标题
The biology and therapeutic targeting of the proprotein convertases
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 11, Issue 5, Pages 367-383
出版商
Springer Nature
发表日期
2012-04-20
DOI
10.1038/nrd3699
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Small-Molecule Furin Inhibitor Inhibits Cancer Cell Motility and Invasiveness
- (2015) Julia M. Coppola et al. NEOPLASIA
- Proprotein Convertase Inhibition Results in Decreased Ski Proliferation, Tumorigenesis, and Metastasis
- (2015) Daniel E. Bassi et al. NEOPLASIA
- Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice
- (2012) Maxime Denis et al. CIRCULATION
- SKI-1 and Furin Generate Multiple RGMa Fragments that Regulate Axonal Growth
- (2012) Nardos G. Tassew et al. DEVELOPMENTAL CELL
- An Anti-PCSK9 Antibody Reduces LDL-Cholesterol On Top Of A Statin And Suppresses Hepatocyte SREBP-Regulated Genes
- (2012) Liwen Zhang et al. International Journal of Biological Sciences
- Internalization of Proprotein Convertase PC7 from Plasma Membrane Is Mediated by a Novel Motif
- (2012) Jeroen Declercq et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PCSK9 antibody reduces LDL cholesterol
- (2012) Sarah Crunkhorn NATURE REVIEWS DRUG DISCOVERY
- Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol
- (2012) Evan A. Stein et al. NEW ENGLAND JOURNAL OF MEDICINE
- Human Subtilase SKI-1/S1P Is a Master Regulator of the HCV Lifecycle and a Potential Host Cell Target for Developing Indirect-Acting Antiviral Agents
- (2012) Andrea D. Olmstead et al. PLoS Pathogens
- What lies ahead for the proprotein convertases?
- (2011) Nabil G. Seidah Annals of the New York Academy of Sciences
- Circulating Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Regulates VLDLR Protein and Triglyceride Accumulation in Visceral Adipose Tissue
- (2011) Anna Roubtsova et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Clinical aspects of PCSK9
- (2011) Bertrand Cariou et al. ATHEROSCLEROSIS
- Identification of proprotein convertase substrates using genome-wide expression correlation analysis
- (2011) Hannu Turpeinen et al. BMC GENOMICS
- The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease
- (2011) Jonathan Z. Long et al. CHEMICAL REVIEWS
- Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension
- (2011) Kenichiro Kitamura et al. Clinical and Experimental Nephrology
- Rosuvastatin, Proprotein Convertase Subtilisin/Kexin Type 9 Concentrations, and LDL Cholesterol Response: the JUPITER Trial
- (2011) Z. Awan et al. CLINICAL CHEMISTRY
- Novel Loss-of-Function PCSK9 Variant Is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture
- (2011) J. Mayne et al. CLINICAL CHEMISTRY
- Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity
- (2011) J. W. M. Creemers et al. DIABETES
- Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH
- (2011) Paola Lo Surdo et al. EMBO REPORTS
- PCSK9: an emerging target for treatment of hypercholesterolemia
- (2011) Christopher J Duff et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities
- (2011) D. Mesnard et al. GENES & DEVELOPMENT
- Site-1 Protease Is Essential to Growth Plate Maintenance and Is a Critical Regulator of Chondrocyte Hypertrophic Differentiation in Postnatal Mice
- (2011) Debabrata Patra et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proprotein Convertase PC7 Enhances the Activation of the EGF Receptor Pathway through Processing of the EGF Precursor
- (2011) Estelle Rousselet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Latent Transforming Growth Factor β-Binding Proteins-2 and -3 Inhibit the Proprotein Convertase 5/6A
- (2011) Xiaowei Sun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Furin Is the Major Processing Enzyme of the Cardiac-specific Growth Factor Bone Morphogenetic Protein 10
- (2011) Delia Susan-Resiga et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy
- (2011) Chiara Marchesi et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines
- (2011) James D. Wylie et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents
- (2011) Robert J Konrad et al. Lipids in Health and Disease
- Phase I Trial of “bi-shRNAifurin/GMCSF DNA/Autologous Tumor Cell” Vaccine (FANG) in Advanced Cancer
- (2011) Neil Senzer et al. MOLECULAR THERAPY
- PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates
- (2011) Marie W Lindholm et al. MOLECULAR THERAPY
- Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
- (2011) Georg B. Ehret et al. NATURE
- Proprotein Convertases in Health and Disease
- (2011) Andrew W. Artenstein et al. NEW ENGLAND JOURNAL OF MEDICINE
- Computational Reverse-Engineering of a Spider-Venom Derived Peptide Active Against Plasmodium falciparum SUB1
- (2011) Giacomo Bastianelli et al. PLoS One
- A Key Enzyme in the Biogenesis of Lysosomes Is a Protease That Regulates Cholesterol Metabolism
- (2011) K. Marschner et al. SCIENCE
- Cellular therapies supplement: the role of granulocyte macrophage colony-stimulating factor and dendritic cells in regulatory T-cell homeostasis and expansion
- (2011) Tao Zou et al. TRANSFUSION
- Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242
- (2011) Antonella Pasquato et al. VIROLOGY
- Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions
- (2010) Sangwon Byun et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Increased Secretion of Lipoproteins in Transgenic Mice Expressing Human D374Y PCSK9 Under Physiological Genetic Control
- (2010) Bronwen Herbert et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Associations between genetic variations in the FURIN gene and hypertension
- (2010) Nanfang Li et al. BMC Medical Genetics
- The Influence of PCSK9 Polymorphisms on Serum Low-Density Lipoprotein Cholesterol and Risk of Atherosclerosis
- (2010) Jean Davignon et al. Current Atherosclerosis Reports
- Proprotein Convertase Inhibitory Activities of Flavonoids Isolated from Oroxylum Indicum
- (2010) S. Majumdar et al. CURRENT MEDICINAL CHEMISTRY
- Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels
- (2010) Konrad Oexle et al. HUMAN MOLECULAR GENETICS
- PCSK6 is associated with handedness in individuals with dyslexia
- (2010) Thomas S. Scerri et al. HUMAN MOLECULAR GENETICS
- Inhibition of Proprotein Convertase SKI-1 Blocks Transcription of Key Extracellular Matrix Genes Regulating Osteoblastic Mineralization
- (2010) Jeff P. Gorski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake
- (2010) Yan G. Ni et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- In VivoEvidence That Furin from Hepatocytes Inactivates PCSK9
- (2010) Rachid Essalmani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Proprotein Convertase PC7
- (2010) Estelle Rousselet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Angiopoietin-like Protein 3 Inhibits Lipoprotein Lipase Activity through Enhancing Its Cleavage by Proprotein Convertases
- (2010) Jun Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst
- (2010) Daniel Mesnard et al. JOURNAL OF CELL BIOLOGY
- A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo
- (2010) Yan G. Ni et al. JOURNAL OF LIPID RESEARCH
- Antiviral Activity of a Small-Molecule Inhibitor of Arenavirus Glycoprotein Processing by the Cellular Site 1 Protease
- (2010) S. Urata et al. JOURNAL OF VIROLOGY
- Disrupted recycling of the low density lipoprotein receptor by PCSK9 is not mediated by residues of the cytoplasmic domain
- (2010) Thea Bismo Strøm et al. MOLECULAR GENETICS AND METABOLISM
- A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo
- (2010) Nidhi Gupta et al. PLoS One
- Subtilases: The superfamily of subtilisin-like serine proteases
- (2010) Roland J. Siezen et al. PROTEIN SCIENCE
- Commentary PCSK9 variants: A new database
- (2009) Sarah E.A. Leigh et al. ATHEROSCLEROSIS
- In Vivo Bioluminescence Imaging of Furin Activity in Breast Cancer Cells Using Bioluminogenic Substrates
- (2009) Anca Dragulescu-Andrasi et al. BIOCONJUGATE CHEMISTRY
- Comprehensive Whole-Genome and Candidate Gene Analysis for Response to Statin Therapy in the Treating to New Targets (TNT) Cohort
- (2009) John F. Thompson et al. Circulation-Cardiovascular Genetics
- Genetic Variation at the Proprotein Convertase Subtilisin/Kexin Type 5 Gene Modulates High-Density Lipoprotein Cholesterol Levels
- (2009) Iulia Iatan et al. Circulation-Cardiovascular Genetics
- Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal
- (2009) Daniel B Constam CURRENT OPINION IN GENETICS & DEVELOPMENT
- PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
- (2009) Majambu Mbikay et al. FEBS LETTERS
- The role of furin in papillomavirus infection
- (2009) Patricia M Day et al. Future Microbiology
- PCSK9 impedes hepatitis C virus infectionin vitroand modulates liver CD81 expression
- (2009) Patrick Labonté et al. HEPATOLOGY
- Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease
- (2009) Marianne Abifadel et al. HUMAN MUTATION
- Inhibition of Furin/Proprotein Convertase-catalyzed Surface and Intracellular Processing by Small Molecules
- (2009) Tomoko Komiyama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells
- (2009) Markey C. McNutt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation
- (2009) Steve Poirier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic and Metabolic Determinants of Plasma PCSK9 Levels
- (2009) Susan G. Lakoski et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- A new method for measurement of total plasma PCSK9: clinical applications
- (2009) Geneviève Dubuc et al. JOURNAL OF LIPID RESEARCH
- Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics
- (2009) Gero L. Becker et al. JOURNAL OF MEDICINAL CHEMISTRY
- Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis
- (2009) Xin Zhang et al. JOURNAL OF NEUROCHEMISTRY
- The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model
- (2009) Xiaowei Sun et al. Molecular Cancer
- A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9
- (2009) Øystein L. Holla et al. MOLECULAR GENETICS AND METABOLISM
- MEROPS: the peptidase database
- (2009) Neil D. Rawlings et al. NUCLEIC ACIDS RESEARCH
- Obesity-related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Study
- (2009) Eva Corpeleijn et al. Obesity
- A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
- (2009) J. C. Y. Chan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Different Mechanisms of Recognition and ER Retention by Transmembrane Transcription Factors CREB-H and ATF6
- (2009) Marta Llarena et al. TRAFFIC
- Proprotein convertase activation of aggrecanases in cartilage in situ
- (2008) Anne-Marie Malfait et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation
- (2008) Marie-Hélène Blanchet et al. EMBO JOURNAL
- Proprotein convertases as therapeutic targets
- (2008) Michel Chrétien et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- PCSK9 as a therapeutic target of dyslipidemia
- (2008) Nabil G Seidah EXPERT OPINION ON THERAPEUTIC TARGETS
- Knock-out mouse models of proprotein convertases: unique functions or redundancy?
- (2008) John et al. Frontiers in Bioscience-Landmark
- VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5
- (2008) D. Szumska et al. GENES & DEVELOPMENT
- Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7
- (2008) N Scamuffa et al. GUT
- Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration
- (2008) Ahmed Zaid et al. HEPATOLOGY
- Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review
- (2008) Charles Gyamera-Acheampong et al. HUMAN REPRODUCTION UPDATE
- The activation and physiological functions of the proprotein convertases
- (2008) N SEIDAH et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Inhibition of Chikungunya Virus Infection in Cultured Human Muscle Cells by Furin Inhibitors
- (2008) Simona Ozden et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells
- (2008) Nathalie Scamuffa et al. JOURNAL OF CLINICAL INVESTIGATION
- PCSK9: a convertase that coordinates LDL catabolism
- (2008) Jay D. Horton et al. JOURNAL OF LIPID RESEARCH
- Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals
- (2008) J. L. Hawkins et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Synthetic Small-Molecule Prohormone Convertase 2 Inhibitors
- (2008) D. Kowalska et al. MOLECULAR PHARMACOLOGY
- T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
- (2008) Marko Pesu et al. NATURE
- Common nonsynonymous variants in PCSK1 confer risk of obesity
- (2008) Michael Benzinou et al. NATURE GENETICS
- Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: Implications for understanding the “switch” to opiate addiction
- (2008) V. Paez Espinosa et al. NEUROSCIENCE
- Molecular basis for LDL receptor recognition by PCSK9
- (2008) H. J. Kwon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
- (2008) D.-W. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate
- (2008) R. Essalmani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of furin in granular acidification in the endocrine pancreas: Identification of the V-ATPase subunit Ac45 as a candidate substrate
- (2008) E. Louagie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
- (2008) M. Frank-Kamenetsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases
- (2007) Yong Xiao et al. VIROLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now