Proprotein convertase subtilisin/kexin type 9 inhibits hepatitis C virus replication through interacting with NS5A

Direct-acting antivirals: the endgame for hepatitis C?

(2017) Roberta D’Ambrosio et al.   Current Opinion in Virology

The role of PTEN - HCV core interaction in hepatitis C virus replication

(2017) Qi Wu et al.   Scientific Reports

PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs

(2016) Qing Shi et al.   VIROLOGY

Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain

(2016) Steve Poirier et al.   PLoS One

Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)

(2015) Rainer Schulz et al.   BASIC RESEARCH IN CARDIOLOGY

Downregulation of viral RNA translation by hepatitis C virus non-structural protein NS5A requires the poly(U/UC) sequence in the 3′ UTR

(2015) Brett Hoffman et al.   JOURNAL OF GENERAL VIROLOGY

PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: Evidence for genotype-specific regulation of lipoprotein metabolism

(2015) Simon H. Bridge et al.   JOURNAL OF HEPATOLOGY

Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry

(2015) Chorong Park et al.   JOURNAL OF VIROLOGY

The Inhibitory Effects of Anacardic Acid on Hepatitis C Virus Life Cycle

(2015) Jana Hundt et al.   PLoS One

PCSK9: From discovery to therapeutic applications

(2014) Michel Farnier   Archives of Cardiovascular Diseases

PCSK9

(2014) Nabil G. Seidah et al.   CIRCULATION RESEARCH

Targeting the NS5A protein of HCV: An emerging option

(2014) D.G. Cordek et al.   DRUGS OF THE FUTURE

Hepatitis C virus NS5A: enigmatic but still promiscuous 10 years on!

(2014) D. Ross-Thriepland et al.   JOURNAL OF GENERAL VIROLOGY

Natural history of hepatitis C

(2014) Rachel H. Westbrook et al.   JOURNAL OF HEPATOLOGY

HCV Core Residues Critical for Infectivity Are Also Involved in Core-NS5A Complex Formation

(2014) Katarzyna Gawlik et al.   PLoS One

Nonstructural Protein 5A Is Incorporated into Hepatitis C Virus Low-Density Particle through Interaction with Core Protein and Microtubules during Intracellular Transport

(2014) Chao-Kuen Lai et al.   PLoS One

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors

(2014) Sebastian M. Lambert et al.   PROTEIN SCIENCE

Targeting PCSK9 for Hypercholesterolemia

(2013) Giuseppe Danilo Norata et al.   Annual Review of Pharmacology and Toxicology

Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource

(2013) Donald B. Smith et al.   HEPATOLOGY

The Multifaceted Proprotein Convertases: Their Unique, Redundant, Complementary, and Opposite Functions

(2013) Nabil G. Seidah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation

(2013) Tanja Kosenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune Responses to Hepatitis C Virus (HCV) Infection and the Prospects for an Effective HCV Vaccine or Immunotherapies

(2013) Georg M. Lauer   JOURNAL OF INFECTIOUS DISEASES

Hepatitis C Virus Stimulates Low-Density Lipoprotein Receptor Expression To Facilitate Viral Propagation

(2013) G. H. Syed et al.   JOURNAL OF VIROLOGY

The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol

(2013) Gaétan Mayer et al.   Drug Design Development and Therapy

Natural history of acute and chronic hepatitis C

(2012) Benjamin Maasoumy et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Proprotein convertase subtilisin/kexin type 9 inhibition

(2012) David A. Marais et al.   CURRENT OPINION IN LIPIDOLOGY

Correlation between NS5A Dimerization and Hepatitis C Virus Replication

(2012) Precious J. Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of Viral RNA Binding and the Assembly of Infectious Hepatitis C Virus Particles In Vitro by Cyclophilin Inhibitors

(2012) A. Nag et al.   JOURNAL OF VIROLOGY

Novel Loss-of-Function PCSK9 Variant Is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture

(2011) J. Mayne et al.   CLINICAL CHEMISTRY

Role of low-density lipoprotein receptor in the hepatitis C virus life cycle

(2011) Anna Albecka et al.   HEPATOLOGY

Novel Domain Interaction Regulates Secretion of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Protein

(2011) Fen Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Application of a split luciferase complementation assay for the detection of viral protein–protein interactions

(2011) Qiji Deng et al.   JOURNAL OF VIROLOGICAL METHODS

Proprotein convertase subtilisin/kexin type 9 (PCSK9): From structure–function relation to therapeutic inhibition

(2011) G. Tibolla et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

An overview of HCV molecular biology, replication and immune responses

(2011) Usman A Ashfaq et al.   Virology Journal

Hepatitis C Virus Nonstructural Protein 5A: Biochemical Characterization of a Novel Structural Class of RNA-Binding Proteins

(2010) J. Hwang et al.   JOURNAL OF VIROLOGY

Impaired antiviral activity of interferon alpha against hepatitis C virus 2a in Huh-7 cells with a defective Jak-Stat pathway

(2010) Sidhartha Hazari et al.   Virology Journal

Hepatitis B, hepatitis C and HIV transfusion-transmitted infections in the 21st century

(2010) D. M. Dwyre et al.   VOX SANGUINIS

PCSK9 impedes hepatitis C virus infectionin vitroand modulates liver CD81 expression

(2009) Patrick Labonté et al.   HEPATOLOGY

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

(2009) R. A. Love et al.   JOURNAL OF VIROLOGY

Hepatitis C virus hijacks host lipid metabolism

(2009) Gulam H. Syed et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Molecular basis of PCSK9 function

(2008) Gilles Lambert et al.   ATHEROSCLEROSIS

Self-Association of Human PCSK9 Correlates with Its LDLR-Degrading Activity†

(2008) Daping Fan et al.   BIOCHEMISTRY

Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity

(2008) V Romero et al.   CELL DEATH AND DIFFERENTIATION