标题
PCSK9 and cancer: Rethinking the link
作者
关键词
PCSK9, Cancer, LDL cholesterol, LDL receptor, Monoclonal antibodies, Vaccine, Safety
出版物
BIOMEDICINE & PHARMACOTHERAPY
Volume 140, Issue -, Pages 111758
出版商
Elsevier BV
发表日期
2021-05-29
DOI
10.1016/j.biopha.2021.111758
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Pooled Patient-Level Analysis of Inclisiran Trials in Patients With Familial Hypercholesterolemia or Atherosclerosis
- (2021) R. Scott Wright et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ageing: Molecular mechanisms
- (2020) Afsane Bahrami et al. AGEING RESEARCH REVIEWS
- Beyond cholesterol metabolism: The pleiotropic effects of proprotein convertase subtilisin/kexin type 9 (PCSK9). Genetics, mutations, expression, and perspective for long‐term inhibition
- (2020) Arturo Cesaro et al. BIOFACTORS
- PCSK9 is a promising prognostic marker in patients with advanced NSCLC
- (2020) Aldo Bonaventura et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer
- (2020) James Yarmolinsky et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Pseurotin A as a novel suppressor of hormone dependent breast cancer progression and recurrence by inhibiting PCSK9 secretion and interaction with LDL receptor
- (2020) Khaldoun S. Abdelwahed et al. PHARMACOLOGICAL RESEARCH
- Contribution of the Low-Density Lipoprotein Receptor Family to Breast Cancer Progression
- (2020) Océane Campion et al. Frontiers in Oncology
- PCSK9 Levels Are Raised in Chronic HCV Patients with Hepatocellular Carcinoma
- (2020) Silvano Fasolato et al. Journal of Clinical Medicine
- Long-term generation of antiPCSK9 antibody using a nanoliposome-based vaccine delivery system
- (2019) Amir Abbas Momtazi-Borojeni et al. ATHEROSCLEROSIS
- Serum PCSK9 levels at the second nivolumab cycle predict overall survival in elderly patients with NSCLC: a pilot study
- (2019) Aldo Bonaventura et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- PCSK9 and inflammation: a review of experimental and clinical evidence
- (2019) Amir Abbas Momtazi-Borojeni et al. European Heart Journal-Cardiovascular Pharmacotherapy
- The effects of statins on microglial cells to protect against neurodegenerative disorders: A mechanistic review
- (2019) Hossein Bagheri et al. BIOFACTORS
- Therapeutic effect of nanoliposomal PCSK9 vaccine in a mouse model of atherosclerosis
- (2019) Amir Abbas Momtazi-Borojeni et al. BMC Medicine
- Could PCSK9 be a new therapeutic target of Eugenol? In vitro and in silico evaluation of hypothesis
- (2019) Saadiya Zia et al. MEDICAL HYPOTHESES
- Hepatitis C virus regulates proprotein convertase subtilisin/kexin type 9 promoter activity
- (2018) Zhubing Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- PCSK9 and neurocognitive function: Should it be still an issue after FOURIER and EBBINGHAUS results?
- (2018) Massimo R. Mannarino et al. Journal of Clinical Lipidology
- Cholesterol negatively regulates IL-9–producing CD8+T cell differentiation and antitumor activity
- (2018) Xingzhe Ma et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Proprotein convertase subtilisin/kexin type 9 inhibits hepatitis C virus replication through interacting with NS5A
- (2018) Zhubing Li et al. JOURNAL OF GENERAL VIROLOGY
- EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
- (2018) Peter R. Galle et al. JOURNAL OF HEPATOLOGY
- A Mendelian randomization study of the effects of blood lipids on breast cancer risk
- (2018) Christoph Nowak et al. Nature Communications
- The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice
- (2017) Christine Landlinger et al. EUROPEAN HEART JOURNAL
- LOX-1 and Its Splice Variants: A New Challenge for Atherosclerosis and Cancer-Targeted Therapies
- (2017) Barbara Rizzacasa et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hepatitis C virus and proprotein convertase subtilisin/kexin type 9: a detrimental interaction to increase viral infectivity and disrupt lipid metabolism
- (2017) Matteo Pirro et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- PCSK9 at the crossroad of cholesterol metabolism and immune function during infections
- (2017) Francesco Paciullo et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Pro-inflammation NF-κB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells
- (2017) Mingyan He et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Lipid and lipoprotein abnormalities in acute lymphoblastic leukemia survivors
- (2017) Sophia Morel et al. JOURNAL OF LIPID RESEARCH
- Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia
- (2017) E J Gallagher et al. ONCOGENE
- Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance
- (2017) J Vaquero et al. ONCOGENE
- Inhibition of PCSK9 protects against radiation-induced damage of prostate cancer cells
- (2017) Si-Shun Gan et al. OncoTargets and Therapy
- PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways
- (2017) Xiaohui Xu et al. Experimental and Therapeutic Medicine
- Membrane cholesterol access into a G-protein-coupled receptor
- (2017) Ramon Guixà-González et al. Nature Communications
- Actinidia chinensis Planch root extract inhibits cholesterol metabolism in hepatocellular carcinoma through upregulation of PCSK9
- (2017) Mingyan He et al. Oncotarget
- PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
- (2017) Amand F Schmidt et al. Lancet Diabetes & Endocrinology
- Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015
- (2017) et al. JAMA Oncology
- Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9
- (2017) Anastasia Hyrina et al. EBioMedicine
- Lipid biomarkers and long-term risk of cancer in the Women’s Health Study
- (2016) Paulette D Chandler et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Blood Lipid Concentrations and Colorectal Adenomas: A Systematic Review and Meta-Analysis of Colonoscopy Studies in Asia, 2000–2014
- (2016) Michael N. Passarelli et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†
- (2016) S. Novello et al. ANNALS OF ONCOLOGY
- Targeting PCSK9 for therapeutic gains: Have we addressed all the concerns?
- (2016) Yajnavalka Banerjee et al. ATHEROSCLEROSIS
- Cancer immunotherapy: the beginning of the end of cancer?
- (2016) Sofia Farkona et al. BMC Medicine
- An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers
- (2016) Genaro R. Villa et al. CANCER CELL
- The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice
- (2016) Claudia Lanterna et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- The Role of Cholesterol in Cancer
- (2016) Omer F. Kuzu et al. CANCER RESEARCH
- Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling
- (2016) Pengxiang Huang et al. CELL
- Long-Term Effectiveness and Safety of Pravastatin in Patients With Coronary Heart DiseaseCLINICAL PERSPECTIVE
- (2016) Wendy E. Hague et al. CIRCULATION
- Possible involvement of PCSK9 overproduction in hyperlipoproteinemia associated with hepatocellular carcinoma: A case report
- (2016) Shuichi Nagashima et al. Journal of Clinical Lipidology
- Statins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational Studies
- (2016) Marjan Mansourian et al. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
- Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
- (2016) Wei Yang et al. NATURE
- The impact of statin therapy on plasma levels of von Willebrand factor antigen
- (2016) Amirhossein Sahebkar et al. THROMBOSIS AND HAEMOSTASIS
- Proprotein convertase subtilisin kexin type 9 and high-density lipoprotein metabolism: experimental animal models and clinical evidence
- (2016) Nicola Ferri et al. Translational Research
- High expression of cholesterol biosynthesis genes is associated with resistance to statin treatment and inferior survival in breast cancer
- (2016) Siker Kimbung et al. Oncotarget
- A retrospective study of NENs and miR-224 promotes apoptosis of BON-1 cells by targeting PCSK9 inhibition
- (2016) Jian’an Bai et al. Oncotarget
- Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer
- (2016) Jia Li et al. Scientific Reports
- Tumor-Induced Hyperlipidemia Contributes to Tumor Growth
- (2016) Jianfeng Huang et al. Cell Reports
- Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
- (2016) Giovanni Luchetti et al. eLife
- Alirocumab, a Therapeutic Human Antibody to PCSK9, Does Not Affect CD81 Levels or Hepatitis C Virus Entry and Replication into Hepatocytes
- (2016) Aarti Ramanathan et al. PLoS One
- Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia
- (2015) Eliano Pio Navarese et al. ANNALS OF INTERNAL MEDICINE
- Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)
- (2015) Rainer Schulz et al. BASIC RESEARCH IN CARDIOLOGY
- Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study
- (2015) David de Gonzalo-Calvo et al. BMC CANCER
- Decreased PCSK9 expression in human hepatocellular carcinoma
- (2015) Mamatha Bhat et al. BMC GASTROENTEROLOGY
- Cholesterol and breast cancer risk: a systematic review and meta-analysis of prospective studies
- (2015) Mathilde Touvier et al. BRITISH JOURNAL OF NUTRITION
- Plasma lipid levels and colorectal adenoma risk
- (2015) John-Anthony Coppola et al. CANCER CAUSES & CONTROL
- Cross-talk between LOX-1 and PCSK9 in vascular tissues
- (2015) Zufeng Ding et al. CARDIOVASCULAR RESEARCH
- A link between hypercholesterolemia and chronic lymphocytic leukemia
- (2015) Signy Chow et al. LEUKEMIA & LYMPHOMA
- Metabolites Produced by the Endophytic Fungus Aspergillus fumigatus from the Stem of Erythrophloeum fordii Oliv.
- (2015) Yu-Sheng Shi et al. MOLECULES
- In vivo genome editing using Staphylococcus aureus Cas9
- (2015) F. Ann Ran et al. NATURE
- Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events
- (2015) Marc S. Sabatine et al. NEW ENGLAND JOURNAL OF MEDICINE
- Serum Lipids and Breast Cancer Risk: A Meta-Analysis of Prospective Cohort Studies
- (2015) Haibo Ni et al. PLoS One
- MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer
- (2015) Ri Cui et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma
- (2015) Fabienne Guillaumond et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis
- (2015) Yun Tian et al. PUBLIC HEALTH NUTRITION
- A cholesterol-lowering VLP vaccine that targets PCSK9
- (2015) Erin Crossey et al. VACCINE
- The HMG-CoA reductase inhibitor, simvastatin, exhibits anti-metastatic and anti-tumorigenic effects in ovarian cancer
- (2015) Jessica E. Stine et al. Oncotarget
- MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7
- (2015) Ri Cui et al. Oncotarget
- Combination of body mass index and oxidized low density lipoprotein receptor 1 in prognosis prediction of patients with squamous non-small cell lung cancer
- (2015) Long Jiang et al. Oncotarget
- MicroRNA-224 Induces G1/S Checkpoint Release in Liver Cancer
- (2015) Fangmei An et al. Journal of Clinical Medicine
- Suppression of Annexin A11 in Ovarian Cancer: Implications in Chemoresistance
- (2015) Jin Song et al. NEOPLASIA
- Proprotein Convertase Subtilisin/Kexin Type 9 Deficiency Reduces Melanoma Metastasis in Liver
- (2015) Xiaowei Sun et al. NEOPLASIA
- Incidence of Cancer and Mortality in Patients from the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) Trial
- (2014) Anders Green et al. AMERICAN JOURNAL OF CARDIOLOGY
- Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression
- (2014) Catarina Rodrigues dos Santos et al. BMC CANCER
- Obesity, Cholesterol Metabolism, and Breast Cancer Pathogenesis
- (2014) D. P. McDonnell et al. CANCER RESEARCH
- Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness
- (2014) Shuhua Yue et al. Cell Metabolism
- Design and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro
- (2014) Christina I. Schroeder et al. CHEMISTRY & BIOLOGY
- PCSK9
- (2014) Nabil G. Seidah et al. CIRCULATION RESEARCH
- Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing
- (2014) Qiurong Ding et al. CIRCULATION RESEARCH
- Prospective associations between serum biomarkers of lipid metabolism and overall, breast and prostate cancer risk
- (2014) Mathilde His et al. EUROPEAN JOURNAL OF EPIDEMIOLOGY
- Subcutaneous Adipocytes Promote Melanoma Cell Growth by Activating the Akt Signaling Pathway
- (2014) Hiu Yee Kwan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Statin Use After Colorectal Cancer Diagnosis and Survival: A Population-Based Cohort Study
- (2014) Chris R. Cardwell et al. JOURNAL OF CLINICAL ONCOLOGY
- Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
- (2014) Jayaprakash K. Nair et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- LDL-cholesterol signaling induces breast cancer proliferation and invasion
- (2014) Catarina Rodrigues dos Santos et al. Lipids in Health and Disease
- LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses
- (2014) Shao-hua Wang et al. Lipids in Health and Disease
- Lectin-Like Oxidized LDL Receptor-1 Is an Enhancer of Tumor Angiogenesis in Human Prostate Cancer Cells
- (2014) Iván González-Chavarría et al. PLoS One
- Peptide-Based Anti-PCSK9 Vaccines - An Approach for Long-Term LDLc Management
- (2014) Gergana Galabova et al. PLoS One
- Statin Use and Breast Cancer Survival: A Nationwide Cohort Study from Finland
- (2014) Teemu J. Murtola et al. PLoS One
- Lipid levels in serum and cancerous tissues of colorectal cancer patients
- (2014) Xin Zhang WORLD JOURNAL OF GASTROENTEROLOGY
- The Association of Serum Lipids With Colorectal Adenomas
- (2013) Moon Hee Yang et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Molecular Pathways: Sterols and Receptor Signaling in Cancer
- (2013) L. Gabitova et al. CLINICAL CANCER RESEARCH
- Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors in the Treatment of Hypercholesterolemia and other Pathologies
- (2013) Nabil G. Seidah CURRENT PHARMACEUTICAL DESIGN
- Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor
- (2013) Yingnan Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Total Serum Cholesterol and Cancer Incidence in the Metabolic Syndrome and Cancer Project (Me-Can)
- (2013) Susanne Strohmaier et al. PLoS One
- Alterations in Gene Expression of Proprotein Convertases in Human Lung Cancer Have a Limited Number of Scenarios
- (2013) Ilya V. Demidyuk et al. PLoS One
- Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)
- (2013) Maryssa Canuel et al. PLoS One
- Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease
- (2013) Daniel Felmlee et al. Viruses-Basel
- Association of colorectal adenoma with components of metabolic syndrome
- (2012) Byung Chang Kim et al. CANCER CAUSES & CONTROL
- Dysregulation of Cholesterol Homeostasis in Human Prostate Cancer through Loss of ABCA1
- (2012) B. H. Lee et al. CANCER RESEARCH
- PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling
- (2012) Kai Kysenius et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Control of the immune system by oxysterols and cancer development
- (2012) Catia Traversari et al. CURRENT OPINION IN PHARMACOLOGY
- Cholesterol and prostate cancer
- (2012) Kristine Pelton et al. CURRENT OPINION IN PHARMACOLOGY
- Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice
- (2012) Elena Fattori et al. JOURNAL OF LIPID RESEARCH
- The biology and therapeutic targeting of the proprotein convertases
- (2012) Nabil G. Seidah et al. NATURE REVIEWS DRUG DISCOVERY
- Statin Use and Reduced Cancer-Related Mortality
- (2012) Sune F. Nielsen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model
- (2012) N Alikhani et al. ONCOGENE
- LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease
- (2012) Veerle Bieghs et al. PLoS One
- The Importance of LDL and Cholesterol Metabolism for Prostate Epithelial Cell Growth
- (2012) Teemu J. Murtola et al. PLoS One
- SILAC-based quantitative proteomic analysis of gastric cancer secretome
- (2012) Arivusudar Marimuthu et al. Proteomics Clinical Applications
- Lipids and HCV
- (2012) M. F. Bassendine et al. Seminars in Immunopathology
- Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins
- (2012) Ren Sheng et al. Nature Communications
- Role of Cholesterol in the Development and Progression of Breast Cancer
- (2011) Gemma Llaverias et al. AMERICAN JOURNAL OF PATHOLOGY
- Serum total and HDL cholesterol and risk of prostate cancer
- (2011) Alison M. Mondul et al. CANCER CAUSES & CONTROL
- Long-term Use of Cholesterol-Lowering Drugs and Cancer Incidence in a Large United States Cohort
- (2011) E. J. Jacobs et al. CANCER RESEARCH
- Migration of MDA-MB-231 breast cancer cells depends on the availability of exogenous lipids and cholesterol esterification
- (2011) Caryl J. Antalis et al. CLINICAL & EXPERIMENTAL METASTASIS
- Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition
- (2011) F. J. B. van Duijnhoven et al. GUT
- Novel Domain Interaction Regulates Secretion of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Protein
- (2011) Fen Du et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Total Cholesterol and Cancer Risk in a Large Prospective Study in Korea
- (2011) Cari M. Kitahara et al. JOURNAL OF CLINICAL ONCOLOGY
- PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke
- (2011) Estelle Rousselet et al. JOURNAL OF LIPID RESEARCH
- The Lipogenesis Pathway as a Cancer Target
- (2011) Hanley N. Abramson JOURNAL OF MEDICINAL CHEMISTRY
- Low-Density Lipoprotein Cholesterol and the Risk of Cancer: A Mendelian Randomization Study
- (2011) Marianne Benn et al. JNCI-Journal of the National Cancer Institute
- PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates
- (2011) Marie W Lindholm et al. MOLECULAR THERAPY
- Knockdown of scavenger receptor Class B Type I reduces prostate specific antigen secretion and viability of prostate cancer cells
- (2011) Alexis L. Twiddy et al. PROSTATE
- An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway
- (2011) D. Guo et al. Cancer Discovery
- Risk of colorectal cancer in self-reported inflammatory bowel disease and modification of risk by statin and NSAID use
- (2010) N. Jewel Samadder et al. CANCER
- Low Cholesterol is Associated With Mortality From Stroke, Heart Disease, and Cancer: The Jichi Medical School Cohort Study
- (2010) Naoki Nago et al. JOURNAL OF EPIDEMIOLOGY
- PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain
- (2010) Mali Liu et al. JOURNAL OF LIPID RESEARCH
- Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
- (2010) Themistocles L. Assimes et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Ceramide and ceramide 1-phosphate in health and disease
- (2010) Lide Arana et al. Lipids in Health and Disease
- High-Density Lipoprotein Induces Proliferation and Migration of Human Prostate Androgen-Independent Cancer Cells by an ABCA1-Dependent Mechanism
- (2010) Y. Sekine et al. MOLECULAR CANCER RESEARCH
- A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain
- (2010) John Wojcik et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo
- (2010) Nidhi Gupta et al. PLoS One
- Proliferation of human mammary cancer cells exposed to 27-hydroxycholesterol
- (2010) PAMELA CRUZ et al. Experimental and Therapeutic Medicine
- Time-dependent association of total serum cholesterol and cancer incidence in a cohort of 172 210 men and women: a prospective 19-year follow-up study
- (2009) A. M. Strasak et al. ANNALS OF ONCOLOGY
- High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation
- (2009) Caryl J. Antalis et al. BREAST CANCER RESEARCH AND TREATMENT
- Loss-of-function mutation R46L in the PCSK9 gene has little impact on the levels of total serum cholesterol in familial hypercholesterolemia heterozygotes
- (2009) Thea Bismo Strøm et al. CLINICA CHIMICA ACTA
- PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
- (2009) Majambu Mbikay et al. FEBS LETTERS
- PCSK9 impedes hepatitis C virus infectionin vitroand modulates liver CD81 expression
- (2009) Patrick Labonté et al. HEPATOLOGY
- Hepatitis C virus infection and its clearance alter circulating lipids: Implications for long-term follow-up
- (2009) Kathleen E. Corey et al. HEPATOLOGY
- Serum cholesterol levels in relation to the incidence of cancer: The JPHC study cohorts
- (2009) Hiroyasu Iso et al. INTERNATIONAL JOURNAL OF CANCER
- Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation
- (2009) Steve Poirier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A new method for measurement of total plasma PCSK9: clinical applications
- (2009) Geneviève Dubuc et al. JOURNAL OF LIPID RESEARCH
- Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer
- (2009) Toshiro Migita et al. JNCI-Journal of the National Cancer Institute
- A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9
- (2009) Øystein L. Holla et al. MOLECULAR GENETICS AND METABOLISM
- Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
- (2009) Carlos G. Leon et al. PROSTATE
- Primary prevention of cardiovascular disease with statins: cautionary notes
- (2009) M.R. Goldstein et al. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
- Statins and Cancer Risk
- (2008) Igor Karp et al. AMERICAN JOURNAL OF MEDICINE
- PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide
- (2008) LiXin Shan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Lipid Bodies Are Reservoirs of Cyclooxygenase-2 and Sites of Prostaglandin-E2 Synthesis in Colon Cancer Cells
- (2008) M. T. Accioly et al. CANCER RESEARCH
- PCSK9 as a therapeutic target of dyslipidemia
- (2008) Nabil G Seidah EXPERT OPINION ON THERAPEUTIC TARGETS
- Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration
- (2008) Ahmed Zaid et al. HEPATOLOGY
- The activation and physiological functions of the proprotein convertases
- (2008) N SEIDAH et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Association between plasma cholesterol and prostate cancer in the PSA era
- (2008) Elizabeth A. Platz et al. INTERNATIONAL JOURNAL OF CANCER
- Genome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9
- (2008) Trine Ranheim et al. JOURNAL OF CELLULAR PHYSIOLOGY
- PCSK9 function and physiology,: Fig. 1.
- (2008) Andrew S. Peterson et al. JOURNAL OF LIPID RESEARCH
- Sorafenib in Liver Cancer — Just the Beginning
- (2008) Lewis R. Roberts NEW ENGLAND JOURNAL OF MEDICINE
- Molecular basis for LDL receptor recognition by PCSK9
- (2008) H. J. Kwon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
- (2008) D.-W. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
- (2008) M. Frank-Kamenetsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised
- (2008) S GILL et al. PROGRESS IN LIPID RESEARCH
- Reduced expression of low-density lipoprotein receptor in hepatocellular carcinoma with paraneoplastic hypercholesterolemia
- (2007) Tetsuro Sohda et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
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