Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury

Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis

(2019) QiXing Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polydatin mediates Parkin-dependent mitophagy and protects against mitochondria-dependent apoptosis in acute respiratory distress syndrome

(2019) Tao Li et al.   LABORATORY INVESTIGATION

Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis

(2019) Ning-Ping Zhang et al.   LABORATORY INVESTIGATION

α-Mangostin suppresses NLRP3 inflammasome activation via promoting autophagy in LPS-stimulated murine macrophages and protects against CLP-induced sepsis in mice

(2019) Yun Ge et al.   INFLAMMATION RESEARCH

Caspase-11 Mediates Pyroptosis of Tubular Epithelial Cells and Septic Acute Kidney Injury

(2019) Zhiming Ye et al.   KIDNEY & BLOOD PRESSURE RESEARCH

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Involvement of phosphatase and tensin homolog-induced putative kinase 1–Parkin-mediated mitophagy in septic acute kidney injury

(2019) Xin-Gui Dai et al.   CHINESE MEDICAL JOURNAL

PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury

(2018) Chengyuan Tang et al.   Autophagy

Mitophagy Contributes to the Pathogenesis of Inflammatory Diseases

(2018) Yan Zhao et al.   INFLAMMATION

Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation

(2018) Tao-Tao Tang et al.   Cell Death & Disease

A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma

(2018) Zhi-qiang Yao et al.   Cell Death & Disease

PINK1/Parkin-Mediated Mitophagy Promotes Resistance to Sonodynamic Therapy

(2018) Lin Song et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

(2018) Anthea Di Rita et al.   Nature Communications

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

(2018) Jaye M. Platnich et al.   Cell Reports

Pink1/Parkin-mediated mitophagy play a protective role in cisplatin induced renal tubular epithelial cells injury

(2017) Chuanyan Zhao et al.   EXPERIMENTAL CELL RESEARCH

Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 pathway

(2017) Lvyi Chen et al.   Food & Function

Mitophagy: a balance regulator of NLRP3 inflammasome activation

(2016) Min-Ji Kim et al.   BMB Reports

Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury

(2016) Youguang Gao et al.   Molecular Medicine Reports

Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial DysfunctionviaSIRT1 Activation and p53 Deacetylation

(2016) Zhenhua Zeng et al.   Oxidative Medicine and Cellular Longevity

Hyperin protects against LPS-induced acute kidney injury by inhibiting TLR4 and NLRP3 signaling pathways

(2016) Gong Chunzhi et al.   Oncotarget

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages

(2016) Qing-Bing Zha et al.   Frontiers in Immunology

Loss of Sirt1 Promotes Prostatic Intraepithelial Neoplasia, Reduces Mitophagy, and Delays Park2 Translocation to Mitochondria

(2015) Gabriele Di Sante et al.   AMERICAN JOURNAL OF PATHOLOGY

Polydatin Inhibits Mitochondrial Dysfunction in the Renal Tubular Epithelial Cells of a Rat Model of Sepsis-Induced Acute Kidney Injury

(2015) Youguang Gao et al.   ANESTHESIA AND ANALGESIA

Polydatin: a new therapeutic agent against multiorgan dysfunction

(2015) Zhenhua Zeng et al.   JOURNAL OF SURGICAL RESEARCH

Sepsis-Associated AKI: Epithelial Cell Dysfunction

(2015) David R. Emlet et al.   SEMINARS IN NEPHROLOGY

Mitophagy mechanisms and role in human diseases

(2014) Matthew Redmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Renoprotective effect of red ginseng in gentamicin-induced acute kidney injury

(2014) Hyun-Soo Shin et al.   LABORATORY INVESTIGATION

Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN

(2014) Somak Das et al.   Oxidative Medicine and Cellular Longevity

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY