial disparities in cardiotoxicity and their impact on disease outcomes, although data on variations in cardiotoxicity across diverse populations is limited.
Review
Cardiac & Cardiovascular Systems
Jean C. Bikomeye, Janee D. Terwoord, Janine H. Santos, Andreas M. Beyer
Summary: Anticancer therapies can have cardiotoxic side effects, with mitochondrial damage being a key factor. Further research is needed to understand the secondary signaling events that occur in response to such damage, as mitochondria also play important roles in other pathologies.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Flavio D'Ascenzi, Francesca Anselmi, Caterina Fiorentini, Roberta Mannucci, Marco Bonifazi, Sergio Mondillo
Summary: This review focuses on investigating the origin, prevention, and reversal strategies of cardiac damage, and explores the beneficial effects of physical exercise on cancer patients. It suggests personalized exercise prescriptions and emphasizes the importance of cardiac evaluation in prescribing exercise for these patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Daniela Di Lisi, Antonella Moreo, Grazia Casavecchia, Christian Cadeddu Dessalvi, Corinna Bergamini, Concetta Zito, Cristina Madaudo, Rosalinda Madonna, Matteo Cameli, Giuseppina Novo
Summary: This study aimed to assess the impact of anti-cancer drugs on atrial function in breast cancer women and found that PALS and LASi, which are associated with GLS, significantly changed during chemotherapy. Atrial strain is an additional parameter that could be measured together with GLS to detect cardiotoxicity early.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Sarath Babu Nukala, Jordan Jousma, Yoonje Cho, Won Hee Lee, Sang-Ging Ong
Summary: Cancer survivors have an increased risk of cardiovascular diseases, leading to the emergence of the field of cardio-oncology. The review summarizes the role of non-coding RNAs in cancer therapy-induced cardiotoxicities and discusses potential therapeutic strategies.
CELL AND BIOSCIENCE
(2022)
Review
Oncology
Drishti Tolani, Julia Wilcox, Sharvari Shyam, Neha Bansal
Summary: As chemotherapy improves, understanding the effects on the cardiovascular system is increasingly important. Cardiotoxicity is a major determinant of morbidity and mortality in cancer survivors. New imaging modalities and biomarkers may detect subclinical cardiotoxicity earlier. Dexrazoxane remains the most effective therapy for preventing anthracycline-induced cardiomyopathy. Neurohormonal modulating drugs have not been effective in preventing cardiotoxicity. Advanced cardiac therapies, like heart transplant, should be considered for cancer survivors with end-stage HF. Research on genetic associations may produce treatments to reduce cardiovascular morbidity and mortality.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Claire Tonry, Adam Russell-Hallinan, Claire McCune, Patrick Collier, Mark Harbinson, Lana Dixon, Chris J. Watson
Summary: Cancer therapeutics-related cardiac dysfunction (CTRCD) is a major cause of disease and death in cancer survivors. The clinical management of CTRCD is hindered by a lack of sensitive diagnostic and prognostic strategies. Circulating molecular markers could potentially be useful in the diagnosis and management of CTRCD. Researchers have been searching for new biomarkers and hope that these markers can also guide the development of cardio-protective therapies.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Carlo G. Tocchetti, Alessandra Ghigo, Emilio Hirsch
Summary: This editorial discusses the study conducted by Lu et al. on the protective effect of circular RNA derived from the insulin receptor locus against doxorubicin-induced cardiotoxicity.
EUROPEAN HEART JOURNAL
(2022)
Article
Cell Biology
Chaojun Yan, Longlong Gong, Li Chen, Meng Xu, Hussein Abou-Hamdan, Mingliang Tang, Laurent Desaubry, Zhiyin Song
Article
Chemistry, Medicinal
Sabria Elderwish, Anais Audebrand, Canan G. Nebigil, Laurent Desaubry
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Dong Wang, Redouane Tabti, Sabria Elderwish, Hussein Abou-Hamdan, Amel Djehal, Peng Yu, Hajime Yurugi, Krishnaraj Rajalingam, Canan G. Nebigil, Laurent Desaubry
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Xin Jin, Jianling Xie, Michael Zabolocki, Xuemin Wang, Tao Jiang, Dong Wang, Laurent Desaubry, Cedric Bardy, Christopher G. Proud
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Cell Biology
Hajime Yurugi, Yinyin Zhuang, Farid Siddiqui, Hong Liang, Sebastian Rosigkeit, Yongpeng Zeng, Hussein Abou-Hamdan, Ernesto Bockamp, Yong Zhou, Daniel Abankwa, Wenting Zhao, Laurent Desaubry, Krishnaraj Rajalingam
JOURNAL OF CELL SCIENCE
(2020)
Article
Chemistry, Organic
Dong Wang, Yuanyang Jiang, Linru Dong, Gaoyu Li, Baoying Sun, Laurent Desaubry, Peng Yu
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Canan G. Nebigil, Christiane Moog, Stephan Vagner, Nadia Benkirane-Jessel, Duncan R. Smith, Laurent Desaubry
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Laurent Desaubry, Anumantha G. Kanthasamy, Canan G. Nebigil
PHARMACOLOGICAL RESEARCH
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Canan G. Nebigil, Michael W. Y. Chan, Tienush Rassaf
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)
Article
Peripheral Vascular Disease
Ferda Demir, Kyoji Urayama, Anais Audebrand, Ayca Toprak-Semiz, Marja Steenman, Hitoshi Kurose, Canan G. Nebigil
Summary: This study reveals that pressure overload-mediated PKR2 signaling in cardiomyocytes contributes to cardiac hypertrophy through autocrine signaling, and vascular rarefaction via cardiac cytokine-mediated cardiomyocyte-endothelial cell communications. Our results may contribute to the development of potential therapeutic targets for heart failure.
Article
Chemistry, Medicinal
Dong Wang, Redouane Tabti, Sabria Elderwish, Amel Djehal, Nora Chouha, Franck Pinot, Peng Yu, Canan G. Nebigil, Laurent Desaubry
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Multidisciplinary
Dong Wang, Yu Fan, Peng Yu, Laurent Desaubry
CHEMICAL COMMUNICATIONS
(2020)
Review
Cardiac & Cardiovascular Systems
Anais Audebrand, Laurent Desaubry, Canan G. Nebigil
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)
