Article
Pharmacology & Pharmacy
Giorgio Minotti, Emanuela Salvatorelli, Giorgio Reggiardo, Fabio Mangiacapra, Massimiliano Camilli, Pierantonio Menna
Summary: Diastolic dysfunction (DD) may occur before heart failure (HF) in cancer patients treated with chemotherapy. By analyzing data from patients treated with anthracyclines, it was found that the risk of DD is lower than the risk of HF and the levels of B-type natriuretic peptide (BNP) can help identify patients with high or low risk of DD.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Tom Kretzschmar, Jasmine M. F. Wu, P. Christian Schulze
Summary: Heart failure remains the most common cause of death in the industrialized world, and despite new therapeutic interventions, complete prevention of its development and progression is still not possible, highlighting the need for further research to understand the underlying mechanisms. This review provides a detailed overview of the contribution of impaired mitochondrial dynamics and energy homeostasis during heart failure progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Liam S. Couch, Jan Fiedler, Giles Chick, Rory Clayton, Eef Dries, Laura M. Wienecke, Lu Fu, Jerome Fourre, Pragati Pandey, Anselm A. Derda, Brian X. Wang, Richard Jabbour, Mayooran Shanmuganathan, Peter Wright, Alexander R. Lyon, Cesare M. Terracciano, Thomas Thum, Sian E. Harding
Summary: The circulating biomarkers miR-16 and miR-26a were found to be involved in the pathophysiology of Takotsubo syndrome (TTS), sensitizing the heart to TTS-like changes produced by adrenaline. These miRs are associated with anxiety and depression and may provide a mechanism whereby previous stress primes the heart, increasing the likelihood of TTS in the future.
CARDIOVASCULAR RESEARCH
(2022)
Review
Environmental Sciences
Zihan Chen, Xia Huo, Guangcan Chen, Xiuli Luo, Xijin Xu
Summary: Lead, a heavy metal widely used in industry, is also a common environmental contaminant with toxicological consequences on many species. It adversely affects the cardiovascular system in humans, potentially leading to heart failure, pressure overload, arrhythmia, myocardial ischemia, and cardiotoxicity. Research indicates that lead exposure may play a significant role in the occurrence and development of heart failure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, Research & Experimental
David de Gonzalo-Calvo, Pablo Martinez-Camblor, Thalia Belmonte, Ferran Barbe, Kevin Duarte, Martin R. Cowie, Christiane E. Angermann, Andrea Korte, Isabelle Riedel, Josephine Labus, Wolfgang Koenig, Faiez Zannad, Thomas Thum, Christian Baer
Summary: This study found that the combination of clinical information, circulating miRNAs, and decision tree learning allows the identification of specific risk subphenotypes in patients with HFrEF and CSA.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Donghyun Kim, Gyuho Jang, Jaetaek Hwang, Xiaofan Wei, Hyunsoo Kim, Jinbae Son, Sang-Jae Rhee, Kyeong-Ho Yun, Seok-Kyu Oh, Chang-Myung Oh, Raekil Park
Summary: In this study, the combination of low-dose ARNI and SGLT2i was found to have greater benefits in improving cardiac dysfunction induced by doxorubicin, with minimal adverse effects. This finding is significant for the management of CTRCD patients.
Article
Pharmacology & Pharmacy
Yihai Liu, Xuan Wei, Mingyue Wu, Jiamin Xu, Biao Xu, Lina Kang
Summary: The study found that BHB could protect from DOX-induced cardiotoxicity by inhibiting cell apoptosis and oxidative stress, and maintaining mitochondrial membrane integrity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Cheng-Ken Tsai, Bo-Hau Chen, Hsin-Hung Chen, Rebecca Jen-Ling Hsieh, Jui-Chen Lee, Yi-Ting Chu, Wen-Hsien Lu
Summary: This study investigated the therapeutic effects of propranolol in a model of hyper-acute catecholamine-induced heart failure. The results showed that low-dose propranolol exerted cardio-preventative effects through downregulation of FGF-23 and improvement of hemodynamic parameters.
Article
Food Science & Technology
Oksana P. Gerzen, Salavat R. Nabiev, Svetlana V. Klinova, Ilzira A. Minigalieva, Marina P. Sutunkova, Boris A. Katsnelson, Larisa V. Nikitina
Summary: Moderate lead intoxication in male rats led to altered actin-myosin interaction and regulation in the heart chambers, affecting myosin isoform composition, filament sliding velocity, and light chain phosphorylation. The impact of lead on myosin functional characteristics varied in different heart chambers, showing a dose-dependent effect.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Lin Tan, Nikolay Bogush, Emmen Naqvi, John W. Calvert, Robert M. Graham, W. Robert Taylor, Nawazish Naqvi, Ahsan Husain
Summary: The study demonstrates that therapy with DUSP5 suppression plus T3 can rebuild cardiac muscle by increasing cardiomyocyte numbers, thereby reversing heart dysfunction and preventing progressive chamber dilatation.
Article
Cardiac & Cardiovascular Systems
Joohee Choi, Joshua B. Holmes, Kenneth S. Campbell, Julian E. Stelzer
Summary: OM and danicamtiv increase myocardial force output through different mechanisms, with OM significantly increasing Ca2+ sensitivity of force generation and danicamtiv having a less pronounced effect. Both drugs slow down cross-bridge kinetics, but danicamtiv has a more pronounced inhibitory effect on the OM-induced dynamic delay.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Piotr Z. Sobanski, David C. Currow
Summary: Breathlessness is a common symptom that significantly affects the quality of life for patients with advanced diseases. This article explores the use of low-dose methadone as an alternative treatment to morphine for reducing breathlessness in patients experiencing neurotoxic effects or at risk of developing them following treatment with morphine.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Michael J. Engwall, Nancy Everds, James R. Turk, Hugo M. Vargas
Summary: Chronic dosing of doxorubicin in cynomolgus monkeys resulted in progressive heart failure characterized by decreased left ventricular function, reduced arterial pressure, decreased cardiac contractility, and prolonged QTc interval. Histopathology revealed vacuolar degeneration of cardiomyocytes. Telemetry and echocardiography measurements were effective in tracking the gradual onset of left ventricular dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Seho Kweon, Yoo-Seong Jeong, Seung Woo Chung, Hanul Lee, Ha Kyeong Lee, Seong Jin Park, Jeong Uk Choi, Jooho Park, Suk-Jae Chung, Youngro Byun
Summary: This study aims to identify the optimal metronomic chemotherapy (MCT) regimen of doxorubicin (DOX) by determining the concentration-response relationships of tumor suppression and cardiac toxicity. By utilizing an oral DOX formulation complexed with deoxycholic acid, a physiologically-based pharmacokinetic model was linked to toxicodynamic and pharmacodynamic models to generate drug profiles. The established mathematical model facilitates the calculation of adequate in vivo-relevant dosages and intervals, providing a useful guideline for the design and evaluation of oral DOX formulations.
Article
Cardiac & Cardiovascular Systems
Michael J. Domanski, Colin O. Wu, Xin Tian, Ahmed A. Hasan, Xiaoyang Ma, Yi Huang, Rui Miao, Jared P. Reis, Sejong Bae, Anwar Husain, David R. Jacobs Jr, Norrina B. Allen, Mei-Ling T. Lee, Charles C. Hong, Michael E. Farkouh, Donald M. Lloyd-Jones, Valentin Fuster
Summary: The quantitative relationship between incident cardiovascular disease (CVD) and lifetime cumulative risk factor exposure is not well understood. Using CARDIA study data, regression models were developed to examine the associations between cumulative exposure to multiple risk factors and CVD incidence. The study found that cumulative exposure to certain risk factors, such as low-density lipoprotein cholesterol and triglycerides, as well as blood pressure variables, were independently associated with CVD risk.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Annalisa Bonelli, Pierantonio Menna, Giorgio Minotti, Silvia Angeletti, Alessandro Comandini, Rossella Picollo, Elisa Quarchioni, Vincenzo Russo, Enrica Salvatori, Francesca Ferravante, Sara Emerenziani, Michele Cicala, Maurizio Muscaritoli
Summary: This study investigated a novel FSMP for subjects with impaired digestion or gastrointestinal absorption, showing good gastrointestinal tolerance, acceptable palatability, and no impact on physiological glucose or triglycerides levels. The investigational product was well tolerated by study subjects.
CLINICAL NUTRITION
(2021)
Review
Oncology
Massimiliano Camilli, Marco Lombardi, Giovanni Maria Vescovo, Marco Giuseppe Del Buono, Mattia Galli, Nadia Aspromonte, Giuseppe Biondi Zoccai, Giampaolo Niccoli, Rocco A. Montone, Filippo Crea, Giorgio Minotti
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2020)
Editorial Material
Hematology
Pierantonio Menna, Emanuela Salvatorelli, Giorgio Minotti
ACTA HAEMATOLOGICA
(2021)
Article
Oncology
Pierantonio Menna, Emanuela Salvatorelli, Maria Ilaria Del Principe, Salvatore Perrone, Livio Pagano, Francesco Marchesi, Giorgio Minotti
Summary: The study found that posaconazole significantly increases plasma levels of midostaurin in patients, leading to decreased exposure to its metabolites. Hematologists may replace posaconazole with antifungals like micafungin or isavuconazole in response to the risk perception of CYP3A4 inhibition, which may affect midostaurin pharmacokinetics in a different manner. Further large studies are needed to evaluate the risk-benefit ratio of this decision.
Editorial Material
Oncology
Robert S. Benjamin, Giorgio Minotti
Summary: Doxorubicin cardiac toxicity is widely misunderstood but largely preventable. Dexrazoxane cardioprotection can be safely initiated on day 1, minimizing the risk of doxorubicin cardiac toxicity.
CLINICAL CANCER RESEARCH
(2021)
Letter
Cardiac & Cardiovascular Systems
Massimiliano Camilli, Marco Lombardi, Juan Guido Chiabrando, Marco Giuseppe Del Buono, Rocco Antonio Montone, Giuseppe Biondi-Zoccai, Filippo Crea, Giorgio Minotti
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Review
Hematology
Massimiliano Camilli, Giulia Iannaccone, Giulia La Vecchia, Luigi Cappannoli, Roberto Scacciavillani, Giorgio Minotti, Massimo Massetti, Filippo Crea, Nadia Aspromonte
Summary: The relationship between platelets, cardiovascular diseases and cancer is analyzed in this review. Platelets play a significant role in linking inflammation to thrombosis and in cancer development and progression. Inhibiting platelets may offer an innovative therapeutical strategy for cancer patients.
EXPERT REVIEW OF HEMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Massimiliano Camilli, Marco Lombardi, Juan G. Chiabrando, Andrea Zito, Marco G. Del Buono, Rocco Vergallo, Nadia Aspromonte, Antonella Lombardo, Rocco A. Montone, Giampaolo Niccoli, Giuseppe Biondi-Zoccai, Filippo Crea, Giorgio Minotti
Summary: This meta-analysis investigated the role of SGLT2i in patients with heart failure (HF), finding that it can reduce cardiovascular risk and mortality in HF patients. The results support the routine use of these drugs as standard-of-care.
AMERICAN JOURNAL OF THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Joerg Herrmann, Daniel Lenihan, Saro Armenian, Ana Barac, Anne Blaes, Daniela Cardinale, Joseph Carver, Susan Dent, Bonnie Ky, Alexander R. Lyon, Teresa Lopez-Fernandez, Michael G. Fradley, Sarju Ganatra, Giuseppe Curigliano, Joshua D. Mitchell, Giorgio Minotti, Ninian N. Lang, Jennifer E. Liu, Tomas G. Neilan, Anju Nohria, Rupal O'Quinn, Iskra Pusic, Charles Porter, Kerry L. Reynolds, Kathryn J. Ruddy, Paaladinesh Thavendiranathan, Peter Valent
Summary: The discipline of Cardio-Oncology focuses on the cardiovascular care of cancer patients and the management of cardiovascular complications of cancer therapies. This document provides consensus definitions for common cardiovascular toxicities and aims to improve communication and outcomes in clinical practice and research.
EUROPEAN HEART JOURNAL
(2022)
Review
Oncology
Pier Luigi Zinzani, Giorgio Minotti
Summary: Anti-CD19 monoclonal antibodies, including bispecific T-cell engager, modified anti-CD19 with enhanced affinity, and antibody-drug conjugate, show promising results in the treatment of relapsed or refractory B-cell malignancies, offering improved outcomes for certain patients with limited therapeutic options and poor prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Giorgio Minotti, Massimiliano Camilli
JACC: CARDIOONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Giorgio Minotti, Emanuela Salvatorelli, Giorgio Reggiardo, Fabio Mangiacapra, Massimiliano Camilli, Pierantonio Menna
Summary: Diastolic dysfunction (DD) may occur before heart failure (HF) in cancer patients treated with chemotherapy. By analyzing data from patients treated with anthracyclines, it was found that the risk of DD is lower than the risk of HF and the levels of B-type natriuretic peptide (BNP) can help identify patients with high or low risk of DD.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Letter
Oncology
Giorgio Minotti, Giorgio Reggiardo, Massimiliano Camilli, Emanuela Salvatorelli, Pierantonio Menna
JACC: CARDIOONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Giorgio Minotti, Pierantonio Menna, Massimiliano Camilli, Emanuela Salvatorelli, Giorgio Reggiardo
Summary: This study found that both anthracycline-based and nonanthracycline chemotherapy can induce early or delayed diastolic dysfunction (DD), with early DD being influenced by the patient's cardiovascular profile and delayed DD being influenced by postchemotherapy adjuvant treatments. The type of chemotherapy did not directly predict the risk of DD.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)