Article
Food Science & Technology
Dongsheng Yu, Jiye Li, Yu Wang, Danfeng Guo, Chunsheng Zhu, Bao Sun, Zheng Zhou
Summary: Oridonin has a protective effect against doxorubicin-induced cardiotoxicity by improving myocardial structure, reducing apoptotic cells, alleviating oxidative damage and mitochondrial dysfunction. Its mechanism involves modulation of the E2F1/Sirt6/PGC1 alpha pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Food Science & Technology
The-Hiep Hoang, Young Yoon, Seon-Ah Park, Hwa-Young Lee, Cheng Peng, Jung-Hyun Kim, Geum-Hwa Lee, Han-Jung Chae
Summary: The study found that Rhus verniciflua extract has a protective effect against obesity in mice by modulating liver steatosis, adipocyte metabolism, and BAT function. These modulations include reducing lipogenesis and adipogenesis, increasing mitochondrial biogenesis and thermogenesis markers, and influencing the recovery of PGC1 alpha deacetylation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Xiaoqi Li, Xin Wang, Binyu Wang, Weiqun Chi, Zhangyi Li, Min Zhang, Yifu Shen, Xu Liu, Youmei Lu, Yu Liu
Summary: The study evaluated the protective effect of DHM on DOX-induced cardiotoxicity in vivo and in vitro. The results showed that DHM pretreatment significantly alleviated DOX-induced cardiotoxicity.
Article
Pharmacology & Pharmacy
Yanqing Zhang, Zhenzhen Zhang, Yiwei Zhang, Leiming Wu, Lu Gao, Rui Yao, Yanzhou Zhang
Summary: The study demonstrates that baicalin (BAI) can limit weight gain, improve glucose tolerance, enhance cold tolerance, and promote brown-like tissue formation in diet-induced obesity mice. BAI increases mitochondrial copy number and activates the AMPK/PGC1 alpha pathway, leading to the upregulation of UCP1 and other browning-related genes in brown adipose tissue and white adipose tissue.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jie A. Wang, Yufeng Tang, Jingjing Zhang, Jie B. Wang, Mengjie Xiao, Guangping Lu, Jiahao Li, Qingbo Liu, Yuanfang Guo, Junlian Gu
Summary: In this study, the researchers investigated the role of the interaction between SIRT1 and SESN2 in DOX-induced cardiomyopathy. They found that SIRT1 deficiency aggravated cardiac damage, while the activation of SIRT1 had protective effects. Further studies revealed that SIRT1 reduced oxidative damage and apoptosis by attenuating the interaction between SESN2 and MDM2, thereby protecting the heart from DOX-induced toxicity.
Article
Medicine, Research & Experimental
Wei Zhang, Xi Wang, Yanhong Tang, Congxin Huang
Summary: Melatonin has cardioprotective effects on various cardiovascular diseases, including doxorubicin-induced cardiomyopathy. It has been shown to enhance mitochondrial function and mitigate myocardial injuries caused by Doxorubicin, but its role in regulating the Sirt1/Nrf2 pathway in lessening the onset of cardiomyopathy is still unclear.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
Guangping Lu, Qingbo Liu, Ting Gao, Jiahao Li, Jingjing Zhang, Ou Chen, Cong Cao, Min Mao, Mengjie Xiao, Xiaohui Zhang, Jie Wang, Yuanfang Guo, Yufeng Tang, Junlian Gu
Summary: This study aimed to explore the therapeutic potential and underlying mechanisms of the co-treatment of resveratrol (RES) and fibroblast growth factor 1 (FGF1) in a doxorubicin (DOX)-treated model. The results showed that RES could reduce the growth-promoting activity of FGF1 and exhibited a more powerful antioxidative capacity in a DOX-treated model, with cardioprotective action mediated through the SIRT1/NRF2 pathway.
Review
Cardiac & Cardiovascular Systems
Manrose Singh, Akito T. Nicol, Jaclyn DelPozzo, Jia Wei, Mandeep Singh, Tony Nguyen, Satoru Kobayashi, Qiangrong Liang
Summary: Current research suggests that metformin (MET) may reduce the cardiotoxicity of doxorubicin (DOX) and enhance its anticancer effects through the activation of AMP-activated protein kinase (AMPK). However, further studies are needed to fully understand the role and mechanism of the MET-AMPK axis in DOX cardiotoxicity and antitumor efficacy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Peter Tsvetkov, Julia Adler, Romano Strobelt, Yaarit Adamovich, Gad Asher, Nina Reuven, Yosef Shaul
Summary: This passage demonstrates the interaction between SIRT1 and NQO1, indicating that SIRT1 can regulate the expression of NQO1 and exert a protective role under mitochondrial stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Siqi Zhang, Yixin Fan, Binbin Zheng, Yu Wang, Chen Miao, Yue Su, Kun Li, Yan E, Xueli Wang, Xueming He, Xuefeng Wu, Chenjie Xu, Yulin Tang, Wen-Tao Liu, Xiangqing Kong, Liang Hu
Summary: This study demonstrates that bilirubin has a potential protective effect against doxorubicin-induced cardiotoxicity. By activating the AMPK-Axl-SOCS3 signaling axis, bilirubin upregulates gap junction function, thereby attenuating doxorubicin-induced arrhythmia and myocardial damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Benluvankar Varghese, Ugo Chianese, Lucia Capasso, Veronica Sian, Paola Bontempo, Mariarosaria Conte, Rosaria Benedetti, Lucia Altucci, Vincenzo Carafa, Angela Nebbioso
Summary: In this study, it was found that SCIC2.1 promoted mitochondrial biogenesis and ATP production under glucose deprivation by activating SIRT1, while also reprogramming glucose metabolism and fatty acid oxidation. The activation of SIRT1 by SCIC2.1 also modulated antioxidant response and stress response in hepatocellular carcinoma cells, indicating its potential as a therapeutic target for metabolic diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Atsushi Kuno, Ryusuke Hosoda, Miki Tsukamoto, Tatsuya Sato, Hiromi Sakuragi, Nami Ajima, Yukika Saga, Kouhei Tada, Yoshiki Taniguchi, Naotoshi Iwahara, Yoshiyuki Horio
Summary: The study suggests that SIRT1 protects against doxorubicin-induced cardiotoxicity by mediating H2AX phosphorylation through its deacetylation in cardiomyocytes. Treatment with resveratrol, a SIRT1 activator, attenuates doxorubicin-induced cardiac dysfunction by reducing the acetyl-Lys5-H2AX level and preserving the phospho-Ser139-H2AX level.
CARDIOVASCULAR RESEARCH
(2022)
Article
Chemistry, Medicinal
Jiayu Song, Luyao Ren, Zhenzhu Ren, Xing Ren, Yang Qi, Yuxi Qin, Xiaohui Zhang, Yuan Ren, Yunlan Li
Summary: The mitochondria are key targets in nonalcoholic fatty liver disease (NAFLD), and this study identified several mitochondrial biogenesis-related proteins as therapeutic targets for NAFLD. By synthesizing a series of compounds, it was found that hydroxyl and ketone groups influence mitochondrial biogenesis activity, with the o-hydroxyl group on the benzene ring exhibiting stronger activity. In vitro and in vivo experiments confirmed that these compounds could improve mitochondrial dysfunction and NAFLD by activating the PGC1a signaling pathway in a SIRT1-dependent manner.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xuechen Li, Zhengbing Zhuge, Lucas Rannier R. A. Carvalho, Valdir A. Braga, Ricardo Barbosa Lucena, Shuijie Li, Tomas A. Schiffer, Huirong Han, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlstrom
Summary: The study indicates that treatment with inorganic nitrate and nitrite can attenuate the development of kidney fibrosis by targeting oxidative stress and lipid metabolism. Mechanisms include modulation of AMPK and AKT-PGC1α pathways.
Article
Biochemistry & Molecular Biology
Panagiotis Efentakis, Garyfalia Psarakou, Aimilia Varela, Eleni Dimitra Papanagnou, Michail Chatzistefanou, Panagiota-Efstathia Nikolaou, Costantinos H. Davos, Maria Gavriatopoulou, Ioannis P. Trougakos, Meletios Athanasios Dimopoulos, Ioanna Andreadou, Evangelos Terpos
Summary: The study confirmed carfilzomib-induced cardiotoxicity in aged mice, which was significantly reversed by metformin. Metformin as a prophylactic therapy has translational importance in supporting its clinical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)